Macrophages and dendritic cellsPlasmacytoidDifferentiationMonocyte-derived dendritic cellsBone marrow-derivedVivoVitroInflammationSecretionPatients with metastatic renal cell carcSplenicReceptorsAlveolar macrophagesMediatorsMaturationInduceType I interferonProliferationCytokinesImmunotherapySpleenCytotoxic T-celLymphocytesMiceSolubleUptakeMonocytesAntibodyInterleukinAntibodiesEpitheliumInfectionProteinsHematopoietic stemHumanBlockadeTumor cellsInductionInflammatoryLungTumorsProteinCancerCytokineAntigen-preseActivationEpithelialProgenitorsPrecursors2022TransductionGeneAdaptive immuneMyeloidImmune cellsVaccinesApoptoticMigrationTherapeuticIntegrinStem CellELISAReceptor2018
Macrophages and dendritic cells4
- It is well established that both macrophages and dendritic cells recognize the cyst form of PC through the â-glucan receptor dectin-1. (uky.edu)
- In this study, we investigated the transformation of macrophages and dendritic cells (DCs) in the tumor microenvironment during 5-aminolevulinic acid (5-ALA)-mediated SDT in mice transplanted with B16F10 melanomas. (psu.edu)
- The original stabilized immune state in the tumor microenvironment can be interrupted by low-intensity therapeutic ultrasound combined with 5-ALA, which enhanced the pro-inflammatory response and reversed the passive properties of macrophages and dendritic cells. (psu.edu)
- Once inhaled by the host, the fungus interacts with alveolar macrophages and dendritic cells present in the lungs, where it can form a pulmonary focus or spread through the blood and lymphatic vessels [ 6 ]. (hindawi.com)
Plasmacytoid3
- Plasmacytoid dendritic cells (pDCs) are rare central regulators of antiviral immunity and unsurpassed producers of interferon-α (IFN-α). (nih.gov)
- Plasmacytoid dendritic cells (pDCs) are the professional producers of IFN-I in response to many viruses, including all of the herpesviruses tested. (mdpi.com)
- Assessing the Innate Sensing of HIV-1 Infected CD4 + T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System. (jove.com)
Differentiation6
- Despite their crucial role as a link between innate and adaptive immunity, little is known about the modulation of pDC differentiation by other bone marrow (BM) cells. (nih.gov)
- In this study, we investigated the modulation of pDC differentiation in Flt-3 ligand (Flt3L)-supplemented BM cultures, using highly purified mesenchymal stem cells (MSCs) that were FACS-isolated from murine BM based on surface marker expression and used after in vitro expansion. (nih.gov)
- Receptor tyrosine kinases (RTKs) play fundamental tasks in varied cell functions including proliferation differentiation survival migration and rate of metabolism (16). (exposed-skin-care.net)
- Combined signaling through interleukin-7 receptors and Flt3 selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells. (biolegend.com)
- However, murine models, including knockout and transgenic mice, have been useful in understanding the mechanisms of B lymphopoiesis, B-cell differentiation, and antibody formation. (medscape.com)
- Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)
Monocyte-derived dendritic cells2
- It is produced by activated macrophages, microglia, and monocyte-derived dendritic cells in response to pathogens. (rndsystems.com)
- Maturation and trafficking of monocyte-derived dendritic cells in monkeys: implications for dendritic cell-based vaccines. (nwbio.com)
Bone marrow-derived2
- Methods: Bone marrow-derived DC from C57BL/6 mice were loaded with UV-irradiated, syngeneic Panc02 carcinoma cells and were administered subcutaneously. (uni-muenchen.de)
- Therefore, this research is focused on the rational design of pathogen-mimicking adjuvants for vaccine delivery by utilizing flow cytometry and confocal microscopy in concert with materials informatics to identify key properties responsible for nanoparticle uptake and downstream activation of murine bone marrow derived dendritic cells (BMDCs). (aiche.org)
Vivo5
- Background: Tumor-specific cytotoxic T lymphocytes (CTL) can be activated in vivo by vaccination with dendritic cells (DC). (uni-muenchen.de)
- Cell Culture Infectivity Assay for Norovirus cally resemble in vivo tissues and organs ( 25 ). (cdc.gov)
- Soluble Axl (sAxl) is present in cell-conditioned medium of CUDC-305 (DEBIO-0932 ) tumor cells growing in vivo and in vitro and in the sera of humans mice and rats (23 50 However the identities of the sAxl-generating protease(s) and the mechanism(s) that account for this process remain unknown. (exposed-skin-care.net)
