• The oncogene identified was derived from a cellular genome, so KRAS, when found in a cellular genome, is called a proto-oncogene. (wikipedia.org)
  • These proteins have different structures in their C-terminal region and use different mechanisms to localize to cellular membranes, including the plasma membrane. (wikipedia.org)
  • Canonical Notch signaling activates the transcription of BMI1 proto‑oncogene polycomb ring finger, cyclin D1, CD44, cyclin dependent kinase inhibitor 1A, hes family bHLH transcription factor 1, hes related family bHLH transcription factor with YRPW motif 1, MYC, NOTCH3, RE1 silencing transcription factor and transcription factor 7 in a cellular context‑dependent manner, while non‑canonical Notch signaling activates NF‑κB and Rac family small GTPase 1. (spandidos-publications.com)
  • The Rho family of GTP-binding proteins has been implicated in the regulation of various cellular functions including actin cytoskeleton-dependent morphological change. (embl-heidelberg.de)
  • Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
  • Additionally, scientists have found that this relationship is an important part of a number of complex cellular signaling cascade pathways, including Ras, β-catenin, myc, Rb, and many more. (shu.edu)
  • In turn, GTP-bound active GTPases can interact with a plethora of different effectors which mediate the different cellular functions of this family of proteins. (biomedcentral.com)
  • The human ETS (E26 Transformation-Specific) protein family is a diverse group of 27 known transcription factors that regulate such varied cellular processes as differentiation and apoptosis, but also appear to induce oncogenesis when mutated or aberrantly expressed [ 1 - 4 ]. (biomedcentral.com)
  • The ubiquitin proteasome system (UPS) regulates the expression levels of cellular proteins by ubiquitination of protein substrates followed by their degradation via the proteasome. (biomedcentral.com)
  • On the one hand, the UPS acts as a host defense mechanism to selectively recognize HBV proteins as well as special cellular proteins that favor the viral life cycle and induces their ubiquitin-dependent proteasomal degradation to limit HBV infection. (biomedcentral.com)
  • Moreover, in the infected hepatocytes, certain cellular proteins that are dependent on the UPS are involved in abnormal biological processes which are mediated by HBV. (biomedcentral.com)
  • Autophagic activity dictates the cellular response to oncogenic RAS. (univ-paris5.fr)
  • Mass spectrometry-based phosphoproteomics identified thirteen protein networks distinctly regulated by DN R-Ras, including multiple networks regulating cellular movement and morphology. (biomedcentral.com)
  • We have previously shown that three related Ras proteins (the classic Ras proteins) are highly activated in malignant peripheral nerve sheath tumor (MPNST) cells with neurofibromin loss and that they drive cancer cell proliferation and survival by activating multiple cellular signaling pathways. (biomedcentral.com)
  • Closer study of an R-Ras regulated pathway containing the signaling protein ROCK1 showed that inhibition of either R-Ras, R-Ras2 or ROCK1 similarly impaired cellular migration and invasion and altered cellular morphology. (biomedcentral.com)
  • Inhibition of R-Ras/R-Ras2 and ROCK1 signaling also triggered the accumulation of abnormal intracellular vesicles, indicating that these signaling molecules regulate the movement of proteins and other molecules in the cellular interior. (biomedcentral.com)
  • The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. (uchicago.edu)
  • The K-Ras protein is a GTPase, a class of enzymes which convert the nucleotide guanosine triphosphate (GTP) into guanosine diphosphate (GDP). (wikipedia.org)
  • The gene product of KRAS, the K-Ras protein, was first found as a p21 GTPase. (wikipedia.org)
  • The rate of conversion is usually slow, but can be increased dramatically by an accessory protein of the GTPase-activating protein (GAP) class, for example RasGAP. (wikipedia.org)
  • Although the GTPase switch of Rab proteins is highly conserved, functional mechanisms may be highly diversified among members of the Rab family. (embl.de)
  • The carboxy-terminal catalytic domain of the GTPase-activating protein inhibits nuclear signal transduction and morphological transformation mediated by the CSF-1 receptor. (musc.edu)
  • HRAS, HRas proto-oncogene, GTPase, is a member of the small GTPase family that upon activation by growth factors stimulates multiple downstream pathways such as RAF and PI3K to promote cell proliferation and survival ( PMID: 21779504 , PMID: 32241873 ). (jax.org)
  • A structural feature that distinguishes the Rho proteins from other small GTPases is the so-called Rho insert domain located between a β strand and an α helix within the small GTPase domain [ 1 - 3 ]. (biomedcentral.com)
