• Regenerative rehabilitation of the musculoskeletal system. (chop.edu)
  • Micro/nano-engineered strategies and engineered biological systems developed at CASE BML enable broad applications in musculoskeletal research, regenerative medicine, clinical diagnostics, pharmaceutical research, in vitro models of human diseases, and national security. (uhhospitals.org)
  • Cato T. Laurencin, M.D., Ph.D., founded the field of musculoskeletal regenerative engineering more than three decades ago. (odtmag.com)
  • When I first started my laboratory at the Massachusetts Institute of Technology in 1988, bone was a primary target to study and develop as scientists had just learned how to actually grow human bone cells outside the body,' said Dr. Laurencin, the Albert and Wilda Van Dusen Distinguished Endowed Professor of Orthopaedic Surgery and CEO of the Connecticut Convergence Institute for Translation in Regenerative Engineering at the University of Connecticut. (odtmag.com)
  • His work is focused on biomaterials and scaffold development, tissue engineering and regenerative therapies, mostly for musculoskeletal tissues. (selectbiosciences.com)
  • The combination of ligamentous laxity and low muscle tone contributes to increased risk of a number of musculoskeletal disorders and a delay in acquisition of motor milestones. (bmj.com)
  • Children with Down syndrome are at increased risk of a number of musculoskeletal disorders. (bmj.com)
  • This, combined with hypotonia, also a well-described feature of DS, has significant and widespread functional impact, and contributes to increased risk of a number of musculoskeletal disorders, a delay in acquisition of motor milestones and lower levels of physical activity in children with DS. (bmj.com)
  • An increase in the prevalence of bone and joint disorders have garnered the bone graft substitutes segment to generate maximum revenue in 2016. (medgadget.com)
  • However, the joint reconstruction segment is projected to grow at the fastest rate during the forecast period, registering a CAGR of 6.2%, due to an upsurge in incidences of bone and joint disorders. (medgadget.com)
  • Clinical treatment strategies for musculoskeletal disorders have been a hot research topic. (hindawi.com)
  • Despite a lack of research, manufacturers of these devices claim productivity gains, work quality improvements, and a reduction of the risk of work‐related musculoskeletal disorders (WMSDs). (cdc.gov)
  • These PTH fragments, which increase in serum as CKD progresses, could potentially modulate the effects of PTH 1-84 and contribute to CKD-associated bone disorders. (cdc.gov)
  • Arthritis and related musculoskeletal disorders are frequently chronic, disabling and painful. (cdc.gov)
  • During pregnancy, the skeletal structure that will one day support your baby's whole body starts out as cartilage, a firm tissue that's softer and more flexible than bone. (whattoexpect.com)
  • As your little one absorbs more calcium (from you during your pregnancy and then from the foods he eats well beyond), his cartilage gradually ossifies to become hard bone. (whattoexpect.com)
  • When babies are born, some of their "bones" are technically cartilage that eventually hardens into bone as they grow. (whattoexpect.com)
  • Most of the cartilage in adults is located at the ends of bones to help them to glide smoothly over each other at the joints. (whattoexpect.com)
  • The kneecap starts out as cartilage and starts significantly hardening into bone between the ages of 2 and 6 years old. (whattoexpect.com)
  • In most cases, several areas of cartilage in the knee begin to harden at the same time and eventually fuse together to form one solid bone. (whattoexpect.com)
  • Contrary to popular opinion, research has shown exercising young horses in mindful moderation decreases the probability of lameness and improves the musculoskeletal development of bone, cartilage, tendons, and ligaments. (msucares.com)
  • Although there have been numerous reports of hydrogels loaded with MSC-derived EVs for the repair of musculoskeletal injuries, such as intervertebral disc injury, tendinopathy, bone fractures, and cartilage injuries, there are still many hurdles to overcome before the clinical application of modified hydrogels. (hindawi.com)
