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  • Gene
  • OPN (also known as early T cell activation gene-1, or eta-1 ), is a secreted, highly acidic glycoprotein with pleiotropic effects ( 5 - 11 ). (rupress.org)
  • Goodell has been on the faculty of Baylor College of Medicine since 1997 as a member of the Center for Cell and Gene Therapy, and the Departments of Pediatrics, Molecular and Human Genetic, and Immunology. (wikipedia.org)
  • She is also a member of the Center for Cell and Gene Therapy. (wikipedia.org)
  • HOX B6 gene is only expressed in erythoid progenitor cells, which are the precursor to red blood cells used for transport of oxygen and carbon dioxide throughout the body. (wikipedia.org)
  • This gene has also been shown to encourage the growth of granulocytes and monocytes, but at the cost of other blood cells. (wikipedia.org)
  • Moreover, signaling pathways related to neurogenesis and myogenesis were also investigated by studying gene expression or generating mutants of P19 cells. (wikipedia.org)
  • The NOD/ShiLtJ background also contributes an allele of the Sirpa gene that renders the bone marrow niche very permissive to colonization by human hematopoietic stem cells. (wikipedia.org)
  • This interaction is best characterized in the co-regulation of HOXA9 gene by SALL4 and MLL in leukemic cells. (wikipedia.org)
  • apoptosis
  • Apoptosis has proven to be tightly interwoven with other essential cell pathways. (wikipedia.org)
  • In later stages of apoptosis the entire cell becomes fragmented, forming a number of plasma membrane-bounded apoptotic bodies which contain nuclear and or cytoplasmic elements. (wikipedia.org)
  • PTEN is a tumor suppressor that keeps uncontrolled cell growth in check through inducing programmed cell death, or apoptosis. (wikipedia.org)
  • regulates
  • Stem cells reside in a specialized niche that regulates their abundance and fate. (rupress.org)
  • Kocabas F, Zheng J, Thet S, Copeland NG, Jenkins NA, DeBerardinis RJ et al (2012) Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells. (springer.com)
  • CD97 in colonic enterocytes strengthens E-cadherin-based adherens junctions to maintain lateral cell-cell contacts and regulates the localization and degradation of β-catenin through glycogen synthase kinase-3β (GSK-3β) and Akt signaling. (wikipedia.org)
  • Since it is a transcriptional factor, HOX B6 regulates erythpoigenesis (red blood cell formation) using mRNA as the basis for certain protein productions. (wikipedia.org)
  • pathways
  • Components of the niche have generally been defined in terms of cells and signaling pathways. (rupress.org)
  • Components of stem cell niches have generally been defined in terms of cells and molecular pathways. (rupress.org)
  • OPN binds to cells through an arginine-glycine-aspartate-mediated interaction with integrins and non-arginine-glycine-aspartate-mediated interactions with CD44, activating multiple and varied signaling pathways. (rupress.org)
  • The roles of BMP and IL-3 signaling pathways in the control of hematopoietic stem cells in the mouse embryo. (semanticscholar.org)
  • differentiate
  • The CMP can then further differentiate into the megakaryocyte-erythroid progenitor cell (MEP), which goes on to make RBCs and platelets, or the granulocyte/macrophage progenitor (GMP), which gives rise to the granulocytes of the innate immune response. (wikipedia.org)
  • The cell line is pluripotent and can differentiate into cell types of all three germ layers. (wikipedia.org)
  • Also, exposing P19 cells to retinoic acid (RA) can differentiate them into neuronal cells. (wikipedia.org)
  • The difference between these subtype cell lines is the ability to differentiate into neuronal cells or muscle cells in response to treatment with retinoic acid or DMSO, respectively. (wikipedia.org)
  • Since embryonal carcinoma can differentiate into cells of all three germ layers, P19 cells can also differentiate into those ectoderm, mesoderm and endoderm-like cells. (wikipedia.org)
  • Studies have shown that a certain concentration of RA can induce P19 cells to differentiate into neuronal cells, including neurons and glial cells. (wikipedia.org)
  • while 0.5% - 1% DMSO led P19 cells differentiate to cardiac or skeletal muscle cells. (wikipedia.org)
  • Other than into neurons and astrocytes, P19 cells can also differentiate to oligodendrocytes, which can be detected using the specific markers, myelin-associated glycoprotein and 2',3'-Cyclic-nucleotide 3'-phosphodiesterase. (wikipedia.org)
  • cytokine
  • For example, granulomatous responses are associated with high levels of OPN expression ( 16 , 17 , 20 ) and OPN can function as a Th1 cell cytokine, enhancing IL-12 while inhibiting expression of the Th2 cell cytokine IL-10 ( 17 , 19 , 21 ). (rupress.org)
  • Furthermore, OPN can alter the sensitivity of hematopoietic cells to other cytokine stimuli ( 22 ). (rupress.org)
  • Flt3 ligand (FL) is a hematopoietic four helical bundle cytokine. (wikipedia.org)
  • 2001). "Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor gamma-chain signaling and inhibited by cyclosporin A". Blood. (wikipedia.org)
  • mammalian
  • Whether the same is true for mammalian stem cell niches has not been well defined. (rupress.org)
  • Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. (wikipedia.org)
  • CD34
  • CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. (wikipedia.org)
  • Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. (wikipedia.org)
  • Regardless of its mode of action, under all circumstances CD34, and its relatives podocalyxin and endoglycan, facilitates cell migration. (wikipedia.org)
