Most influenza A virus-specific memory cytotoxic T lymphocytes react with antigenic epitopes associated with internal virus determinants. (rupress.org)
By Db competitive binding analysis, only two of these 11 GP peptides and 1 of these 20 NP peptides bound to the MHC Db molecule with an affinity equivalent to the measured affinities for the three known GP1, GP2, and NP cytotoxic T-lymphocyte (CTL) epitopes. (ox.ac.uk)
Clinically relevant3
To elucidate the biological mechanisms underlying pulmonary metastasis and identify superior therapeutic strategies, we developed a novel and clinically relevant murine RCC model exhibiting enhanced pulmonary metastasis. (biologists.com)
Our results demonstrated impressive antilymphoma activity and profound destruction of normal B cells caused by anti-CD19-CAR-transduced T cells in a clinically relevant murine model. (ashpublications.org)
Co-administration of a clinically relevant dexamethasone dosage with ablative radiotherapy reduces peripheral lymphocytes but does not alter in vivo intratumoral lymphocyte phenotype or inhibit efficacy of radiotherapy in a murine colorectal tumor model. (rochester.edu)
In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
To investigate whether carbamate pesticides also induce apoptosis in human T lymphocytes, in the present study Jurkat human T cells were treated in vitro with thiram, maneb, carbaryl or ziram. (researchgate.net)
Consistent with downregulated MHC I expression, the elimination of Nlrc5(Δ/Δ) lymphocytes by cytotoxic T cells was markedly reduced and, in addition, we observed low NLRC5 expression in several murine and human lymphoid-derived tumor cell lines. (unige.ch)
Epstein-Barr virus (EBV)-associated B-cell lymphoproliferation is a life-threatening complication after hematopoietic stem cell or solid organ transplantation resulting from outgrowth of EBV-infected B cells that would normally be controlled by EBV-cytotoxic T cells. (nih.gov)
Treatment options include manipulation of the balance between outgrowing EBV-infected B cells and the EBV cytotoxic T lymphocyte response and targeting the B cells with monoclonal antibodies or chemotherapy. (nih.gov)
These cells are phagocytosed by macrophages and moDCs but do not induce their maturation, which does not therefore generate any stimulation of the immune system.The use of a murine model of rheumatoid arthritis (CIA) allowed us to show the effectiveness of PCE in the treatment of this pathology. (theses.fr)
To evaluate anti-CD19-CAR-transduced T cells in a murine model of adoptive T-cell therapy, we developed a CAR that specifically recognized murine CD19. (ashpublications.org)
We used T cells that were retrovirally transduced with this CAR to treat mice bearing a syngeneic lymphoma that naturally expressed the self-antigen murine CD19. (ashpublications.org)
To establish a murine model in which a completely syngeneic lymphoma could be treated by adoptive transfer of syngeneic CAR-transduced T cells, we developed a CAR that could specifically recognize murine CD19. (ashpublications.org)
Cytotoxic T lymphocytes (CTL) bind to class I molecules, sample the peptides being presented, and lyse those cells that display unusual fragments derived from viruses or tumors. (the-scientist.com)
IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and natural killer (NK) cells. (rndsystems.com)
This interaction induces IFN-gamma gene expression, enhancing the cytotoxic activity of resting NK and T cells, inducing and synergizing with IL-2 in the generation of lymphokine-activated killer (LAK) cells, acting as a co-mitogen to stimulate proliferation of resting T cells, and inducing proliferation of activated T and NK cells. (rndsystems.com)
TMEM123 localizes in the protrusions of infiltrating T cells, it contributes to lymphocyte migration and cytoskeleton organization. (bvsalud.org)
Using tumoroid-lymphocyte co-culture assays, we found that lymphocytes form clusters through TMEM123, anchoring to cancer cells and contributing to their killing. (bvsalud.org)
In vitro , doxorubicin microparticles were less cytotoxic to DCs than to B lymphoma cells, did not require internalization by tumor cells, and significantly enhanced phagocytosis of tumor cells by DCs as compared with soluble doxorubicin. (aacrjournals.org)
Adoptive transfer of expanded natural killer cells inhibited the growth of established OPM2 and high-risk primary myeloma tumors grown in the murine model. (haematologica.org)
In the present study, we identified a novel subpopulation of CD11b + Gr-1 + cells from murine lung carcinoma tumors according to their strongly adherent abilities. (oncotarget.com)