  • Intra-articular bleeding produces a direct chemical effect on the synovium, cartilage, and bone. (medscape.com)
  • Damage to the bone and articular cartilage appears later. (medscape.com)
  • The synovial masses erode the juxta-articular cartilage and the subchondral bone (see the first image below). (medscape.com)
  • My research team has driven the development of mechanobiological prediction models forward, previously for bones and recently for cartilage and tendons. (lu.se)
  • Accumulating evidence suggests that hydrogels loaded with MSC-derived EVs show great potential in improving musculoskeletal injuries. (hindawi.com)
  • This special issue of Journal of Biomechanical Engineering (JBME) highlights young investigators and their scientific contributions to emerging frontiers and challenges in musculoskeletal biomechanics. (asme.org)
  • By highlighting young investigators working on these critical frontiers, we describe research of emerging leaders and laboratories working in musculoskeletal biomechanics. (asme.org)
  • In particular, these papers introduce new ideas, innovative solutions, and novel approaches to key challenges in musculoskeletal biomechanics. (asme.org)
  • Covering the key areas including the properties of biomaterials, common measuring techniques and modelling, Biomechanics of the Musculo-skeletal System, Third edition also integrates historical aspects thus building a bridge between old and familiar knowledge and the latest developments in biomechanics. (chipsbooks.com)
  • At the American College of Sports Medicine's 47th annual meeting in Indianapolis, Indiana, David Hawkins, MD, of the University of California, Irvine, chaired a symposium on the biomechanics of musculoskeletal injuries in young athletes. (medscape.com)
  • The Enneking system for surgical staging of bone and soft tissue tumors is based on grade (G), site (T), and metastasis (M), and uses histologic, radiologic, and clinical criteria. (medscape.com)
  • Clinical Applications of Bone Tissue Engineering in Orthopaedic Trauma. (chop.edu)
  • This review analyzes recent evidence on the safety of SGLT2i with respect to bone and mineral metabolism in people with CKD, and discusses potential underlying mechanisms and clinical implications. (lww.com)
  • Clinical trials have not demonstrated an increased risk of bone fracture associated with SGLT2i use among patients with CKD with or without diabetes mellitus. (lww.com)
  • Relevant musculoskeletal history and clinical findings were documented. (bmj.com)
  • An annual musculoskeletal assessment for all children with DS could potentially enable early detection of problems, allowing for timely multidisciplinary team intervention and better clinical outcomes. (bmj.com)
  • Its scope embraces all aspects of clinical drug development and therapeutics. (hindawi.com)
  • In this context, the efficacy of hydrogels loaded with MSC-derived EVs in different musculoskeletal injuries is discussed in detail to provide a reference for the future application of hydrogels loaded with MSC-derived EVs in the clinical treatment of musculoskeletal injuries. (hindawi.com)
  • Di Matteo A, Mankia K, Nam JL, Cipolletta E, Garcia-Montoya L, Duquenne L, Rowbotham E, Emery P. In anti-CCP+ at-risk individuals, radiographic bone erosions are uncommon and are not associated with the development of clinical arthritis. (nihr.ac.uk)
  • Matthew J. Major, PhD , studies the application of engineering-based principles to improve the quality of evidence-based clinical practice for rehabilitation of persons with neuromuscular or musculoskeletal insult, and to develop user-centered, optimized assistive device technology to enhance function and quality of life of these patient groups. (northwestern.edu)
  • The research activities of our group focus on two major clinical areas: musculoskeletal pain and bone. (northwestern.edu)
  • In addition, we develop better diagnostic methods for musculoskeletal diseases such as osteoarthritis, by combining knowledge from clinical images with computer simulation models. (lu.se)
  • Micro/nano-scale technologies for biomanufacturing complex multiscale biological systems and musculoskeletal tissues. (uhhospitals.org)
  • Inspired by modern advanced manufacturing methods, the primary focus of CASE-BML is developing micro/nano-scale technologies for biomanufacturing complex, multiscale, biological systems and musculoskeletal tissues. (uhhospitals.org)
