Murine major. Medical search. Frequent questions

Both variations were shown to influence bacterial colonization in a murine infection model. (uni-muenchen.de)

To examine whether expression of class I major histocompatibility complex on tumor cells influenced the generation and antitumor activity of TILs, we used clones of murine B16BL6 melanoma either transfected with or lacking the class I gene K b to generate TILs at a high dose (1, 000 U/mL) or at a low dose (20 U/mL) of human rIL-2. (johnshopkins.edu)
Weber, JS & Rosenberg, SA 1990, ' Effects of murine tumor class i major histocompatibility complex expression on antitumor activity of tumor-infiltrating lymphocytes ', Journal of the National Cancer Institute , vol. 82, no. 9, pp. 755-761. (johnshopkins.edu)
A phenotypically dominant regulatory mechanism suppresses major histocompatibility complex class II gene expression in a murine plasmacytoma. (ox.ac.uk)
The expression of major histocompatibility complex (MHC) class II antigens is down-regulated when B cells differentiate into plasma cells. (ox.ac.uk)
Donald F. Hunt (Departments of Chemistry and Pathology, University of Virginia, Charlottesville): "A complex mixture containing more than 10,000 peptide fragments derived from cellular proteins is displayed on the cell surface in association with molecules of the major histocompatibility complex (MHC), class I glycoproteins. (the-scientist.com)
Murine models have demonstrated that the major histocompatibility complex (MHC) is associated with pain-like behavior in peripheral nerve injury, however, the same association has not been shown when considering injury to the central nervous system (CNS), which more closely mimics the damage to the CNS experienced by MS patients. (iasp-pain.org)

In addition, experience in targeted gene disruption (gene knockouts) is most highly developed in the murine model. (stanford.edu)
The Phenotyping Core has also been a valuable resource for the development of new physiologic monitoring techniques in the murine model and for expanding our knowledge of normal murine physiology. (stanford.edu)
Over the past 15 years, a select group of laboratories, including ours, have adapted physiologic monitoring techniques used previously in larger animals to the murine model. (stanford.edu)
The Phenotyping Core has pioneered the adaptation of chronic non-anesthetized physiologic monitoring techniques, previously established as a superior methodology in larger animals, to the murine model. (stanford.edu)
We adapted the human whole-blood model to murine blood. (frontiersin.org)
Our results reveal substantial differences between murine and human whole-blood models infected with C. albicans and thereby demonstrate limitations in the translatability of this ex vivo model between hosts. (frontiersin.org)
The resulting recommendations for standard design parameters are presented in this document and will provide the basis for the development of a harmonized and bench-marked efficacy studies in preclinical murine pneumonia model. (frontiersin.org)
Expression of SOX9 did not decrease during aging and was instead upregulated by reactive astrocytes in a number of settings, including a murine model of amyotrophic lateral sclerosis (SOD1G93A), middle cerebral artery occlusion, and multiple mini-strokes. (jneurosci.org)
Flow cytometry analysis of tumor infiltrating T-cells in a murine model of PDAC was performed to investigate the therapeutic effects and mechanism of anti-CSF-1R/anti-PD-1/GVAX combination immunotherapy. (bmj.com)
In the pre-clinical murine model, administering anti-CSF-1R antibody prior to and after GVAX/αPD-1 ("pre/post-αCSF-1R + αPD-1 + GVAX") enhanced the survival rate compared to GVAX/αPD-1 dual therapy ( p = 0.005), but administering anti-CSF-1R only before GVAX/αPD-1 did not ( p = 0.41). (bmj.com)
The mutation attenuates KP in a murine pneumonia model, which accounts for its limited clonal expansion observed by phylogenetic analysis. (imperial.ac.uk)
To elucidate the biological mechanisms underlying pulmonary metastasis and identify superior therapeutic strategies, we developed a novel and clinically relevant murine RCC model exhibiting enhanced pulmonary metastasis. (biologists.com)
Because PS372424 activates human (but not murine) CXCR3, the O'Boyle/Kirby team had to establish a murine model of human T cell migration. (jax.org)
16S rRNA pyrosequencing identified three enterotype-like clusters (E1, E2, and E3) in this murine model. (aacrjournals.org)
Using an immunocompetent murine K7M2-luc lung metastases model, the efficacy of MYXV armed with murine LIGHT (TNFSF14/CD258) expressed under virus -specific early/late promoter was tested in an advanced later-stage disease K7M2-luc model. (bvsalud.org)
The demonstration of antibodies, mixed T-helper (Th) type 1/2 responses diisocyanate occupational asthma in a murine model after sub- and the involvement of CD8 T lymphocytes in chronic inhalation exposure at relevant exposure levels should diisocyanate OA. (cdc.gov)
New target molecules and mediators as well animal model, diisocyanate, diphenyl-methane diisocyanate, as new therapeutic approaches for allergic asthma have hexamethylene diisocyanate, murine model, occupational been identified using animal models. (cdc.gov)
Furthermore, the vps4Δ null mutant has been shown to be markedly hypovirulent in a murine model. (medscape.com)
Here, we used pharmacoproteomics to score time-dependent treatment impact in a murine Escherichia coli sepsis model after administering beta-lactam antibiotic meropenem (Mem) and/or the immunomodulatory glucocorticoid methylprednisolone (Gcc). (lu.se)

