• Three bacterial pectate lyases, a pectin lyase from Aspergillus niger, thestructures of rhamnogalacturonase A from Aspergillus aculeatus, RGase A,and the P22-phage tailspike protein, TSP, display the right-handedparallel beta-helix architecture first seen in pectate lyase. (embl.de)
  • citation.id primary _citation.title 'Bacteriophage P22 Tailspike: Structure of the Complete Protein and Function of the Interdomain Linker' _citation.journal_abbrev 'Acta Crystallogr. (rcsb.org)
  • Interestingly, neither of these functions is required for the S . Typhimurium virulence for Balb/C mice since a mutant without the whole SPI-1 was as virulent as the control wild type strain [ 8 ]. (biomedcentral.com)
  • Finally, based on the chromosomal localization and the expression pattern of the mouse Six3 gene, the human Six3 cognate could be a good candidate to be at least one of the genes affected in patients with holoprosencephaly type 2 due to an interstitial deletion of 2p21-p22. (nih.gov)
  • A-Cm mutant via P22-mediated transduction, and the other hand, the metabolic defects arising from deletion of gre genes likely predispose Salmonella to oxidative stress. (chesterlecturesociety.org)
  • The deletion mutants of DEGs in the treatment group (pH=5.8) compared to the control group (pH=7.5) were constructed by λ recombinant. (bvsalud.org)
  • 0.3% solid LB was used for flagellar motility assay and Hela was used to study flagellar gene deletion mutants and WT adhesion and invasion ability. (bvsalud.org)
  • Biochemically, PNH is a consequence of nonmalignant clonal expansion of hematopoietic stem cells with somatic mutation of PIGA [ 2 , 3 ], and mutant, inactive PIGA explains the deficiency of glycosyl phosphatidylinositol-anchored proteins [ 4 ]. (annexpublishers.co)
  • In the mouse, a sec8 mutant has been identified, but these mice die shortly after gastrulation of the embryo, precluding a more detailed analysis of the role of the complex (Friedrich, 1997). (sdbonline.org)
  • Uncanny X-Men#322 (fb) - BTS) - Gene Nation attacked a disco, killing dozens of humans there in the name of mutants. (marvunapp.com)
  • They described two patients with PNH with an acquired rearrangement of chromosome 12 affecting the HMGA2 gene, which encodes a chromatin remodeling protein, in the PIGA mutant cells [ 12 ]. (annexpublishers.co)
  • The exocyst complex, a set of eight proteins first identified from secretory mutants in yeast, is an attractive candidate for mediating directed traffic. (sdbonline.org)
  • In Small eye (Pax6) mouse mutants Six3 expression is not affected. (nih.gov)
  • The mutant lacking all 5 major SPIs was still capable of colonising the caecum while colonisation of the liver and spleen was dependent on the presence of both SPI-1 and SPI-2. (biomedcentral.com)
  • Two of the mutants were capable of growth in media supplemented only with δ -aminolaevulinic acid, the first intermediate of porphyrin synthesis. (microbiologyresearch.org)
  • In this study, we therefore constructed Salmonella Enteritidis mutants with each SPI deleted separately, with single individual SPIs (i.e. with the remaining four deleted) and a mutant with all 5 SPIs deleted, and assessed their virulence in one-day-old chickens, together with the innate immune response of this host. (biomedcentral.com)
  • Three bacterial pectate lyases, a pectin lyase from Aspergillus niger, thestructures of rhamnogalacturonase A from Aspergillus aculeatus, RGase A,and the P22-phage tailspike protein, TSP, display the right-handedparallel beta-helix architecture first seen in pectate lyase. (embl.de)
  • loop_ _audit_author.name _audit_author.pdbx_ordinal 'Steinbacher, S.' 1 'Baxa, U.' 2 'Weintraub, A.' 3 'Huber, R.' 4 'Seckler, R.' 5 # _citation.id primary _citation.title 'Mutations improving the folding of phage P22 tailspike protein affect its receptor binding activity. (rcsb.org)
  • Here we report that the long-standing ERP program is an observation of the experimentally favored Salmonella phage P22 tsc229 heat-inducible mutant, and that wild-type P22 actually follows the replication-packaging-excision (RPE) program. (bvsalud.org)
  • We find that P22 tsc229 excises early after induction, but P22 delays excision to just before it is detrimental to phage production. (bvsalud.org)
  • Notably, the P22 phage annealing protein Erf, which does not mediate the same DSBR reactions, also delivers ssOR activity. (biomedcentral.com)
