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  • therapeutic
  • However, the immunosuppressive drugs and TCD hamper the therapeutic potential of allo-HCT, resulting in attenuated graft-vs.-leukemia (GVL) effect as well as increased vulnerability to infection. (frontiersin.org)
  • vitro
  • Unlike creating xenograft mouse models using existing cancer cell lines, there are no intermediate in vitro processing steps before implanting tumor fragments murine host to create a PDX. (wikipedia.org)
  • Reaction
  • It can also lead to an anaphylactic reaction against the mouse protein, which may be difficult to distinguish from a CRS. (wikipedia.org)
  • activation
  • Treatment using imatinib or nilotinib abolished the aberrant activation of c-Abl and PDGFR and protected against experimental cGvHD. (uzh.ch)
  • work
  • GCH is a Max Eder Research Fellow of the Deutsche Krebshilfe e.V. and this work was supported by the German Cancer Foundation (Deutsche Krebshilfe e.V.), Project #106647. (springer.com)