- In this study, we tested whether preventative and therapeutic vaccination could be achieved by direct injection of antigen-expressing lentiviral vector, obviating the need for ex vivo transduction of dendritic cells. (jci.org)
- Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1. (southernbiotech.com)
Vitro5
- Mouse DCs (in form of the DC2.4 cell line) were treated in vitro with a fraction of bovine milk fermented with Lactobacillus helveticus-2 (LH-2) or three synthetic peptides identified within the fermented milk fraction. (uoguelph.ca)
- Recently, the first in vitro norovirus cell culture model results demonstrate that the highly differentiated 3-D cell was reported for a norovirus that infects mice ( 18,19 ). (cdc.gov)
- In order to determine whether adoptive transfer of induced Treg cells generated in vitro can be used as an effective therapeutic approach to suppress airway allergic inflammation, exogenously induced Treg cells were infused into ovalbumin-sensitized mice prior to or during intranasal ovalbumin challenge. (ca.gov)
- Therefore, adoptive transfer of in vitro induced Treg cells may be a promising therapeutic approach to prevent and treat severe asthma. (ca.gov)
- Described here are some of the general requirements of in vitro test methods for skin sensitization, and progress that has been made in developing suitable approaches with particular emphasis on the utility of dendritic cell culture systems. (cdc.gov)
Inflammation7
- Vi beskriver en strategi för att övervaka mognad och migration av pulmonella dendritiska celler som svar på ovalbumin i inställningen av ovalbumin-inducerad allergisk inflammation i luftvägarna. (jove.com)
- The data suggest that diabetic mice present impaired immunological response to Pb18 infection and insulin modulates inflammation by reducing IL-6 levels in lung and CINC-1 levels in spleen and liver homogenates, restoring leukocyte concentrations in PeLF and also restoring populations of dendritic cells and B lymphocytes in lungs of diabetic mice, permitting the host to better control the infection. (hindawi.com)
- Atherosclerosis, which is characterized by chronic inflammation in the arterial wall, is driven by immune cells and cytokines. (hindawi.com)
- Many studies have indicated that numerous immune cells promote chronic inflammation and progressive plaque growth [ 4 ]. (hindawi.com)
- Adoptive transfer of induced-treg cells effectively attenuates murine airway allergic inflammation. (ca.gov)
- Defects in endogenous Treg cells have been reported in patients with allergic asthma, suggesting that disrupted Treg cellmediated immunological regulation may play an important role in airway allergic inflammation. (ca.gov)
- Moreover, adoptive transfer of induced Treg cells during allergen challenge also effectively attenuate airway inflammation and improve airway function, which are comparable to those by natural Treg cell infusion. (ca.gov)
Secretion3
- Preferential induction of polyclonal IgA secretion by murine Peyer's patch dendritic cell-T cell mixtures. (rupress.org)
- Morphine has been shown to negatively impact macrophage function by impairing the proliferation of macrophage progenitor cells, inhibiting cytokine secretion leading to decreased chemotaxis, hindering the ability of macrophages to directly phagocytize pathogens, and inhibiting nitric oxide production. (uspharmacist.com)
- Although, several approaches to target cancer cell secretion of EVs are detailed in the literature, there is still no defined way to currently apply them in clinical settings. (springer.com)
Patients with metastatic renal cell carc2
- Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma: University of Tokyo experience. (nwbio.com)
- Peripheral blood mononuclear cells from 123 patients with metastatic renal cell carcinoma, prior to treatment, were found to have a significantly increased arginase activity. (aacrjournals.org)
Splenic2
- The Dectin-1 ligands zymosan, glucan phosphate and the anti-Dectin-1 monoclonal antibody (mAb) 2A11 had no effect on influenza virus induced IFNα/β production by murine splenic pDC. (reading.ac.uk)
- Injected lentiviral vector preferentially transduced splenic dendritic cells and resulted in long-term expression. (jci.org)
Receptors4
- The goal of this project is to identify the receptors that dendritic cells and macrophages use to recognize the trophic forms of PC, particularly early during infection before specific antibody is formed, and whether the trophic forms stimulate the cells to produce immune mediators. (uky.edu)
