CellsCytomegalovirusAntitumorDendriticInfectionImmunotherapyVivoVitroInterleukinModelImmuneInhibitoryLymphocyteMiceMonocytesDefensesActivityVirusTransferLymphocytesSpleenTumor growthImmunityReceptorMCMVCytokineBone marrowDifferentiation of Human Natural KilleDeciduaMaturationMacrophagesCytotoxic T lymphocyActivationThymicGrowthLiverImmunoglobulinImmunologicalImplantationImmune cellsProteinLymphoidHuman Natural KilleProgenitors1991Inhibitory receptorsInsightsExpressionViralHealthyCells towardsEffectorSubstancesCell linesStudies
Cells34
- In the last years, adoptive transfer of natural killer (NK) cells came into the focus of translational medicine, because of their high cytotoxic potential against transformed malignant cells. (frontiersin.org)
- With their ability to detect and directly destroy virally infected or malignant cells, natural killer (NK) cells form an important part of the first line defense of the immune system. (frontiersin.org)
- Effect of cyclosporin a on murine natural killer cells. (jax.org)
- Depletion of CD4+CD25+ regulatory T cells enhances natural killer T cell-mediated anti-tumour immunity in a murine mammary breast cancer model. (ox.ac.uk)
- Both invariant natural killer T (NK T) cells and CD4(+)CD25(+) T regulatory cells (T(regs)) regulate the immune system to maintain homeostasis. (ox.ac.uk)
- CBL-1, a murine monoclonal antibody, recognises an antigen on activated T cells, B cells, and natural killer cells. (nih.gov)
- In: NK Cells and other natural effector cells. (springer.com)
- Flexman JP, Holt PG, Mayrhofer G, Latham BI, Shellam GR (1985) The role of the thymus in the maintenance of natural killer cells in vivo. (springer.com)
- Herberman RB, Nunn ME, Lavrin DH (1975) Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. (springer.com)
- Herberman RB, Ortaldo JR, Mantovani A, Hobbs DS, Kung HF, Pestka S (1982) Effect of human recobinant interferon on cytotoxic activity of natural killer (NK) cells and monocytes. (springer.com)
- Huddlestone JF, Marigan TC, Oldstone MB (1979) Induction and kinetics of natural killer cells in humans following interferon therapy. (springer.com)
- Hurme M, Sihvola M (1984) High expression of the Thy-1 antigen on natural killer cells recently derived from bone marrow. (springer.com)
- Karinieni AL, Timonen T, Kousa M (1980) Effect of leukocyte interferon on natural killer cells in healthy volunteers. (springer.com)
- Evaluation of her immune status detected a low percentage of natural killer cells. (cdc.gov)
- Antiviral activity of NK 1.1+ natural killer cells in C57BL/6 scid mice infected with murine cytomegalovirus. (umassmed.edu)
- IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and natural killer (NK) cells. (rndsystems.com)
- This interaction induces IFN-gamma gene expression, enhancing the cytotoxic activity of resting NK and T cells, inducing and synergizing with IL-2 in the generation of lymphokine-activated killer (LAK) cells, acting as a co-mitogen to stimulate proliferation of resting T cells, and inducing proliferation of activated T and NK cells. (rndsystems.com)
- Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy. (ucdavis.edu)
- Bortezomib Augments Natural Killer Cell Targeting of Stem-Like Tumor Cells. (ucdavis.edu)
- Role of natural-killer group 2 member D ligands and intercellular adhesion molecule 1 in natural killer cell-mediated lysis of murine embryonic stem cells and embryonic stem cell-derived cardiomyocytes. (tum.de)
- A distinctive leukocyte perhaps related to natural killer cells. (silverchair.com)
- We previously found that ziram, a carbamate pesticide, significantly reduced perforin, granzyme A (GrA), granzyme B (GrB), granzyme 3/K (Gr3/K), and granulysin (GRN) levels in NK-92MI cells, a human natural killer (NK) cell line. (researchgate.net)
- We previously found that carbamate pesticides induced significant apoptosis in human natural killer cells. (researchgate.net)
- Early suppression of 9464D-GD2 tumors by CAIR does not require T or natural killer (NK) cells, but eventual tumor cures are NK cell dependent. (bmj.com)
- Description: The PK136 monoclonal antibody reacts with mouse NK1.1, an antigen expressed by natural killer cells and a subset of T cells in the NK1.1 mouse strains including C57BL and NZB. (thermofisher.com)
- NK1.1 (Killer cell lectin-like receptor subfamily B, member 1, KLRB1, NKR-P1A, CD161, cluster of differentiation 161), refers to Natural Killer (NK) cells, lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. (thermofisher.com)
