Mutant ProteinsMutationMolecular Sequence DataMutagenesis, Site-DirectedAmino Acid SequenceProtein FoldingEscherichia coliProtein BindingCell AggregationProtein ConformationAmino Acid SubstitutionModels, MolecularBinding SitesMolecular ChaperonesKineticsBacterial ProteinsProtein DenaturationProtein Structure, TertiaryPhenotypeAmyloidTemperatureMutation, MissenseBase SequenceCell LinePoint MutationProtein Structure, QuaternaryProtein Structure, Secondaryalpha-Crystallin B ChainInclusion BodiesStructure-Activity RelationshipProtein MultimerizationProteinsNeurodegenerative DiseasesCircular DichroismGenetic Complementation TestPeptidesalpha-SynucleinPlasmidsProtein StabilityTransfectionRecombinant Fusion ProteinsEscherichia coli ProteinsSequence Homology, Amino AcidRecombinant ProteinsMice, Mutant StrainsHSP40 Heat-Shock ProteinsCloning, MolecularSequence DeletionSolubilityalpha-Crystallin A ChainDNA-Binding ProteinsNerve Tissue ProteinsCOS CellsMembrane ProteinsDimerizationCysteineSaccharomyces cerevisiae ProteinsHeat-Shock ProteinsProteostasis DeficienciesNuclear Proteinsgamma-CrystallinsHuntington DiseaseHot TemperatureGene DeletionPlatelet Aggregation InhibitorsSequence AlignmentProtein TransportProteasome Endopeptidase ComplexDNA PrimersThermodynamicsTranscription FactorsGenes, DominantDNA Mutational AnalysisHydrophobic and Hydrophilic InteractionsMutagenesis, InsertionalModels, BiologicalAdenosine TriphosphatasesCell MembraneElectrophoresis, Polyacrylamide GelFungal ProteinsErythrocyte AggregationSignal TransductionEnzyme StabilityBlotting, WesternCercopithecus aethiopsAmyotrophic Lateral SclerosisHydrogen-Ion ConcentrationHSP70 Heat-Shock ProteinsSpectrometry, FluorescencePhysical PhenomenaGreen Fluorescent ProteinsMutagenesisGenes, BacterialBlood PlateletsUbiquitinAllelesPhosphorylationMuramidaseSubstrate SpecificityCatalysis