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Mutagenicity TestsMutagensSalmonella typhimuriumAntimutagenic AgentsBiotransformationCarcinogensMicronucleus TestsPolycyclic CompoundsDNA AdductsPyrenesEthylene DibromideSalmonellaCarcinogens, EnvironmentalBenzidinesBenz(a)AnthracenesChrysenesBenzo(a)pyreneEpoxy CompoundsCarcinogenicity TestsBenzopyrenesMutagenesisHypoxanthine PhosphoribosyltransferaseMicrosomes, Liver7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideRubberAzaguanineGasolineCricetinaePolycyclic Hydrocarbons, AromaticMutationAminacrineCarbolinesDNA DamageFossil FuelsNitrofuransFluorenesCricetulusHydrocarbons, BrominatedAflatoxin B1Nitro CompoundsAroclorsFuel OilsDihydroxydihydrobenzopyrenesLac RepressorsStructure-Activity RelationshipAminesDeoxyguanosineChromatesNitrosaminesDiethylaminesDimethylnitrosamineHycanthoneAflatoxinsHydrocarbons, HalogenatedAlkylating AgentsOxamic AcidAcroleinPotassium DichromateAir PollutantsSister Chromatid ExchangeCaptanMethylnitronitrosoguanidineNiridazolePiperCokeCoalComfreyWater PollutantsDNAChlorineUndariaNetropsinPhenalenesDose-Response Relationship, DrugN-substituted GlycinesVehicle EmissionsTriallateHeterocyclic CompoundsPlant ExtractsMicronuclei, Chromosome-DefectiveCooking and Eating UtensilsPrintingNitrogen Mustard CompoundsNitroreductasesDiterpenes, KauraneComet AssayPhenanthrenesCarminePentoxylOchratoxinsCytochrome P-450 CYP1A2Drug Evaluation, PreclinicalAlkylationGuanineEthylnitrosoureaDNA RepairDNA BreaksCycasinEscherichia coliSOS Response (Genetics)
AmesAssaySalmonellaGenotoxicityAssaysToxicityToxicologyParticulateStrainsPredictionSolventsExtractsSubstancesCigarettesAssessmentAbstractTestDataExposureModelsTestingStudyEffectCarcinogenicityGerm Cell MutagenicityGenotoxicity and mutagenicityBacterialToxicologyTransgenicMutationMetabolismVitroChemicalsStrainAnalysesUnitDevelopment
Ames8
  • The primary emissions and smoke condensates were analyzed for a standardized suite of chemical species, and the condensates were studied for pulmonary toxicity in female CD-1 mice and mutagenic activity in Salmonella (Ames) mutagenicity assay using the frameshift strain TA98 and the base-substitution strain TA100 with and without metabolic activation (S9 from rat liver). (nih.gov)
  • We assessed its mutagenicity using Ames test. (nih.gov)
  • Our aim was to investigate the mutagenicity and antimutagenicity of C. odontophyllum acetone leaves extracts by using the Ames test (Salmonella reverse mutagenicity assay).The Ames test also involved the pre-incubation method against Salmonella typhimurium TA98 and TA100 bacterial strains in the absence and presence of metabolic activator S9 system. (ccsenet.org)
  • Experimentally, mutagenicity is assessed by Ames test performed on Salmonella typhimurium bacterial strains where each bacterial strain is sensitive to specific chemical mutagen [ 2 ]. (biomedcentral.com)
  • Moreover, mutagenicity of 1,2-NphQ has been evaluated thanks to Ames assay. (hal.science)
  • Ames mutagenicity assays. (cdc.gov)
  • In the present work, a strategy integrating a number of (Quantitative) Structure Activity Relationship ((Q)SAR) models for Ames mutagenicity predictions is proposed. (altex.org)
  • Two Ames mutagenicity test strains of Salmonella typhimurium, TA98 and TA102, were used. (ox.ac.uk)
Assay1
  • This report presents the FORTRAN V programs utilized for the production of labels and cards for the Drosophila melanogaster sex-linked recessive lethal mutagenicity assay. (dtic.mil)
Salmonella2
Genotoxicity1
  • Mutagenicity is the ability of a substance to cause genotoxicity. (biomedcentral.com)
Assays1
  • A study carried out at a pilot plant for drinking water disinfection of lake water revealed mutagenic activity of three different disinfectants (sodium hypochlorite, chlorine dioxide and peracetic acid) in different seasons using in situ mutagenicity assays, both in animal (micronucleus test) and in plant organisms (anaphase chromosomal aberration and micronucleus tests). (scirp.org)
Toxicity1