- Insight into the functions of these cells has come from a previous study of two independent lines of mice deficient in natural killer (NK) cells. (elsevierpure.com)
- Killer-immunoglobulin-like (KIR)-receptors on natural killer (NK) cells and their corresponding HLA ligands play an important role in self-/non-self-discrimination of NK cells. (uni-tuebingen.de)
- Normal splenocytes that are cultured in the lymphokine, interleukin 2 (IL-2), for as short as 2 days develop lytic activity for fresh syngeneic natural killer-resistant tumor cells as well as natural killer-sensitive YAC cells in a 4-hr 51Cr release assay. (archive.org)
- Lymphokine-activated killer (LAK) cells do not lyse syngeneic fresh lymphocytes but do lyse syngeneic concanavalin A-induced lymphocyte blasts. (archive.org)
- The primary response to the early phase of viral infection is the release of natural killer (NK) cells, which lyse infected myocytes. (medscape.com)
- First, in a murine colon cancer model, we showed that the intratumoral delivery of Ab significantly increased the number of effector T cells infiltrated into tumors, and suppressed tumor growth more effectively than the intraperitoneal and intravenous injections did. (bvsalud.org)
- NKT: Natural killer T innate lymphoid cells and their role in asthma. (cdc.gov)
- Impact of adaptive natural killer cells, KLRC2 genotype and cytomegalovirus reactivation on late mortality in patients with severe COVID-19 lung disease. (cdc.gov)
Cytomegalovirus4
- Here we found that the regulation of natural killer (NK) cell function by the glucocorticoid receptor (GR) was required for host survival after infection with mouse cytomegalovirus (MCMV). (nature.com)
- Heterologous Immunity and Persistent Murine Cytomegalovirus Infection. (umassmed.edu)
- Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo. (umassmed.edu)
- Long-term immune protection against SARS-CoV-2 escape variants upon a single vaccination with murine cytomegalovirus expressing the spike protein. (cdc.gov)
Antitumor3
- CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models. (rochester.edu)
- Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer. (rochester.edu)
- Since tumor-reactive lymphocytes preferentially proliferate during reconstitution of the immune system, we examined whether the priming of donor lymphocytes can strengthen the antitumor effect by HSCT in a CT26 murine colon cancer model. (bvsalud.org)
Dendritic1
- 13 Morphine has been shown to decrease IL-23 production in murine models, decreasing dendritic cell antimicrobial protein production. (uspharmacist.com)
Infection2
- Natural infection occurs by way of the respiratory tract. (wikipedia.org)
- Bifidobacterium longum MM-2 (MM-2), a very safe bacterium in humans, was isolated from healthy humans and its protective effect against IFV infection in a murine model shown. (nih.gov)
Immunotherapy1
- Dr. Canter's research has a strong focus on multi-species models for natural killer (NK) cell immunotherapy, including adoptive therapy in dogs with spontaneous cancers and murine models of solid tumors. (ucdavis.edu)
Vivo1
- Co-administration of a clinically relevant dexamethasone dosage with ablative radiotherapy reduces peripheral lymphocytes but does not alter in vivo intratumoral lymphocyte phenotype or inhibit efficacy of radiotherapy in a murine colorectal tumor model. (rochester.edu)
Vitro1
- Kaiserlian D, Bardos P, Bach JF (1983) In vitro modulation of mouse natural killer (NK) cell activity by the serum thymic factor (FTS). (springer.com)
Interleukin1
- Interleukin 12, also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines. (rndsystems.com)
Model2
- Development of an Orthotopic Murine Model of Rectal Cancer in Conjunction With Targeted Short-Course Radiation Therapy. (rochester.edu)
- Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model. (rochester.edu)
Immune1
- It has been reported, in murine studies, that TCE can both exacerbate autoimmune disease and suppress immune function. (cdc.gov)
Inhibitory1
- Killer cell inhibitory receptors. (embl.de)
Lymphocyte1
- Endpoints assessed included splenic and thymic weights and cellularity, natural killer cell (NK) activity, antibody plaque forming cell (PFC) response, lymphocyte proliferation, and T-cell immunophenotypes. (cdc.gov)
Mice1