  • Experimental and theoretical models of musculoskeletal tissues and structures. (uhhospitals.org)
  • Now, as 3D printing bone and other tissues becomes more commonplace, Dr. Laurencin is being honored for his work, having been named the 2021 Kappa Delta Ann Doner Vaughn Award recipient. (odtmag.com)
  • To discover an alternative, synthetic solution, Dr. Laurencin and his colleagues began to engineer musculoskeletal tissues, applying biological, chemical and engineering principles to repair, restore or regenerate living tissue using biomaterials, cells and additional factors alone and in combination. (odtmag.com)
  • Your body needs nourishment to grow bone, power muscle, repair and replace tissues, and keep your heart beating and your brain functioning. (infoaging.org)
  • The ideal hydrogels should be capable of promoting the development of new tissues and simulating the characteristics of target tissues, with the properties matching the cell-matrix constituents of autologous tissues. (hindawi.com)
  • the periosteum bulges (balloons), extending into the soft tissues, and may be surrounded by new bone formation. (msdmanuals.com)
  • While the development of xenografts (products of animal origin) and bioengineered alternatives is advancing, to date they cannot fully mimic or replace all human-sourced tissues on an equivalent basis. (who.int)
  • However, a child's skeletal system demonstrates pronounced adaptive changes after intensive sports training, and sports injuries, which affect both growing bone and soft tissues, can lead to impairment of growth mechanisms and permanent damage. (medscape.com)
  • It's a broad subject, but my research focuses on the musculoskeletal system's tissues, i.e. bones, joints, and tendons. (lu.se)
  • A range of other musculoskeletal anomalies were observed, with inflammatory arthritis (7%) and scoliosis (4.8%) occurring most frequently after pes planus. (bmj.com)
  • NIH ORBD NRC is supported under a contract from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, with contributions from the National Institute of Child Health and Human Development, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, NIH Office of Research on Women's Health, DHHS Office on Women's Health, and the National Institute on Aging. (rarediseases.org)
  • The study was supported in part by NIH's National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). (nih.gov)
  • Dr Nowlan's group are working on a range of topics relating to foetal movements and skeletal development, funded by grants from the European Research Council and the Arthritis Research UK and Leverhulme Trust charities. (royalsociety.org)
  • We aim to give insight into the more recent trends and developments as well as establish the epidemiology of patella fractures in Germany by analysing treatment and epidemiological data from a national database. (biomedcentral.com)
  • This condition increases the risk of bone fractures, which is a significant health challenge for older adults. (nih.gov)
  • Le type de fracture, sa localisation, le délai avant sa prise en charge, la clinique et la présence de fractures associées guident l'attitude thérapeutique. (bvsalud.org)
  • The mechanical drilling process is a typical step in treating bone fractures to fix broken parts with screws and plates. (bvsalud.org)
  • On the other hand, in the diaphysis and metaphysis, given the remarkable healing potential of bone in young patients, fractures that initially unite with some deformity can later completely remodel normally. (medscape.com)
  • Images show a Z-projected % mineralized bone tissue in the mouse femur midshaft. (charite.de)
  • mechanical properties of bone tissue. (uhhospitals.org)
  • Implant materials performance, wear and degradation of UHMW polyethylene, implant retrieval analysis and implant design, mechanical performance of normal and diseased bone tissue. (uhhospitals.org)
  • Dr. Laurencin's work has led to the development and advancement of biodegradable polymeric materials in bone repair and tissue regeneration. (odtmag.com)
  • In 2010 he was appointed Full Professor at the Faculty of Medicine and head of the Centre for Translational Bone, Joint and Soft Tissue Research (tu-dresden.de/med/tfo). (selectbiosciences.com)