Here, we directly compared the activities of Chol-siRNA and Chol-DsiRNA Polyplexes in primary murine 4T1 breast tumors against STAT3, a therapeutically relevant target gene overexpressed in many solid tumors including breast cancer. (preprints.org)
The serum, in turn, exhibited differential potency in terms of inflammatory bioactivity when incubated with primary murine cerebrovascular endothelial cells. (cdc.gov)

Further, these TILs demonstrated activity in vitro against the non-class I-expressing melanoma treated with the combination of murine recombinant interferony and human recombinant tumor necrosis factor α in vivo, when administered with recombinant interferon γ and recombinant tumor necrosis factor a, TILs from the class I-expressing tumor mediated regression of non-class I-expressing pulmonary metastases, presumably by augmenting class I expression. (johnshopkins.edu)
Since then, I have helped evaluate various murine models of inflammatory lung disease, ran an NIH funded morphology core for the Yale pulmonary section, and ran a basic laboratory at West Haven VA looking at murine models of pulmonary fibrosis. (yale.edu)
RA-RARα activity limited murine Th9-associated pulmonary inflammation, and human allergic inflammation was associated with reduced expression of RA target genes. (nih.gov)

To document the epidemiology, clinical features, and outcomes of murine typhus patients in the Canary Islands (Spain), we analyzed data that were retrospectively collected for 16 years for 221 patients. (cdc.gov)
Murine typhus in the Canary Islands is characterized by a high rate of complications (31.6%), mainly liver, lung, kidney or central nervous system involvement. (cdc.gov)
Murine typhus is a febrile disease caused by Rickettsia typhi ( 1 ). (cdc.gov)
Adaptation to new reservoirs (cats, dogs, opossums) and vectors, in particular Ctenocephalides felis (cat flea), has probably led to the reappearance of murine typhus in industrialized countries ( 3 ). (cdc.gov)
Murine typhus remains a neglected disease despite its worldwide distribution. (cdc.gov)
Our aim was to document the epidemiology, clinical features, and outcome of murine typhus in the Canary Islands (Spain). (cdc.gov)
14 years of age who were inpatients and outpatients at the Hospital Universitario Insular of Las Palmas (Las Palmas de Gran Canaria, Spain), who received a diagnosis of murine typhus during June 1, 1999-December 31, 2015. (cdc.gov)
Diagnosis of murine typhus was based on detection of antibodies against R. typhi by using an indirect immunofluorescence test and 2 criteria. (cdc.gov)
Murine typhus was more frequent during July-November ( Figure 1 ). (cdc.gov)

Here we summarize the factors of variability that we identified in murine lung infection models used for antimicrobial efficacy testing, as well as the workshop presentations, panel discussions and the survey results for the harmonization of key experimental parameters. (frontiersin.org)
My major interests are in diagnostic and experimental lung pathology. (yale.edu)
The lung cytokine profile similarly increased following MWCNT exposure for major inflammatory markers (IL-1beta, IL-6, and TNF-alpha), with minimal impact from MMP inhibition. (cdc.gov)
However, studies investigating how genetic background of mice impacts the murine lung inflammatory response to dsRNA is lacking. (lu.se)
Systemic Delivery of mLIGHT-Armed Myxoma Virus Is Therapeutic for Later-Stage Syngeneic Murine Lung Metastatic Osteosarcoma. (bvsalud.org)