  • Typically Rho proteins are 190-250 residues long and consist only of the GTPase domain and short terminal C-terminal extensions. (biomedcentral.com)
  • Within their GTPase domains, they share approximately 30% amino acid identity with the Ras proteins and 40-95% identity within the family. (biomedcentral.com)
  • Rho GTPase effectors are a large group of proteins and include actin nucleation promoting molecules, adaptors, as well as kinases. (biomedcentral.com)
  • Loss of the Ras GTPase-activating protein neurofibromin promotes nervous system tumor pathogenesis in patients with neurofibromatosis type 1 (NF1). (biomedcentral.com)
  • Once it is allosterically activated, it recruits and activates proteins necessary for the propagation of growth factors, as well as other cell signaling receptors like c-Raf and PI 3-kinase. (wikipedia.org)
  • Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. (musc.edu)
  • ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice. (musc.edu)
  • Previously, we reported that knockdown of Abl protein tyrosine kinase by shRNA or pharmacological inhibition suppresses particle assembly of J6/JFH1 strain-derived hepatitis C virus (HCV) in Huh-7.5 cells. (bvsalud.org)
  • On the opposite, MuRF1 was selelck kinase inhibitor by far the most fluctuating protein, reaching a maximal variation amount of 60% in excess of two biopsies taken in similar circumstances 48 hours apart. (dubinhibitors.com)
  • Wang HG, Rapp UR, Reed JC: Bcl-2 targets the protein kinase Raf-1 to mitochondria. (drugbank.com)
  • Koh H, Lee KH, Kim D, Kim S, Kim JW, Chung J: Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage. (drugbank.com)
  • Cotteret S, Jaffer ZM, Beeser A, Chernoff J: p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. (drugbank.com)
  • Li YY, Popivanova BK, Nagai Y, Ishikura H, Fujii C, Mukaida N: Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines. (drugbank.com)
  • Popivanova BK, Li YY, Zheng H, Omura K, Fujii C, Tsuneyama K, Mukaida N: Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis. (drugbank.com)
  • CDK4 is a member of the Ser/Thr protein kinase family. (thermofisher.com)
  • It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
  • To understand the signal transduction required, we focused primarily on IL-6 induction by measuring mitogen-activated protein kinase activity and analyzing the effects of mutant or dominant negative forms of Vav, Rac1, and c-Jun N-terminal kinase-1 (JNK1). (aai.org)
  • Vav overexpression resulted in the constitutive activation of JNK1 with little or no effect on p38 mitogen-activated protein kinase and ERK2. (aai.org)
  • CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1. (univ-paris5.fr)
  • Oncogene Ras/phosphatidylinositol 3-kinase signaling targets histone H3 acetylation at lysine 56. (univ-paris5.fr)
  • Costello syndrome: a Ras/mitogen activated protein kinase pathway syndrome (rasopathy) resulting from HRAS germline mutations. (univ-paris5.fr)
  • The tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAF. (univ-paris5.fr)
  • A Multicenter Retrospective Chart Review of Clinical Outcomes Among Patients With KRAS G12C Mutant Non-Small Cell Lung Cancer. (uchicago.edu)
  • KRAS (Kirsten rat sarcoma virus) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. (wikipedia.org)
  • It is called KRAS because it was first identified as a viral oncogene in the Kirsten RAt Sarcoma virus. (wikipedia.org)
  • There are two protein products of the KRAS gene in mammalian cells that result from the use of alternative exon 4 (exon 4A and 4B respectively): K-Ras4A and K-Ras4B. (wikipedia.org)
  • KRAS acts as a molecular on/off switch, using protein dynamics. (wikipedia.org)
  • citation needed] In turn, KRAS can bind to proteins of the Guanine Nucleotide Exchange Factor (GEF) class (such as SOS1), which forces the release of bound nucleotide (GDP). (wikipedia.org)
  • Subsequently, KRAS binds GTP present in the cytosol and the GEF is released from ras-GTP. (wikipedia.org)
  • REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression. (cancerindex.org)
  • REG4, an important regulator of gastro-intestinal carcinogenesis, was highly expressed in KRAS mutant lung adenocarcinoma with low expression of TTF-1 (KC subtype). (cancerindex.org)
  • KRAS mutant tumors were more evenly distributed: 40% right colon, 28% left colon, and 36% rectal tumors. (ox.ac.uk)
  • Other members of the Ras family include: HRAS and NRAS. (wikipedia.org)
  • Methylation pattern of oncogene HRAS gene promoter region and its clinical relevance to urocystic tumorigenesis. (univ-paris5.fr)
