• I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. (uchicago.edu)
  • The murine homologue of the T lymphocyte CD2 antigen: molecular cloning, chromosome assignment and cell surface expression. (ox.ac.uk)
  • Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritus and eczematous skin lesions, associated with enhanced T-helper-2 lymphocyte response. (usp.br)
  • Here, we recovered transcriptome and immune repertoire information for polyclonal T follicular helper cells following lymphocytic choriomeningitis virus (LCMV) infection, CD8+ T cells with binding specificity restricted to two distinct LCMV peptides, and B and T cells isolated from the nervous system in the context of experimental autoimmune encephalomyelitis. (nature.com)
  • Follicular helper T cells (Tfh) regulate the differentiation of germinal center B cells and maintain humoral immunity. (sciencegate.app)
  • Modulation of B-cell tolerance by murine gammaherpesvirus 68 infection: requirement for Orf73 viral gene expression and follicular helper T cells. (mcw.edu)
  • Expansion of follicular helper T cells in the absence of Treg cells: implications for loss of B-cell anergy. (mcw.edu)
  • In murine models of Schistosoma mansoni infection, egg production is associated with a switch from T helper cell (Th)1- to Th2-type responses to both schistosome-specific and unrelated antigens. (rupress.org)
  • Murine Norovirus Infection Induces T1 Inflammatory Responses to Dietary Antigens. (broadinstitute.org)
  • Objectives: The overall aim was therefore, to elucidate the impact of S. mansoni infection on protective T helper immune responses on P. falciparum and S. mansoni co-infection. (scirp.org)
  • Methodology: This study evaluated the T helper immune responses in individuals with independent S. mansoni infection, independent P. falciparum infection, co-infection and non-infection in school attending children in a co-endemic area along Lake Victoria shores, Uganda. (scirp.org)
  • Immune responses were categorized into Th1, Th2, and Th17 based on unique cytokine(s) produced by the T helper subpopulation in ex vivo. (scirp.org)
  • Suboptimal T helper immune responses were detected in independent S. mansoni infections characterized by significantly down regulated Th1 (Z = -1.425, p = 0.0313) response in comparison to the non-infected group. (scirp.org)
  • Suboptimal T helper immune responses were also recorded in the co-infected individuals characterized by significantly down regulated Th1 (Z = -3.260, p = 0.0273) and Th2 (Z = -1.180, p = 0.0078) responses compared to independent P. falciparum . (scirp.org)
  • P. falciparum and S. mansoni infections initiate a T helper immune response [4] [5] , which links the innate and adaptive immune responses against the parasites. (scirp.org)
  • 16 Such observations have initiated the idea that HLA-G might protect tissues from damage by infiltrating cytotoxic T cells during the process of inflammation 2 because HLA-G has been shown to modulate the T helper (Th) cytokine balance in favour of Th2 type anti-inflammatory cytokine responses. (bmj.com)
  • Murine immune responses to L. monocytogenes in vivo are of the appropriate TH1 phenotype. (scienceopen.com)
  • Transgenic animals have identified a role for specific immunity, including the involvement of T-helper type 1/2 responses as well as CD4 and CD8 T cells in diisocyanate occupational asthma. (cdc.gov)
  • Intestinal reovirus infection can trigger T helper 1 (T1) immunity to dietary antigen, raising the question of whether other viruses can have a similar impact. (broadinstitute.org)
  • Here we show that the acute CW3 strain of murine norovirus, but not the persistent CR6 strain, induces T1 immunity to dietary antigen. (broadinstitute.org)
  • The development of cell-mediated immunity during experimental murine dermatophytosis has been studied. (ivoryresearch.com)
  • 13. Zheng B, Han S, Kelsoe G. T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1. (southernbiotech.com)
  • The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system. (wikipedia.org)
  • CD4+ T cells are generally treated as having a pre-defined role as helper T cells within the immune system. (wikipedia.org)
  • T cells require antigens to be processed into short fragments which form linear epitopes on MHC Class II (in the case of helper T cells because they express CD4) or MHC class I (in the case of cytotoxic T cells which express CD8). (wikipedia.org)
  • The human immune response to PRP resembles the murine response to T-cell independent antigens: B cells provide the primary response without a contribution from T-helper cells. (cdc.gov)
  • T-cells are divided into three sub-sets with two important sub-populations: T-helper and T-cytotoxic/ T-suppressor. (ivoryresearch.com)
