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  • Baclofen
  • With the intradermal hypertonic saline (6% saline) behavioral test, baclofen decreased the number of behaviors in a dose-dependent and 5-aminovaleric acid-reversible manner, whereas i.t. administered muscimol was ineffective. (muscimol.xyz)
  • With the i.t. substance P (SP) behavioral test, muscimol was again ineffective, whereas the SP-induced behaviors were differentially modified by baclofen depending on the temporal order of their i.t. administration. (muscimol.xyz)
  • GABAergic
  • It is suggested that the present findings are due to a presynaptic nigral effect of muscimol on the GABAergic autoreceptors of the striatonigral terminals and to a consequent disinhibition of the reticulata GABAergic output. (jneurosci.org)
  • intranigral
  • Intranigral injection of 1.3 microliters 1 microM muscimol (0.15 ng) induced increases in glucose consumption locally in the substantia nigra reticulata (by 87%), distally in the contralateral reticulata, red nucleus, nucleus accumbens, and prefrontal cortex, and bilaterally in the pyriform cortex, as compared to values in control animals. (jneurosci.org)
  • behavioral
  • Muscimol-induced impairments were also observed when a 4-h delay was imposed between the fourth and the fifth maze selection, suggesting that the behavioral deficit represents an inability to store or retain spatial working memories rather than a general performance deficit. (muscimol.xyz)
  • activity
  • Muscimol (i.v.) caused a decrease in ZR cell activity at the same dose that caused a parallel increase in ZC cell firing rate. (muscimol.xyz)