Mutants with enhanced disease susceptibility pathogen disease susceptibility. Medical search. Frequent questions

In this study we explored the involvement of the five Arabidopsis thaliana At-MMPs in plant defence against microbial pathogens. (figshare.com)
Consistent with this, transgenic Arabidopsis plants that expressed At2-MMP constitutively under the Cauliflower mosaic virus 35S promoter showed enhanced resistance to the necrotrophic pathogen. (figshare.com)
Similarly, resistance to the biotrophic Arabidopsis powdery mildew fungus Golovinomyces orontii was also compromised particularly in the at2 , 3-mmp / at2 , 3 , 5-mmp multiplex mutants, and increased in At2- MMP overexpressor plants. (figshare.com)
The degree of disease resistance of at-mmp mutants and At2- MMP overexpressor plants also correlated positively with the degree of MAMP-triggered callose deposition in response to the bacterial flagellin peptide flg22, suggesting that matrix metalloproteinases contribute to pattern-triggered immunity (PTI) in interactions of Arabidopsis with necrotrophic and biotrophic pathogens. (figshare.com)
Arabidopsis jaz2 mutants are partially impaired in pathogen-induced stomatal closing and more susceptible to Pseudomonas. (nih.gov)
To determine whether DDRs induce plant resistance to pathogens, Arabidopsis plants were treated with bleomycin, a DNA damage-inducing agent, and the replication levels of viral pathogens and growth of bacterial pathogens were determined. (ppjonline.org)
Further, the scientists observed a reduced disease susceptibility in Arabidopsis plants in which Ago1 was mutated following B. cinerea inoculation versus wild-type plants, while a B. cinerea mutant that cannot produce the sRNAs under investigation showed reduced pathogenicity on both Arabidopsis and tomato. (genomeweb.com)
Wild type accessions of Arabidopsis (Col-0, Nd-1 and Ws-3) were compared with phytoalexin-deficient mutants (Col-pad1, -pad2, -pad3 and -pad4) and the enhanced disease susceptibility mutant Ws-eds1 for camalexin accumulation following inoculation with virulent or avirulent isolates of Hyaloperonospora parasitica (downy mildew), or treatment with the abiotic elicitor AgNO3. (comu.edu.tr)
CEP peptide was synthesized and tested for induction of disease susceptibility using Arabidopsis Col-0. (elsevierpure.com)
Notably, such induced susceptibility was also evident on Arabidopsis mutants lacking the previously identified receptors, suggesting that the CEP peptide modulates Arabidopsis immunity through an unidentified receptor(s). (elsevierpure.com)

Loss-of-function mutants for all tested At-MMPs displayed increased susceptibility to the necrotrophic fungus Botrytis cinerea and double mutant at2 , 3-mmp and triple mutant at2 , 3 , 5-mmp plants developed even stronger symptoms. (figshare.com)