- A single injection of αβ-interferon (αβ-IFN) (30 000 units/mouse), a major biological modifier of natural killer (NK) cytolytic activity, strongly stimulated NK activity in normal mice, as expected, while the same treatment did not statistically alter the NK response in cyclophosphamide (CY)-suppressed animals. (springer.com)
Monocytes1
- Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. (cancerindex.org)
Defenses1
- Here is a complete guide to understanding and maximizing your natural defenses against various infectious diseases. (squareonepublishers.com)
Activity5
- Thymosin α 1 was, moreover, able to accelerate the recovery rate of NK activity in bone marrow reconstituted murine chimeras. (springer.com)
- Bardos P, Bach JF (1982) Modulation of mouse natural killer cell activity by serum thymic factor. (springer.com)
- Augmentation of mouse natural killer cell activity by interferon and interferon inducers. (springer.com)
- IL-12 apparently shows species specificity with human IL-12 reportedly showing minimal activity in the murine system. (rndsystems.com)
- The natural environment is increasingly recognized as an effective counter to urban stress, and 'Forest Therapy' has recently attracted attention as a relaxation and stress management activity with demonstrated clinical efficacy. (researchgate.net)
Virus1
- Murine respirovirus, formerly Sendai virus (SeV) and previously also known as murine parainfluenza virus type 1 or hemagglutinating virus of Japan (HVJ), is an enveloped, 150-200 nm-diameter, negative sense, single-stranded RNA virus of the family Paramyxoviridae. (wikipedia.org)
Transfer1
- Blood and tissue biomarker analysis in dogs with osteosarcoma treated with palliative radiation and intra-tumoral autologous natural killer cell transfer. (ucdavis.edu)
Lymphocytes8
- Natural killer (NK) cells and T lymphocytes are the major effector cells that can recognize and kill tumor cells. (lu.se)
- The method is used to quantify natural killer (NK) and lymphokine-activated killer (LAK) activities against the human K562 and Daudi cell lines and the murine YAC-1 and L1210 cell lines respectively, as well as cell-mediated lympholysis (CML) exerted by tumor-infiltrating lymphocytes (TIL) against autologous and allogeneic human breast cancer tumor cells. (nih.gov)
- Miller SC, Christopher FL, Dussault I , Population dynamics of natural killer cells and T lymphocytes in murine spleen and bone marrow during the development of erythroleukemia: the effect of indomethacin. (coriell.org)
- Natural Killer (NK) lymphocytes strongly expressing CD56 become abundant in the human uterus three to five days after the mid-menstrual cycle surge in pituitary-derived luteinizing hormone (LH). (immune-source.com)
- Studies on the in vitro activation of Leu-11+ granular lymphocytes with a natural killer-sensitive tumor cell, K562. (silverchair.com)
- Therapy for cancer can be achieved by artificially stimulating antitumor T and natural killer (NK) lymphocytes with agonist monoclonal antibodies (mAb). (cun.es)
- IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and natural killer (NK) cells (4). (bio-techne.com)
- Natural killer (NK) cells are a form of cytotoxic lymphocytes which constitute a major portion of the innate immune system. (nih.gov)
Spleen4
- Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. (southernbiotech.com)
- We demonstrate the utility of STvEA by uncovering the architecture of poorly characterized cell populations in the murine spleen using published mIHC images. (biorxiv.org)
- We used the murine spleen as a test system to assess the feasibility of mapping CITE-seq data to mIHC images, since well-established antibody panels and high-quality mIHC data are readily available for this organ. (biorxiv.org)
- We generated a high-quality CITE-seq dataset of the murine spleen using the same 30-antibody panel (Supplementary Table 1) and mice of the same age, sex, and strain as this CODEX dataset. (biorxiv.org)
Tumor growth2
- Herein, we report that intratumoral CCL21 administration recruited significant numbers of immune cells into murine pancreatic tumors and inhibited tumor growth. (nih.gov)
- NK cells have tumor cytotoxic properties independent of tumor specific antigens and have been shown in murine models to control and prevent tumor growth and dissemination. (nih.gov)
Immunity4
- Trastuzumab also stimulated TAM activation and expansion, but did not require adaptive immunity, natural killer cells, and/or neutrophils. (jci.org)