  • However, cell-based matrices (CBM) segment is expected to grow at the highest rate, a CAGR of 6.1%, during the forecast period, as these materials serve as a cell-based bone grafts substitutes that use cells to generate tissue alone or in combination with support matrix. (medgadget.com)
  • Bone tissue with osteoporosis has more voids than healthy bone. (nih.gov)
  • As these people age, the composition of their bone tissue changes, and voids form to make their bone porous. (nih.gov)
  • Drilling generates a significant amount of heat and elevates the temperature of the bone, which can cause thermal osteonecrosis and damage to the surrounding bone tissue and nerves. (bvsalud.org)
  • Although SGLT2i are associated with abnormalities of bone and mineral metabolism, they have not been linked to a higher risk of fracture among patients with CKD. (lww.com)
  • Patients with MPS have normal development initially, with abnormalities appearing in infancy or later in childhood. (medscape.com)
  • Bone density as measured by radiographic aluminum equivalence (RBAE) and periods during which bone-related injuries occurred. (msucares.com)
  • It is 100% resorbable and also injectable, moldable and biocompatible, and cleared for use in a range of treatments such as complex sport-related injuries to all musculoskeletal extremities trauma cases. (orthoworld.com)
  • Talk to your doctor if you think that you or someone you know may have RED-S. Your doctor will ask you about your periods, eating habits, exercise routine, mental health, and muscle and bone injuries. (aafp.org)
  • Deborah Aaron of the University of Pittsburgh, Pittsburgh, Pennsylvania, who discussed the epidemiology of musculoskeletal injuries in young athletes. (medscape.com)
  • Jack Andrish of the Cleveland Clinic Foundation, Cleveland, Ohio, who spoke about strategies for treating musculoskeletal injuries in athletes. (medscape.com)
  • The approach to radiographic diagnosis of bone tumors goes far beyond conventional radiographs in the present era of multiplanar and functional imaging. (medscape.com)
  • We might not immediately associate chronic pain with children or young adults, but data shows that it is not uncommon for children under the age of 13 and young adults (18-24) to visit a physician's office for a chronic musculoskeletal pain diagnosis. (bethesdaphysiocare.com)
  • Data analyzed from physicians visits of patients under 25 years of age with chronic musculoskeletal pain conditions showed that in a 9-year period 5.57 million children (under 13), 8.71 million adolescents (13 to 17), and 14.35 million young adults (18-24) visited a physician for treatment of chronic pain diagnosis. (bethesdaphysiocare.com)
  • Like other subspecialties in radiology, it has become heavily dependent on cross-sectional and functional imaging, and musculoskeletal interventions play an important role in tumor diagnosis and treatment and in joint diseases. (lu.se)
  • Metastatic bone disease (MBD), which occurs when cancer spreads from the primary site to bone, is a leading cause of cancer-related morbidity and is present in 30% of patients with metastatic disease at cancer diagnosis. (iu.edu)
  • The presence of Rheumatoid Factors (RF) and Anti- citrullinated peptides antibobies (ACPA), as well as the duration of the disease at the time of diagnosis, are independent risk factors for the development of erosive RA. (scirp.org)
  • I hope that mechanical computer models will be accepted in medicine to a greater extent, both to improve the diagnosis of diseases, and to predict disease development and how different treatment methods can affect a patient. (lu.se)
  • During the last 100 years, musculoskeletal radiology has developed from bone-only radiography performed by everyone to a dedicated subspecialty, still secure in its origins in radiography but having expanded into all modalities of imaging. (lu.se)
  • Autografts are the gold standard for use in bone regeneration, but they have limitations in terms of donor site morbidity for harvesting and supply,' said Dr. Laurencin. (odtmag.com)
  • There has been great interest in examining ways to create engineered materials for bone regeneration in a variety of different areas and for different uses. (odtmag.com)
