Murine retrovirus. Medical search. Frequent questions

The XMRV, xenotropic murine retro virus from mice cells contaminates vaccines causing prostate cancer, autism and chronic fatigue. (topdocumentaryfilms.com)
Between 2009 and 2012, the controversy over the retroviruses XMRV/XMLV and their role in ME/CFS involved a tumultuous roller-coaster ride for patients and scientists around the world. (meresearch.org.uk)
As it points out, the finding that XMRV was a "cell culture contaminant" as opposed to a clinically important pathogen highlighted an important fact: that murine endogenous gammaretroviruses were infecting commonly used laboratory human cell lines. (meresearch.org.uk)
Infection of Xenotransplanted Human Cell Lines by Murine Retroviruses: A Lesson Brought Back to Light by XMRV. (meresearch.org.uk)
XMRV, or xenotropic murine leukemia virus-related virus, is a retrovirus that was first reported in 2006 as a potential cause of prostate cancer. (meassociation.org.uk)
Xenotropic murine leukemia virus related virus (XMRV) has been implicated in prostate cancer and chronic fatigue syndrome (CFS). (virology.ws)
Because XMRV is a retrovirus, it has been suggested that it might be susceptible to some of the many drugs available for treatment of AIDS. (virology.ws)
The finding that a retrovirus, XMRV, is associated with chronic fatigue syndrome has lead to the suggestion that the disease might be treated with some of the antiviral drugs used to treat AIDS. (virology.ws)
The integrase inhibitor Raltegravir has been found to block the replication of murine leukemia virus, which is highly related to XMRV. (virology.ws)
En 2009, el Dr. Mikovits dirigi un esfuerzo de investigaci n que condujo al descubrimiento revolucionario de que un retrovirus conocido como Virus xenotr pico relacionado con el virus de la leucemia murina (XMRV) estaba asociado con el SFC (El s ndrome de fatiga cr nica, tambi n conocido como encefalomielitis mialgica). (bibliotecapleyades.net)
In 2009, Dr. Mikovits led a research effort that led to the ground-breaking discovery that a retrovirus known as Murine Leukemia Virus-related xenotropic virus (XMRV) was associated with CFS (Chronic Fatigue Syndrome, also known like myalgic encephalomyelitis). (bibliotecapleyades.net)
Em 2009, o Dr. Mikovits liderou um esfor o de pesquisa que levou descoberta revolucion ria de que um retrov rus conhecido como v rus xenotr pico relacionado ao v rus da leucemia murina (XMRV) estava associado ao CFS (S ndrome de fadiga cr nica, tamb m conhecida como como encefalomielite mialgica). (bibliotecapleyades.net)
XMRV is one of several variants of the MLV family of retroviruses, and the findings clearly support the WPI team's Oct 2009 paper in Science, the researchers stated. (fightingfatigue.org)
It was dubbed "xenotropic murine leukemia virus-related virus" (XMRV). (perfecthealthdiet.com)
Detection of a novel Gammaretrovirus, Xenotropic Murine leukaemia virus-Related Virus (XMRV) has been reported in peripheral blood mononuclear cells of patients with chronic fatigue syndrome, and in prostate cancer tissue. (biomedcentral.com)
As Multiple Sclerosis (MS) is a disease with retroviral association (human endogenous retroviruses (HERVs)), we investigated whether XMRV could be contributing to MS aetiology by testing a well defined cohort of Danish MS patients for the presence of XMRV sequences. (biomedcentral.com)
Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. (medscape.com)
Absence of XMRV retrovirus and other murine leukemia virus-related viruses in patients with chronic fatigue syndrome. (medscape.com)
The transfusion medicine organization AABB has formed a task force to study the transmission potential of xenotropic murine leukemia virus-related virus (XMRV), which has been linked to familial prostate cancer and, more recently, to chronic fatigue syndrome (CFS). (medscape.com)