- CD357) promotes impressive tumor-rejecting immunity in a variety of murine tumor models. (cun.es)
- Homo sapiens] IL10 contributes to antiviral innate immunity during acute infection by restricting activation-induced death in natural killer (NK) cells. (innatedb.com)
- Therapeutic cancer vaccines aim to boost the natural immunity against transformed cancer cells, and a series of adjuvants and co-stimulatory molecules have been proposed to enhance the immune response against weak self-antigens expressed on cancer cells. (biomedcentral.com)
Receptor2
- Using both murine and human versions of trastuzumab, we found its antitumor activity dependent on Fcγ receptor stimulation of tumor-associated macrophages (TAMs) and antibody-dependent cellular phagocytosis (ADCP), but not cellular cytotoxicity (ADCC). (jci.org)
- Cytolytic natural killer (NK) cells were also observed to accumulate in degenerative defects and interact with neutrophils via secretion of chemokine receptor type 1 (CCR1) ligands. (umich.edu)
MCMV1
- Murine CMV (MCMV) infection induces immunological memory independent of T and B cells [ 15 , 16 ]. (hindawi.com)
Cytokine2
- interleukin 12 subunit beta/alpha or IL12b/IL12a is a growth factor cytokine which increases the lytic activity of NK/lymphokine-activated killer cells, activated T and NK cells and prompt IFN-gamma production (through resting PBMC). (prospecbio.com)
- Interleukin 12, also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated B lymphoblastoid cell lines (1). (bio-techne.com)
Bone marrow2
- 4. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. (nih.gov)
- However, some activated T cells, lymphokine activated killer cells (LAK), NK cell progenitors in the bone marrow, and T cells of the lpr/lpr mutant mouse also express this antigen. (thermofisher.com)
Differentiation of Human Natural Kille2
- 13. T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells. (nih.gov)
- A model for the differentiation of human natural killer cells. (silverchair.com)
Decidua3
- 11. Heterogeneity of NK Cells and Other Innate Lymphoid Cells in Human and Murine Decidua. (nih.gov)
- Characterization of murine pregnancy decidua transforming growth factor beta. (mcmaster.ca)
- Murine pregnancy decidua produces a unique immunosuppressive molecule related to transforming growth factor beta-2. (mcmaster.ca)
Maturation5
- 1. Transcriptional regulation of natural killer cell development and maturation. (nih.gov)
- 3. Development and maturation of natural killer cells. (nih.gov)
- 6. A role for Blimp1 in the transcriptional network controlling natural killer cell maturation. (nih.gov)
- 8. Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells. (nih.gov)
- 17. The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. (nih.gov)
Macrophages2
- Liver macrophages in murine listeriosis. (silverchair.com)
- IL10 also has an immunomodulatory role by stimulating NKG2D ligand expression on macrophages, thereby rendering them susceptible to natural killer (NK) cell elimination. (innatedb.com)
Cytotoxic T lymphocy1
- NK cells have a constitutive cytotoxic activity and kill a wide spectrum of tumor cells while T cells recognize specific tumor antigens and need to be activated through their TCR to differentiate into cytotoxic T lymphocyte (CTL) killers or T helper cells. (lu.se)
Activation4
- Activation of murine cytotoxic cells with interelukin-2 and the bacterial superantigen staphylococcal entertoxin A. (lu.se)
- Dive into the research topics of 'Activation of murine cytotoxic cells with interelukin-2 and the bacterial superantigen staphylococcal entertoxin A.'. Together they form a unique fingerprint. (lu.se)
- We further investigated IgG1 binding to natural killer (NK) cells and NK cell activation during ADCC induction to elucidate the mechanism by which low-fucose IgG1 induces ADCC upon target cells with low antigen expression. (aacrjournals.org)
- Natural killer (NK) cells are an important component of the body's natural immune system and play a surveillance role in tumors by killing cancer cells directly or by secreting cytokines following their activation [ 5 ]. (biomedcentral.com)
Thymic2
- 7. Murine thymic NK cells are distinct from ILC1s and have unique transcription factor requirements. (nih.gov)
- Endpoints assessed included splenic and thymic weights and cellularity, natural killer cell (NK) activity, antibody plaque forming cell (PFC) response, lymphocyte proliferation, and T-cell immunophenotypes. (cdc.gov)
