• The first two Ras genes, HRAS and KRAS, were identified from studies of two cancer-causing viruses, the Harvey sarcoma virus and Kirsten sarcoma virus, by Edward M. Scolnick and colleagues at the National Institutes of Health (NIH). (wikipedia.org)
  • These viruses were discovered originally in rats during the 1960s by Jennifer Harvey and Werner H. Kirsten, respectively, hence the name Rat sarcoma. (wikipedia.org)
  • This cell line was derived from the HOS cell line (TE-85) by transformation using Kirsten murine sarcoma virus (Ki-MSV). (cls.shop)
  • Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. (edu.au)
  • Complementarity between Rous sarcoma virus (RSV) RNA and the in vitro-synthesized DNA of the virus-associated DNA polymerase. (wikidata.org)
  • Livingston and Jackson also collaborated on work on the Rous sarcoma virus ( RSV ) at Lederle Laboratories. (ichacha.net)
  • In 1903 it was suggested for the first time that Rous sarcoma virus 1 and understood to be a retrovirus. (ichacha.net)
  • She continued her studies on the Rous sarcoma virus ( RSV ) that she had discovered in her postdoctorate work. (ichacha.net)
  • In 2006 an alleged new virus, xenotropic murine leukemia virus XMRV, was thought to be involved in prostate cancer. (biomedcentral.com)
  • Here, we use murine gammaherpesvirus 68 (γHV68) to demonstrate that ABCs remain elevated long-term during latent infection and express IFNγ and TNF. (nature.com)
  • Reactivation of the gammaherpesviruses Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV) and murine gammaherpesvirus 68 (MHV68) from latently infected B cells has been linked to plasma cell differentiation. (prelekara.sk)
  • 4. UsherwoodEJ, StewartJP, RobertsonK, AllenDJ, NashAA (1996) Absence of splenic latency in murine gammaherpesvirus 68-infected B cell-deficient mice. (prelekara.sk)
  • RNA in mammalian sarcoma virus transformed nonproducer cells homologous to murine leukemia virus RNA. (wikidata.org)
  • This gene is the putative transforming gene of avian sarcoma virus 17. (ichacha.net)
  • V-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. (ichacha.net)
  • Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. (edu.au)
  • Conditional lethal mutants of adenovirus 2-simian virus 40 hybrids. (cshl.edu)
  • Kelly, F. , Sambrook, J. (1974) Variants of Simian Virus 40-Transformed Mouse Cells Resistant to Cytochalasin-B. Cold Spring Harbor Symposia on Quantitative Biology, 39. (cshl.edu)
  • We find that mice without ABCs display defects in anti-viral IgG2a/c antibodies and are more susceptible to reactivation of γHV68 following virus challenges that typically do not break latency. (nature.com)
  • Cells carry the Ki-MSV genome but do not produce infectious virus particles or viral antigens. (cls.shop)
  • Aberrant Cellular Glycosylation May Increase the Ability of Influenza Viruses to Escape Host Immune Responses through Modification of the Viral Glycome. (cdc.gov)
  • Infectious causes of glomerulonephritis included streptococcal infections, human immunodeficiency virus (HIV) infection, and hepatitis viral infections, both hepatitis C (HCV) and hepatitis B (HBV). (medscape.com)
  • Does the Kaposi's sarcoma virus speed up progression of infection with HIV to AIDS? (ichacha.net)
  • Does the Kaposi's sarcoma virus suppress the immune system independently of the AIDS virus? (ichacha.net)
  • Does the Kaposi's sarcoma virus infect many people but cause disease in only a few? (ichacha.net)
  • The study was too limited in scope to prove that Kaposi's sarcoma virus causes myeloma. (ichacha.net)
  • The Columbia researchers said they began hunting for a Kaposi's sarcoma virus about 18 months ago. (ichacha.net)
  • The Los Angeles scientists found the Kaposi's sarcoma virus in two of eight patients with the gammopathy condition. (ichacha.net)
  • In: Cold Spring Harbor Symposia on Quantitative Biology XXXIX: Tumor Viruses, Cold Spring Harbor, N. Y. (cshl.edu)
  • A chicken sarcoma virus was found to carry mutated versions of the normal cellular Src gene. (ichacha.net)
  • The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. (edu.au)
  • Using a recombinant γHV68 that is cleared following acute infection, we show that ABCs persist in the absence of latent virus, though their expression of IFNγ and TNF is decreased. (nature.com)
  • AAV belongs to the Parvoviridae family and Dependovirus genus, whose members require co-infection with a helper virus such as adenovirus to promote replication, and AAV establishes a latent infection in the absence of a helper. (justia.com)
  • Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)
  • Diminished potential for B-lymphoid differentiation after murine leukemia virus infection in vivo and in EML hematopoietic progenitor cells. (harvard.edu)
  • Feline Leukemia Virus Frequently Spills Over from Domestic Cats to North American Pumas. (harvard.edu)