In a matched case-control study, we studied the effect phenomenon by using individual patient-level data, i.e., of prior receipt of fluoroquinolones on isolation of three whether fluoroquinolone use, in addition to lowering the third-generation cephalosporin-resistant gram-negative likelihood of emergence of resistance in an individual nosocomial pathogens. (cdc.gov)
We found that the COR and jasmonate isoleucine (JA-Ile) co-receptor JAZ2 is constitutively expressed in guard cells and modulates stomatal dynamics during bacterial invasion We analyzed tissue expression patterns of AtJAZ genes and measured stomata opening and pathogen resistance in loss- and gain-of-function mutants. (nih.gov)
Due to the antagonistic interactions between the salicylic acid (SA) and JA defense pathways, efforts to increase resistance to biotrophs result in enhanced susceptibility to necrotrophs, and vice versa. (nih.gov)
Remarkably, dominant jaz2Δjas mutants are resistant to Pseudomonas syringae but retain unaltered resistance against necrotrophs. (nih.gov)
Receptor-like kinases are well-known to play key roles in disease resistance. (biomedcentral.com)
Among them, the Wall-associated kinases (WAKs) have been shown to be positive regulators of fungal disease resistance in several plant species. (biomedcentral.com)
Here we show using rice ( Oryza sativa ) loss-of-function mutants of four selected OsWAK genes, that individual OsWAKs are required for quantitative resistance to the rice blast fungus, Magnaporthe oryz ae. (biomedcentral.com)
This work also shows that some OsWAKs , like OsWAK112d , may act as negative regulators of disease resistance. (biomedcentral.com)
Plant disease resistance protects plants from pathogens in two ways: by pre-formed structures and chemicals, and by infection-induced responses of the immune system. (wikipedia.org)
Relative to a susceptible plant, disease resistance is the reduction of pathogen growth on or in the plant (and hence a reduction of disease), while the term disease tolerance describes plants that exhibit little disease damage despite substantial pathogen levels. (wikipedia.org)
Although obvious qualitative differences in disease resistance can be observed when multiple specimens are compared (allowing classification as "resistant" or "susceptible" after infection by the same pathogen strain at similar inoculum levels in similar environments), a gradation of quantitative differences in disease resistance is more typically observed between plant strains or genotypes. (wikipedia.org)
resistance is usually specific to certain pathogen species or pathogen strains. (wikipedia.org)
Plant disease resistance is crucial to the reliable production of food, and it provides significant reductions in agricultural use of land, water, fuel and other inputs. (wikipedia.org)
Plants in both natural and cultivated populations carry inherent disease resistance, but this has not always protected them. (wikipedia.org)
Disease control is achieved by use of plants that have been bred for good resistance to many diseases, and by plant cultivation approaches such as crop rotation, pathogen-free seed, appropriate planting date and plant density, control of field moisture, and pesticide use. (wikipedia.org)
We observed that DDR-mediated resistance was specifically activated against viral pathogens, including turnip crinkle virus (TCV). (ppjonline.org)
Knowledge of these intrinsic resistance determinants provides alternative targets for compounds that may potentiate the efficacy of existing antimicrobial agents against this important pathogen. (frontiersin.org)
The combined results suggest that camalexin biosynthesis is most likely a consequence of disease caused by H. parasitica, and does not therefore confer resistance to primary infection by this parasite. (comu.edu.tr)
Blast disease assay identified that the mutants of FLR1 and FLR13 showed increased susceptibility, whereas the mutants of FLR2 and FLR11 displayed enhanced resistance. (biomedcentral.com)
Together, these data indicate that at least 4 FLR genes are involved in rice- M. oryzae interaction and thus are potentially valuable in blast disease resistance. (biomedcentral.com)
Occasionally, the perturbations caused by these effectors trigger innate immunity via plant disease resistance proteins as described by the "guard hypothesis. (ox.ac.uk)
They can modulate various biochemical and physiological processes, including plant response and resistance to fungal pathogens, by regulating the expression of numerous genes. (researchsquare.com)
Book entitled "Foodborne Pathogens and Antibiotic Resistance" Edited by Dr. Singh, Published by Wiley Blackwell, John Wiley and Sons, Inc. (umd.edu)
RNL activation drives cytoplasmic Ca 2+ influx, transcriptional reprogramming, pathogen resistance, and host cell death. (nsf.gov)
Current research in the Grumet lab focuses on fruit development and disease resistance in Cucumis (cucumber and melon) crops using a combination of molecular genetic, genomic and transgenic approaches. (msu.edu)
We are especially interested in early stages of fruit growth and factors influencing fruit size, shape, cuticle and surface properties and resistance to infection by the oomycete pathogen, Phytophthora capsici . (msu.edu)
R. Grumet is also the lead PI for the USDA-SCRI CucCAP project: CucCAP: Leveraging applied genomics to increase disease resistance in cucurbit crops ( https://cuccap.org/ ). (msu.edu)
The CucCAP project: leveraging applied genomics to improve disease resistance in cucurbit crops. (msu.edu)

