Point MutationMutation, MissenseMutationras ProteinsFrameshift MutationGerm-Line MutationProto-Oncogene Proteins B-rafDNA Mutational AnalysisMutation RatePedigreeProto-Oncogene ProteinsExonsBase SequencePolymerase Chain ReactionAmino Acid SubstitutionHeterozygoteGenes, rasAllelesMolecular Sequence DataColorectal NeoplasmsGenotypePolymorphism, Single-Stranded ConformationalProto-Oncogene Proteins p21(ras)Sequence Analysis, DNAMutagenesis, Site-DirectedAmino Acid SequenceCodon, NonsenseHomozygoteMutagenesisCodonGenetic TestingGenes, RecessivePhenotypeDNA PrimersSequence DeletionReceptor, Epidermal Growth FactorGenes, DominantProtein Structure, TertiaryEscherichia coliSuppression, GeneticModels, MolecularCell LineChromosome MappingDNA-Binding ProteinsBinding SitesGenes, p53DNA, NeoplasmLung NeoplasmsGene DeletionTranscription FactorsSequence Homology, Amino AcidGenetic Complementation TestGenetic Predisposition to DiseaseMutant ProteinsDNAAdenocarcinomaMicrosatellite InstabilityFounder EffectSignal TransductionSyndromeProtein BindingCloning, MolecularMembrane ProteinsSequence AlignmentGenetic LinkageNuclear ProteinsCell Line, TumorCarcinoma, Pancreatic DuctalModels, GeneticSaccharomyces cerevisiaePlasmidsTransfectionConsanguinityBacterial ProteinsPromoter Regions, GeneticPolymorphism, GeneticTranscription, GeneticGenes, LethalGene FrequencyMicrosatellite RepeatsHeterozygote DetectionExomeDNA, MitochondrialRNA, MessengerGenes, erbB-1Genetic VariationGenes, BRCA1Mutagenesis, InsertionalTumor Suppressor Protein p53Family HealthCarrier ProteinsPancreatic NeoplasmsNoonan SyndromeGene Expression Regulation, NeoplasticCell Transformation, NeoplasticIntronsGenes, BacterialProtein ConformationMice, TransgenicAntibodies, Monoclonal, Humanized