It is closely related to murine leukemia viruses, which cause a wide variety of cancers as well as immunological and neurological diseases in mice. (meassociation.org.uk)
When retroviruses infect germ cells (sperm or egg), heritable forms of the viruses can arise. (meassociation.org.uk)
Some viruses like Epstein-Barr, human papillomavirus, and retroviruses are even oncogenic, causing the insertion of cancer-causing genes into cellular genomes. (biopharminternational.com)
This gamma retrovirus shared a lot of RNA with a family known as the xenotropic murine leukemia viruses (MuLVs). (perfecthealthdiet.com)
Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus. (medscape.com)
No evidence of murine leukemia virus-related viruses in live attenuated human vaccines. (cdc.gov)

Middlebrook EA, Stark DL, Cornwall DH, Kubinak JL, Potts WK (2021) Deep sequencing of MHC-adapted viral lines reveals complex recombinational exchanges with endogenous retroviruses leading to high-frequency variants. (utah.edu)
Although many of the endogenous retroviruses are defective, several contain one or more intact viral genes that are expressed under certain physiological or pathological conditions. (bvsalud.org)

Raltegravir inhibits murine leukemia virus: implications for chronic fatigue syndrome? (virology.ws)
A retrovirus that has been implicated in prostate cancer has now been found in the blood of patients with chronic fatigue syndrome. (virology.ws)
A good example of emerging science is the progress made since 2002 in understanding a retrovirus family that is now firmly linked to cancer and chronic fatigue syndrome and may soon be linked to other diseases. (perfecthealthdiet.com)

A new gamma retrovirus was found in 8 of 20 prostate cancer patients with double R462Q mutations, but only 1 of 66 patients without the double mutation. (perfecthealthdiet.com)
June 17, 2010 - Concern that a new human gamma-retrovirus may be transmissible through blood has led one infectious diseases specialist to recommend new steps to protect the US blood supply against possible infection with the virus. (medscape.com)

Can a 50 Hz electromagnetic field influence the preintegrative steps of replication of a murine retrovirus responsible for leukemia/lymphoma? (emf-portal.org)
The new virus is a retrovirus similar to HIV, but with apparent differences, including fewer cycles of virus replication. (medscape.com)

This study was undertaken to examine the efficacy of extracellular SOD (EC-SOD) gene therapy in murine collagen-induced arthritis. (nih.gov)
1] "A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection. (tcdb.org)
A second area of emphasis is in the development of gene transfer and transplantation protocols to optimize gene transfer and engraftment of FA deficient cells using murine models. (iu.edu)

1989). Immortalization of murine microglial cells by a v-raf/ v-myc carrying retrovirus. (igem.org)

Embryonic DBA/1 mouse fibroblasts were infected with a recombinant retrovirus expressing human EC-SOD. (nih.gov)

The infection with Friend murine leukemia virus (FMuLv) is being used as a retrovirus infection model for searching the potential anti-viral medicinal preparations or establishing new treatment strategies. (oldcitypublishing.com)

Detection of murine leukemia virus or mouse DNA in commercial RT-PCR reagents and human DNAs. (cdc.gov)

Integrated retrovirus DNA (provirus) derived from infection of the germline of an ancestral animal. (nationalacademies.org)

Retroviruses are found in a wide range of mammals, and they can contribute to the development of cancers, such as leukemia or lymphoma, as well as neurological diseases. (meassociation.org.uk)

2] "Transport of cationic amino acids by the mouse ecotropic retrovirus receptor. (tcdb.org)
Receptor de la superficie celular implicado en el reclutamiento de la proteína G y en la transducción de señales acopladas a la proteína G. El receptor también interviene en la homeostasia del fosfato. (bvsalud.org)

HTLV-1, the first human retrovirus identified, causes adult T cell leukemia. (meassociation.org.uk)
The second human retrovirus, HTLV-2 has not been associated with any disease. (meassociation.org.uk)