  • Mutagenicity was observed in the fibroblast cells, but the greater toxicity of PhIP to the epithelial cells prevented a definitive evaluation of mutagenicity. (uoguelph.ca)
Toxicology1
  • The new field of applied genetic research, genetic toxicology and mutation research investigates the mutagenicity and cancerogenicity of chemicals and other agents. (powells.com)
Particulate2
  • Commonly the atmospheric pollution research is focussed on particulate indicators especially when mutagenicity was studied. (unito.it)
  • This work is focussed on the assessing of the total mutagenicity shifting the gas-phase and particulate phase, during two seasons, in Turin. (unito.it)
Strains1
  • In conclusion, C. odontophyllum acetone leaves extract was not mutagenic and had significant inhibitory effects on mutagenicity in both bacterial strains with and without the metabolic activator S9 system. (ccsenet.org)
Prediction1
  • Prior work on prediction of mutagenicity has primarily involved identification of toxicophores rather than whole-molecule predictive models. (biomedcentral.com)
Solvents1
Extracts2
  • To determine the mutagenicity effects of the extracts, each concentration of the extract was evaluated based on the two-fold value of the number of revertant's colony in negative control plate as the cut-of point. (ccsenet.org)
  • Mutagenicity evaluations were conducted on extracts of particulates and bulk samples. (cdc.gov)
Substances1
  • In particular, mutagenicity assessment has a particular relevance and is a mandatory requirement for all substances released from plastic FCM, regardless how low migration and exposure are. (altex.org)
Cigarettes1
  • To compare the mutagenicity of the cigarettes, the dose-response curve for the mutant frequency was calculated by nonlinear regression analysis. (pmiscience.com)
Assessment1
  • In particular, a scheme to integrate mutagenicity estimations into a single final assessment was developed, resulting in an increased domain of applicability. (altex.org)
Abstract1
  • original abstract available at http://connection.ebscohost.com/c/articles/59352328/mutagenicity-test-morinda-citrifolia-noni-leaves ). (noniresearch.org)
Test3
  • Mutagenicity test of Morinda citrifolia (noni) leaves. (noniresearch.org)
  • The same welding fume sample was used for a mutagenicity test (resistance to 6-thioguanine) with V 79 hamster cells. (sjweh.fi)
  • A test program was conducted to evaluate the mutagenicity of toxaphene residuals extracted from aged soils and from fish collected in creeks near a toxaphene-contaminated site. (unl.edu)
Data3
  • The Bursi mutagenicity data set containing 4337 compounds (Set 1) and a Benchmark data set of 6512 compounds (Set 2) were taken as input data set in this work. (biomedcentral.com)
  • To validate the developed models two external data sets, AID1189 and AID1194, with mutagenicity data were tested showing 62% accuracy with 67% precision and 65% ROC area and 91% accuracy, 91% precision with 96.3% ROC area respectively. (biomedcentral.com)
  • We have created a new mutagenicity benchmark data set with around 8,000 compounds. (biomedcentral.com)
Exposure2
  • These results show that temperature is an important variable which should be taken into account when in situ exposure of plants is planned for mutagenicity testing. (scirp.org)
  • In this manuscript, we report the in vitro mutagenicity of waterpipe smoke condensate (WSC), the alteration in cellular parameters of lung alveolar cells in response to WSC exposure and discuss the implication of cellular responses in the pathophysiology of chronic obstructive pulmonary disease (COPD). (nih.gov)
Models1
  • Our work shows that highly accurate predictive mutagenicity models can be built using machine learning methods based on chemical descriptors and trained using this set, and these models provide a complement to toxicophores based methods. (biomedcentral.com)
Testing1
  • Computer Assisted Labelling in Mutagenicity Testing. (dtic.mil)
Study1