  • 106b Walker, G. C. (1978) Inducible Reactivation and Mutagenesis of UV-Irradiated Bacteriophage P22 in Salmonella typhimurium LT2 Containing the Plasmid pKM101. (brucenames.org)
  • 2. Wang C, Tu J, Liu J, Molineux IJ: Structural Dynamics of Bacteriophage P22 Infection Initiation Revealed by Cryo-electron Tomography,Nature Microbiology,2019. (cryoet.org)
  • In this study, we therefore constructed Salmonella Enteritidis mutants with each SPI deleted separately, with single individual SPIs (i.e. with the remaining four deleted) and a mutant with all 5 SPIs deleted, and assessed their virulence in one-day-old chickens, together with the innate immune response of this host. (biomedcentral.com)
  • 101 Alper, M. D. and Ames, B. N. (1978) Transport of Antibiotics and Metabolite Analogs by Systems Under Cyclic AMP Control: Positive Selection of Salmonella typhimurium cya and crp Mutants. (brucenames.org)
  • Histidine regulatory mutants in Salmonella typhimurium. (wikidata.org)
  • AKT1 mutant (T308 / S473A) recombinant protein is ideal for investigators involved in Cell Signaling, Neuroscience and Signal Transduction research. (rockland.com)
  • Human AKT1 mutant recombinant protein has been tested in SDS-Page and western blot and is suitable as a control protein for immunoassays using antibodies targeting the T308 or S473 key phosphorylation sites. (rockland.com)
  • We generated a new mouse model, in which the P23H-Rho mutant allele is fused to the fluorescent protein Tag-RFP-T (P23HhRhoRFP). (nih.gov)
  • In heterozygotes, outer segments formed, and wild-type (WT) rhodopsin was properly localized, but mutant P23H-Rho protein was mislocalized in the inner segments. (nih.gov)
  • 20. Expression of mitotic spindle checkpoint protein hsMAD1 correlates with cellular proliferation and is activated by a gain-of-function p53 mutant. (nih.gov)
  • 89. Zhang K, Qin Z, Chang Y, Liu J, Malkowski MG, Shipa S, Li L, Qiu W, Zhang JR, Li C: Analysis of a flagellar filament cap mutant reveals that HtrA serine protease degrades unfolded flagellin protein in the periplasm of Borrelia burgdorferi . (cryoet.org)
  • 2. The proliferation-associated early response gene p22/PRG1 is a novel p53 target gene. (nih.gov)
  • This temporal program is considered universal for P22-like temperate phages, though there is no direct evidence to support the timing and sequence of these events. (bvsalud.org)
  • Escherichia coli mutants lacking polyphosphate kinase (PPK), the enzyme responsible for the syn- thesis of poly P from ATP, are deficient in responses to stresses and stringencies and fail to survive in stationary phase (3, 4). (nih.gov)
  • the mutant was also deficient in biofilm formation and was not lethal in a burned-mouse pathogenesis model (7). (nih.gov)
  • 106a Walker, G. C. (1978) Isolation and Characterization of Mutants of the Plasmid pKM101 Deficient in Their Ability to Enhance Mutagenesis and Repair. (brucenames.org)
  • In some of these mutants lacking ppk, the phenotypes included features indicative of de- creased virulence such as: (ij) growth defects, (ii) defective re- sponses to stress and starvation, (ii/) loss of viability, (/v) polymyxin sensitivity, (v) intolerance to acid and heat, and (vi) diminished invasiveness in epithelial cells. (nih.gov)
  • Vibrio cholerae ppk mutants also show defects in growth, motility, and surface attachment, features linked to virulence (8). (nih.gov)
  • Interestingly, neither of these functions is required for the S . Typhimurium virulence for Balb/C mice since a mutant without the whole SPI-1 was as virulent as the control wild type strain [ 8 ]. (biomedcentral.com)
  • We find that in mutants of the GATOR2 component mio , meiotic DSBs trigger the constitutive downregulation of TORC1 activity and a permanent arrest in oocyte growth. (nih.gov)
  • Conversely, in GATOR1 mutants, high TORC1 activity results in the delayed repair of meiotic DSBs and the hyperactivation of p53. (nih.gov)
  • 3. Molecular characterization of oncostatin M-induced growth arrest of MCF-7 cells expressing a temperature-sensitive mutant of p53. (nih.gov)
  • A positive selection for polar histidine-requiring mutants from histidine operator constitutive mutants. (wikidata.org)
  • 14. B-MYB is required for recovery from the DNA damage-induced G2 checkpoint in p53 mutant cells. (nih.gov)