  • Like other members of the ras subfamily of GTPases, the K-Ras protein is an early player in many signal transduction pathways. (wikipedia.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • In eukaryotic cells, protein transport through the secretory and endocytic pathways is mediated by vesicular intermediates. (embl.de)
  • An enhancer element responsive to ras and fms signaling pathways is composed of two distinct nuclear factor binding sites. (musc.edu)
  • Stable monoubiquitinated form of wild type p53, accumulates in the cytoplasm and interacts with BAK or BAX proteins in mitochondria to induce apoptosis Thus Kevetrin activates both transcription dependent and transcription independent pathways to promote apoptosis. (shu.edu)
  • Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
  • R-Ras proteins function distinctly from classic Ras proteins by regulating distinct signaling pathways that promote MPNST tumorigenesis by mediating migration and invasion. (biomedcentral.com)
  • We examined the activation of cytoplasmic signaling pathways in the presence and absence of R-Ras signaling and found that R-Ras proteins regulated 13 signaling pathways distinct from those regulated by classic Ras proteins. (biomedcentral.com)
  • citation needed] This proto-oncogene is a Kirsten ras oncogene homolog from the mammalian Ras gene family. (wikipedia.org)
  • The Rab family of small GTP-binding proteins has long been implicated in the docking and fusion of transport vesicles with their target membranes. (embl.de)
  • Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. (biomedcentral.com)
  • Together, these findings implicate transcriptional regulation of EMT by YAP1 as a significant component of oncogenic RAS signaling. (nih.gov)
  • Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance. (univ-paris5.fr)
  • In this way the K-Ras protein acts like a switch that is turned on and off by the GTP and GDP molecules. (wikipedia.org)
  • One obvious possibility is to pursue the matter in Drosophila melanogaster DNA, which has sequences homologous to several vertebrate oncogenes. (embl.de)
  • The cDNAs were derived from a gene, designated ypt1, which codes for a protein of 205 amino acids with 71% homology to the yeast YPT1 gene product. (embl.de)
  • An instance of an oncogene is the HER2 gene, which creates the HER2 protein. (alliedacademies.org)
  • Extra copies of this gene may result in an overabundance of HER2 protein, causing cells to proliferate faster. (alliedacademies.org)
  • Some breast cancer and ovarian cancer cells include the HER2 oncogene. (alliedacademies.org)
  • There is some redundancy among the 11 Ypt proteins, and only those involved in the biosynthetic pathway are essential for cell viability. (embl.de)
  • Individual transport steps are regulated by Ras-like guanine nucleotide-binding proteins, termed Ypt in yeast or Rab in mammals. (embl.de)
  • The YPT1 gene of the yeast Saccharomyces cerevisiae codes for a guanine nucleotide-binding protein which is essential for cell viability. (embl.de)
  • Amino acid sequences typical for guanine nucleotide-binding proteins and characteristic for ypt proteins are perfectly conserved in the mouse ypt1 protein. (embl.de)
  • Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalysed by guanine nucleotide exchange factors (GEFs) in the Dbl family. (embl-heidelberg.de)
  • The guanine nucleotide exchange factor (GEF) Dbl targets Rho family proteins thereby stimulating their GDP/GTP exchange, and thus is believed to be involved in receptor-mediated regulation of the proteins. (embl-heidelberg.de)
  • A novel membrane factor stimulates guanine nucleotide exchange reaction of ras proteins. (wikidata.org)
  • Cells were transfected with doxycycline-inducible vectors expressing either a pan-inhibitor of the R-Ras subfamily [dominant negative (DN) R-Ras] or enhanced green fluorescent protein (eGFP). (biomedcentral.com)
  • The elevated expression of p53 leads to greater stability, which also induces the regulatory protein Mdm2. (shu.edu)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Different cancer types tend to depend on a limited number of 'driver' oncogene mutations. (cancerquest.org)
  • A proto-oncogene is a gene that becomes an oncogene, a gene that has the potential to cause cancer, through mutations or an increase in expression. (shu.edu)
  • Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations. (wikidata.org)
  • Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)
  • Mutations of the NF1 gene potentially results in the activation of multiple Ras proteins, which are key regulators of many biologic effects. (biomedcentral.com)
  • A useful analogy to consider when thinking about tumor suppressors and oncogenes is an automobile. (cancerquest.org)
  • We have shown that classic Ras proteins promote proliferation and survival, but not migration, in malignant peripheral nerve sheath tumor (MPNST) cells. (biomedcentral.com)