  • Some of our work focused on the fact that we could create engineered materials that are actually inductive, that is, they can foster bone regeneration by themselves without the addition of morphogenetic factors. (odtmag.com)
  • The research showed that the use of a matrix system could facilitate bone regeneration, providing a framework which osteoblasts (cells that form new bone) may bind its extracellular matrix (ECM) and bridge bone defects. (odtmag.com)
  • They then confirmed these associations using personal genetics data from hundreds of thousands of people collected by 23andMe, Inc. Using the larger data set, they also showed that the genetic factors for lower BMD were linked to increased risk of bone fracture. (nih.gov)
  • This work revealed the principles of bone shape formation, mapping coalescence and transformation of mineral islands from a foamy scaffold into the mature tube-like long-bone form. (charite.de)
  • Bone substitutes are minimally invasive, provide an osteoconductive scaffold, and are relatively easy to use. (ox.ac.uk)
  • It is the most widely used staging system and has been adopted by the Musculoskeletal Tumor Society. (medscape.com)
  • The musculoskeletal system benefits from regular and varied activity. (skillastics.com)
  • In contrast, modularity and integration among other features of the limb musculoskeletal system, including for example the presence/absence of muscles, and the physical connections among bones and muscles, have yet to be comprehensively investigated, in part because these features are not amenable to the same types of quantitative analyses as morphometric traits. (nature.com)
  • Diet directly affects the minerals and elements in the body that are essential for the healthy operation of the musculoskeletal system. (infoaging.org)
  • The musculoskeletal system in humans changes as they grow. (infoaging.org)
  • He also is member of the ESA Facility Science Team (FST) for the development of a bioprinter and 3D cell culture system for the ISS. (selectbiosciences.com)
  • This editorial presents a very brief history of the science of the neuromusculoskeletal system's 4 main components: the central nervous system, musculotendon units, the musculoskeletal system, and joints, and how they biomechanically integrate to enable an understanding of the generation and control of human movement. (humankinetics.com)
  • Nontuberculous mycobacteria represent an uncommon but important cause of infection of the musculoskeletal system. (cdc.gov)
  • In the last years, the musculoskeletal ultrasonography (MSUS) has emerged as a useful imaging technique since it allows to identify synovitis and bone alteration earlier than the radiological examination. (scirp.org)
  • Increased feed rate reduces necrosis penetration distance and increases intense bone necrosis. (bvsalud.org)
  • Background Musculoskeletal complications of Down syndrome (DS) are common but infrequently reported. (bmj.com)
  • CASE-BML is part of the Musculoskeletal Mechanics and Materials Consortium at CWRU. (uhhospitals.org)
  • Recent developments in treatment for simple bone cysts. (ox.ac.uk)
  • PURPOSE OF REVIEW: The purpose of this paper is to review treatment strategies for simple bone cysts (SBCs). (ox.ac.uk)
  • Children with DS, aged 0-21 years, were invited to attend a musculoskeletal assessment clinic conducted by a paediatric physician. (bmj.com)
  • Musculoskeletal assessment should be part of the normal annual health surveillance programme for all children with Down syndrome. (bmj.com)
  • Neonatal anthropometric variables and 25(OH)D level will be measured at birth, and bone and fat mass assessment by DXA, at one month of age. (who.int)
  • Positron emission tomography (PET) CT/PET MRI has further revolutionized imaging of bone tumors by providing details of anatomic and morphologic characteristics simultaneously and by combining whole body scan in the same sitting. (medscape.com)
  • The prognosis of patients with musculoskeletal tumors has improved markedly because of the advent of new chemotherapeutic drugs and regimens and as the result of advances in imaging and surgical techniques. (medscape.com)
  • Accurate preoperative surgical staging of musculoskeletal tumors is currently possible because imaging techniques provide prognostic information and aid clinicians in choosing the most appropriate treatment option for each patient. (medscape.com)