We reported previously that CD4 + T cells and B cells in mice with retrovirus-induced murine acquired immunodeficiency syndrome (MAIDS) caused by LP-BM5 murine leukemia virus (MuLV) mixtures increased the expression of Fas antigen (Fas) during progression of the disease. (elsevierpure.com)
Taken together, these results suggest that MAIDS is inducible independently with functional Fas expression and the possibility of accelerated progression of murine AIDS and lpr-associated autoimmune disease in B6 lpr/lpr mice infected with LP-BM5 MuLV. (elsevierpure.com)
However, it was recently demonstrated that TREX1-deficient mice lacking the innate immune sensor stimulator of IFN genes (STING) completely alleviates TREX1-mediated disease and lethality in murine models ( 15 ). (aai.org)

Mechanism of action of regulatory proteins encoded by complex retroviruses. (microbiologyresearch.org)

Specific ablation of HIV-Tat expressing cells by conditionally toxic retroviruses. (microbiologyresearch.org)
We showed that incubation of murine ovarian cancer cells (MOSEC) with doxorubicin led to the intracellular uptake of the drug (MOSEC-dox cells) and the eventual death of the tumor cell. (biomedcentral.com)
In the current study, we hypothesized that local administration of doxorubicin delivered by irradiated tumor cells may reduce the dose required to treat murine ovarian cancer cells and decrease the systemic circulation of doxorubicin. (biomedcentral.com)

Investigators in his lab have recently generated unique murine models to address these questions. (iu.edu)

A recently published study evaluated the thermostability of murine retroviruses inocculated into factor concentrates, using a cell transformation assay (5). (cdc.gov)

All animals are thought to carry numerous endogenous (but nonfunctional) retroviruses, some of which were inserted many millions of years ago. (nationalacademies.org)

In this study, a convenient assay for assessing KoRV infectivity in vitro was employed: the use of DERSE cells (initially developed to search for infectious xenotropic murine leukemia-like viruses). (biomedcentral.com)
They are divided into different classes, one of which is xenotropic murine leukemia viruses. (nih.gov)
Which antriretroviral drugs work best for patients infected with xenotropic murine leukemia virus-related virus (XMVR). (medscape.com)
Rodriguez & Goff, (2009): Xenotropic Murine Leukemia Virus-Related Virus Establishes an Efficient Spreading Infection and Exhibits Enhanced Transcriptional Activity In Prostate Carcinoma Cells. (phoenixrising.me)
Kim et al, (2008): Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer. (phoenixrising.me)

Origin and functional role of antisense transcription in endogenous and exogenous retroviruses. (medscape.com)
ERVs are unique in that they arise from germline infections by exogenous retroviruses. (biomedcentral.com)

Syncytin-1 also known as enverin is a protein found in humans and other primates that is encoded by the ERVW-1 gene ( endogenous retrovirus group W envelope member 1). (wikipedia.org)
Human retroviruses exert a high level of control over their own gene expression as well as that of their host cell. (open.ac.uk)
In the human T cell leukaemia virus type 1 (HTLV-I) retrovirus, the regulatory gene is known as rex . (open.ac.uk)
The Gag gene from each of these retroviruses was introduced into an expression construct with a C-terminal green fluorescent protein (GFP) tag. (umsystem.edu)
The human ATP-binding cassette superfamily G (White) member 2 ( ABCG2 ) gene and its murine homologue breast cancer resistance protein 1 ( Bcrp1 ) are recently described ATP-binding cassette transporters associated with drug resistance in tumor cell lines, including the MCF-7 cell line, selected for its resistance to mitoxantrone (MCF-7/MitoR). (aacrjournals.org)

Since glyco-gag mediates resistance of Moloney murine leukemia virus to the restriction factor APOBEC3, the sensitivity of KoRV (wt or putatively mutant for glyco-gag) to restriction by murine (mA3) or human APOBEC3s was investigated. (biomedcentral.com)
Interestingly, unlike HIV-1 Gag protein, the Gag protein of the gammaretrovirus Moloney murine leukemia virus is rod-shaped in solution, just as it is in immature virus particles, and does not dimerize significantly in solution. (nih.gov)