Finally, we show that OsWAK91 is required for H 2 O 2 production and sufficient to enhance defense gene expression during infection. (biomedcentral.com)
Although the plants showed normal morphology and development in the absence of pathogen challenge, even though the target genes were suppressed, all three displayed "enhanced susceptibility" to infection upon introduction of B. cinerea . (genomeweb.com)
Sánchez EG, Riera E, Nogal M, Gallardo C, Fernández P, Bello-Morales R, López-Guerrero JA, Chitko-McKown CG, Richt JA, Revilla Y. Phenotyping and susceptibility of established porcine cells lines to African Swine Fever Virus infection and viral production. (k-state.edu)
Consistently, the mutant of FLR1 enhanced, but the mutant of FLR2 delayed the M. oryzae infection progress, which might be associated with the altered expression of defense-related genes. (biomedcentral.com)
We report that CC strains vary dramatically in their susceptibility to infection and produce qualitatively distinct immune states. (elifesciences.org)
Short-term starvation (STS) positively influenced the survival of mutant flies following Gram-negative bacterial infection. (bioinbrief.com)
RNL mutants that cannot sustain this pattern of gene expression are unable to prevent disease spread beyond localized infection sites, suggesting that this pattern corresponds to a pathogen containment mechanism. (nsf.gov)
These are accompanied by increased gut permeability, which, together, are likely contributors to local and systemic tissue degeneration and increased susceptibility to infection with ageing. (biomedcentral.com)

Detection of pathogen through PRRs triggers PAMP-triggered immunity (PTI, also called basal defense) which is accompanied with rapid production of reactive oxygen species (ROS), activation of mitogen-activated protein kinases (MAPKs) and changes in expression of immune-related genes [ 2 ]. (biomedcentral.com)
The majority of the identified genes have not previously been associated with antimicrobial susceptibility in S. aureus . (frontiersin.org)
In other bacterial pathogens, genes important for pathogenicity and host range include secreted protein effectors that suppress host immunity, alter host metabolism, and enable colonization, providing a fitness advantage. (biorxiv.org)
Genetic and molecular analyses have led to the identification, cloning and characterization of a few genes that contribute to parasitic fitness in the pathogens. (sisef.it)

University of California, Riverside researchers this month reported the discovery that a fungal pathogen known to infect a wide variety of vegetable and fruit crops is capable of hijacking a plant's RNA interference pathway to suppress host immunity, thereby enhancing its virulence. (genomeweb.com)
When a pathogenic microbe colonizes on the plant surface, the cell membrane-localized RLKs are employed to specifically recognize the cognate pathogen-associated molecular pattern (PAMP) via their extracellular domains to activate an innate immunity, termed PAMP-triggered immunity (PTI). (biomedcentral.com)
The first layer of immunity, known as pathogen-associated molecular pattern- (PAMP-) triggered immunity (PTI), is activated following recognition of the fungal pattern molecule chitin, by four lysin motif- (LysM-) containing protein (LYP) receptors, i.e., chitin elicitor binding protein (CEBiP), chitin elicitor receptor kinase (CERK1), LYP4 and LYP6 (Shimizu et al. (biomedcentral.com)
We leveraged the genetically diverse Collaborative Cross (CC) mouse panel in conjunction with a library of Mtb mutants to create a resource for associating bacterial genetic requirements with host genetics and immunity. (elifesciences.org)
3]. This pathway offers been proven to have impressive similarities with those found in immunity and makes the fruit fly a robust genetically tractable model organism for the analysis of the 1st line sponsor defence to disease [reviewed in 4]. (bioinbrief.com)
Innate immunity is considered the first line of defense against microbial invasion, and its dysregulation can increase the susceptibility of hosts to infections by invading pathogens. (mdpi.com)
Our data show that limiting levels of telomerase lead to alterations in gut immunity, impacting on the ability to clear pathogens in vivo. (biomedcentral.com)

ETI is typically activated by the presence of specific pathogen "effectors" and then triggers strong antimicrobial responses (see R gene section below). (wikipedia.org)
Sixty-eight mutants were confirmed by E -test to display at least twofold increased susceptibility to one or more antimicrobial agents. (frontiersin.org)
Clinical use of potentiators have been applied successfully to the antimicrobial class of β-lactams, where β-lactamase inhibitors can significantly enhance the efficacy of β-lactams ( Drawz and Bonomo, 2010 ). (frontiersin.org)
This review paper will focus on the plant-derived products as antimicrobial agents for use in food preservation and to control foodborne pathogens in foods. (hindawi.com)
Rapid antimicrobial susceptibility testing of clinical isolates by digital time-lapse microscopy. (cdc.gov)
This project aims to achieve a paradigm shift in antimicrobial drug discovery by finding next generation anti-infectives that prevent disease by blocking pathogen adaptation to host physiology. (nih.gov)