Murine Norovirus Infection Induces T1 Inflammatory Responses to Dietary Antigens. (broadinstitute.org)

The following is a list of Murinae genus divisions ordered by the continents that they are endemic to. (wikipedia.org)

We have performed the necessary background studies by establishing baseline data for different murine strains, evaluated the cardiovascular and metabolic responses to anesthesia and restraint, determined normal murine pharmacokinetics, and established one of the nation's leading laboratories for evaluation of murine cardiovascular responses. (stanford.edu)

We previously found that polymer complexes (polyplexes) formed between 3'-cholesterol-modified siRNA (Chol-siRNA) or DsiRNA (Chol-DsiRNA) and the cationic diblock copolymer PLL[30]-PEG[5K] greatly increase RNAi potency against stably expressed LUC mRNA in primary syngeneic murine breast tumors after daily i.v. dosing. (preprints.org)
Tumor-infiltrating lymphocytes (TILs) are T cells that can be grown from enzyme-digested murine or human tumors. (johnshopkins.edu)

The Old World rats and mice, part of the subfamily Murinae in the family Muridae, comprise at least 519 species. (wikipedia.org)
Mice underwent intrarenal implantation using luciferase-expressing Renca, a murine renal adenocarcinoma cell line. (biologists.com)
However, murine models, including knockout and transgenic mice, have been useful in understanding the mechanisms of B lymphopoiesis, B-cell differentiation, and antibody formation. (medscape.com)
Murine gene mutations in human counterparts may be associated with a clinical illness different from the illness seen in mice. (medscape.com)

The Stanford Murine Cardiovascular Phenotyping Core Facility was established in 1994 for two purposes: first, to develop new methods for studying in vivo cardiovascular and metabolic physiology in the mouse and second, to support Stanford investigators in performing physiologic studies in rodent models. (stanford.edu)
Murine infection models are widely used to study systemic candidiasis caused by C. albicans . (frontiersin.org)
13 Morphine has been shown to decrease IL-23 production in murine models, decreasing dendritic cell antimicrobial protein production. (uspharmacist.com)
Antitumor efficacy of N-809 or N-803+αPD-L1 was evaluated in two murine carcinoma models and an extensive analysis of immune correlates was performed in the tumor and tumor-draining lymph node (dLN). (bmj.com)
[ 13-15 ] In murine models that lack FGF-23 or klotho, the resultant hyperphosphatemia is associated with cell toxicity, premature aging and vascular calcifications. (medscape.com)

2008), which analyzes African murine species based on the mitochondrial cytochrome b gene and two nuclear gene fragments. (wikipedia.org)
The following phylogeny of 16 Murinae genera, based on molecular phylogenetic analysis of the Interphotoreceptor Retinoid Binding Protein (IRBP) gene, is from Jansa & Weksler (2004: 264). (wikipedia.org)
A BAC encompassing the full Bcl11b gene still required addition of the Major Peak to exhibit T-cell specific expression. (ca.gov)
The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. (nih.gov)

They treated the Otomyinae as a separate subfamily, but all molecular analyses conducted to date have supported their inclusion in the Murinae as relatives of African genera. (wikipedia.org)

A hybrid murine myeloma (2-13F5) secreting a monoclonal antibody that specifically bound and neutralized murine interferon β has been isolated. (microbiologyresearch.org)
Affinity chromatography with immobilized 2-13F5 monoclonal antibody of murine IFN (containing both IFN-α and IFN-β) separated an IFN-β preparation that demonstrated one band with Coomassie Brilliant Blue staining of SDS-PAGE at a molecular weight of 35000 and a specific activity of 4.3 × 10 8 units/mg of protein. (microbiologyresearch.org)
This monoclonal antibody neither bound nor neutralized murine IFN-α. (microbiologyresearch.org)

The lower neutrophil number in murine blood only partially explains insufficient infection and filamentation control, as spiking with murine neutrophils had only limited effects on fungal killing. (frontiersin.org)
Diabetic neutrophils, isolated from diabetic individuals, exhibit chemotaxis impairment but this peculiar functional impairment has been largely ignored because it appears to contradict the clinical findings which blame excessive neutrophil influx as a major impediment to healing in chronic diabetic ulcers. (elifesciences.org)

