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  • limb
  • During acute exacerbations of chronic obstructive pulmonary disease (COPD), limb and respiratory muscle dysfunction develops rapidly and functional recovery is partial and slow. (nih.gov)
  • While they are also subjected to the same systemic elements as the limb muscles (except for inactivity), they also face a specific mechanical disadvantage caused by changes in lung volume during exacerbation. (nih.gov)
  • So the striations on skeletal muscles actually perform a vital function for limb and/or joint movements. (knowswhy.com)
  • physiological
  • We then show how we can calibrate our model based on experimental data-taken here for skeletal muscles-and numerical simulations demonstrate the adequacy of the model to represent complex physiological phenomena, in particular the fast isometric transients in which the power stroke is known to have a crucial role, thus circumventing a limitation of many classical models. (springer.com)
  • half-sarcomeres
  • The functional units of muscle are the half-sarcomeres. (hindawi.com)
  • Campbell KS (2009) Interactions between connected half-sarcomeres produce emergent mechanical behavior in a mathematical model of muscle. (springer.com)
  • Campbell SG, Hatfield PC, Campbell KS (2011) A mathematical model of muscle containing heterogeneous half-sarcomeres exhibits residual force enhancement. (springer.com)
  • generalized muscle dysfunction
  • Because acute exacerbations of COPD are associated with an increase in both prevalence and severity of generalized muscle dysfunction, and both remain present even during recovery, early interventions to minimize muscle dysfunction during exacerbation are warranted. (nih.gov)
  • Drosophila
  • Monoclonal antibodies raised against four proteins from insect asynchronous flight muscle have been used to characterize the cross-reacting proteins in synchronous muscle of Drosophila melanogaster . (springer.com)
  • Basi, G. S., Boardman, M. & Storti, R. V. (1984) Alternative splicing of a Drosophila tropomyosin gene generates muscle tropomyosin isoforms with different carboxyterminal ends. (springer.com)
  • Chun, M. & Falkenthal, S. (1988) Ifm(2)2 is a myosin heavy chain allele that disrupts myofibrillar assembly only in the indirect flight muscle of Drosophila melanogaster . (springer.com)
  • Deak, I. I. (1977) A histochemical study of the muscles of Drosophila melanogaster . (springer.com)
  • George, E. L., Ober, M. B. & Emerson, C. P. , Jr. (1989) Functional domains of the Drosophila melanogaster muscle myosin heavy chain gene are encoded by alternatively spliced exons. (springer.com)
  • aspects
  • Contributions reporting all aspects of normal striated muscle function and pathophysiology are welcome. (frontiersin.org)
  • Different aspects of the force-generating transition are reflected in the changes in tension development by muscle cells, myofibrils and single molecules upon changes in temperature, altered phosphate concentration, or length perturbations. (hindawi.com)
  • insect
  • The ruler hypothesis also does not seem to be applicable to insect muscle, as individual insect titin homologs are too short to span across half a sarcomere. (biologists.org)
  • dysfunction
  • In addition, reports that investigate cross-talk between cardiac and skeletal muscle function are welcome, as well as dysfunction of this cross-talk in disease. (frontiersin.org)
  • Mechanisms of striated muscle dysfunction during acute exacerbations of COPD. (nih.gov)
  • The mechanisms leading to this muscle dysfunction are not yet fully established. (nih.gov)
  • herein, I have found that the continued muscle dysfunction is linked to a delay in relaxation, likely from slower cross-bridge detachment, and that this is not from an overexpression of embryonic myosin. (washington.edu)
  • functional
  • This review addresses the functional role of α-dystrobrevin in muscle as well as its possible implication for muscular dystrophy. (mdpi.com)
  • Despite
  • Despite their different locations, the projectins of synchronous and asynchronous muscles are very similar, but not identical, as judged by SDS-PAGE and by peptide mapping. (springer.com)
  • Despite this detailed textbook knowledge about the adult muscle structure, it is still unclear how cross-striated myofibrils are built in vivo . (biologists.org)
  • novel
  • The Specialty welcomes contributions that provide insights gained from the study of novel, as well as more traditional, muscle systems, as an enticing multitude of frontiers remains to be explored. (frontiersin.org)
  • findings
  • Authors are encouraged to discuss their results in an integrated manner to facilitate the understanding of new findings among all striated muscle biologists, regardless of their particular areas of expertise. (frontiersin.org)
  • cell
  • The fetal cardiac muscle is a good milestone for assessing the maturity of human induced pluripotent stem cell derived cardiomyocytes, which are used to model heart disease and therapeutics, and produce force at rates of activation and relaxation that are close to those of fetal cardiac myofibrils and not adult cardiac myofibrils. (washington.edu)
  • J Muscle Res Cell Motil. (nih.gov)
  • relaxation
  • Reports of striated muscle studies that advance the understanding of the fundamental mechanisms that drive cross-bridges during muscle force generation, shortening and relaxation are welcome. (frontiersin.org)
  • Fetal cardiac muscle develops more force as gestation increase, showing an increase in activation and relaxation rates, though the cross-bridge cycling rates appear to fluctuate, potentially as a function of structure. (washington.edu)
  • Finally, failing adult cardiac muscle demonstrates that the activation rate and force production of the myofilament can be enhanced without slowing the relaxation through using 2-deoxy-ATP. (washington.edu)
  • content
  • Parathyroid hormone administration to thyroparathyroidectomized rats resulted in a significant reduction in inorganic phosphate content of a variety of striated muscles. (springer.com)