Furthermore, immunotherapy has revolutionized the management of melanoma, specifically, with inhibition of cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), which is expressed on lymphocytes, and programmed death ligand-1, which is expressed on tumor cells. (medscape.com)
This antibody is commonly used as a phenotypic marker for murine T cells. (exbio.cz)
The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkynje cells in the cerebellum. (exbio.cz)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
LFA-1 also plays a role of cytotoxic killing by T cells. (medscape.com)
CTLs2
Here, we show that during chronic murine lymphocytic choriomeningitis virus infection, activation of AKT and mTOR are impaired in antiviral cytotoxic T lymphocytes (CTLs), resulting in enhanced activity of the transcription factor FoxO1. (nih.gov)
Following determination of sensitivities to standard therapies using MTT assays, flow cytometry was used to characterize induction of immunogenic cell stress following sublethal exposure to radiation or cisplatin, and the functional consequence of this induction was determined using impedance-based real time cell analysis cytotoxicity assays employing HPV16 E7-specific cytotoxic lymphocytes (CTLs) with or without N803 (IL-15/IL-15-Rα superagonist) or exogenous death receptor ligands. (bmj.com)
Mice5
Murine coronavirus (M-CoV) is a virus in the genus Betacoronavirus that infects mice. (wikipedia.org)
Murine hepatitis virus is highly infectious and is one of the most common pathogens in laboratory mice. (wikipedia.org)
Mice underwent intrarenal implantation using luciferase-expressing Renca, a murine renal adenocarcinoma cell line. (biologists.com)
Moreover, our results show that the effectiveness of the treatment is based on the presence of T lymphocytes derived from "arthritic" mice in the treated sample.In conclusion, the mechanisms of action of PCE do not seem to be associated with the concept of immunogenic death. (theses.fr)
We discovered that the protein TMEM123 is over-expressed in tumour-infiltrating CD4 and CD8 T lymphocytes and it contributes to their effector phenotype. (bvsalud.org)
MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
Receptor2
Together with James P. Allison, who worked on another co-inhibitory receptor called cytotoxic T-lymphocyte-associated Protein 4 (CTLA-4), Tasuku Honjo was awarded the Nobel Prize in Physiology or Medicine 2018 for the discovery of cancer therapy by inhibition of negative immune regulation ( Wolchok, 2018 ). (frontiersin.org)
Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer. (rochester.edu)
Pancreatic2
Dendritic cell-based vaccination combined with gemcitabine increases survival in a murine pancreatic carcinoma model. (uni-muenchen.de)
Here, we used a murine pancreatic carcinoma model to investigate whether combination with gemcitabine increases therapeutic efficacy of DCbased vaccination. (uni-muenchen.de)
Melanoma3
Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model. (rochester.edu)
In this instrument we identify a normal accumulation remarkableiation antigen, tyrosinaserelated protein 2 (TRP-2), expressed mask cancelled to the murine B16 melanoma which was organize berepresentinge screening a cDNA library from B16 with tumor-reactive cytotoxic T lymphocytes (CTL). (ebionet.com)
During the past decade, advancement within the field of genomics has led to the identification of melanoma-specific mutations, namely, v-Raf murine sarcoma viral oncogene homolog B and neuroblastoma RAS viral oncogene homolog, as well as to the development of agents that target these driver mutations. (medscape.com)
Macrophages1
Unlike known MDSCs, MLACs lack the ability to suppress cytotoxic T lymphocytes and differentiate into tumor-associated macrophages (TAMs), but could still directly facilitate tumor growth and angiogenesis through secreting CCL2, CXCL1/2/5, PAI-1, MMPs, and VEGFA. (oncotarget.com)
Protein1
A functional antibody cross-reactive to both human and murine cytotoxic T-lymphocyte-associated protein 4 via binding to an N-glycosylation epitope. (wuxibiologics.com)
Monoclonal1
The Armenian hamster monoclonal antibody 145-2C11 reacts with an extracellular epitope of murine CD3 (epsilon subunit). (exbio.cz)
Proliferative2
Azathioprine inhibits DNA synthesis and, as a purine antimetabolite, exerts its effect on activated lymphocytes, which requires purines during their proliferative phase. (illnesshacker.com)
while the lymphocyte proliferative responses to the direct acting haptens OX, EtOX and NABQI were comparable. (cdc.gov)
Therapeutic2