  • Overview of Bone and Joint Tumors Bone tumors may be benign or malignant. (msdmanuals.com)
  • Osteosarcoma (osteogenic sarcoma) Primary malignant bone tumors are much less common than metastatic bone tumors, particularly in adults. (msdmanuals.com)
  • Benign giant cell tumors of bone, which most commonly affect people in their 20s and 30s, occur in the epiphyseal and distal metaphyseal-epiphyseal areas. (msdmanuals.com)
  • Similarly, the surge in occurrences of musculoskeletal conditions and an increased risk of degenerative joint diseases due to obesity and diabetes drive the growth of the global market. (medgadget.com)
  • The NIH/Osteoporosis and Related Bone Diseases National Resource Center (ORBDNRC) provides patients, health professionals, and the public with an important link to resources and information on metabolic bone diseases such as osteoporosis, Paget's disease of bone, osteogenesis imperfecta, and primary hyperparathyroidism. (rarediseases.org)
  • OBJECTIVES: Bone defects caused by diseases and trauma are usually accompanied by inflammation, and the implantation of biomaterials as a common repair method has also been found to cause inflammatory reactions, which affect bone metabolism and new bone formation. (bvsalud.org)
  • The focus of the Akkus lab is on musculoskeletal biomaterials and mechanobiology. (uhhospitals.org)
  • In the mechanobiology realm, the lab has been breaking ground in understanding the role of VEGF in osteogenesis by studying 3D cultures of ossifying bone marrow explants. (uhhospitals.org)
  • The meeting focused on the role of mechanobiology in multiple aspects of embryonic development. (royalsociety.org)
  • From the lab-based cellular level of understanding injury to rehabilitation and recovery, our researchers are dedicated to the development and translation of more effective strategies to promote prevention, functional recovery, and improved quality of life after spinal cord injury. (ubc.ca)
  • The Kappa Delta Awards recognize research in musculoskeletal disease and injury. (odtmag.com)
  • Horses that are stalled for long periods of time experience weakened, less dense bones that leave them susceptible to catastrophic injury. (msucares.com)
  • The decreased bone density caused by keeping horses in stalls has been seen in association with high rates of injury in training, as seen in Figure 2. (msucares.com)
  • When young horses in training are confined to stalls, their bones lose density and make them more susceptible to injury. (msucares.com)
  • Additionally, our group has initiated studies aimed at treating patients with acute spinal cord injury to attempt to maintain bone mass during their immediate post-injury period. (northwestern.edu)
  • Direct links between cachexia and metastatic bone disease are emerging, with evidence of IL-6, TNF-a, and TGF-b-mediated crosstalk between tumor, muscle, and bone that culminates in muscle weakness and wasting. (iu.edu)
  • Therefore, there is a critical need to elucidate mechanisms of cachexia-related muscle and bone dysfunction in the setting of metastatic bone disease. (iu.edu)
  • The lesion has the typical appearance of a unicameral bone cyst. (medscape.com)
  • SGLT2i may alter renal tubular phosphate reabsorption and are associated with increased serum concentrations of phosphate, fibroblast growth factor-23 (FGF-23), parathyroid hormone (PTH), decreased 1,25-hydroxyvitamin D levels, as well as increased bone turnover. (lww.com)
  • However, astronomical cost of surgeries along with ethical issues related to bone grafting procedures impede market growth. (medgadget.com)
  • Journal of Musculoskeletal Medicine 15:70-81, 1998Kim HW, Morcuende JA, Dolan LA, Weinstein SL: Acetabular Development in Developmental Dysplasia of the Hip Complicated by Lateral Growth Disturbance of the Capital Femoral Epiphysis. (hipdysplasia.org)
  • James Renwick of the University of Virginia, Charlottesville, who spoke on the physiology of musculoskeletal growth and development. (medscape.com)
  • Different fore- vs hindlimb patterns are also seen for anatomical network complexity (i.e., complexity in the arrangement of bones and muscles). (nature.com)
