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  • environmental
  • On 30 June 1980 John Coulter was sacked from his job at the Institute of Medical and Veterinary Science (IMVS) in Adelaide, and the environmental mutagens testing unit which he headed was closed down. (edu.au)
  • Exposure
  • Assessments of impacts of hazardous agents (i.e., chemical and physical mutagens) on human health have focused on defining the effects of chronic exposure on individuals, with cancer being the main effect of concern. (unt.edu)
  • When sufficient evidence establishes a causal connection between human exposure to a chemical and heritable genetic effects, the substance is classified as a mutagen. (ehspublishing.com)
  • Lastly, although other meat-derived HCA mutagens have been shown to bind DNA in pancreatic tissue, indicating that exposure to HCAs from cooked meat cannot be discounted as a risk factor for pancreatic cancer, the results from this current study show that exposure to a single dietary dose of MeIQx does not readily form measurable DNA adducts under the conditions of the experiment. (osti.gov)
  • genetic
  • We conducted a pilot study of 28 patients with HCC and 110 healthy controls matched for age, sex, and ethnicity to determine whether constitutional genetic instability, based on the quantification of mutagen-induced chromatid breaks in cultured lymphocytes, modifies an individual's risk of HCC development. (aacrjournals.org)
  • Resistance
  • Genetical analysis of the yeast insert DNAs revealed three genes SNG1, SNQ2 , and SNQ3 that confer the phenotype hyper-resistance to MNNG, to 4-NQO and triaziquone, and to mutagens 4-NQO, MNNG, and triaziquone, respectively. (springer.com)
  • human
  • H. Hayatsu, S. Arimoto, K. Togawa, and M. Makita, Inhibitory effect of the ether-extract of human feces on activities of mutagens: Inhibition of oleic and linoleic acids, Mut. (springer.com)
  • induction
  • Although TNF-α is not known to damage DNA directly and there is no published report of other cytokine-induced instability, our study revealed that TNF-α is a potent mutagen that causes DNA damage through the induction of reactive oxygen species (ROS). (aacrjournals.org)
  • Cancer
  • Mutagens change DNA by punching holes in it or forcing parts of DNA to stay bound together even when they should separate, according to the Irish Cancer Society. (reference.com)
  • cause
  • These are the result of the way in which mutagens cause effects on DNA repair systems or on metabolic activation or detoxification systems. (springer.com)
  • physical
  • The alchemist's mutagen now grants a +6 natural armor bonus, a +8 alchemical bonus to one ability score ( Strength , Dexterity , or Constitution ), a +6 alchemical bonus to a second physical ability score, and a +4 alchemical bonus to a third physical ability score. (d20pfsrd.com)
  • known
  • The exact nucleotide site at which DNA synthesis is blocked in vitro by reaction with mutagens can be observed in a øX174 system in which the nucleotide sequence is known. (springer.com)
  • long
  • Planet of the Mutagens has a story with long enough legs for a full-length play, which makes it all the more a pity that it was not successfully adapted to that medium. (oobr.com)