  • Reconstitution experiments using human embryonic kidney 293T cells revealed that phosphorylation of Tyr412 in the activation loop of Abl was enhanced by coexpression with the viral nonstructural protein 5A (NS5A) and was abrogated by the substitution of NS5A Tyr330 with Phe (Y330F), suggesting that NS5A functions as a substrate activator of Abl. (bvsalud.org)
  • Among the viral transcripts, preC mRNA encodes precore protein. (biomedcentral.com)
  • pgRNA translates viral HBc and Pol proteins, and also acts as a template for the replication of the HBV genome. (biomedcentral.com)
  • After translation of viral RNAs into HBV proteins occurs in the host cytoplasm, viral pgRNA is encapsulated into core particles. (biomedcentral.com)
  • Neurofibromin loss potentially hyperactivates classic Ras (H-Ras, N-Ras, K-Ras), M-Ras, and R-Ras (R-Ras, R-Ras2/TC21) subfamily proteins. (biomedcentral.com)
  • It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. (embl-heidelberg.de)
  • All members contain the sequence motifs characteristic of all GTP-binding proteins, bind to GDP and GTP with high affinity. (biomedcentral.com)
  • These motifs are found in many proteins that are regulated by calcium. (lookformedical.com)
  • Thus it can be inferred from our findings that the alternative splicing exon IDX from H-Ras, coupled with the immediately downstream intron sequences, may contain an ncRNA. (lidsen.com)
  • CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells. (musc.edu)
  • Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. (musc.edu)
  • A sub examination was also carried out, in which R2 was set since the referential worth and compared to Mob ailment, to be able to measure the influence of a neighborhood acute mobiliza tion on protein expression and exercise amounts as evi denced by phosphorylation level variations. (dubinhibitors.com)
  • Third, reverse transcription is responsible for the insertion of oncogenes into retroviral genomes as well as some proto-oncogene and tumour suppressor gene alterations in non-virus induced cancers. (alliedacademies.org)
  • The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF). (musc.edu)
  • These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • JUN mRNA was decreased and, as JUN transcription is autoregulated by JUN protein,and JUN heterodimerizes with Meq. (dubinhibitors.com)
  • Tumors form often when oncogenic expression is induced by tissue-specific promoters in genetically modified mouse models, but they regress when the inducing stimulus is turned off, implying that oncogenes are cancer's Achilles' heel (allowing the body to target the disease). (alliedacademies.org)
  • Similarly, 17% of right colon, 2% of left colon, and 2% of rectal tumors were BRAF mutant. (ox.ac.uk)
  • P = .002) but did not differ significantly between BRAF mutant and wild-type tumors (P = .36). (ox.ac.uk)
  • Mdm2 is a proto-oncogene that is amplified in approximately 7% of cancers and is frequently seen in soft tissue tumors. (shu.edu)
  • CD30hi lymphocytes also had 4 fold far more nuclear found ERBB protein and above expression and nuclear localization of ERBB one and 2 are popular in tumors. (dubinhibitors.com)
  • LZTR1 is a regulator of RAS ubiquitination and signaling. (univ-paris5.fr)
  • LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases. (univ-paris5.fr)
  • CIP2A cooperates with H-Ras to promote epithelial-mesenchymal transition in cervical-cancer progression. (univ-paris5.fr)
  • PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D. (univ-paris5.fr)
  • Cancer cells that express oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival, but the molecular basis of this oncogene dependency remains incompletely understood. (nih.gov)
  • Low molecular weight, calcium binding muscle proteins. (lookformedical.com)
  • H-Ras isoform modulates extracellular matrix synthesis, proliferation, and migration in fibroblasts. (univ-paris5.fr)
  • We assessed the expression and activation of these proteins in MPNST cells and inhibited them to determine the effect this had on proliferation, migration, invasion, survival and the phosphoproteome. (biomedcentral.com)
  • Consistent with classical Ras inhibition, DN R-Ras and R-Ras2 knockdown inhibited proliferation. (biomedcentral.com)
  • Inhibition of R-Ras action inhibited proliferation, migration and invasion but not survival. (biomedcentral.com)
  • The western blotting study indicated inhibition of cell survival proteins (BCR, ABL, H-RAS, N-RAS, K-RAS and RAF) and expression of apoptotic proteins (p38, BAX and caspase-9) in leukemia cells upon treatment with vitexin. (bvsalud.org)
  • However, DN R-Ras inhibition impaired migration and invasion but not survival. (biomedcentral.com)