Higher rates of infection for formed in 1993 and they also failed for unknown both retroviruses and herpesviruses are found in cap- reasons. (who.int)
plant community more aware of the problems, and For retroviruses the time between infection and dis- steered them towards using nonprimate species. (who.int)
We evaluated the influence of host genetic factors on the course of murine cytomegalovirus (MCMV) lung infection after intranasal inoculation and on the development of interstitial pneumonitis after virus and cyclophosphamide (CP) administration. (microbiologyresearch.org)
We are also studying the mechanism by which the restriction factor mouse APOBEC3 blocks infection by murine retroviruses. (nih.gov)

We demonstrate that TERT can activate a subclass of endogenous retroviruses (ERVs) independent of its telomerase activity to form double-stranded RNAs (dsRNAs), which are sensed by the RIG-1/MDA5-MAVS signalling pathway and trigger interferon signalling in cancer cells. (sens.org)
Using PCR and Capture-based chromosome conformation capture (3C) approaches, collectively called 4Tran, we take advantage of the repetitive nature of transposons to capture interactions from multiple copies of endogenous retrovirus (ERVs) in the human and mouse genomes. (biomedcentral.com)
Crocodilians are thought to be hosts to a diverse and divergent complement of endogenous retroviruses (ERVs) but a comprehensive investigation is yet to be performed. (biomedcentral.com)
Endogenous retroviruses (ERVs) are one group of vertebrate transposable elements that replicate through an RNA intermediate. (biomedcentral.com)

From murine leukemia virus-related retrovirus ( 1 ). (cdc.gov)
2. Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning. (nih.gov)
7. Various modes of basic helix-loop-helix protein-mediated regulation of murine leukemia virus transcription in lymphoid cell lines. (nih.gov)
13. Transcriptional activity of core binding factor-alpha (AML1) and beta subunits on murine leukemia virus enhancer cores. (nih.gov)
Studies on the mechanism of 1,3-butadiene-induced leukemogenesis: the potential role of endogenous murine leukemia virus. (nih.gov)
Susceptibility to virus replication in the lungs of various inbred murine strains was inherited as an autosomal dominant trait, which was associated with the H-2 locus. (microbiologyresearch.org)
To better understand the binding mechanism of TRIM5α to retrovirus capsid, we had previously selected N-tropic murine leukemia virus (N-MLV) mutants escaping from rhesus macaque TRIM5α (rhTRIM5α) by passaging the virus in rhTRIM5α-expressing cells and selecting for nonrestricted variants. (crick.ac.uk)
Género de RETROVIRIDAE que comprende secuencias endógenas en mamíferos, VIRUS DE LA RETICULOENDOTELIOSIS AVIAR relacionados y un virus de reptiles. (bvsalud.org)
In the course of these studies, he isolated the Gross murine leukemia virus strain as well as the first polyomavirus, so named for its proclivity to cause cancers in multiple tissue types. (eilatgordinlevitan.com)
Gross murine leukemia virus is a retrovirus whose counterpart in humans is human T cell lymphotropic virus I (HTLV-I), while murine polyomavirus is closely related to the human Merkel cell polyomavirus that causes most forms of Merkel cell carcinoma. (eilatgordinlevitan.com)
The retroviruses studied were Murine Leukemia Virus (MLV), Human T-cell Leukemia Virus (HTLV), Feline Immunodeficiency Virus (FIV), Mason Pfizer Monkey Virus (MPMV), and Human Immunodeficiency Virus type 1 (HIV-1). (umsystem.edu)

Koala retrovirus (KoRV) is an endogenous and exogenous retrovirus of koalas that may cause lymphoma. (biomedcentral.com)

