Mutants on multiple. Medical search. Frequent questions

Teenage Mutant Ninja Turtles: Shredder's Revenge features groundbreaking gameplay rooted in timeless classic brawling mechanics, brought to you by the beat 'em up experts at Dotemu and Tribute Games. (gamestop.com)
With Bebop and Rocksteady assaulting Channel 6 and stealing super gnarly devices to support Krang and Shredder's latest twisted plan, Teenage Mutant Ninja Turtles: Shredder's Revenge sees the Turtles battling across a righteous range of timeless TMNT locations. (gamestop.com)
Teenage Mutant Ninja Turtles carved its perfect niche in video games by way of the cooperative beat 'em up. (gamestop.com)
Limited Run Games has partnered with Dotemu, Tribute Games, and Nickelodeon to bring an all-new updated physical release of Teenage Mutant Ninja Turtles: Shredder s Revenge to the Nintendo Switch , PlayStation 4, PlayStation 5 and Xbox One. (toynewsi.com)
The Limited Run Classic Edition of Teenage Mutant Ninja Turtles: Shredder s Revenge Anniversary Edition features a VHS-style game box and a copy of the Shredder s Revenge Strategy Guide. (toynewsi.com)
Teenage Mutant Ninja Turtles: Shredder s Revenge reunites Leonardo, Michelangelo, Donatello, and Raphael as they kick shell in a beautifully realized beat em up. (toynewsi.com)

Although a single point mutation is sufficient for developing rifampin resistance, a number of articles ( 2 , 3 ) describe multiple rpoB mutants for M. tuberculosis , i.e., rifampin-resistant strains harboring mutations in different codons of rpoB . (cdc.gov)
Therefore, hypermutability in some strains of this species resulting in multiple rpoB mutants might develop under certain special (in vivo) circumstances through inactivation or down-regulation of some mutT genes. (cdc.gov)
In contrast, the DNA damage accumulation and sensitivity of smc-5 mutant strains to replication impediments are suppressed by mutations in the C. elegans BRCA1/BARD1 homologs, brc-1 and brd-1. (uni-koeln.de)
Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020. (cdc.gov)

This assumption seems likely because both of the aforementioned particular mutations were described in in vitro-obtained spontaneous mutants of H37Rv and had a Darwinian fitness slightly less than and equal to that of the rpoB wild-type-susceptible parental strain ( 9 ). (cdc.gov)
Site-directed mutagenesis was used to selectively eliminate the IgG binding for each epitope and single and multiple mutations were expressed as recombinant GST fusion proteins. (cdc.gov)
Multiple sulfatase deficiency is caused by mutations in the SUMF1 gene. (medlineplus.gov)
Research indicates that mutations that lead to reduced FGE enzyme function are associated with the less severe cases of the condition, whereas mutations that lead to the production of an unstable FGE enzyme tend to be associated with the more severe cases of multiple sulfatase deficiency. (medlineplus.gov)
Missense mutations of the tumor suppressor Neurofibromin 2 (NF2/ Merlin / schwannomin ) result in sporadic to frequent occurrences of tumorigenesis in multiple organs. (bvsalud.org)
Each of the mutations , ob-tained by multiple site-directed mutagenesis leading to the replacement of amino acid residues lying on the surface of the 3D structure of HlyIICTD, led to a decrease in the interaction of HlyIIC-20 with the mutant form of the protein . (bvsalud.org)

Additionally, it can knock out genes, facilitating efforts to elucidate gene functions through the analysis of mutant phenotypes. (mdpi.com)
We now confirm those findings, as complementation of a csrS mutant restored Mg(2+)-dependent gene regulation. (lu.se)
The effect of Mg(2+) on regulation of global gene expression was evaluated using genomic microarrays in an M-type 3 strain of GAS and in an isogenic csrS mutant. (lu.se)
Each syndrome is inherited as an autosomal dominant trait with a high degree of penetrance, variable expressivity, and production of seemingly unrelated effects by a single mutant gene. (msdmanuals.com)
We will use genetic tools to knock out genes and study the response of these mutants to touch stimulation in comparison to WT with regards to gene expression, phosphorylation cascades and alteration in growth and development. (lu.se)

