src Homology DomainsTyrosinePoint MutationMutation, MissenseMutationSequence Homology, Amino AcidMolecular Sequence DataProtein Tyrosine PhosphatasesAmino Acid SequencePhosphorylationBase SequenceProtein BindingSignal TransductionProtein Tyrosine Phosphatase, Non-Receptor Type 11Adaptor Proteins, Signal TransducingPhosphotyrosineProtein Tyrosine Phosphatase, Non-Receptor Type 6Binding SitesCloning, MolecularRecombinant Fusion Proteinssrc-Family KinasesCell LinePhosphoproteinsMutagenesis, Site-DirectedFrameshift MutationSequence AlignmentProto-Oncogene Proteins pp60(c-src)Intracellular Signaling Peptides and ProteinsTransfectionRecombinant ProteinsAmino Acid SubstitutionSequence Homology, Nucleic AcidProtein Structure, TertiaryTyrosine 3-MonooxygenaseGRB2 Adaptor ProteinProtein-Tyrosine KinasesModels, MolecularProto-Oncogene ProteinsSH2 Domain-Containing Protein Tyrosine PhosphatasesCarrier ProteinsEnzyme ActivationProtein ConformationAmino Acid MotifsGerm-Line MutationMembrane ProteinsDNA-Binding ProteinsProteinsProto-Oncogene Proteins c-fynDNA PrimersMutagenesisDNA, ComplementarySequence DeletionEscherichia coliKineticsPolymerase Chain ReactionStructure-Activity RelationshipCells, CulturedPedigreeExonsProtein Interaction Domains and MotifsProtein Structure, SecondaryPhospholipase C gammaDNA Mutational AnalysisDNAReceptor Protein-Tyrosine KinasesTranscription FactorsLymphocyte Specific Protein Tyrosine Kinase p56(lck)Precipitin TestsProto-Oncogene Proteins c-ablCOS CellsConserved Sequence3T3 CellsPlasmidsGenes, srcShc Signaling Adaptor ProteinsSequence Analysis, DNAProto-Oncogene Proteins c-crkRNA, MessengerBacterial ProteinsProlineReceptor, Epidermal Growth FactorCell MembraneGlutathione TransferasePeptide FragmentsOncogene Protein pp60(v-src)LigandsNuclear ProteinsBlotting, WesternCrystallography, X-RayTranscription, GeneticPhosphatidylinositol 3-KinasesMutation RateDimerizationAllelesProtein TransportSaccharomyces cerevisiaeHeterozygotePhenotypePhosphoric Monoester HydrolasesTwo-Hybrid System Techniques