  • In the past few years, anatomical network analysis (AnNA) has enabled the study of connectivity patterns (e.g., bone-bone and bone-muscle connections) in a quantitative way, by using mathematical tools borrowed from network theory. (nature.com)
  • Changes in bone density as measured by lateral radiographic bone aluminum equivalence (RBAE, mm AI) versus day of project. (msucares.com)
  • The Development of Mineralization Group studies composition and function of teeth and bones, focusing on understanding the arrangement and mechanical adaptation of two complementary types of materials: tooth dentine versus rodent bone material. (charite.de)
  • In a series of lab tests with bone cells and genetically modified mice, the scientists showed that DAAM2 influences bone density, mineralization, porosity, and strength. (nih.gov)
  • Abnormally low bone mineral density (BMD), known as osteoporosis, is a common health problem that runs in families. (nih.gov)
  • This life stage is critical for a young person's development and the exploration of personal, professional, and health trajectories, so the treatment of chronic pain in this critical stage of life comes with added layers of complexities. (bethesdaphysiocare.com)
  • On a more applied level, the development and characterization of analgesic agents for the management of chronic musculoskeleletal pain has been a major focus for over the past decade. (northwestern.edu)
  • Journal of Bone and Joint Surgery 76A: 1777-1792, December 1994 PMID: 7989383Morcuende JA, Weinstein SL: New Developments in Developmental Dysplasia of the Hip. (hipdysplasia.org)
  • The 3D evolution of bone material and porosity in developing murine long-bones are central models for human skeletal research. (charite.de)
  • Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (cdc.gov)
  • INTRODUCTION: The metabolomics quality assurance and quality control consortium (mQACC) is enabling the identification, development, prioritization, and promotion of suitable reference materials (RMs) to be used in quality assurance (QA) and quality control (QC) for untargeted metabolomics research. (cdc.gov)
  • Nugegoda, Sri Lanka, 19 Department for Medical Research and Management for Musculoskeletal Pain, by anyone for any lawful purpose. (cdc.gov)
  • emerging uses of rodent models to study musculoskeletal systems. (asme.org)
  • In those individuals with SCI who have already lost significant bone mass, we have undertaken a second set of studies aimed at evaluating approaches to increase bone mass in these individuals, using physical and pharmacological interventions as well as attempting to assess the interaction between bone and the metabolic status of these individuals. (northwestern.edu)
  • Safety of SGLT2i with regard to bone and mineral metabolism. (lww.com)
  • Emerging evidence suggests that SGLT2i may also affect bone and mineral metabolism. (lww.com)
  • Over the past 30 years, he has explored the use of biodegradable polymeric and ceramic materials for use in bone repair, focusing on poly(ester), poly(anhydride) and poly(phosphazene) biomaterials alone or in combination with hydroxyapatite, a naturally occurring mineral, and other ceramics to form two- and three-dimensional (2D, 3D) matrices. (odtmag.com)
  • 25-hydroxyvitamin D [25(OH)D] level, and to positively impact infant bone mineral content (BMC). (who.int)
  • The Journal Of Bone And Joint Surgery , 2019, 15;101(10):904-911. (uniklinikum-saarland.de)
  • Journal of Bone and Joint Surgery 78A: 1048-1055, 1996 PMID: 8698722Morcuende JA, Meyer MD, Dolan LA, Weinstein SL: Long Term Outcome After Open Reduction Through an Anteromedial Approach in Congenital Dislocation of the Hip. (hipdysplasia.org)
  • Increased use of bone graft substitutes facilitates minimally invasive surgeries and short surgical procedures. (medgadget.com)
  • The lab's long-term goal is to develop surgical and medical therapies targeting cachexia-related muscle and bone dysfunction. (iu.edu)
  • The Collier Lab strives to ask thoughtful questions pertaining to the musculoskeletal oncology patient, ranging from the origins of sarcoma to the development of epigenetic therapies for osteosarcoma to understanding the significance of oligometastatic disease to bone. (iu.edu)
  • The use of bone grafts and substitutes reduces the need to harvest autograft bones from patients, which in turn reduces postoperative pain and healing time. (medgadget.com)