  • The ultimate objective was to determine if the residual toxaphene congeners were more or less mutagenic than those in technical- grade toxaphene.The study showed that the mutagenicity of the bioaccumulated toxaphenecongeners in fish, expressed as colony revertants per mg of residual toxaphene, was no greater than that of technical-grade toxaphene.Themutagenicimpactofthetoxapheneresidualsinagedsoilstatistically was less than that for technical-grade toxaphene. (unl.edu)
Effect1
  • While no mutagenicity was found with mild steel welding, a mutagenic effect was established with samples from stainless steel welding. (sjweh.fi)
Carcinogenicity6
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Germ Cell Mutagenicity2
  • To address these data gaps, the Germ Cell workgroup of the Genetic Toxicology Technical Committee of the Health and Environmental Sciences Institute reviewed the available TGR mutagenicity data in male germ cells, and, characterized the exposure history of tubule germ cells for different sampling times to evaluate its impact on germ cell mutagenicity testing using TG 488. (nih.gov)
  • Finally, recommendations are provided to guide the experimental design for germ cell mutagenicity data for regulatory submission, as well as other possible approaches to increase the reliability of the TGR assay. (nih.gov)
Genotoxicity and mutagenicity1
  • A comprehensive overview of genotoxicity and mutagenicity associated with outdoor air pollution exposure in Brazil. (qxmd.com)
Bacterial2
  • Each chemical was tested at a minimum of five concentrations using standard procedures.2 All of the chemicals evaluated in the bacterial mutagenicity studies, including MCHM and crude MCHM, were inactive. (nih.gov)
  • The method described the above mentioned guidelines conforms to the guidelines for bacterial mutagenicity testing published by the major Japanese Regulatory Authorities including METI, MHLW and MAFF. (europa.eu)
Toxicology1
  • Kiyohara, C & Hirohata, T 1994, ' Effects of vitamin C and PCB metabolites on the inhibition of aryl hydrocarbon hydroxylase and suppression of mutagenicity of benzo[a]pyrene ', Toxicology in Vitro , vol. 8, no. 6, pp. 1185-1189. (elsevierpure.com)
Transgenic2
  • Details for: Transgenic animal mutagenicity assays. (who.int)
  • The Organisation for Economic Co-operation and Development Test Guideline 488 (TG 488) provides recommendations for assessing germ cell and somatic cell mutagenicity using transgenic rodent (TGR) models. (nih.gov)
Mutation2
  • Since urinary mutagenicity is a biomarker associated with genetic damage, temazcal use may therefore be expected to contribute to an increased risk of DNA damage and mutation, effects associated with the initiation of cancer. (flutrackers.com)
  • Plewa, MJ & Gentile, JM 1976, ' Mutagenicity of atrazine: A maize-microbe bioassay ', Mutation Research/Environmental Mutagenesis and Related Subjects , vol. 38, no. 4, pp. 287-292. (illinois.edu)
Metabolism1
  • Metabolism and mutagenicity of isoprene. (nih.gov)
Vitro1
  • Mutagenicity study of TCDD and ashes from urban incenerator in vivo and in vitro using yeast D7 strain. (unibo.it)
Chemicals1
  • The studies to evaluate the mutagenicity of eight of the spil ed chemicals in bacteria are complete. (nih.gov)
Strain2
  • Mutagenicity of styrene on metabolizing D7 strain of S. cerevisiae . (unibo.it)
  • an equivocal response was obtained in S. typhimurium strain TA98 in the absence of S9, and no mutagenicity was detected with strain TA1535 or TA1537, with or without S9. (nih.gov)
Analyses1
  • The analyses carried out show the conservation of the mutagenicity of cytotoxic drugs found in very low quantities in the environment. (asstsas.com)
Unit1
  • The aim of this study was to assess the mutagenicity of several cytotoxic mixtures prepared at fixed concentrations, and the mutagenicity of environmental samples collected in a hospital centralized reconstitution unit. (asstsas.com)
Development1
  • Nano-insecticides against the black cutworm Agrotis ipsilon (Lepidoptera: Noctuidae): Toxicity, development, enzyme activity, and DNA mutagenicity. (bvsalud.org)