Growth1
- Flickinger RA , Protein kinase activity, growth and differentiation of murine erythroleukemia cells. (coriell.org)
Liver1
- The first demonstration of antigen-specific recall responses by NK cells was in the setting of hapten-induced contact hypersensitivity, where CXCR6 + liver-derived murine NK cells could mediate antigen-specific contact hypersensitivity independently from B and T cells [ 13 , 14 ]. (hindawi.com)
Immunoglobulin2
- Ligation of killer immunoglobulin like receptors (KIRs) by MHC class I on both normal and malignant tissues suppresses the function of NK cells. (nih.gov)
- CD94/NKG2A and killer immunoglobulin-like receptors (KIR)) that recognize MHC class I molecules. (hindawi.com)
Immunological1
- Low natural killer syndrome: clinical and immunological features. (gmushrooms.com)
Implantation1
- Murine uNK cells traffic from the circulation to the anti-mesometrial side of the uterus and migrate to the mesometrial side of each implantation site. (immune-source.com)
Immune cells1
- Natural killer (NK) cells are innate immune cells specialized in the recognition and killing of virus-infected or tumor cells. (ashpublications.org)
Protein2
- 10. Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity. (nih.gov)
- Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. (cancerindex.org)
Lymphoid2
- Culturing of lymphoid cells with IL-2 preferentially expanded NK cells and induced lymphokine activated killer (LAK). (lu.se)
- Culturing of lymphoid cells with IL-2 preferentially expanded NK cells and induced lymphokine activated killer (LAK) activity that preferentially was mediated by IL-2 activated NK cells (NK-LAK) and only to a minor extent by T cells (T-LAK). (lu.se)
Human Natural Kille1
- The activity is determined by the IFN-g ELISA in a using NK-92 human natural killer cells. (prospecbio.com)
Progenitors1
- 14. Effect of Schlafen 2 on natural killer and T cell development from common T/natural killer progenitors. (nih.gov)
19912
- GATA binding factor 2 (GATA2) was initially cloned (1991) as a critical regulator of murine endothelial development, the complete absence of which was incompatible with life. (nih.gov)
- CIT): The NIH Director's Wednesday Afternoon Lecture Series The Annual G. Burroughs Mider Lecture GATA binding factor 2 (GATA2) was initially cloned (1991) as a critical regulator of murine endothelial development, the complete absence of which was incompatible with life. (nih.gov)
Inhibitory receptors1
- Killer cell inhibitory receptors. (embl.de)
Insights1
- Recently we provided the first direct evidence for self-renewal and long-term persistence of mature natural killer cells, explaining aspects of natural killer cell memory and providing insights into dynamics of these cells following infections or as therapies to fight cancer. (nih.gov)
Expression1
- Lai W, Chang CH, Farber DL (2003) Gene transfection and expression in resting and activated murine CD4 T cell subsets. (springer.com)
Viral1
- Our laboratory has demonstrated that natural killer cells become activated during viral infections and contribute to natural resistance to viruses, though they sometimes can act antagonistically by interfering with anti-viral T cell responses. (umassmed.edu)
Healthy1
- We detected CD75s in 6 out of 7 human GBM tissues but not in human and murine healthy brain tissue. (uni-tuebingen.de)
Cells towards2
- Right here we review the latest books about the adhesion substances cytokines chemokines and human hormones regarded as mixed up in trafficking of NK cells towards the murine uterus. (immune-source.com)
- They enhanced the vulnerability of GBM cells towards natural killer (NK) cell and T cell mediated killing. (uni-tuebingen.de)
Effector1
- Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived, hyperfunctional populations, dubbed memory or memory-like NK cells. (hindawi.com)
Substances1
- RBAC was also shown to work synergistically with other natural anti-cancer substances, such as Baker's yeast [51] and curcumin [53]. (researchgate.net)
Cell lines1
- Background Human natural killer (NK) cell lines serve as an attractive source for adoptive immunotherapy, but NK-92 remains the only cell line being assessed in the clinic. (bmj.com)
Studies1
- It has been reported, in murine studies, that TCE can both exacerbate autoimmune disease and suppress immune function. (cdc.gov)