• Methylmalonyl-CoA mutase (EC 5.4.99.2) catalyzes a reversible isomerization between L-methylmalonyl-CoA and succinyl-CoA. (nih.gov)
  • The most similar archaeal sequences are separate chains, such as AF2215 and AF2219 of Archaeoglobus fulgidus, that correspond roughly to the first 500 and last 130 residues, respectively of known methylmalonyl-CoA mutases. (nih.gov)
  • Vitamin B12 functions as a cofactor for two enzymes, methionine synthase and L-methylmalonyl-CoA mutase [ 1-3 , 5 ]. (nih.gov)
  • L-methylmalonyl-CoA mutase converts L-methylmalonyl-CoA to succinyl-CoA in the metabolism of propionate, a short-chain fatty acid [ 2 ]. (nih.gov)
  • Clb is a cofactor for only 2 enzymes in mammals, methionine synthase and L-methylmalonyl-CoA mutase. (medscape.com)
  • Methyl-Clb is the cofactor for methionine synthase, and 5'-deoxyladenosyl-Clb is the cofactor for L-methylmalonyl-CoA mutase. (medscape.com)
  • L-methylmalonyl-CoA mutase requires cofactor 5-deoxyadenosylcobalamin and catalyzes the conversion of L-methylmalonyl-CoA to succinyl-CoA, a key component of the tricarboxylic acid cycle. (medscape.com)
  • Vitamin B12 (B12) is an essential cofactor for two enzymes involved in one-carbon metabolism: methylmalonyl CoA mutase (reduced function of this enzyme results in increased serum methylmalonic acid (MMA) levels) and methionine synthetase (this enzyme catalyzes the remethylmation of homocysteine to methionine) (IOM 1998). (cdc.gov)
  • Well known examples include the reduction of an alcohol to an alkane catalyzed by ribonucleotide reductase or carbon chain rearrangements catalyzed by methylmalonyl CoA mutase or glutamate mutase. (hawaii.edu)
  • Animal and prokaryotic methylmalonyl-CoA mutase (EC 5.4.99.2 ). (expasy.org)
  • How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 A resolution. (expasy.org)
  • L-methylmalonyl-CoA mutase converts L-methylmalonyl-CoA to succinyl-CoA in the degradation of propionate an essential biochemical reaction in fat and protein metabolism. (plants-extracts.com)
  • methylmalonyl CoA mutase. (oftalmic.ru)
  • This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. (oftalmic.ru)
  • In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. (oftalmic.ru)
  • The methylmalonyl coenzyme A mutase (MUT) catalyzes the isomerization of L-methyl-malonyl-CoA in succinyl-CoA, a key molecule in the tricarboxylic acid cycle, essential for ATP generation, ketone bodies metabolism, myelinization, and heme biosynthesis. (mjhid.org)
  • Organic radicals are used by a number of enzymes to catalyze biochemical transformations with high-energy barriers that would be difficult to accomplish through non-radical heterolytic chemistry. (hawaii.edu)
  • Enzymes that catalyze the reduction of AdoMet all contain a [4Fe-4S] cluster that interacts covalently with the methionyl portion of AdoMet. (hawaii.edu)
  • Enzymes that require adenosylcobalamin catalyze reactions in which the first step is the cleavage of adenosylcobalamin to form cob(II)alamin and the 5'-deoxyadenosyl radical and thus act as radical generators. (expasy.org)
  • The general name mu- tase is given to enzymes that catalyze the transfer of a functional group from one position to another in the same molecule. (binaryoptionstradinglist.com)
  • Mutases are enzymes that facilitate the movement of part of a molecule from one place to another on the same molecule. (cdghub.com)
  • Prokaryotic glutamate mutase (EC 5.4.99.1 ). (expasy.org)
  • Glucose 6-phosphate isomerase catalyzes the interconversion of glucose 6-phosphate and fructose 6-phosphate. (allanimalsguide.com)
  • The third step is the phosphorylation of fructose-6-phosphate, catalyzed by the enzyme phosphofructokinase. (unizin.org)
  • BACKGROUND AND AIMS: ATP-dependent phosphofructokinases (PFKs) catalyse phosphorylation of the carbon-1 position of fructose-6-phosphate, to form fructose-1,6-bisphosphate. (bvsalud.org)
  • Phosphofructokinase is the enzyme that catalyzes the conversion of fructose-6-phosphate andATP to fructose 16-bisphosphate and ADP. (allanimalsguide.com)
  • Methionine synthase catalyzes the conversion of homocysteine to the essential amino acid methionine [ 1 , 2 ]. (nih.gov)
  • It catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. (expasy.org)
  • Methionine synthase catalyzes the conversion of homocysteine to methionine. (plants-extracts.com)
  • The methionine-synthase catalyzes the conversion of methyl-tetrahydrofolate (methyl-THF) and homocysteine (Hcy) into THF and methionine, a basilar step toward DNA synthesis. (mjhid.org)
  • A Hidden B12 Cofactor Catalyzes a Radical Methylation. (hawaii.edu)