  • We reported previously that CD4 + T cells and B cells in mice with retrovirus-induced murine acquired immunodeficiency syndrome (MAIDS) caused by LP-BM5 murine leukemia virus (MuLV) mixtures increased the expression of Fas antigen (Fas) during progression of the disease. (elsevierpure.com)
  • It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. (rndsystems.com)
  • IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-gamma. (rndsystems.com)
  • At a cellular and molecular level, the hormone preferentially targets helper T cell activity (Th1) by inhibiting the secretion of both IL-2 and IFN-gamma by Th1 and by suppressing the secretion pro-Th1 cytokine IL-12 by antigen-presenting cells. (nih.gov)
  • S. mansoni infection is a major contributor of a reduced effective T helper immune response against P. falciparum in P. falciparum and S. mansoni co-infection. (scirp.org)
  • Clones encoding the murine homologue were isolated from a murine T helper cell cDNA library. (ox.ac.uk)
  • A rabbit antiserum raised against purified human CD2, precipitated from surface-labeled mouse thymocytes a glycoprotein of Mr 55,000-66,000 which decreased to Mr 35,000 on digestion with endo-beta-acetylglucosaminidase F. These sizes are consistent with those predicted for the murine CD2 antigen from the cDNA sequence. (ox.ac.uk)
  • To explain these observations, we investigated actions of Th1 cytokines (TNF-α and IFN-γ) on murine and human breast cancer cell lines that varied in the surface expression of HER-family receptor tyrosine kinases. (oncotarget.com)
  • Murine and human studies have demonstrated an increased expression of T-helper 1 (Th1) cytokines by lamina propria lymphocytes. (nih.gov)
  • We demonstrate using murine models that the removal of PD-1 restriction is effective in alleviating autoimmune disease symptoms. (nature.com)
  • Taken together, these results suggest that MAIDS is inducible independently with functional Fas expression and the possibility of accelerated progression of murine AIDS and lpr-associated autoimmune disease in B6 lpr/lpr mice infected with LP-BM5 MuLV. (elsevierpure.com)
  • In animal models of autoimmunity, 1,25-(OH)2D3 prevents the development of experimental autoimmune encephalomyelitis, reduces the incidence of diabetes, and attenuates murine lupus. (nih.gov)
  • The T helper human immune response to infections can be categorized into Th1, Th2 and Th17. (scirp.org)
  • An alternative approach to the identification of the murine homologue was to use cross-species DNA hybridization, employing human CD2 cDNA as a probe. (ox.ac.uk)
  • The murine cDNA sequence encoded a predicted mature polypeptide of 322 amino acids that showed 54% identity with the predicted human sequence. (ox.ac.uk)
  • In this study, we used a murine model of AD induced by 2,4-dinitrochlorobenzene (DNCB) and evaluated the effects of H 2 S releasing dexamethasone derivative compounds (hybrids with thiobenzamide - TBZ and anethole dithiolethione - ADT) and the mitochondria-targeted H 2 S donors AP39 and RT01. (usp.br)
  • The demonstration of diisocyanate occupational asthma in a murine model after sub-chronic inhalation exposure at relevant exposure levels should provide opportunities for more accurate risk assessment data. (cdc.gov)
  • The present study conducted analyses of serum chemistries, immune phenotyping, gene expression, and histology to evaluate the systemic toxicity of a sub-chronic 28-day dermal exposure of alternative PFAS (1.25-5% or 31.25-125mg/kg/dose) in a murine model. (cdc.gov)
  • The loss of function in a lineage specifying transcription factor results in the absence of the corresponding class of helper T cell which can be devastating for the health of the host. (wikipedia.org)
  • Development of the appropriate CD4+ T helper (TH) subset during an immune response is important for disease resolution. (scienceopen.com)
  • Interestingly, there is growing evidence that CIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain early microbiome-host interactions during fetus development Curr Envir Health Rpt (2018) 5:512-521 513 and early infancy are critical factors that will determine life- early onset of type 2 diabetes [33], and, in the latter case, the long health or disease states [9-11]. (sagepub.com)
  • We aimed to develop a laboratory test-based murine FI tool (FI-Lab) and to investigate the effects of age and sex on FI-Lab scores, FI-Clinical scores, and the combination (FI-Combined), as well as to explore links between frailty and inflammation. (deepdyve.com)
  • Results: We observed an up regulated Th1 T helper subpopulation in independent P. falciparum infections compared to the uninfected group. (scirp.org)
  • Evidence for helper-independent murine sarcoma virus. (wikidata.org)
  • Malignant histiocytosis sarcoma virus (MHSV) arose as a recombinant of c-Harvey-ras murine sarcoma virus (Ha-MuSV) and Friend mink cell focus- forming virus (F-MCFV). (umn.edu)
  • EVIDENCE FOR VIRAL GENES IN NORMAL CELLS Viral antigen (many species) Helper factor which forms pseudotype with replica- tion-defective sarcoma virus (mainly chicken) 3. (nih.gov)