  • Multiple Introductions of Domestic Cat Feline Leukemia Virus in Endangered Florida Panthers. (harvard.edu)
  • Epizootiology and management of feline leukemia virus in the Florida puma. (harvard.edu)
  • Genetic characterization of feline leukemia virus from Florida panthers. (harvard.edu)
  • During serial passage of mouse embryo fibroblasts in vitro it was found that an established line of cells was more susceptible to murine sarcoma virus transformation than early passages of the cells from which it was derived. (microbiologyresearch.org)
  • An explanation can be made in terms of the growth rates of the cells involved, although primary cells were more susceptible to murine sarcoma virus than would be expected from their rate of growth. (microbiologyresearch.org)
  • Non-dividing (amitotic) cells were not susceptible to murine sarcoma virus transformation. (microbiologyresearch.org)
  • Characteristics of the in vitro assay of murine sarcoma virus (moloney) and virus-infected cells. (microbiologyresearch.org)
  • Requirements for RNA and DNA synthesis in the transformation of mouse embryo cells by murine sarcoma virus (moloney). (microbiologyresearch.org)
  • The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. (justia.com)
  • We have previously shown that the MHV68 M2 protein is important for virus reactivation from B cells and, when expressed alone in primary murine B cells, can drive B cell differentiation towards a pre-plasma cell phenotype. (prelekara.sk)
  • In addition, expression of M2 in primary murine B cells leads to secretion of high levels of IL-10 along with enhanced proliferation and survival. (prelekara.sk)
  • In primary murine B cells, addition of cyclosporine (CsA) resulted in a significant decrease in M2-induced IL-10 levels as well as IRF4 expression, emphasizing the importance of the NFAT pathway in M2- mediated induction of IL-10. (prelekara.sk)
  • Murine Gammaherpesvirus M2 Protein Induction of IRF4 via the NFAT Pathway Leads to IL-10 Expression in B Cells. (prelekara.sk)
  • Miteva K, Haag M, Peng J, Savvatis K, Becher PM, Seifert M. Human cardiac-derived adherent proliferating cells reduce murine acute Coxsackievirus B3-induced myocarditis. (medscape.com)
  • These in vitro, and their expression in these human tumour virus. (who.int)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • Development of a simple restriction fragment length polymorphism assay for subtyping of coxsackie B viruses. (medscape.com)
  • In the context of previous findings, the data presented here provides insights into how M2 facilitates plasma cell differentiation and subsequent virus reactivation. (prelekara.sk)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • For this reason, the infect humans, this virus can infect cordance between humans and ex- question about tumour site concor- several other species - including perimental animals. (who.int)
  • Pathologic and virologic studies of tumors induced in mice by two strains of murine sarcoma vims. (microbiologyresearch.org)
  • For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
  • Bifidobacterium as an oral delivery carrier of interleukin-12 for the treatment of Coxsackie virus B3-induced myocarditis in the Balb/c mice. (medscape.com)
  • The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. (ichacha.net)
  • Guidelines for Plaque-Reduction Neutralization Testing of Human Antibodies to Dengue Viruses. (medscape.com)
  • With respect to viruses and cancer, the conclusive identification of the virus in cancer tissues and a significant odds ratio between cancer and non-cancer tissues, are of special importance. (biomedcentral.com)
  • Case studies in cost effectiveness of molecular diagnostics for infectious diseases: pulmonary tuberculosis, enteroviral meningitis, and BK virus nephropathy. (medscape.com)
  • Not all researchers could find the virus, probably due to the low copy number. (biomedcentral.com)
  • Among the biological agents re- because species specificity limits the causes lymphoproliferative diseas- viewed in Volume 100B of the IARC feasibility of this approach for most of es in New World monkeys and in Monographs (IARC, 2012) are sever- these viruses. (who.int)
  • For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)
  • However, except non-primate species often do not mour viruses is often problematic, for Epstein-Barr virus (EBV), which accurately reflect the mechanism of Part 1 · Chapter 9. (who.int)
  • cell for the virus is placed in a mu- studies costly and difficult. (who.int)
  • Infectivity and RNA patterns as functions of high- and low-dilution passage of murine sarcoma-leukemia virus: evidence for autointerference within an oncornavirus population. (wikidata.org)
  • Ras, from "Rat sarcoma virus", is a family of related proteins that are expressed in all animal cell lineages and organs. (wikipedia.org)
  • An antigenic analysis of respiratory syncytial virus isolates by a plaque reduction neutralization test. (medscape.com)