Based on the amino acid sequence homology and biological activity in macrophages, Shimamoto et al ( 15 ) identified that HLP was identical to MSP ( 15 ). (spandidos-publications.com)
The consensus core of HRE sequence is 5′-RCGTG-3′ (where R is A or G). (biomedcentral.com)
Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs (Olsen et al. (beauty104.com.tw)
HER2 is found in a variety of tumours and some of these tumours carry point mutations in the sequence specifying the transmembrane domain of HER2. (iiab.me)
Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. (iiab.me)
Kinase5
Here, employing an inducible B cell expression system, we have determined that M2 activates the NFAT pathway in a Src kinase-dependent manner - leading to induction of the plasma cell-associated transcription factor, Interferon Regulatory Factor-4 (IRF4). (prelekara.sk)
Sequencing revealed that the portion carried by the retrovirus encoded a tyrosine kinase binding domain, and that this was the oncogenic form as retroviruses carrying full-length c-Cbl did not induce tumor formation. (wikipedia.org)
Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. (embl.de)
Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. (embl.de)
Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
Together, these kind of meats get and also activate phospholipase C-gamma Only two (PLC-gamma 2), a critical effector in which induces increases throughout intra cellular Ca2+ as well as triggers various signaling pathways downstream of the BCR. (prmtsignal.com)
Secretion2
In addition, expression of M2 in primary murine B cells leads to secretion of high levels of IL-10 along with enhanced proliferation and survival. (prelekara.sk)
Vav expression, but not expression of domain-mutated Vav, increased IL-6 secretion from nonimmortalized bone marrow-derived mast cells upon FcεRI engagement. (aai.org)
Amino2
Three mammalian homologues have been characterized, which all differ in their ability to function as adaptor proteins due to the differing lengths of their C-terminal UBA domains: c-Cbl: ubiquitously expressed, 906 and 913 amino acids in length in humans and mice respectively Cbl-b: ubiquitously expressed, 982 amino acids long. (wikipedia.org)
Cbl-c: lacks the UBA domain and is therefore only 474 amino acids in length. (wikipedia.org)
Cysteine-rich1
The DEC-205 monomer forms a compact structure comprising two intercalated rings of C-type lectin-like domains, where the N-terminal cysteine-rich and fibronectin domains reside at the central intersection. (uci.edu)
Receptor1
3-5 The immunological importance of these lysophospholipid receptors is illustrated by the profound immunodeficiency observed in mice lacking expression of the S1P 1 receptor in hematopoietic cells. (ashpublications.org)
We have previously shown that the MHV68 M2 protein is important for virus reactivation from B cells and, when expressed alone in primary murine B cells, can drive B cell differentiation towards a pre-plasma cell phenotype. (prelekara.sk)
Murine Gammaherpesvirus M2 Protein Induction of IRF4 via the NFAT Pathway Leads to IL-10 Expression in B Cells. (prelekara.sk)
The Tudor domain protein p100-TSN reads the symmetric methylation mark, and binding of p100-TSN downregulates E2F-1 apoptotic activity. (embl.de)
Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing PH domain in the selected taxonomic class. (embl.de)
HGF forms a family with HGF-like protein (HLP), a unique protein with a domain structure similar to that of HGF ( 12 ). (spandidos-publications.com)
Substitution of a valine for a glutamic acid in the transmembrane domain can result in the constitutive dimerisation of this protein in the absence of a ligand. (iiab.me)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
Residues3
There are no totally invariant residues within the PH domain. (embl.de)
Isoform gamma contains two PH domains, the second one is split into two parts separated by about 400 residues. (embl.de)
A download Hanging Sam: A Military Biography of General Samuel T. Williams: From Pancho Villa to of residues are experienced regulated for the high 3-phosphate by which SP1 assemblies present to connected formation phagosome by UCP1 in transmembrane C1q-mediated fusion momenta, and preferentially by the intracellular genes as Once. (evakoch.com)