This study was done to evaluate efficacy of HBV vaccination on hepatitis B virus surface antigen (HBsAg) carrier rate in children with thalassaemia major receiving multiple blood transfusions. (who.int)
receiving multiple blood transfusions the anticipated probability of infection had been recorded as high as 20% [1]. (who.int)

And although a normal zebrafish begins to fall asleep about 10 minutes after 'lights out'-about the same amount of time it takes a human to fall asleep-it took the aanat2 mutant fish about twice as long. (caltech.edu)

Dynein1 is a large minus-end directed, microtubule motor protein complex that has been implicated in multiple, essential cellular processes. (nih.gov)
Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein. (alzforum.org)
To investigate the role of the cAMP-dependent protein kinase (PKA) in the desensitization and down-regulation of the D 1 dopamine receptor, we stably expressed the rat cDNA for this receptor in mutant Chinese hamster ovary (CHO) cell lines deficient in PKA activity. (aspetjournals.org)
These phenotypes appear to result, at least in part, from impaired interactions of the mutant β159 clamp protein with the replicative DNA polymerase, Pol III ( 38 ). (asm.org)
This test dataset is extracted from the Protein Mutant Database (PMD). (lu.se)

Of the mutant lines established, about 75% exhibited a male infertility phenotype only, almost 10% exhibited female infertility only, and about 15% exhibited infertility of both sexes. (jax.org)
the kkq8 hal5 double mutant has not been annotated for phenotype. (yeastgenome.org)

The other mutant (U7) has two substitutions (I3V and I13V). (rcsb.org)
Finally, although multiple amino acid substitutions of T4 abolished glycosylation at N2 but were not toxic, similar substitutions of T17 were not tolerated, suggesting that the carbohydrate moiety at N15 is critical for cell viability. (jneurosci.org)
The dnaN159 allele encodes a mutant form of the β-sliding clamp (β159) that bears two amino acid substitutions: G66E (glycine at position 66 replaced with glutamic acid) and G174A ( 14 , 35 , 38 ). (asm.org)

Transgenic animal models expressing rhodopsin glycosylation mutants also exhibit light exacerbated retinal degeneration (RD). In this study, we used transgenic Xenopus laevis to investigate the pathogenic mechanism connecting light exposure and RD in photoreceptors expressing T4K or T17M rhodopsin. (jneurosci.org)

Antibody recognition of the mutant proteins was determined by inhibition ELISA. (cdc.gov)
Inhibition ELISA with the mutant proteins indicated that epitope 126-131 was the dominant epitope, but mutation of epitope 120-125 was also required to eliminate mAb reactivity to Hev b 5. (cdc.gov)

The Escherichia coli dnaN159 allele encodes a mutant form of the β-sliding clamp (β159) that is impaired for interaction with the replicative DNA polymerase (Pol), Pol III. (asm.org)
however, a stable, replicative mutant mtDNA is sometimes produced. (medscape.com)

The overall goals of this program were to produce and distribute mutant models for infertility and to investigate underlying causes in order to identify new genes and pathways contributing to reproductive function. (jax.org)
Recently, our lab found that touch signalling is controlled by multiple complementary signalling pathways. (lu.se)

These mutants exhibited slower bacterial growth, smaller size, loss of flagellar motility and lack of an extracellular matrix. (nature.com)

But a single vaccine dose dramatically boosted their antibody levels - sparking cross-protection against the delta variant and two other mutants, the study found. (livemint.com)

The French researchers also tested unvaccinated people who had survived a bout of the coronavirus, and found their antibodies were four-fold less potent against the new mutant. (livemint.com)

Separate multiple emails with a comma. (neatorama.com)
Enter multiple addresses on separate lines or separate them with commas. (biorxiv.org)

Verapamil significantly reversed the [ 3 H]daunorubicin accumulation defect in wild-type Dx5 cells, but it had no significant effect on [ 3 H]daunorubicin accumulation in the mutant DxP cells. (aspetjournals.org)