Expression of At2-MMP was most responsive to inoculation with fungi and a bacterial pathogen followed by At3-MMP and At5-MMP , while At1-MMP and At4-MMP were non-responsive to these biotic stresses. (figshare.com)
Streptococcus pyogenes is a major human-specific bacterial pathogen that causes a wide array of manifestations ranging from mild localized infections to life-threatening invasive infections. (nih.gov)
Similarly, the CEP peptide-mediated disease susceptibility was also effective to a non-adapted bacterial pathogen. (elsevierpure.com)

To date, small RNAs have been identified in various fungi and oomycetes, but data has been inconclusive as to whether they regulate host-pathogen interaction. (genomeweb.com)
Both immunological and bacterial traits can be associated with genetic variants distributed across the mouse genome, making the CC a unique population for identifying specific host-pathogen genetic interactions that influence pathogenesis. (elifesciences.org)

During my 25+ year scientific career, I have studied pathogen-host interactions in various infectious disease models including Avian and Swine Influenza viruses (AIV, SIV), African Swine Fever virus (ASFV), Rift Valley Fever virus (RVFV), Vesicular Stomatitis virus (VSV), Schmallenberg virus (SBV), animal prion diseases and Borna Disease Virus (BDV). (k-state.edu)
Current models of plant-pathogen interactions stipulate that pathogens secrete effector proteins that disable plant defense components known as virulence targets. (ox.ac.uk)
During the last decades, the development of ever more powerful genetic, molecular and omic approaches has provided plant pathologists with a wide array of experimental tools for elucidating the intricacies of plant-pathogen interactions and proposing new control strategies. (sisef.it)

Apoplastic effectors secreted by two unrelated eukaryotic plant pathogens target the tomato defense protease Rcr3. (ox.ac.uk)
Considering that virulence targets are important components of defense, different effectors from unrelated pathogens are expected to evolve to disable the same host target. (ox.ac.uk)
In conclusion, our findings fulfill a key prediction of the guard hypothesis and suggest that the effectors Avr2, EPIC1, and EPIC2B secreted by two unrelated pathogens of tomato target the same defense protease Rcr3(pim). (ox.ac.uk)
Finally, SpaFED pili are clearly important effectors since an L. rhamnosus ΔspaF mutant failed to provide the same benefits as the wild type strain. (nature.com)
Successful pathogens can counteract the plant basal immune response by deploying the effectors into the cytoplasm of plant cells to attenuate defence. (researchsquare.com)

Two hundred eighty-two cases with patient, also results in reduced initial isolation of resistant a third-generation cephalosporin-resistant pathogen (203 strains in a given population. (cdc.gov)

PRR proteins recognize Pathogen Associated Molecular Patterns (PAMPs) that are conserved motifs in the pathogen and Damage Associated Molecular Patterns (DAMPs) that derive from the damages caused by pathogen ingress [ 2 ]. (biomedcentral.com)
The two systems detect different types of pathogen molecules and classes of plant receptor proteins. (wikipedia.org)
2015 ). The successful pathogens secret effector proteins to overcome PTI for pathogenesis (Tsuda and Katagiri 2010 ). (biomedcentral.com)
Recent research has revealed that carbohydrate-binding proteins, also known as agglutinins or lectins, are found in a wide range of plant species and have an important biological function in pathogen defense responses [ 23 ]. (biomedcentral.com)
This proposal tests the paradigm-shifting hypothesis that mitochondrial-derived proteins (MPDs) play a previously unappreciated role in the regulation of cellular and organismal function, and that disregulation of MDPs is important in disease development. (nih.gov)