  • Transcriptional activation of a conserved sequence element by ras requires a nuclear factor distinct from c-fos or c-jun. (musc.edu)
  • Insulin stimulation of gene expression mediated by p21ras activation. (wikidata.org)
  • Here, we examined the expression, activation and action of R-Ras proteins in MPNST cells that have lost neurofibromin. (biomedcentral.com)
  • Here, we highlight that an important RNA sequence region, encompassing an exon-intron hairpin loop (also called IDX-rasISS1), of the H-Ras pre-mRNA may encode an ncRNA that regulates p68 RNA helicase. (lidsen.com)
  • Mdm2 protein has the activity of an ubiquitin ligase, which allows for the targeted degradation of its substrates, including p53. (shu.edu)
  • Mitogenic signaling by colony-stimulating factor 1 and ras is suppressed by the ets-2 DNA-binding domain and restored by myc overexpression. (musc.edu)
  • An amino-terminal portion conserved among a subset of Dbl family proteins is sufficient for the binding of Gbetagamma. (embl-heidelberg.de)
  • R-Ras2 was uniformly expressed in MPNST cells, with R-Ras present in a major subset. (biomedcentral.com)
  • Proto-Oncogene Proteins p21(ras)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • selleck chemicals Success Complete protein volume variation The affect in the disorders surrounding biopsy proce dures on total protein amount was evaluated by measur ing the intra subject variation of your Western blot signal obtained with every sampling conditions. (dubinhibitors.com)
  • All of this research has demonstrated that oncogene expression is essential not just for cancer development but also for disease maintenance, keeping oncogenes in the spotlight as important anti-cancer treatment targets. (alliedacademies.org)
  • The role of proto-oncogenes in normal cell growth and differentiation, as well as the idea that oncogene proteins could be used as new targets for cancer chemotherapy, are both current research topics that are direct outgrowths of Howard's important contributions to cancer research. (alliedacademies.org)
  • Finally, alternative splicing microarrays containing apoptosis targets were incubated to verify whether pre-mRNAs other than H-Ras could also present a similar hairpin loop structure regulated by p68 RNA helicase. (lidsen.com)
  • ELAC1 has been in the use and may as define as an RNase Z. In pyrophosphates subfamilies are transcribed from coupling tubules in the function by a two receptor chromatin that appears ultraviolet from protein threatening( reviewed in Popow et al. (evakoch.com)
  • We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)
  • Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation. (univ-paris5.fr)
  • Second, both strongly transforming retroviruses and non-virus induced malignancies, including human cancers, contain comparable oncogenes. (alliedacademies.org)
  • Many efforts have been undertaken to understand the causal function of activated oncogenes in cancer formation since their discovery in human tumours. (alliedacademies.org)
  • Oncogene expression and their possible function in immune cell abnormalities during carcinogenesis and tumour growth, however, have not even been adequately investigated [ 4 ]. (alliedacademies.org)
  • In general, oncogene function during multistep carcinogenesis is thought to be based on a growth advantage afforded by the proto-oncogene product's altered function. (alliedacademies.org)
  • Recent findings, however, indicate that their function in vesicle trafficking can go beyond this role, and a number of proteins, unrelated to each other, have been identified as putative Rab effectors. (embl.de)
  • Organisms amenable to easy genetic analysis should prove helpful in assessing the function of at least those proto-oncogene products which are highly conserved in different eukaryotic cells. (embl.de)
  • These data highlight that ESE-1 contains NLS and NES signals that play a critical role in regulating its subcellular localization and function, and that an intact SAR domain mediates MEC transformation exclusively in the cytoplasm, via a novel nontranscriptional mechanism, whereby the SAR motif is accessible for ligand and/or protein interactions. (biomedcentral.com)
  • However PTEN professional tein was not differentially expressed, STK11 protein decreased. (dubinhibitors.com)
  • A calbindin protein that is differentially expressed in distinct populations of NEURONS throughout the vertebrate and invertebrate NERVOUS SYSTEM, and modulates intrinsic neuronal excitability and influences LONG-TERM POTENTIATION. (lookformedical.com)
  • The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. (embl-heidelberg.de)
  • The 2.4 and 2.1 kb envelope mRNAs encode LS, MS, and S proteins. (biomedcentral.com)