  • Focusing on musculoskeletal pain and bone, specifically understanding the basis for pain chronification through brain imaging and psychophysical methodologies. (northwestern.edu)
  • Here we provide the first network analysis of the musculoskeletal anatomy of both the fore- and hindlimbs of the two species of chimpanzee and humans. (nature.com)
  • Visual diagnostics will include X-rays for all suspected musculoskeletal causes, and computed tomography (CT) and magnetic resonance imaging (MRI) to help identify and differentiate between causes. (petmd.com)
  • As for imaging, both traditional X-ray and Magnetic Resonance Imaging (MRI) highlight respectively the Rapid Radiological Progression (RRP) and the presence of bone edema which are associated to a more aggressive disease. (scirp.org)
  • Arthrex is a German-based medical device company that is engaged in the development and manufacture of the shoulder, knee, elbow, hand & wrist, foot & ankle, hip, and related products, orthobiologics, and imaging & resection products. (marketsandmarkets.com)
  • We revealed how bones become fully mechanically functional within the first 2 weeks after birth. (charite.de)
  • Real-time mapping of the neuromechanical origin and generation of muscle force resulting in joint torques should be combined with musculoskeletal models to address time-varying parameters such as adaptation to exos and fatigue. (humankinetics.com)
  • Osteosarcoma, an aggressive bone malignancy that primarily affects children and young adults, is notable for widespread genetic and epigenetic instability. (iu.edu)
  • Each year, more than 2 million bone graft procedures worldwide are performed. (odtmag.com)
  • Based on the type, the report categorizes the market into allograft, bone graft substitutes, and cell-based matrices. (medgadget.com)
  • The segment is expected to dominate the global market through 2025, owing to advancements in bone graft materials and the development of innovative products. (medgadget.com)
  • Calsol provides a nonanimal source of calcium and phosphorus to supports bone health. (standardprocess.com)
  • Silverman and her group applied musculoskeletal modeling to experimental kinematic and kinetic data and quantified the mechanical power delivered by passive and powered prostheses and validated the models with electromyographic data. (asme.org)
  • The primary aim of this study was to describe musculoskeletal anomalies reported in a national cohort of children with DS. (bmj.com)
  • The laboratory is developing novel models of metastatic renal cell carcinoma (RCC) to bone to study its effects on normal muscle and bone. (iu.edu)
  • This study investigated whether exosomes from adipose-derived stem cells (ADSC-Exos) plays an immunomodulatory role in traumatic bone defects and elucidated the underlying mechanisms. (bvsalud.org)
  • With the emphasis in this survey on the health of the elderly, NHANES III provides a particularly appropriate context and population for the study of musculoskeletal conditions. (cdc.gov)
  • Primate limbs are morphologically diverse, and much of this variation in musculoskeletal anatomy correlates with locomotor function. (nature.com)
  • Therefore, in addition to external/ecological pressures, development may constrain the evolution of limb musculoskeletal anatomy. (nature.com)
  • Morscheid S., Rey-Rico A., Schmitt G., Madry H., Cucchiarini M., Venkatesan J.K. Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells. (uniklinikum-saarland.de)
  • [ 2 ] Acute bleeding increases the pressure in the synovial cavity and bone marrow, which possibly leads osteonecrosis or a pseudotumoral mass. (medscape.com)
  • RCC is of particular interest because it frequently metastasizes to bone and 40% of patients with the disease develop cachexia. (iu.edu)
  • In young athletes, given the stiffness characteristics of their bones, sudden overload may cause bones to bow or buckle. (medscape.com)
  • RECENT FINDINGS: Recent studies have focused on disrupting the wall of the cyst in combination with injectable bone substitutes. (ox.ac.uk)
  • Our findings represent significant progress in highlighting drug development opportunities," Richards says. (nih.gov)
  • Engineering in vitro vascularized bone models for drug screening and predictive toxicology. (chop.edu)