Protein StabilityPoint MutationMutation, MissenseMutationEnzyme StabilityDrug StabilityProtein DenaturationFrameshift MutationMolecular Sequence DataProtein FoldingThermodynamicsModels, MolecularAmino Acid SequenceAmino Acid SubstitutionGerm-Line MutationProtein Structure, TertiaryMutagenesis, Site-DirectedBase SequenceProtein ConformationProteinsProtein BindingRNA StabilityPedigreeTemperatureProtein Structure, SecondaryCell LineMutation RateCircular DichroismUbiquitinationEscherichia coliProteasome Endopeptidase ComplexDNA Mutational AnalysisProteolysisBinding SitesPolymerase Chain ReactionMutagenesisExonsHeterozygoteAllelesUbiquitinDNA-Binding ProteinsProtein EngineeringKineticsMutant ProteinsTranscription FactorsRNA, MessengerGuanidineSequence Homology, Amino AcidSequence DeletionDNA PrimersUbiquitin-Protein LigasesRecombinant ProteinsBacterial ProteinsNuclear ProteinsStructure-Activity RelationshipSequence AlignmentTranscription, GeneticPolymorphism, Single-Stranded ConformationalPhenotypeHEK293 CellsProtein UnfoldingTransfectionPlasmidsPhosphorylationGenotypeProtein Processing, Post-TranslationalSequence Analysis, DNAHot TemperatureSaccharomyces cerevisiaeSignal TransductionCodon, NonsenseDNAHomozygoteMembrane ProteinsRecombinant Fusion ProteinsCell Line, TumorCOS CellsAmino Acid MotifsCalorimetry, Differential ScanningTumor Suppressor Protein p53Carrier ProteinsGene Expression RegulationCloning, MolecularGene DeletionHydrogen BondingHalf-LifeGenes, RecessiveHydrogen-Ion ConcentrationModels, BiologicalUreaGenetic Complementation TestTransition TemperatureHeLa CellsGenes, DominantMuramidaseCrystallography, X-RayPromoter Regions, GeneticModels, ChemicalStatic ElectricitySolvents