The human immune response to PRP resembles the murine response to T-cell independent antigens: B cells provide the primary response without a contribution from T-helper cells. (cdc.gov)

This property of CW3 is dependent on its major capsid protein, a virulence determinant. (broadinstitute.org)
Survival in blood can thus be considered a major virulence trait in the development of systemic infections. (frontiersin.org)
We conclude that even small variations in the expression of virulence factors can provoke a major difference in the virulence properties of closely related pathogens which may confer better survival or a higher pathogenic potential in a certain host or host environment. (uni-muenchen.de)
The polyribosylribitol phosphate (PRP) capsule of Hib is a major virulence factor for the organism. (cdc.gov)

Since 1994, we have trained dozens of fellows, students, and research assistants and associates in the latest murine physiologic techniques. (stanford.edu)

Two prominent murine species have become vital laboratory animals: the brown rat and house mouse are both used as medical subjects. (wikipedia.org)
The presence of this core laboratory is also a major added value for Stanford investigators in competing for NIH grants and initiatives. (stanford.edu)
Ensuring quality and safety during laboratory processes is a major concern for laboratory managers. (who.int)

Functional dissection of the Major Peak sequence revealed distinct subregions, in which TCF-1 sites and a conserved element were required for T lineage-specific activation and silencing in non-T cells. (ca.gov)
Thus, promoter-proximal and Major Peak sequences are cis-regulatory elements that interact over 850 kb to control expression of Bcl11b in hematopoietic cells. (ca.gov)
IL4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation. (lu.se)

Chemotherapy-induced alopecia (CIA) is a common side effect of conventional chemotherapy and represents a major problem in clinical oncology. (mdpi.com)
Cancers that metastasize to the lungs represent a major challenge in both basic and clinical cancer research . (bvsalud.org)

Here we show that the acute CW3 strain of murine norovirus, but not the persistent CR6 strain, induces T1 immunity to dietary antigen. (broadinstitute.org)

Lipopolysaccharide (LPS), the major outer membrane component in Gram-negative bacteria, is one of the most characterized PAMPs ( 10 ). (spandidos-publications.com)

To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)

Unlike human blood, murine blood was unable to reduce fungal burden and more substantial filamentation of C. albicans was observed. (frontiersin.org)

Molecular phylogenetic studies of Murinae include Lecompte, et al. (wikipedia.org)
Sepsis is the major cause of mortality across intensive care units globally, yet details of accompanying pathological molecular events remain unclear. (lu.se)

Infection is a major co-morbidity that contributes to impaired healing in diabetic wounds. (elifesciences.org)
8] These authors found VPS4 contributes to several key aspects of oral epithelial but not uroepithelial infection, and in contrast to systemic infection, plays no major role in the pathogenesis of candidal vaginitis. (medscape.com)

Underdiagnosis represents a major health cost because unnecessary diagnostic tests might be performed and treatment might be inadequate ( 6 ). (cdc.gov)

We have studied the mechanism of down-regulation of MHC class II expression in a BALB/c strain-derived murine plasmacytoma cell line, NS1. (ox.ac.uk)

With a basis in stem cell biology, genetics, immunology and cancer, the major goal of our research is to develop new immunotherapies that target leukemia and other malignancies. (lu.se)

BACKGROUND: Lower respiratory infections caused by ssRNA viruses are a major health burden globally. (lu.se)

Effects of tunicamycin on the physical properties and antiviral activities of murine L cell interferon. (microbiologyresearch.org)

including validated, reproducible and standardized phenotyping of the 3 major microvascular complications: diabetic polyneuropathy (DPN), nephropathy (DN) and retinopathy (DR). (mmpc.org)

In 2021, a major revision was taken of Praomyini. (wikipedia.org)

A far downstream enhancer for murine Bcl11b controls its T-cell specific expression. (ca.gov)
Looping interactions between promoter-proximal elements including the differentially methylated region and downstream elements in the Major Peak are required to recapitulate the T-cell specific expression of Bcl11b in stable reporter assays. (ca.gov)

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (nih.gov)

We also observed host-dependent differences for interaction of platelets with C. albicans , showing enhanced platelet aggregation, adhesion and activation in murine blood. (frontiersin.org)

We strongly recommend adding 20 units Murine RNase Inhibitor ( NEB #M0314 ) in each reaction. (neb.com)

My PhD was on aspects of the murine MHC. (yale.edu)

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