  • citation needed] CD34 is expressed in roughly 20% of murine hematopoietic stem cells, and can be stimulated and reversed. (wikipedia.org)
  • mutation
  • The clone of eosinophils bear a mutation in any one of several genes that code for proteins that regulate cell growth. (wikipedia.org)
  • receptor
  • We reasoned that the potential for OPN to affect stem cell function in the niche was great given its abundance in the proper geographic location, its receptor expression on stem cells, and the evidence for it affecting processes in other cells that might be relevant for stem cell physiology. (rupress.org)
  • Publications] Nosaka K: 'Mechanism of hypercalcemia in adult T-cell leukemia : Overexpression of receptor activator of nuclear kB ligand on adult T-cell leukemia cells'Blood. (nii.ac.jp)
  • Kit (CD117) is the receptor of Stem Cell Factor. (wikipedia.org)
  • T cells can be distinguished from other lymphocytes, such as B cells and natural killer cells, by the presence of a T-cell receptor on the cell surface. (wikipedia.org)
  • The majority of human T cells rearrange their alpha and beta chains on the cell receptor and are termed alpha beta T cells (αβ T cells) and are part of the adaptive immune system. (wikipedia.org)
  • Memory T cell subtypes: Central memory T cells (TCM cells) express CD45RO, C-C chemokine receptor type 7 (CCR7), and L-selectin (CD62L). (wikipedia.org)
  • marrow
  • Globally, our results indicate that although osteoclast-dependent HSC mobilization from bone marrow to spleen is triggered in murine blood stage malaria, this activity is not essential for stress erythropoiesis. (hindawi.com)
  • MSC were obtained from C3H/He bone marrow cells (BMC). (springer.com)
  • At MIT, she developed a method for isolating blood-forming stem cells from mouse bone marrow based on a fortuitous observation that stem cells efflux fluorescent lipophillic dyes. (wikipedia.org)
  • Absent these causes, patients were diagnosed in the World Health Organization's classification as having either 1) Chronic eosinophilic leukemia, not otherwise specified, (CEL-NOS) if blood or bone marrow blast cells exceeded 2% or 5% of total nucleated cells, respectively, and other criteria were met or 2) idiopathic hypereosinophilic syndrome (HES) if there was evidence of eosinophil-induced tissue damage but no criteria indicating chronic eosinophilic leukemia. (wikipedia.org)
  • dendritic cell
  • The genetic background, derived from inbred NOD mouse strain NOD/ShiLtJ, contributes reductions in innate immunity that include an absent hemolytic complement system, reduced dendritic cell function, and defective macrophage activity. (wikipedia.org)
  • autologous
  • It appears to be an alternative to the more traditional treatment with melphalan in people who are ill-suited for autologous stem cell transplant. (wikipedia.org)
  • human
  • Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding. (semanticscholar.org)
  • Many human blood cells, such as red blood cells (RBCs), immune cells, and even platelets all originate from the same progenitor cell, the hematopoietic stem cell (HSC). (wikipedia.org)
  • The human homolog was isolated in 1980 as a 25kDa protein (p25) of T-lymphoblastoid cell line MOLT-3 binding with anti-monkey-thymocyte antisera. (wikipedia.org)
  • The 162aa (murine, 161 for human) Thy1 precursor has 19 amino acid (aa 1-19) signal sequence and 31 amino acid (aa 132-162) C-terminal transmembrane domain that is present in pro form but removed when transferring the 112 amino acid (aa 20-131) mature peptide to GPI anchor which would attach through the aa 131. (wikipedia.org)
  • There have been some reports of Thy1 monoclonal antibodies cross reacting with some cytoskeletal elements: anti Thy-1.2 with actin in marsupial, murine, and human cells and anti Thy-1.1 with vimentin, and were suggested to be due to sequence homology by studies done more than 20 years back. (wikipedia.org)
  • Specialized gamma delta T cells, (a small minority of T cells in the human body, more frequent in ruminants), have invariant T-cell receptors with limited diversity, that can effectively present antigens to other T cells and are considered to be part of the innate immune system. (wikipedia.org)
  • endothelial cells
  • In pre-active lesion, increased expression of CD55 in endothelial cells and robust CD97 expression on infiltrating leukocytes suggest a possible role of both molecules in immune cell migration through the blood-brain barrier. (wikipedia.org)
  • factor
  • Hematopoietic stem cells in the blood after stem cell factor and interleukin‐11 administration: Evidence for different mechanisms of mobilization. (currentprotocols.com)
  • However, contradictory evidences demonstrate that inhibition of osteoclast activity by bisphosphonate does not impair HSPC mobilization in response to Granulocyte-Colony Stimulating Factor (G-CSF) treatment [ 1 , 10 ], suggesting that osteoclasts may only intervene in certain types of hematopoietic stresses. (hindawi.com)
  • Publications] Ohneda O: 'WECHE : a novel hematopoietic regulatory factor. (nii.ac.jp)
  • in a cell surface glycoprotein and functions as a cell-cell adhesion factor. (wikipedia.org)
  • It is structurally homologous to stem cell factor (SCF) and colony stimulating factor 1 (CSF-1). (wikipedia.org)
  • For example, it is a major growth factor stimulating the growth of dendritic cells. (wikipedia.org)
  • subtypes
  • Signalling from the APC directs T cells into particular subtypes. (wikipedia.org)
  • Historically, memory T cells were thought to belong to either the effector or central memory subtypes, each with their own distinguishing set of cell surface markers (see below). (wikipedia.org)