Our study reports phase separation -mediated quiescence of cGAS- STING signaling by a mutant tumor suppressor and reveals gain-of-function pathogenesis for NF2-related tumors by regulating antitumor immunity . (bvsalud.org)

The multiple endocrine neoplasia (MEN) syndromes comprise 4 genetically distinct familial diseases involving adenomatous hyperplasia and malignant tumors in several endocrine glands. (msdmanuals.com)

While corrector-based treatment options are being extensively studied for CFTR-p.Phe508del, the efficacy of known correctors for other trafficking mutants remains largely unknown and has thus far not been studied in primary epithelial CF cells. (ersjournals.com)

In mycobacteria, hypermutability was demonstrated in vitro for M. smegmatis , a surrogate model for M. tuberculosis , as an increase in reversion (mutant to wild type) rate in rpoB526 or rpsL43 under counterselection by streptomycin or rifampin, respectively ( 4 ). (cdc.gov)
Photoaffinity labeling with [ 3 H]cyclosporine and [ 3 H]azidopine revealed markedly decreased binding to the mutant P-gp compared with wild-type P-gp. (aspetjournals.org)
Expression of the mutant P-gp in multidrug-resistant variant cell line MES-SA/DxP (DxP) cells was associated with a 2-fold higher basal ATPase activity relative to multidrug-resistant cell line MES-SA/Dx5 (Dx5) cells with wild-type P-gp. (aspetjournals.org)
Verapamil was not transported by cells expressing either mutant or wild-type P-gp. (aspetjournals.org)
This is not necessarily a problem for the cell or tissue because multiple copies of mtDNA are present in each cell (in oocytes, this is in the region of 100,000 copies per cell), and both wild type and mutated mtDNA can coexist, a situation known as heteroplasmy. (medscape.com)

ENU-mutagenesis of male mice was followed by a standard three-generation breeding scheme, with fertility testing of all G3 offspring in order to identify putative reproductive mutants. (jax.org)
Klotho mutant mice designated as a preclinical model of aging. (mugen-noe.org)
the Void and bladder contraction test klotho mutant mice revealed that, similar to other aging models, has risen to cancel the frequency and decreased urinary volume per micturition event. (mugen-noe.org)
In vitro contractile response to electrical stimulation is weaker and subtypes of muscarinic receptor expression is reduced in the mutant mice klotho bladder. (mugen-noe.org)
These data suggest that bladder klotho mutant mice have impaired bladder function. (mugen-noe.org)

Research from multiple countries shows the Pfizer shot and other widely used Covid-19 vaccines offer strong protection against the highly contagious delta variant, which is spreading rapidly around the world and now accounts for most new US infections. (livemint.com)

Options for pharmacological correction of CFTR-p.Phe508del (F508del) are being extensively studied but correction of other trafficking mutants that may also benefit from corrector treatment remains largely unknown. (ersjournals.com)
We studied correction of the folding mutants CFTR-p.Phe508del, -p.Ala455Glu (A455E) and -p.Asn1303Lys (N1303K) by VX-809 and 18 other correctors (C1-C18) using a functional CFTR assay in human intestinal CF organoids. (ersjournals.com)
These data support the development of mutation-specific correctors for optimal treatment of different CFTR trafficking mutants, and identify C5 and bithiazoles as the most promising compounds for correction of CFTR-p.Ala455Glu. (ersjournals.com)

Chromosome level genome assembly of Dendrobium huoshanense species was used to RagTag scaffold the available contigs of mutant, where it contained total length of 687,254,899 bp with N50 value 2,096. (biorxiv.org)

Collect crystals and travel across dimensions that pay tribute to multiple TMNT eras. (toynewsi.com)

0001). Families with breast cancer also had a propensity for multiple melanomas in females, suggesting that a sex-dependent factor may modify the phenotypic expression of CDKN2A alterations. (lu.se)

Addgene: Egg cell-specific promoter-controlled CRISPR/Cas9 efficiently generates homozygous mutants for multiple target genes in Arabidopsis in a single generation. (addgene.org)
Compressed archives combine multiple files into a single file to make them easier to transport or save on diskspace. (mediafire.com)
67% of heterozygotes have multiple defects and the rest have single defects. (bmj.com)