We also found that the rcr3-3 mutant of tomato that carries a premature stop codon in the Rcr3 gene exhibits enhanced susceptibility to P. infestans, suggesting a role for Rcr3(pim) in defense. (ox.ac.uk)
Plant mannose binding lectins detect specific protein-carbohydrate combinations on pathogen surfaces and serve a key role in plant defense mechanisms against pathogens [ 24 , 25 ]. (biomedcentral.com)

To answer this question, the scientists looked to Botrytis cinerea , the fungus responsible for gray mold disease and a key research model given its broad host range. (genomeweb.com)
Botrytis cinerea , a fungal pathogen that causes gray mold, displays a high degree of phenotypic diversity. (frontiersin.org)

The first tier is primarily governed by pattern recognition receptors that are activated by recognition of evolutionarily conserved pathogen or microbial-associated molecular patterns (PAMPs or MAMPs). (wikipedia.org)
The first layer of defence is represented by pattern recognition receptors (PRRs) present at the cell membrane surface that recognize conserved pathogen-associated molecular patterns (PAMPs). (researchsquare.com)

Disease outcome is determined by the three-way interaction of the pathogen, the plant and the environmental conditions (an interaction known as the disease triangle). (wikipedia.org)
This model is nicely illustrated by the interaction between the fungal plant pathogen Cladosporium fulvum and tomato. (ox.ac.uk)

The immune system utilizes sensors on immune cells named pattern recognition receptors to recognize invading pathogens and foreign substances. (exeter.ac.uk)

The upregulation of p53 induces immune responses to viral pathogens. (ppjonline.org)

Across large regions and many crop species, it is estimated that diseases typically reduce plant yields by 10% every year in more developed nations or agricultural systems, but yield loss to diseases often exceeds 20% in less developed settings. (wikipedia.org)
Each Candida species holds unique characteristics comparative to invasive potential, virulence, and antifungal susceptibility pattern [ 1 ]. (encyclopedia.pub)
Common bunt, caused by two fungal species, Tilletia caries and Tilletia laevis , is one of the most potentially destructive diseases of wheat. (mdpi.com)
A number of non-tuberculous mycobacterium species are opportunistic pathogens and ubiquitously form biofilms. (microbialcell.com)
Dr. Biswas's research projects focused on the reduction of pre- and post-harvest levels of colonization and contamination these foodborne bacterial pathogens in foods specifically meat and meat products and development of vaccines that prevent colonization of animals by E. coli O157, C. jejuni and Salmonella enterica species which may reduce human gastrointestinal infections. (umd.edu)
In the case of DED, three fungal species are known to induce the disease. (sisef.it)

In this study we confirm this prediction using a different pathogen of tomato, the oomycete Phytophthora infestans that is distantly related to fungi such as C. fulvum. (ox.ac.uk)

For example, the restricted genetic diversity in the endangered black-tailed prairie dog has resulted in their susceptibility to an exotic, introduced pathogen that causes plague. (vin.com)
Here, we present a suite of tools for genetic manipulation in the tomato pathogen C. michiganensis including a markerless deletion system, an integrative plasmid, and an R package for identification of permissive sites for plasmid integration. (biorxiv.org)
August 5, 2022 - Mount Sinai researchers have achieved an unprecedented understanding of the genetic and molecular machinery in human microglia-immune cells that reside in the brain-that could provide valuable insights into how they contribute to the development and progression of Alzheimer's disease (AD). (mssm.edu)
February 3, 2022 - Previous studies of a genetic on/off switch may have been confounded by contamination, but Mount Sinai scientists have created a new tool for accurately determining whether it plays a role in human disease. (mssm.edu)
After nearly 100 years of documented Dutch elm disease (DED) presence, it seems only fitting to revisit this pathosystem from a genetic standpoint encompassing both traditional Mendelian genetics and the most recent developments in omic-based approaches. (sisef.it)
Mendelian genetic analysis of the pathogens is therefore easy and the heritability of any scorable phenotypic or genotypic trait can be assessed rapidly. (sisef.it)
Molecular and omic approaches, however, represent technological advances that should allow rapid developments in the genetic analysis of elms and bark beetle vectors of the disease. (sisef.it)

Although the tuberculosis case trol and endorsed by the Infectious Disease Society of America. (cdc.gov)

