• The tunica media of the artery and the lumen increased significantly with age, but the proportion of smooth muscle cell to paracellular matrix did not alter. (ahajournals.org)
  • Denervation significantly upregulated the expression of anti-fibrotic genes, such as glypican-1 and decorin-1, in the gastrocnemius muscle of osteoactivin-transgenic mice, compared with wild-type mice. (tokushima-u.ac.jp)
  • However, renal denervation is used less frequently in recent years due to new evidence suggesting that blood pressure is not significantly reduced after the procedure and there are even recommendations against using the procedure since there has been little proof to show that renal denervation leads to reduced blood pressure. (wikipedia.org)
  • After lateral gastrocnemius-soleus (LGS) nerve section in intact cats, a rapid locomotor compensation involving synergistic muscles occurs and is accompanied by spinal reflex changes. (semanticscholar.org)
  • There are more α-MNs in the spinal cord than in the brainstem, as the number of α-MNs is directly proportional to the amount of fine motor control in that muscle. (wikipedia.org)
  • In general, α-MNs on one side of the brainstem or spinal cord innervate muscles on that same side of body. (wikipedia.org)
  • As in the brainstem, higher segments of the spinal cord contain α-MNs that innervate muscles higher on the body. (wikipedia.org)
  • For example, the biceps brachii muscle, a muscle of the arm, is innervated by α-MNs in spinal cord segments C5, C6, and C7, which are found rostrally in the spinal cord. (wikipedia.org)
  • On the other hand, the gastrocnemius muscle, one of the muscles of the leg, is innervated by α-MNs within segments S1 and S2, which are found caudally in the spinal cord. (wikipedia.org)
  • Like other regions of the spinal cord, cells in this lamina are somatotopically organized, meaning that the position of neurons within the spinal cord is associated with what muscles they innervate. (wikipedia.org)
  • Dancing Doberman disease primarily affects the gastrocnemius muscle in Dobermans. (wikipedia.org)
  • Inserial sections these segments frequently showed positivestaining also for acid phosphatase.It is concluded that exogenously applied horseradishperoxidase is taken up into the lysosomal system, whichafter denervation becomes organized into characteristicspindle-shaped segments in the muscle fibres. (diva-portal.org)
  • The endocyticactivity of muscle fibres increases early after denervation.This is followed by a more gradual increase in activity oflysosomal enzymes and finally by an organization of thelysosomal system into characteristic spindle-shaped segments.The results are compatible with the working hypothesisthat increased endocytosis may initiate lysosomal activationin denervated skeletal muscle. (diva-portal.org)
  • Sometimes a group of muscle fibres from teres minor may be fused with infraspinatus. (wikipedia.org)
  • Upper airway muscle inflammation and denervation changes in obstructive sleep apnea. (nih.gov)
  • Then I lost some muscle mass for my left leg (upper leg). (healthcaremagic.com)
  • It arises from the dorsal surface of the axillary border of the scapula for the upper two-thirds of its extent, and from two aponeurotic laminae, one of which separates it from the infraspinatus muscle, the other from the teres major muscle. (wikipedia.org)
  • The gluteus maximus muscle is a large and very thick muscle (6-7 cm) located on the sacrum, which is the large, triangular bone located at the base of the vertebral column, and at the upper- and back-part of the pelvic cavity, where it is inserted (like a wedge) between the two hip bones. (wikipedia.org)
  • Objective To assess clinical, electrophysiological and whole-body muscle MRI measurements of progression in patients with motor neuron disease (MND), as tools for future clinical trials, and to probe pathophysiological mechanisms in vivo. (bmj.com)
  • Twenty-nine patients with MND and 22 age-matched and gender-matched healthy controls were assessed with clinical measures, electrophysiological motor unit number index (MUNIX) and T2-weighted whole-body muscle MRI, at first clinical presentation and 4 months later. (bmj.com)