Mice1
4. UsherwoodEJ, StewartJP, RobertsonK, AllenDJ, NashAA (1996) Absence of splenic latency in murine gammaherpesvirus 68-infected B cell-deficient mice. (prelekara.sk)
Possess1
PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. (embl.de)
Proteins6
Domain commonly found in eukaryotic signalling proteins. (embl.de)
Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of proteins. (embl.de)
Pleckstrin is one of the rare proteins to contains two PH domains. (embl.de)
There are 196127 PH domains in 171590 proteins in SMART's nrdb database. (embl.de)
Taxonomic distribution of proteins containing PH domain. (embl.de)
The complete taxonomic breakdown of all proteins with PH domain is also avaliable . (embl.de)
Cellular1
Using in vitro and cellular techniques, we present a mVP40 assembly model highlighting two distinct oligomerization interfaces: the (N-terminal domain (NTD) and C-terminal domain (CTD)) in mVP40. (uci.edu)
Lipid1
Nevertheless, it is involved in a wide range of activities, from phospholipid synthesis to a number of physiological responses as a lipid mediator [ 3 ]. (hindawi.com)
Physiological1
Mutations in K + channel sequences can lead to a variety of clinical disorders exemplifying their physiological importance [ 3 ]. (ersjournals.com)
Virus2
Reactivation of the gammaherpesviruses Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV) and murine gammaherpesvirus 68 (MHV68) from latently infected B cells has been linked to plasma cell differentiation. (prelekara.sk)
The virus used in the experiment was a mouse-tropic strain of Murine leukemia virus isolated from the brain of a mouse captured at Lake Casitas, California known as Cas-Br-M, and was found to have excised approximately a third of the original c-Cbl gene from a mouse into which it was injected. (wikipedia.org)
Distinct1
Alternate mRNA splicing gives rise to two distinct forms (b and c) of FGFRs1-3 which differ significantly in their ligand-binding profiles. (beauty104.com.tw)
Differ1
The loops connecting the beta-strands differ greatly in length, making the PH domain relatively difficult to detect. (embl.de)
Activation1
This was dependent on Vav-mediated activation of Rac1 as a Dbl domain-mutated Vav, inactive Rac N17, and inactive JNK1 down-regulated the Vav-induced JNK1 or IL-6 responses. (aai.org)
Chain1
The main pathway is the cleavage of membrane phospholipids into lysophospholipids by the removal of a fatty acid chain by phospholipase A (PLA1 or PLA2). (hindawi.com)
Expression2
In primary murine B cells, addition of cyclosporine (CsA) resulted in a significant decrease in M2-induced IL-10 levels as well as IRF4 expression, emphasizing the importance of the NFAT pathway in M2- mediated induction of IL-10. (prelekara.sk)
Treatment with E. crassipes inhibited the expression levels of tumor necrosis factor-α (TNF-α), interleukins (IL-1ß and IL-6), nuclear factor KappaB (NF-κB), matrix metalloproteinase (MMP-2 and MMP-3), and vascular endothelial growth factor (VEGF). (bvsalud.org)
Belongs1
TWIK-related acid-sensitive potassium channel 1 (TASK-1 encoded by KCNK3) belongs to the family of two-pore domain potassium channels. (ersjournals.com)
Levels1
Little or no effect was observed on the mRNA levels of IL-3, IL-4, GM-CSF, TNF-α, and TGF-β. (aai.org)
Control1
Three-dimensional hMSC-derived macropellets had been incubated in regular chondrogenic moderate for 28 d with either substance supplemented frequently (Fig. S3 appearance compared with substance B and control (Fig. 3and appearance weighed against control (Fig. 3 and appearance was decreased, even if not really statistically considerably (Fig. 3confirmed the immunohistochemistry staining. (bakingandbakingscience.com)
This methylation is formed below with: an phosphorylation acetyl-CoA with an calcium maltose, a level with a setting a004614, a consistent domain with an alpha, and a process with A, water and actomyosin dynamics to occur these three melanocytes of loop. (evakoch.com)
Appearance1
appearance was up-regulated in every conditions weighed against basal amounts, with substance A-treated constructs displaying the least boost of (Fig. 4exhibited rather a variable development (Fig. 4and Fig. S6and Fig. S6and Fig. S6and Fig. S6= 3 donors). (bakingandbakingscience.com)