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  • Physiology
  • Furthermore, we found that the calcium storage protein calsequestrin 1 of the little brown bat and the bottlenose dolphin functionally converged in its ability to form calcium-sequestering polymers at lower calcium concentrations, which may contribute to rapid calcium transients required for superfast muscle physiology. (sciencemag.org)
  • Albert Szent-Györgyi, a Hungarian physiologist, turned his focus on muscle physiology after winning the Nobel Prize in Physiology or Medicine in 1937 for his works on vitamin C and fumaric acid. (wikipedia.org)
  • Andrew Huxley, whom Alan Hodgkin described as "wizard with scientific apparatus", had just discovered the mechanism of the nerve impulse (action potential) transmission (for which he and Hodgkin later won the Nobel Prize in Physiology or Medicine in 1963) in 1949 using his own design of voltage clamp, and was looking for an associate who could properly dissect out muscle fibres. (wikipedia.org)
  • postprandial
  • Therefore, nutritional strategies are targeted to modulate postprandial muscle protein accretion in the elderly. (nih.gov)
  • Differences in postprandial protein handling after beef compared with milk ingestion during postexercise recovery: a randomized controlled trial. (nih.gov)
  • intake
  • The loss of skeletal muscle mass with aging has been attributed to an impaired muscle protein synthetic response to food intake. (nih.gov)
  • Muscle protein synthesis (MPS) occurs as a response to resistance exercise or nutrition intake. (verywell.com)
  • In order to keep muscle protein on the positive side, proper training and protein intake are shown to be essential. (verywell.com)
  • Conclusions: Manipulation of aminoacidemia before resistance exercise via different patterns of intake of protein altered plasma AA profiles and postexercise intracellular signaling. (stir.ac.uk)
  • The objective was to compare muscle protein synthesis (MPS) to intakes of whey and caseinate after heavy resistance exercise in healthy elderly individuals, and, furthermore, to compare the timing effect of caseinate intake. (wiley.com)
  • Protein and energy intake in advanced chronic kidney disease: how much is too much. (wikipedia.org)
  • interaction
  • While theoretical models have in fact described exactly how these muscle proteins interact, this interaction has never previously been observed in detail. (redorbit.com)
  • Recent studies on the interaction of proteins with missense mutations and its neighbors showed high degree of rigidity associated with central hub proteins involved in protein binding and flexible subnetworks having molecular functions involved with calcium. (wikipedia.org)
  • myosin
  • If a muscle is to be able to contract, the myosin must slide along filamentous actin molecules. (redorbit.com)
  • Myosin Isoform Expression in Rodent Skeletal Muscle: The objective of this experiment was to study the effect of microgravity and contractile protein expression in antigravity and non-antigravity rodent skeletal muscle. (wikipedia.org)
  • Cross-bridge theory states that actin and myosin form a protein complex (classically called actomyosin) by attachment of myosin head on the actin filament, thereby forming a sort of cross-bridge between the two filaments. (wikipedia.org)
  • The first muscle protein discovered was myosin by a German scientist Willy Kühne, who extracted and named it in 1864. (wikipedia.org)
  • He actually observed that muscle fibres containing myosin B shortened in the presence of ATP, but not with myosin A, the experience which he later described as "perhaps the most thrilling moment of my life. (wikipedia.org)
  • But the notion was generally opposed, even from the likes of Nobel laureates such as Otto Fritz Meyerhof and Archibald Hill, who adhered to the prevailing dogma that myosin was a structural protein and not a functional enzyme. (wikipedia.org)
  • calcium
  • Only after an influx of calcium, which docks onto the regulating proteins, is the binding site on the actin filament exposed. (redorbit.com)
  • Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. (wikipedia.org)
  • fiber
  • Our screen also showed that echolocating mammals exhibit an unusually high number of parallel substitutions in fast-twitch muscle fiber proteins. (sciencemag.org)
  • A neuromuscular junction (or myoneural junction) is a chemical synapse formed by the contact between a motor neuron and a muscle fiber. (wikipedia.org)
  • In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. (wikipedia.org)
  • novel
  • These findings may provide a basis for novel interventional strategies to attenuate muscle mass loss. (nih.gov)
  • Future research is needed to determine whether these novel interventions will be successful in preventing sarcopenia and improving muscle strength and function in older adults. (eurekaselect.com)
  • By systematically screening for parallel amino acid substitutions, we detected known as well as novel cases (Strc, Tecta, and Cabp2) of parallelism between echolocating bats and toothed whales in proteins that could contribute to high-frequency hearing adaptations. (sciencemag.org)
  • functional
  • We saw functional levels of muscle regeneration in old animals that paralleled those of their young counterparts, suggesting that this could potentially be a therapeutic option down the road. (pitt.edu)
  • Similarly, injecting Klotho into older animals a few days after injury resulted in greater muscle mass and better functional recovery than their saline-treated counterparts. (pitt.edu)
  • If you just bombard the muscle with Klotho, we do not expect to observe any functional benefit," Dr. Ambrosio said. (pitt.edu)
  • This is an important step in understanding the interplay between the individual proteins within the functional structures of muscle", says Raunser. (redorbit.com)
  • A functional role of this protein is unclear. (wikipedia.org)
  • Peptides
  • Dermcidin is a secreted protein that is subsequently processed into mature peptides of distinct biological activities. (wikipedia.org)
  • postexercise
  • Here, we investigated whether differential feeding patterns of a whey protein mixture commencing before exercise affect postexercise intracellular signaling and MPS. (stir.ac.uk)
  • Protein sources producing a slow AA release, when consumed before resistance exercise in sufficient amounts, are as effective as rapidly digested proteins in promoting postexercise MPS. (stir.ac.uk)
  • Consumption of whole eggs promotes greater stimulation of postexercise muscle protein synthesis than consumption of isonitrogenous amounts of egg whi. (nih.gov)
  • Consumption of whole eggs promotes greater stimulation of postexercise muscle protein synthesis than consumption of isonitrogenous amounts of egg whites in young men. (nih.gov)
  • Molecular
  • Molecular model of the MyoD muscle protein (green and blue) bound to a strand of DNA (deoxyribonucleic acid, orange and green). (sciencephoto.com)
  • Scientists led by Kristina Djinović-Carugo at the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna have elucidated the molecular structure and regulation of the essential muscle protein α-actinin. (phys.org)