Evolution, MolecularMutagenesisMutagenesis, Site-DirectedMolecular Sequence DataMutagenesis, InsertionalAmino Acid SequencePhylogenyBase SequenceDirected Molecular EvolutionMutationModels, MolecularBinding SitesEscherichia coliSequence AlignmentSelection, GeneticSequence Homology, Amino AcidStructure-Activity RelationshipProtein Structure, TertiarySpecies SpecificityAmino Acid SubstitutionModels, GeneticSequence Analysis, DNAKineticsProtein ConformationBacterial ProteinsCloning, MolecularDNA Transposable ElementsModels, ChemicalGenetic VariationProtein BindingConserved SequenceRecombinant ProteinsCultural EvolutionPlasmidsProtein Structure, SecondaryCatalysisGenes, BacterialAdaptation, BiologicalSubstrate SpecificityMultigene FamilyMutagensDNA PrimersCysteineModels, BiologicalPhenotypeClonal EvolutionMagnetic Resonance SpectroscopyCell LinePoint MutationDNAChemical PhenomenaEvolution, ChemicalMolecular StructureCrystallography, X-RaySequence Homology, Nucleic AcidCatalytic DomainEthylnitrosoureaGenomeProtein EngineeringRecombination, GeneticDNA, BacterialAlaninePrimatesEscherichia coli ProteinsMultiple Chemical SensitivityFossilsSaccharomyces cerevisiaeMammalsHistidinePolymerase Chain ReactionCodonDNA Mutational AnalysisAmino AcidsChemical IndustryComputer SimulationProteinsPlantsChromosome MappingTime FactorsTranscription, GeneticAmino Acid MotifsGenetic Complementation TestRestriction MappingAdaptation, PhysiologicalOrganic ChemicalsChemical WarfareLysineTemperatureGenome, BacterialTransfectionInorganic ChemicalsSOS Response (Genetics)Promoter Regions, GeneticNucleic Acid ConformationSequence DeletionTranscription FactorsComputational BiologyRecombinant Fusion ProteinsEnzyme StabilityGene Transfer, Horizontal