In conclusion, DDRs activated basal immune responses to viral pathogens. (ppjonline.org)

Although a defect in the chemokine receptor CX3CR1 increases susceptibility of mice and humans to systemic candidiasis, it does not in mucosal candidosis. (medscape.com)

The intestinal barrier separates the self from the non-self and serves as the first line of defence against external threats such as toxins and pathogens. (nature.com)

Meanwhile, tomato plants in which MAPKKK4 was suppressed using a virus-induced gene silencing approach showed enhanced disease susceptibility in response to B. cinerea and contained over 15 times more fungal biomass than control plants. (genomeweb.com)
This pathogen secretes an array of protease inhibitors including EPIC1 and EPIC2B that inhibit tomato cysteine proteases. (ox.ac.uk)
The corn pathogen C. nebraskensis has been problematic for many corn-producing Midwestern states and the tomato pathogen C. michiganensis has caused notable losses in years past (Ahmad et al. (biorxiv.org)

On the other hand, STS flies contaminated with the Gram-positive bacterium demonstrated similarly high degrees of susceptibility to disease as their AL siblings and passed away quickly after septic damage (Fig 1C). (bioinbrief.com)

However, disease susceptibility increases due to certain conditions such as AIDS and tuberculosis (TB), immunosuppressive use and cancer drugs, prolonged antibiotic therapy, and prolonged hospitalisation [ 14 ]. (encyclopedia.pub)
[4] There are several mechanisms of TEI that have shown to affect germline reprogramming, such as transgenerational increases in susceptibility to diseases, mutations, and stress inheritance. (cloudfront.net)

the disease caused by the cognate cel s from human cord blood. (who.int)

Quantitative high-throughput, real-time bioassay for plant pathogen growth in vivo. (msu.edu)

To qualify for inclusion, scribing patterns through formulary modification and an isolate had to grow from a culture taken no earlier than enhanced education of prescribers (5). (cdc.gov)

In the United States, the Centers for Disease Control and Prevention (CDC) estimate that each year about 1 in 6 Americans becomes ill and thousands die of foodborne diseases ( http://www.cdc.gov/foodborneburden/2011-foodborne-estimates.html ). (hindawi.com)
Playground observations were conducted by the Centers for Disease Control and Prevention. (ambi.productions)

B. cinerea is a highly versatile pathogen. (frontiersin.org)

October 25, 2022 - A new approach to cancer immunotherapy that uses one type of immune cell to kill another-rather than directly attacking the cancer-provokes a robust anti-tumor immune response that shrinks ovarian, lung, and pancreatic tumors in preclinical disease models, according to researchers at the Icahn School of Medicine at Mount Sinai in New York. (mssm.edu)

The development of knockout mutants and expression variants are critical for understanding genotype-phenotype relationships. (biorxiv.org)
Whereas it seems intuitive that an immune cell type that depends on regular proliferation outbursts for function may have evolved to modulate telomerase expression it is less obvious why others may also do so, as has been suggested for macrophages and neutrophils in some chronic inflammation disease settings. (biomedcentral.com)

oroquinolone was protective against isolation of a third- generation cephalosporin-resistant pathogen (p = 0.005). (cdc.gov)
Exploitation of blast-resistant cultivars is rated to be the most appropriate strategy to control this disease. (biomedcentral.com)
Microbes that cause disease are becoming resistant to antibiotics faster than we can find new ones, making many common infections untreatable and life threatening. (nih.gov)

He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
Candida glabrata is a successful pathogen colonising epithelial surfaces (mouth, gastrointestinal tract, vagina, skin, and present in stool) as healthy microbial flora with no age specificity [ 10 ]. (encyclopedia.pub)
They will take this work one step further and create new model systems to determine the 3-D relationships and functions of different epithelial cell types as the basal cells detect and respond to various drugs, hormones, chemicals and pathogens that appear in the cavity of the organ. (nih.gov)

A switch from normal flora to the pathogenic state may occur, leading to disease setting in, ranging from superficial (mucosal and skin) to systemic with an alarming mortality rate [ 16 ]. (encyclopedia.pub)
May 19, 2022 - In this newly funded study, Dr. Jose Clemente and team will try to reconstruct and analyze how the microbiome may work in several autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and Sjögren's disease. (mssm.edu)

