EVIDENCE FOR VIRAL GENES IN NORMAL CELLS Viral antigen (many species) Helper factor which forms pseudotype with replica- tion-defective sarcoma virus (mainly chicken) 3. (nih.gov)
[ 11-13 ] The dimeric nature of the retroviral RNA genome is largely responsible for the high genetic variability of highly replicating viruses such as Rous sarcoma virus (RSV) and HIV-1 by means of forced and non-forced copy-choice recombinations during reverse transcription. (medscape.com)
REPLICATION5
Transcription-lote functions acct TBI Site of cleavage by Eco Ri Termination of s % v DNA replication Malor coat protein (VP1) Minor coat protein (VP3) - Origin of wen Traneription-aurly functions Key: REGGHONA Pima) RNA GZ Protein Replication ~ genes Other genes SOME POSSIBLE FORMS OF RNA TUMOR VIRUSES Tronsforming genes TRANSFORMATION-DEFECTIVE NON. (nih.gov)
[ 29-34 ] Thus NC is a multifunctional virus structural protein necessary for the completion of the early and late phases of retrovirus replication (reviewed in [ 28 , 35-38 ] ). (medscape.com)
Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines. (academicinfluence.com)
As its name implies, AAV is dependent upon the presence of a helper virus, such as an adenovirus or herpes virus, for active replication. (justia.com)
Overexpression of DDX5 inhibited IFN production induced by Spring viremia of carp virus (SVCV) and poly(I:C) and enhanced virus replication by targeting key elements of the RLR signaling pathway (MAVS, MITA, TBK1, IRF3 and IRF7). (bvsalud.org)
Simian1
The human and simian immunodeficiency viruses HIV-1, HIV-2 and SIV interact with similar epitopes on their cellular receptor, the CD4 molecule. (academicinfluence.com)
Tumor7
Microbiology 100A -1- Harold Varmus, M.D. Spring 1976 TUMOR VIRUSES I. Recommended Readings: D.W. Allen and P. Cole, Viruses and Human Cancer, New England Journal of Medicine 286:70-82, 1972. (nih.gov)
Some examples of such findings and their significance will be considered in the herpes virus lecture and in the seminar on tumor viruses. (nih.gov)
but a profound understanding of the molecular behavior of tumor viruses may be required to know how to look for human agents. (nih.gov)
Whether or not human cancer is virus-related, animal tumor viruses offer an important opportunity to learn how cells work and how their behavior can be altered by a very small number of viral genes. (nih.gov)
And I guess it was a very natural transition from that into the Polyoma virus which was the first real tumor virus that was worked with in this lab. (nih.gov)
But I've always felt that one of the key things to sort of opening up tumor virology was the isolation of a virus that you could work with in the lab that produced changes in tissue culture. (nih.gov)
TRANSFORMATION1
I. Complete regression of virus-induced transformation in cultures of seropositive donor leukocytes. (nih.gov)
Polyoma1
And when Sarah Stewart and Bernice Eddy isolated Polyoma virus, we got involved in seeing how it could be handled in the laboratory and began a whole series of experiments that had to do with studying the natural history of Polyoma virus infection in lab mice, and Bob Huebner's particular interest in mice in the wild. (nih.gov)
Tissue2
Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI. (academicinfluence.com)
This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
Characterization2
And then we progressed, or moved, from there to studying indigenous viruses of mice, because we were beginning to use mice a lot for experimental purposes, and it became very clear that there were a lot of viruses already in the mice that weren't recognized, hadn't been classified, or tests worked out for their characterization. (nih.gov)
PMID- 214398 TI - Characterization of an adenosine triphosphatase of the avian myeloblastosis virus and the virus-infected myeloblast. (nih.gov)
Particles2
Topic Outline for Lecture The evidence for a role for viruses in the etiology of human tumors remains sparse: epidemiological studies do not suggest that conventional, horizontally-transmitted infectious agents are important in human cancer, and virus particles or virus-specific proteins or nucleic acids have only rarely been found in human tumors. (nih.gov)
[ 1-6 ] At almost the same time, RT activity was also found in virus-like particles purified from human fluids and cells. (medscape.com)
Transcription1
The role of two members of the ETS (E26 avian leukemia oncogene) family of transcription factors, ETS-1 and ETS-2, has been investigated in many cancers but has not yet been studied in ocular tumors. (molvis.org)
Antibodies2
PMID- 214407 TI - Antibodies to Herpes simplex virus types 1 and 2 in patients with squamous-cell carcinoma of uterine cervix in India. (nih.gov)
The present invention provides mutant adeno-associated virus (AAV) that exhibit altered capsid properties, e.g., reduced binding to neutralizing antibodies in serum and/or altered heparin binding and/or altered infectivity of particular cell types. (justia.com)
Infection3
The first isolations had been made from cultivated tonsils and adenoids, and the work was just beginning to try to understand what a broad spectrum of viruses was involved and what they had to do with human disease, with respiratory disease in the military, and with Trachoma and with pink eye and all the things that are now known to be associated with Adenovirus infection. (nih.gov)
Human immunodeficiency virus type 2 infection associated with AIDS in West Africa. (academicinfluence.com)
Vesicular stomatitis virus (VSV) and herpes simplex virus type 1 (HSV-1) infection induced a higher level of IFN-ß protein in NOG1 deficient mice. (bvsalud.org)
Retroviruses differ from other positive-strand RNA viruses in the sense that their genomic RNA is reverse transcribed to generate a double stranded DNA flanked by two long terminal repeats (LTR). (medscape.com)
The discovery of HIV-1 and the AIDS epidemic fueled unprecedent interest in and support for basic research on retroviruses as well as extensive efforts aimed at combating the AIDS virus. (medscape.com)
So, we got rather deeply into mouse viruses. (nih.gov)
Molecular1
J. Tooze, The Molecular Biology of Tumour Viruses, esp. (nih.gov)
Transmission1
PMID- 214400 TI - Transmission of Japanese encephalitis virus by Culex bitaeniorhynchus Giles. (nih.gov)
Cell5
Transformed cells do not produce virus, but virus can be rescued by cell fusion with permissive host. (nih.gov)
PMID- 214405 TI - Long-term T-cell-mediated immunity to Epstein-Barr virus in man. (nih.gov)
AB - Peripheral blood mononuclear cells from donors of known serological status with respect to EB virus were exposed to the virus in vitro and then cultured at various cell concentrations. (nih.gov)
The results strongly suggest that the regression phenomenon is an in vitro expression of long-term T-cell-mediated immunity to EB virus which the large majority, if not all, infected individuals possess. (nih.gov)
AB - Antibody activity to Herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) was measured by the indirect hemagglutination (IHA) test in sera from 124 women with squamous-cell carcinoma of the uterine cervix, 46 women with non-cervical cancer and 116 matched normal women. (nih.gov)
Cells1
Virus induction (chemical or physical) and spontaneous virus production in cultured cells (many species) 4. (nih.gov)
Cancer2
Baker: Dr. Hartley, before we get into looking at the Viruses Cancer Program itself, could you give us a little bit about your background, where you went to school, and what experiences you've had? (nih.gov)
Baker: It became quite a change because, as you know, before 1955 nobody thought viruses had anything to do with cancer. (nih.gov)