  • Differences between the ribonucleic acids of clone-purified leukemia virus, helper-independent and helper-dependent sarcoma viruses. (wikidata.org)
  • It is a defective acute transforming retrovirus that, along with Friend murine leukemia helper virus (F-MuLV), induces malignant histiocytosis (MH) in susceptible adult mice. (umn.edu)
  • What gave it a lot of impetus was in the murine system you had new isolates on the leukemia side from Rauscher, Moloney and Friend. (nih.gov)
  • A strain of MURINE LEUKEMIA VIRUS associated with mouse tumors similar to those caused by the FRIEND MURINE LEUKEMIA VIRUS . (nih.gov)
  • It is a replication-competent murine leukemia virus. (nih.gov)
  • Genetic transmission of oncogenic viruses (murine leukemia and manmary tumor viruses) 5. (nih.gov)
  • Prior house dust mite-induced skin inflammation aggravates allergic airway inflammation and induces a mixed T helper type 2/T helper type 17 response in the lungs. (ugent.be)
  • Taken together, these results suggest that infestation by M. musculinus in BALB/c mice leads to a significant immunological disorder resulting in a T-helper-2 (Th-2) type response, with marked systemic consequences. (hal.science)
  • CD357) promotes impressive tumor-rejecting immunity in a variety of murine tumor models. (cun.es)
  • PM evoked eosinophil and neutrophil infiltration into airways, elevated BAL protein content, and stimulated secretion of type 1 T helper (TH1) cytokines [interferon-y, interleukin-6 (IL-6), tumor necrosis factor-a] and TH2 cytokines (IL-4, IL-5, eotaxin) into murine airways. (cdc.gov)
  • 13. Mechanisms regulating IgA class-specific immunoglobulin production in murine gut-associated lymphoid tissues. (nih.gov)
  • Murine lung responses to ambient particulate matter: genomic analysis and influence on airway hyperresponsiveness. (cdc.gov)
  • Objective: We investigated pathophysiologic responses to Baltimore, Maryland, ambient PM (median diameter, 1.78 microm) in a murine model of asthma and attempted to identify PM-specific genomic/molecular signatures. (cdc.gov)
  • Results: Consistent with this murine model of asthma, we observed significant increases in airway responsiveness in OVA-treated mice, with PM exposure inducing significant changes in AHR in both naive mice and OVA-induced asthmatic mice. (cdc.gov)
  • This study aimed to investigate whether relief of skin inflammation by glucocorticoids and peroxisome proliferator-activated receptor agonists might influence the subsequent development of asthma in a murine model for the atopic march in which mice were repeatedly exposed to house dust mite via the skin, followed by exposure to house dust mite in lungs. (ugent.be)
  • By contrast, the central role of CTL in murine lymphocytic choriomeningitis virus (LCMV) infection has been very clearly worked out through the use of in vivo depletion and adoptive transfer experiments, as well as knockout and transgenic mice. (ox.ac.uk)
  • We hypothesized that pharmacological inhibition of sEH can modulate the inflammatory response in a murine ovalbumin (OVA) model of asthma. (nih.gov)
  • 12. In vivo immune response to a T-cell-dependent antigen by cultures of disassociated murine Peyer's patch. (nih.gov)
  • Murine diet-induced AP is associated with impaired immune function and increased susceptibility to sepsis and may be a valuable tool in the investigation of immunomodulation in AP. (nih.gov)
  • The TLR3 adjuvant, poly-ICLC, plus helper peptide mixture provided modest immune stimulation. (bmj.com)
  • Production of the eosinophil chemoattractant CCL5 and the type 2 T helper (TH2) associated chemokine CCL17 from PEGstimulated LCs was significantly inhibited by SLEE. (jiaci.org)
  • We show that introducing helper-dependent (HD) CAV-2 vectors results in long-term, neuron-specific expression at the injection site and in afferent nuclei. (jci.org)
  • It can act as a helper virus when complexing with a defective transforming component, RAUSCHER SPLEEN FOCUS-FORMING VIRUS . (nih.gov)
  • Co-activation of glucocorticoid receptor and peroxisome proliferator-activated receptor-γ in murine skin prevents worsening of atopic march," JOURNAL OF INVESTIGATIVE DERMATOLOGY , vol. 138, no. 6, pp. 1360-1370, 2018. (ugent.be)
  • Methods A vaccine consisting of 9 MHC class I-restricted breast cancer-associated peptides (from MAGE-A1, −A3, and -A10, CEA, NY-ESO-1, and HER2 proteins) was combined with a TLR3 agonist, poly-ICLC, along with a helper peptide derived from tetanus toxoid. (bmj.com)
  • The loss of function in a lineage specifying transcription factor results in the absence of the corresponding class of helper T cell which can be devastating for the health of the host. (wikipedia.org)
  • characterization and function of Fc receptors on T-T hybridomas which produce murine IgA-binding factor. (nih.gov)