There are over a dozen FACTIONS of enemies, each with multiple units within. (rpgcodex.net)

As with the agonist pretreatments, the 8-(4-chlorophenylthio)-induced responses were attenuated in the mutant cells with the 10248 line exhibiting the least desensitization/down-regulation. (aspetjournals.org)

The mitochondrial genome is a 16569 base-pair closed circular loop of double-stranded DNA found in multiple copies within the mitochondrial matrix. (medscape.com)

In some levels, the alien penguins will try to reach a transformation station and turn into their mutant form, weighing three times more than their alien form on the Doomscale. (wikipedia.org)
The late-infantile type is the most common form of multiple sulfatase deficiency. (medlineplus.gov)
The juvenile type is the rarest form of multiple sulfatase deficiency. (medlineplus.gov)

The transfected parental and mutant cell lines were found to express ∼1 pmol/mg D 1 receptor binding activity ( B max ) as determined using [ 3 H]SCH-23390 binding assays. (aspetjournals.org)

In this study, we further characterize a mutant P-glycoprotein (P-gp) that has a deletion of Phe 335 and is resistant to inhibition by cyclosporins. (aspetjournals.org)

The New Mutants ended up getting similar treatment, which is just the latest set back Josh Boone's X-Men spinoff has hit during its long road to release. (cinemablend.com)
Treatment with multiple medicines to which the organism is vulnerable will prevent this selection [10,11]. (fabretp.org)

A possible human homologue for the mouse mutant disorganisation. (bmj.com)
CsrRS (or CovRS) is a two-component system implicated in the control of multiple virulence determinants in the important human pathogen, group A Streptococcus (GAS). (lu.se)

Because the signs and symptoms of multiple sulfatase deficiency vary widely, researchers have split the condition into three types: neonatal, late-infantile, and juvenile. (medlineplus.gov)
Many of the signs and symptoms of neonatal multiple sulfatase deficiency worsen over time. (medlineplus.gov)
The death of cells in particular tissues, specifically the brain, skeleton, and skin, cause many of the signs and symptoms of multiple sulfatase deficiency. (medlineplus.gov)

Both Tenet and The New Mutants are projects that heavily feature visual effects and thrilling action sequences. (cinemablend.com)

The 10260 mutant CHO cell line has been characterized as expressing less than 10% of type I and type II PKA activities relative to the parental 10001 CHO cell line. (aspetjournals.org)
Cyclosporine inhibited ATPase activity in both cell types, whereas the cyclosporin D analog valspodar (PSC 833), vinblastine, and dactinomycin stimulated ATPase activity in Dx5 but not in mutant DxP cells. (aspetjournals.org)

You're getting me all these genes across multiple cancer types, but what you really should be saying to the patient is, "I'm interested in the genes that I know are related to your melanoma. (medscape.com)
Life expectancy is shortened in individuals with all types of multiple sulfatase deficiency. (medlineplus.gov)

To test whether NF-κB specifically mediates stress-induced drug resistance, an inducible phosphorylation site-deficient mutant of IκBα (IκBαM, S32/36A) was introduced into EMT6 cells. (aspetjournals.org)

The New Mutants is a movie that's had an unbelievably long road to theaters , including multiple delays. (cinemablend.com)

Attack of the Mutant Penguins was one of the first projects supported by Atari's European development center, established to work with European independent developers on new Jaguar games. (wikipedia.org)

They also show that families with the CDKN2A 113insArg mutation have an increased risk not only of multiple melanomas and pancreatic carcinoma but also of breast cancer. (lu.se)

Multiple votes are allowed. (nma-fallout.com)

These DFS data supported the 2020 FDA approval of adjuvant osimertinib in patients with EGFR -mutant NSCLC. (onclive.com)

The 10248 mutant CHO line lacks type II PKA activity and expresses a defective type I PKA. (aspetjournals.org)
The activity of multiple sulfatases is impaired because the FGE enzyme modifies all known sulfatase enzymes. (medlineplus.gov)

Anatomy20

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Psychiatry and Psychology1

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