Formaldehyde is recognized as carcinogenic and mutagenic. (scienceblogs.com)
Genotoxic2
This study assessed the genotoxic and mutagenic potential of diflubenzuron (DFB) insecticide in mice. (unesp.br)
Data demonstrate that DFB exerts genotoxic and mutagenic effects in a dose-dependent manner. (unesp.br)
Reprotoxic2
Only a recognised organisation is allowed to measure the level of exposure for CMR, Carcinogenic, Mutagenic, Reprotoxic agents in working areas. (atousante.com)
In addition, PEG-IFN α2a (and IFN α2a) is not mutagenic and not known to be reprotoxic or carcinogenic, also, it is not suspected to have bioaccumulative properties nor endocrine activity. (janusinfo.se)
Impurities6
More guidance is needed on the appropriate control of non-mutagenic impurities during clinical development, explains Dave P Elder, JPAG Member and pharmaceutical industry consultant, in this audio interview. (europeanpharmaceuticalreview.com)
Limited guidance is available for the appropriate control of non-mutagenic impurities during clinical development, noted Dave P Elder, JPAG Member and pharmaceutical industry consultant, in the Foreword to the latest edition of European Pharmaceutical Review . (europeanpharmaceuticalreview.com)
Meanwhile, read more about Dr Elder's views about impurities in his article - Safety-based limits for non-mutagenic impurities for early phase clinical studies - in European Pharmaceutical Review , Issue 03 June 2018, page 7. (europeanpharmaceuticalreview.com)
Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control. (allthingsmedicine.com)
The most featured and reviewed on book Mutagenic Impurities: Strategies for Identification and Control PDF is available for grabs now here on our website free for students and professionals sole purpose of teaching and education. (allthingsmedicine.com)
He is the inventor of the purge factor concept applied to risk assessment of mutagenic impurities and has authored over 30 papers on that subject. (allthingsmedicine.com)
Teratogenic1
Chemical contamination may have severe consequences for human health, including mutagenic, carcinogenic and teratogenic effects. (who.int)
Salmonella3
The ability of prostaglandin synthetase (PGS) to cooxidize benzo( a )pyrene, benzo( a )anthracene, chrysene, and several of their dihydrodiol derivatives to mutagenic products was tested with Salmonella typhimurium strains TA98 and TA100. (aacrjournals.org)
Mutagenic capacity was tested by using Salmonella bacteria. (gochemless.com)
The test chemical did not induce mutation in the Salmonella typhimurium strains both in the presence and absence of S9 metabolic activation system and hence is not likely to be mutagenic under the conditions of this study. (europa.eu)
Chromosome1
The test chemical did not induce chromosome aberrations in the mammalian cell line in the presence and absence of S9 metabolic activation system and hence it is not mutagenic in the chromosome aberration study performed. (europa.eu)
Nucleotide1
One of the proposed modes of action of RBV is a direct mutagenic effect on viral genomes, inducing mismatches and subsequent nucleotide substitutions. (mdpi.com)
Mammalian1
PhIP, the most prevalent heterocyclic aromatic amine formed by cooking of proteinaceous food, is mutagenic in mammalian cells and is implicated in mammary and colon tumors. (nyu.edu)
Reproductive1
The researchers decided to look into the carcinogenic mutagenic and reproductive toxicity (CMR) of glyphosate and formulations in view of previously published findings dating from the 1990s, documenting effects on reproduction, such as sperm production and pregnancy, and mutagenic and toxic effects at very low doses in embryonic, foetal and placental cells. (i-sis.org.uk)
Aromatic1
Brüschweiler BJ, Merlot C (2017) Azo dyes in clothing textiles can be cleaved into a series of mutagenic aromatic amines which are not regulated yet. (vegetosindia.org)
Exposure1
Intrinsic factors include the nature of the gene and error in replication while extrinsic factor includes exposure to mutagenic agents that may cause alteration in genes. (thesciencenotes.com)
Toxicity1
Gene mutation toxicity study was performed to evaluate the mutagenic nature of the test chemical. (europa.eu)
Particulate1
Mutagenic activity was found in high volume and bulk particulate samples at two facilities. (cdc.gov)
Concentrations1
Mutagenic concentrations influenced both the callus growth and regeneration, these increasing at the lowest concentrations. (au-plovdiv.bg)
I am referring to taking fluoride internally, where it has been found to cause unscheduled DNA synthesis, sister chromatid exchanges and yes, mutagenic effects on the cells. (drkaslow.com)
Activity3
Results: The results indicate that mutagenic activity of DPM was strongly affected by fuels, engine operating conditions, and exhaust aftertreatment systems. (cdc.gov)
While the mutagenic activity was observed in B50 and B100 samples collected from both light- and heavy-load operating conditions, the ULSD samples were mutagenic only at light-load conditions. (cdc.gov)
Implications for mutagenic activity. (bvsalud.org)
Potential3
The current review presents the untapped potential of mutagenic approach. (vegetosindia.org)
We determined the mutagenic potential of 8ohG in two complementary bacteriophage plaque color assays in which insertion of 8ohG into specified locations in test vectors was followed by replication in E. coli. (the-scientist.com)
This study was conducted to investigate the mutagenic potential of diesel engine emissions (DEE) from neat (B100) and blended (B50) soy-based fatty acid methyl ester (FAME) biodiesel in comparison with ULSD PM using different engine operating conditions and exhaust aftertreatment configurations. (cdc.gov)
The effect of subcultures on callus growth was higher than that of mutagenic treatments. (au-plovdiv.bg)
Cancer2
REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps. (physiciansweekly.com)
Half of the articles said fluoride promotes cancer (mutagenic). (drkaslow.com)
Researchers1
Moreover, researchers proved that these chemicals have mutagenic capacity. (gochemless.com)
Study1
This study identified many new disinfection by-products not identified previously in swimming pool water and found that swimming pool waters are mutagenic. (gochemless.com)
Products2
The microsomal fraction of ram seminal vesicles, a known source of PGS, in the presence of the PGS substrate arachidonic acid, metabolized benzo( a )pyrene-7,8-dihydrodiol, benzo( a )anthracene-3,4-dihydrodiol, and chrysene-1,2-dihydrodiol to mutagenic products. (aacrjournals.org)
Results also revealed that all of the isolated disinfection by-products had mutagenic capacity. (gochemless.com)
No mutagenic response was observed in any of the samples tested. (uri.edu)
The distinctions between a questionable response and a nonmutagenic or weakly mutagenic response, and between a weak mutagenic response and mutagenic response are highly subjective. (europa.eu)
It was not necessary for a response to reach two-fold over background for a trial to be judged mutagenic. (europa.eu)
A chemical was judged mutagenic (+) or weakly mutagenic (+W) if it produced a reproducible, dose-related response over the solvent control, under a single metabolic activation condition, in replicate trials. (europa.eu)
Studies2
Collectively, these studies identify a protective and mutagenic role for REV1-Polζ in BRCA1/2 mutant cells and provide the rationale for using REV1-Polζ inhibitors to treat BRCA1/2 mutant tumors. (physiciansweekly.com)
A number of mutagenic studies were carried out on the sMMO enzyme of Methylosinus trichosporium OB3b in order to gain insight into sMMO and probe how structural aspects relate to function of the enzyme. (shu.ac.uk)
Found1
When compared with drinking water, the mutagenic capacity of swimming pool water was found to be the same as that of drinking water. (gochemless.com)