In 2007, autosomal dominant mutations in signal transducer and activator of transcription-3 (STAT3) gene were identified as the molecular cause of this disease. (medscape.com)
STAT3 mutations have been found in persons of Asian, African, Caucasian, and Hispanic descent and correlate well with HIES disease. (medscape.com)

The atm-2atr-2 double mutants were susceptible to TCV, indicating that the main DDR signaling pathway sensors play an important role in plant immune responses. (ppjonline.org)

The world's first mass-cultivated banana cultivar Gros Michel was lost in the 1920s to Panama disease caused by the fungus Fusarium oxysporum. (wikipedia.org)
Severe Verticillium wilt disease caused by the phytopathogenic fungus Verticillium nonalfalfae is the main factor in yield loss in many crops, including hops ( Humulus lupulus L. (researchsquare.com)

Estimating chronic wasting disease susceptibility in cervids using real-time quaking-induced conversion. (k-state.edu)

We screened for mutants that suppress an RNL activation mimic allele and identified a TNL, SADR1. (nsf.gov)

When barrier function is impaired, altered permeability and barrier dysfunction can occur, leading to inflammatory bowel diseases, irritable bowel syndrome or obesity. (nature.com)
This is accompanied by a decreased ability to clear pathogens and increased gut permeability. (biomedcentral.com)

Other epidemics include Chestnut blight, as well as recurrent severe plant diseases such as Rice blast, Soybean cyst nematode, Citrus canker. (wikipedia.org)

F v /F m showed a strong negative correlation with disease severity and can be an indicator for the early detection of gray mold on strawberry leaves. (frontiersin.org)
In addition, Dr. Biswas's researches also focus to develop the monoclonal antibodies against foodborne bacterial pathogens to improve the detection of pathogens in food and other polluted materials. (umd.edu)
Diversity of foodborne bacterial pathogens and parasites in produce and animal products and limitations of current detection practices. (umd.edu)

Like animals, plants have developed their innate immune systems to counter various pathogens. (ppjonline.org)

I. Drug Susceptibility Testing history, previous as well as current disease is included in J. Genotyping of Mycobacterium tuberculosis the classification. (cdc.gov)
Classification of Persons Exposed to and/or Infected with year more than 8 million new cases of tuberculosis occur and Mycobacterium tuberculosis approximately 3 million persons die from the disease (1). (cdc.gov)

In this study, we identified the intrinsic resistome to a broad spectrum of antimicrobials in the human pathogen, Staphylococcus aureus . (frontiersin.org)
We screened the Nebraska Transposon Mutant Library of 1920 single-gene inactivations in S. aureus strain JE2, for increased susceptibility to the anti-staphylococcal antimicrobials (ciprofloxacin, oxacillin, linezolid, fosfomycin, daptomycin, mupirocin, vancomycin, and gentamicin). (frontiersin.org)
Replacement of conventional antimicrobials and preservatives in food production to improve consumer safety and enhance health benefits. (umd.edu)

Anatomy12

Organisms27

Diseases29

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Psychiatry and Psychology3

Phenomena and Processes88

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena2

Information Science8

Named Groups4

Health Care15

Geographicals3

Arabidopsis10

Displayed increased susceptibility1

Resistance28

Infection8

Genes4

Immunity7

Antimicrobial6

Bacterial pathogen3

Host-pathogen2

Interactions3

Effectors5

Strains1

Proteins5

Defense2

Botrytis2

PAMPs2

Interaction2

Recognize1

Induces1

Species6

Fungi1

Genetic7

Infectious Disease1

Basal immune1

Mice1

Toxins1

Tomato3

Similarly1

Increases2

Cognate1

High-throughput1

Patterns1

Centers for Diseas2

Cinerea1

Immune Response1

Expression2

Resistant3

Epithelial3

Systemic2

Mutations2

Susceptible1

Fungus2

Chronic wasting1

Suppress1

Permeability2

Plant1

Detection3

Innate1

Mycobacterium2

Antimicrobials3