Among the retroviruses of vertebrates, the gammaretroviruses are the most widely spread in mammals, whether as exogenous infectious agents or as bona fide host genes (Endogenous RetroViruses, ERV). (cnrs.fr)
Dong et al, (2007): An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors. (phoenixrising.me)

Scientists in a power postition at the NIH have closed their minds to retroviruses other than HIV and HTLV contributing to human disease. (x-rx.net)

Gammaretroviruses encode the standard three genes of retroviruses, gag , pol and env , but no accessory proteins such as those of lentiviruses, deltaretroviruses, epsilonretroviruses and betaretroviruses. (biomedcentral.com)

However, the precise molecular mechanism of YAP in regulating murine embryonic neural stem cells (NSCs) remains largely unknown. (jneurosci.org)

In addition to the structural genes ( gag , pol and env ), expressed by all retroviruses, human retroviruses also encode additional regulatory genes. (open.ac.uk)

Retroviruses expressing a fluorescent protein, Cas9 and a small guide RNA are used to mimic nonsense PTEN mutations from autism patients in developing mouse neurons. (nature.com)
Our data conclusively shows none of the studied retroviruses except RSV Gag protein assembly with a nuclear step that is Crm1 dependent. (umsystem.edu)

Transport of cationic amino acids by the mouse ecotropic retrovirus receptor. (rhea-db.org)

1. Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers. (nih.gov)

Thus, retroviruses are used to birth-date and genetically manipulate granule neurons in the postnatal mouse brain in vivo 2 . (nature.com)

This contrasts with the situation for endogenous retroviruses in many other species, including humans, where most individual proviruses are shared by all members of the species. (biomedcentral.com)

Prior to coming to UTMB, I conducted research on emerging avian retroviruses and taught course-based research experiences about bacteriophage isolation and characterization. (utmb.edu)

This property makes retroviruses ideal to study genetic mechanisms of neurogenesis and neuronal development because the precise age of labeled neurons is known - allowing for targeted study of specific developmental stages. (nature.com)

A recently published study evaluated the thermostability of murine retroviruses inocculated into factor concentrates, using a cell transformation assay (5). (cdc.gov)
The objective of this study was to determine if other retroviruses also utilize a Crm1 dependent nuclear export system. (umsystem.edu)

20. Transcriptional activation of a retrovirus enhancer by CBF (AML1) requires a second factor: evidence for cooperativity with c-Myb. (nih.gov)

Middlebrook EA, Stark DL, Cornwall DH, Kubinak JL, Potts WK (2021) Deep sequencing of MHC-adapted viral lines reveals complex recombinational exchanges with endogenous retroviruses leading to high-frequency variants. (utah.edu)

Currently, my research in the Smith lab focuses on conformational changes of murine norovirus in response to environmental conditions and how those changes correlate to immune evasion and disease pathologies. (utmb.edu)
Dr. Lowy, deputy director for the Division of Basic Sciences at the National Cancer Institute, has also done pioneering research on murine retroviruses and ras oncogenes and continues to be a recognized leader in the discussion of global public health issues and the HPV vaccine. (cancer.org)

Scholars@Duke publication: Immunologic control of a retrovirus-associated murine adenocarcinoma. (duke.edu)

Anatomy24

Organisms78

Diseases20

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes59

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science4

XMRV19

Viruses6

Endogenous retroviruses2

Chronic fatigue3

Gamma retrovirus2

Replication2

Gene3

Microglial1

Recombinant1

Viral1

Detection1

Infection1

Lymphoma1

Receptor2

Human2

Mice3

Proteins1

Cells3

Models1

Cell1

Animals1

Xenotropic5

Exogenous retroviruses2

Gene5

Moloney2

Infection4

ERVs4

Virus11

Endogenous and exogenous1

Infectious2

HTLV1

Gammaretroviruses1

Embryonic1

Genes1

Protein2

Ecotropic1

Enhancers1

Vivo1

Species1

Isolation1

Mechanisms1

Study2

Factor1

Reveals1

Research2

Control1