Point MutationMutation, MissenseMutationBreast NeoplasmsGene Expression Regulation, NeoplasticCell Line, TumorFrameshift MutationTumor Cells, CulturedGerm-Line MutationApoptosisColonic NeoplasmsCell ProliferationAntineoplastic AgentsMice, NudeOvarian NeoplasmsNeoplasm InvasivenessLung NeoplasmsNeoplasmsBase SequenceDrug Resistance, NeoplasmRNA, MessengerNeoplasm ProteinsPancreatic NeoplasmsReverse Transcriptase Polymerase Chain ReactionPedigreeRNA, Small InterferingEarly Detection of CancerBlotting, WesternNeoplasm MetastasisSignal TransductionMolecular Sequence DataCell SurvivalStomach NeoplasmsTransfectionXenograft Model Antitumor AssaysCell DivisionExonsDrug Screening Assays, AntitumorCell CycleCell MovementPolymerase Chain ReactionDown-RegulationPromoter Regions, GeneticTumor Suppressor Protein p53Mutation RateDNA Mutational AnalysisHeterozygoteDNA, NeoplasmAllelesGenotypeDNA-Binding ProteinsColorectal NeoplasmsTranscription FactorsNeoplasm TransplantationRNA InterferenceAmino Acid SequenceCell LineAmino Acid SubstitutionGene Expression ProfilingHCT116 CellsDNA PrimersPhenotypeGenetic Predisposition to DiseaseAdenocarcinomaPhosphorylationProstatic NeoplasmsMCF-7 CellsTransplantation, HeterologousCarcinomaCell Transformation, NeoplasticCell Growth ProcessesPolymorphism, Single-Stranded ConformationalHT29 CellsAntineoplastic Agents, PhytogenicTranscription, GeneticGenes, p53Gene SilencingProtein BindingCarcinoma, Non-Small-Cell LungDose-Response Relationship, DrugTumor Markers, BiologicalProto-Oncogene ProteinsUp-RegulationReceptors, EstrogenDisease ProgressionNuclear ProteinsUrinary Bladder NeoplasmsReceptor, erbB-2Membrane ProteinsReceptor, Epidermal Growth FactorSequence Analysis, DNAGene ExpressionGene Knockdown TechniquesImmunohistochemistryMutagenesis, Site-DirectedTumor Suppressor ProteinsPrognosisHomozygoteGenetic TestingProto-Oncogene Proteins c-akt