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  • stretch-shortening c
  • Dietary antioxidant supplementation enhances aged skeletal muscle adaptability to repeated exposures of stretch-shortening contractions. (cdc.gov)
  • Identification of DNA-damage-inducible transcript 4 in young and old skeletal muscle following stretch-shortening contractions. (cdc.gov)
  • PURPOSE: The purpose of this study was to determine the morphological localization, distribution, and quantity of DNA-damage-inducible transcript 4 (DDIT4 - a marker of protein degradation and apoptosis that resides within the IGF/PI3K/Akt pathway) and its influence on young and old skeletal muscle of rats following chronic high-intensity mechanical loading via stretch-shortening contractions (SSCs). (cdc.gov)
  • membrane
  • (B) Tetrads of particles (Ca V s) in a freeze-fractured T tubule membrane from toadfish muscle, presented with the same orientation and magnification. (rupress.org)
  • rodent and human
  • These rodent and human studies suggest that the skeletal muscle contraction-mediated reflex sympathetic nerve response is exaggerated in hypertension, thereby contributing to the excess sympathoexcitation and blood pressure elevation seen during exercise in this pathological condition. (physiology.org)
  • sympathetic
  • In humans with hypertension, the elevation in muscle sympathetic nerve activity seen during postexercise ischemia, a maneuver that selectively excites chemically sensitive muscle afferents, was higher than that in normotensive subjects ( 10 ). (physiology.org)
  • To provide this evidence, we recorded renal sympathetic nerve activity in chloralose-anesthetized cats while contracting the triceps surae muscles. (ahajournals.org)
  • insulin
  • Insulin and contraction increase TBC1D1 phosphorylation on phospho-Akt substrate motifs (PASs), but the function of TBC1D1 in muscle is not known. (diabetesjournals.org)
  • CONCLUSIONS TBC1D1 regulates both insulin- and contraction-stimulated glucose transport, and this occurs via distinct mechanisms. (diabetesjournals.org)
  • Insulin and exercise are the most physiologically relevant stimulators of glucose transport in skeletal muscle, and in patients with type 2 diabetes, insulin- but not exercise-stimulated glucose transport can be severely impaired ( 1 - 4 ). (diabetesjournals.org)
  • Insulin, exercise, and the AMPK activator 5′-aminoimidazole-4-carboxymide-1-β- d -ribofuranoside (AICAR) all cause phosphorylation of AS160 on PAS sites in skeletal muscle ( 5 , 7 , 10 ), and there is good evidence that phosphorylation of these sites inhibits AS160 activity, leading to trafficking of GLUT4 vesicles to the cell surface and glucose transport ( 8 , 15 ). (diabetesjournals.org)
  • However, ablation of AS160 phosphorylation at PAS sites only partially inhibits insulin- and contraction-stimulated glucose transport ( 8 , 15 ). (diabetesjournals.org)
  • The response to both insulin and contraction in terms of glucose transport was assessed. (edu.au)
  • Muscles treated with TPA showed an increased basal rate of 3-0-methylglucose uptake, responded partially to insulin, but did not respond to contraction. (edu.au)
  • Improved insulin sensitivity with calorie restriction does not require reduced JNK1/2, p38, or ERK1/2 phosphorylation in skeletal muscle of 9-month-old rats. (semanticscholar.org)
  • gastrocnemius
  • PKc was partially purified from gastrocnemius-plantarissoleus skeletal muscle preparations by DE52 anion exchange chromatography. (edu.au)
  • Electrical-induced contraction of the gastrocnemius' - plantaris-soleus muscle group resulted in a time-dependent translocation of PKc and a 2-fold increase in the concentration of both diacylglycerol and phosphatidic acid. (edu.au)
  • mitochondrial
  • Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization," Journal of Cell Science , vol. 120, no. 22, pp. 3999-4008, 2007. (hindawi.com)
  • Jiang LQ, Garcia-Roves PM, de Castro BT, Zierath JR (2010) Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity. (springer.com)
  • Calcium
  • Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (uniprot.org)
  • dorsal
  • We found that static contraction tripled renal nerve activity within three seconds of its onset, an increase that was abolished by cutting the L6 and S2 dorsal roots. (ahajournals.org)
  • 9 In the polysynaptic reflex, type IA afferent neurons synapse on inhibitory neurons in the dorsal horn and inhibit contraction of the targeted area. (practicalpainmanagement.com)
  • Exercise
  • Regular exercise contributes to maintaining the skeletal muscle mass and quality, which may prevent type II diabetes, hypertension, coronary heart disease, and/or sarcopenia. (springer.com)
  • This muscle-based reflex is termed the exercise pressor reflex ( 35 ). (physiology.org)
  • Nerve
  • On average, the contraction-induced increase in renal nerve activity was observed 0.8 +/- 0.1 seconds after the onset of this maneuver. (ahajournals.org)
  • Excitatory
  • 8,10,13 For example, if a person touches a hot surface, the brain sends an excitatory signal to stimulate the bicep muscles to contract, allowing for the desired motion, and then sends an inhibitory signal. (practicalpainmanagement.com)
  • Exercises
  • As such, isometric exercises can help to strengthen a muscle. (livestrong.com)
  • Exercises involving isokinetic contractions are often used in rehabilitation settings, and generally require the use of special equipment capable of providing consistent resistance and velocity throughout the activity. (livestrong.com)
  • When undertaking a strength training or general fitness regimen, most of the exercises you perform will be isotonic in nature, targeting the body's major muscle groups. (livestrong.com)
  • After a workout, it is important to allow the targeted muscle group a day or two to recover before performing the same set of exercises again. (livestrong.com)