  • Oxalacetate acetylhydrolase (OAH), a member of the phosphoenolpyruvate mutase/isocitrate lyase superfamily, catalyzes the hydrolysis of oxalacetate to oxalic acid and acetate. (rcsb.org)
  • Enolase catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. (allanimalsguide.com)
  • Pyruvate kinase catalyzes the conversion of phosphoenolpyruvate to pyruvate. (allanimalsguide.com)
  • In a neighbor-joining tree (methylaspartate mutase S chain as the outgroup), AF2219 branches with a coenzyme B12-dependent enzyme known not to be 5.4.99.2. (nih.gov)
  • In the seventh step, catalyzed by phosphoglycerate kinase (an enzyme named for the reverse reaction), 1,3-bisphosphoglycerate donates a high-energy phosphate to ADP, forming one molecule of ATP. (cloudaccess.net)
  • Glyceraldehyde 3-phosphate dehydrogenase is the enzyme that catalyzes the conversion of glyceraldehyde 3-phosphate to 13-bisphosphoglycerate. (allanimalsguide.com)
  • Phosphoglycerate kinase catalyzes the conversion of 13-bisphosphoglycerate to 3-phosphoglycerate. (allanimalsguide.com)
  • Such cases exist: for example, a mutase such as phosphoglucomutase catalyses the transfer of a phospho group from one position to another, and isomerase is a more general term for an enzyme that catalyses any one-substrate one-product reaction, such as triosephosphate isomerase . (wikipedia.org)
  • The PMM2 gene encodes a mutase enzyme, phosphomannomutase 2 (PMM2). (cdghub.com)
  • Chorismate mutase catalyzes the Claisen rearrangement of chorismate to prephenate and provides a simple test for modeling an enzyme-catalyzed reaction. (openmopac.net)
  • The first step in glycolysis ( (Figure) ) is catalyzed by hexokinase, an enzyme with broad specificity that catalyzes the phosphorylation of six-carbon sugars. (unizin.org)
  • An enzyme that catalyzes the conversion of prephenate to p-hydroxyphenylpyruvate in the presence of NAD . (nih.gov)
  • This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. (anticorps-enligne.fr)
  • The enzyme catalyzes an essential step in pyrimidine synthesis, the condensation of aspartate and carbamoyl phosphate to produce carbamoyl aspartate. (jove.com)
  • abstract = "Phosphoacetylglucosamine mutase (EC 2.7.5.2) catalyzes the interconversion of N-acetylglucosamine-1-phosphate and of N-acetylglucosamine-6-phosphate. (nebraska.edu)
  • Acidic amino acids are not catalyze by DAOO. (smpdb.ca)
  • An isomerase is an enzyme that catalyzes the conversion of a molecule into one of its isomers. (unizin.org)
  • Triose phosphate isomerase catalyzes the interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. (allanimalsguide.com)
  • Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to N-carbamoyl-L-aspartate. (jove.com)
  • It consists of ten enzyme-catalyzed reactions that can be divided into two phases: an energy-investing phase and an energy-harvesting phase. (stemcelldaily.com)
  • The equation shows that one molecule of glucose (a six-carbon sugar) is converted into two molecules of pyruvate (a three-carbon compound) by a series of enzyme-catalyzed reactions. (stemcelldaily.com)
  • Growth on CO requires the enzyme carbon monoxide dehydrogenase (CODH) that catalyzes the reversible conversion between CO and CO 2 . (hindawi.com)
  • reaction catalyzed by pyruvate carboxylase. (rahulgladwin.com)
  • The pulse of acetogenesis appears to have been collectively catalyzed by a number of different organisms and metabolisms, most prominently pyruvate:ferredoxin oxidoreductase. (frontiersin.org)
  • In the enteric bacteria, this enzyme also possesses chorismate mutase activity, thereby catalyzing the first two steps in the biosynthesis of tyrosine. (nih.gov)
  • It can also catalyze the reaction of EC 5.4.2.1 (mutase) and EC 3.1.3.13 (phosphatase), but with a reduced activity. (avivasysbio.com)
  • UTP and CTP, the end products of the pyrimidine synthesis pathway, inhibit the activity of ATCase, the enzyme that catalyzes the first essential step of this pathway. (jove.com)
  • Aldolase catalyzes the conversion of fructose 16-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. (allanimalsguide.com)
  • Glucose-1,6-diphosphate activates this mutase through the formation of N-acetylglucosamine-1,6-diphosphate and glucose-6-phosphate. (nebraska.edu)
  • The enzyme that catalyzes this step in the reaction contains iron-sulfur clusters and is an AdoMet-dependent radical enzyme. (hawaii.edu)
  • Other names in common use include 3-hydroxylaminophenol mutase, and 3HAP mutase. (wikipedia.org)
  • In enzymology, a 3-(hydroxyamino)phenol mutase (EC 5.4.4.3) is an enzyme that catalyzes the chemical reaction 3-hydroxyaminophenol ⇌ {\displaystyle \rightleftharpoons } aminohydroquinone Hence, this enzyme has one substrate, 3-hydroxyaminophenol, and one product, aminohydroquinone. (wikipedia.org)