  • Patterns of disease spread were modelled using mixed-effects multivariable regression, assessing associations between muscle relative T2 signal and anatomical adjacency to site of clinical onset. (bmj.com)
  • Muscles inaccessible to conventional clinical and electrophysiological assessment may be investigated using this methodology. (bmj.com)
  • 2 Muscle denervation is a major clinical feature of MND and results in fluid shifts detectable as altered T2 signal characteristics 3 that, in contrast to clinical assessments, are independent of participant's effort and premorbid abilities. (bmj.com)
  • In an attempt to provide a clear assessment of the theory that a purely physical facial change, involving only certain facial muscles, can result in an emotion, Strack, Martin, & Stepper (1988) devised a cover story that would ensure the participants adopt the desired facial posing without being able to perceive either the corresponding emotion or the researchers' real motive. (wikipedia.org)
  • We establish that PKB/Akt activation promotes the nuclear import of HDAC4 and is thereby required for epigenetic changes and synaptic gene up-regulation upon denervation. (nih.gov)
  • d - g mRNA levels of Akt1 , Akt2 and Akt3 ( d , e ) and Mtor , Rptor and Rps6 ( f , g ) in TA innervated muscle and after 3 ( d , f ) and 7 ( e , g ) days of denervation, in TSCmKO and control mice. (nih.gov)
  • We have previously shown that osteoactivin, a type I membrane glycoprotein expressed in myofibers, upregulated expression of matrix metalloprotease (MMP)-3 and MMP-9 in fibroblasts infiltrated denervated skeletal muscle in mice. (tokushima-u.ac.jp)
  • Muscle denervation, axonal dysregulation, and myelin disruption together with reduced Schwann cell proliferation are prominent in 129SvSOD1 G93A compared to C57SOD1 G93A mice at the disease onset, and this correlates with a faster disease progression in the first strain. (biomedcentral.com)
  • A study investigating AARP function in cardiac muscle in which AARP was knocked out alone or in combination with the other MARPs showed that mice displayed normal cardiac function at baseline and in response to pressure overload-induced cardiac hypertrophy, suggesting that these proteins are not essential for normal cardiac development or in response to a hypertrophic stimulus. (wikipedia.org)
  • There may be different causes for this denervation and muscle imbalance including: An ulnar nerve neuropathy usually from ulnar nerve entrapment somewhere along its course (most commonly around the cubital tunnel at the elbow where the nerve is exposed to tension, friction and compression). (wikipedia.org)
  • This muscle imbalance between the (intact) radial nerve innervated extensor digiti quinti and the (weak) ulnar innervated interossei in the context of ulnar neuropathy is what Wartenberg described. (wikipedia.org)
  • In contrast, overexpression of osteoactivin caused a significant reduction in denervation-induced expression of elongation factor 1A-1, an indicator for the persistence of degenerated cells. (tokushima-u.ac.jp)
  • 4. Free vascularized split or divided muscle transfer has been also developed for one-stage reconstruction of more complicated dynamic motor function. (nii.ac.jp)
  • Adaptive changes in motor activity associated with functional recovery following muscle denervation in walking cats. (semanticscholar.org)
  • A motor neuron pool contains the cell bodies of all the alpha motor neurons involved in contracting a single muscle. (wikipedia.org)
  • Presynaptic motor axons stop 30 nanometers from the sarcolemma, the cell membrane of a muscle cell. (wikipedia.org)
  • In non-pathologic physiology, AARP mRNA expression in skeletal muscle of patients was shown to be elevated two days following fatiguing jumping exercises. (wikipedia.org)
  • In the 3-week-old animals, denervation resulted in smooth muscle cells with hypertrophied nuclei. (ahajournals.org)
  • AARP localizes to both nuclei and sarcomeres in muscle cells. (wikipedia.org)
  • A role for AARP in regulating muscle gene expression and sensing stress signals was implicated in the finding that AARP colocalizes with the transcriptional co-activator and co-repressor PML in myoblast nuclei, and binds p53 to enhance the p21(WAFI/CIPI) promoter. (wikipedia.org)