In addition, the advent of immunotherapies, specifically, agents that target cytotoxic T-lymphocyte antigen-4, anti-programmed death-1, and programmed death ligand-1, has increased the potential therapeutic options available to patients with both systemic and brain disease. (medscape.com)
Such specific targets as the neuroblastoma RAS viral oncogene homolog ( NRAS ) and v-Raf murine sarcoma viral oncogene homolog B ( BRAF ) have been exploited for therapeutic use. (medscape.com)
Antigen1
Using MB49, we demonstrate that tumor-induced IL-10 inhibits the generation of a type I immune response against a tumor antigen as measured by Interferon (IFN)-γ production, cytotoxic T lymphocyte (CTL) generation, and delayed type hypersensitivity (DTH) reaction. (jefferson.edu)
Strains2
Belonging to the subgenus Embecovirus, murine coronavirus strains are enterotropic or polytropic. (wikipedia.org)
There are more than 25 different strains of murine coronavirus. (wikipedia.org)
Model3
We describe two features of a murine model of transitional cell carcinoma, MB49, that render it an attractive in vivo model with which to study the effect of IL-10 on tumor immunity. (jefferson.edu)
The objective of my thesis was to study these mechanisms of action and set up a murine model to allow an optimization of the clinical protocols. (theses.fr)
Development of an Orthotopic Murine Model of Rectal Cancer in Conjunction With Targeted Short-Course Radiation Therapy. (rochester.edu)
Immune1
Our data show that NLRC5 acts as a key transcriptional regulator of MHC I in lymphocytes and support an essential role for NLRs in directing not only innate but also adaptive immune responses. (unige.ch)
Human3
Interleukin 12, also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines. (rndsystems.com)
IL-12 apparently shows species specificity with human IL-12 reportedly showing minimal activity in the murine system. (rndsystems.com)
Viral1
Discriminated selection among viral peptides with the appropriate anchor residues: implications for the size of the cytotoxic T-lymphocyte repertoire and control of viral infection. (ox.ac.uk)
Cytokine1
T cell activities attributed to CD28 include prevention of anergy, induction of cytokine gene transcription, stabilization of cytokine mRNA and activation of CD8+ cytotoxic T lymphocytes. (ancell.com)
Peptides1
For example, optimal peptides fitting into the murine MHC class I Db groove are 9 to 11 amino acids long and require as MHC anchor residues an Asn (N) at position 5 and also either a hydrophobic residue, a Met (M) or a Cys (C), at the carboxy terminus. (ox.ac.uk)
Effector1
Leigh ND, O'Neill RE, Du W, Chen C, Qiu J, Ashwell J, McCarthy PL, Chen G, Cao X . Host-derived CD70 suppresses murine GVHD by limiting donor T cell expansion and effector function. (umaryland.edu)
Surface3
This paper shows that most murine (C57BL/6) influenza A virus-specific memory cytotoxic T lymphocyte (CTL) clones tested in limiting dilution did not react with the influenza A virus surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA). (rupress.org)
Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation", JOURNAL OF EXPERIMENTAL MEDICINE , vol. 196, 2002, pp. 493-503. (uni-bielefeld.de)
Flow cytometry analysis (surface staining) of CD3 in murine splenocytes with anti-CD3 (145-2C11) PE(red), and blank (black). (exbio.cz)
Activity2
Azathioprine is a purine analog with cytotoxic and immunosuppressive activity. (illnesshacker.com)
Historically, systemic or cytotoxic therapies have not played a prominent role mainly because of the challenges of penetrating the blood-brain barrier and of achieving activity within the CNS. (medscape.com)
Models2
Discovery of beneficial immunomodulatory effects of dasatinib in murine solid tumor models. (helsinki.fi)
CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models. (rochester.edu)
Primarily1
Background While radiation and chemotherapy are primarily purposed for their cytotoxic effects, a growing body of preclinical and clinical evidence demonstrates an immunogenic potential for these standard therapies. (bmj.com)
Therapy1
As with other brain metastases, a multidisciplinary treatment approach that includes surgery and radiation therapy is typically used, with historically little role for systemic, cytotoxic therapy. (medscape.com)
Leggatt, GR and Berzofsky, JA Cytotoxic T-cell adherence assay (CAA) . (edu.au)
Form1
R. typhi is responsible for murine typhus, the endemic fleaborne form of typhus, which is emerging in predominantly tropical coastal regions. (cdc.gov)
Important1
Murine coronavirus is an important pathogen in the laboratory mouse and the laboratory rat. (wikipedia.org)
Virus1
In 1991, Michael M. C. Lai's laboratory completed the whole genome sequencing of the murine hepatitis virus. (wikipedia.org)