- 2 Previous studies have evaluated the opioid receptors on a wide array of immune cells. (uspharmacist.com)
- A549-ASCoV2 NLRP1 cells and their control cell line overexpress the genes encoding the SARS-CoV-2 human receptors, ACE2 and TMPRSS2 [1], and are thus highly permissive to SARS-CoV-2 infection. (invivogen.com)
- 2 The interaction of IVIG with a large number of components of the immune system including Fc receptors, complement molecules, cytokines, B and T lymphocytes, neutrophils and NK cells, may explain at least in part their anti-inflammatory effects. (academie-medecine.fr)
Alveolar macrophages2
- After resolution of primary pneumonia, murine alveolar macrophages (AMs) exhibited poor phagocytic capacity for several weeks. (nature.com)
- Fig. 4: T reg cells and TGF-β are not major contributors to the paralysis program of alveolar macrophages. (nature.com)
Mediators2
- Becker A, Thakur BK, Weiss JM, Kim HS, Peinado H, Lyden D (2016) Extracellular vesicles in cancer: cell-to-cell mediators of metastasis. (springer.com)
- Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. (medscape.com)
Maturation3
- There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
- There his work focused on transcriptional control of hematopoietic stem cell maturation and cell fate. (ubc.ca)
- Although defects may occur in many steps in B-cell development and maturation, resulting in agammaglobulinemia, the most common and well-described defect is the impaired maturation of the pro-B cells to pre-B cells. (medscape.com)
Induce4
- It has been reported that IL-27 performs an anti-inflammatory function by acting on conventional CD4 + T cells to induce IL-10-producing cells that are implicated in controlling inflammatory responses [ 3 ]. (hindawi.com)
- Lentiviral vector-based dendritic cell vaccines induce protective T cell responses against viral infection and cancer in animal models. (jci.org)
- Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)
- Chimeric monoclonal antibodies activate antigen-presenting cells (APCs) and T cells more effectively than murine monoclonal antibodies but can still induce production of human anti-chimeric antibodies. (msdmanuals.com)
Type I interferon1
- Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)
Proliferation4
- Meanwhile IL-27 exerts proinflammatory effects by promoting Th1, CD8, natural killer (NK), T follicular helper (Tfh), and B cell proliferation/functions and by inhibiting Treg and Th2 cell generation in parasites infection [ 4 ]. (hindawi.com)
- Recent studies have shown that extracellular vesicles (EVs) can be exploited by tumors to assist in cancer cell growth, proliferation, migration, invasion and metastasis. (springer.com)
- These cells, described as macrophages or immature dendritic cells, deplete arginine and impair T cell proliferation and cytokine production. (aacrjournals.org)
- Although arginase activity has been described in cancer patients, it is thought to originate from tumor cells metabolizing arginine to ornithine needed to sustain rapid cell proliferation. (aacrjournals.org)
Cytokines2
- This triggers the formation of ASC-GFP specks, the release of cytokines (eg IL-16 and IL-18) and pyroptotic cell death. (invivogen.com)
- Les IgIV intéragissent avec de nombreux composants du système immunitaire comme les récepteurs Fc, le complément, les cytokines, les lymphocytes T et B, les cellules dendritiques, les granulocytes et les cellules NK, ce qui explique en partie leurs effets anti-inflammatoires. (academie-medecine.fr)
Immunotherapy3
- Here, the utility of OX40, a costimulatory molecule mainly expressed on activated effector T cells known to play an important role in eliminating cancer cells, was evaluated as a PET imaging biomarker to quantify and track response to immunotherapy. (aacrjournals.org)
- Large-scale immunomagnetic selection of CD14+ monocytes to generate dendritic cells for cancer immunotherapy: a phase I study. (nwbio.com)
- Studies to antigen uptake, processing and presentation to T cells, the biology of dendritic cells and the regulation of immunity are aimed to raise our understanding of the immune reactions to tumor cells and improve immunotherapy of cancer. (universiteitleiden.nl)
Spleen5
- In the groups (both the initiation and the progression) receiving recombinant IL-27 administration, the formation of atherosclerotic plaques was suspended, and the percentage of regulatory T cells (LAP + or Foxp3 + ) in the spleen and peripheral blood was increased. (hindawi.com)
- Three-color image analysis of F4/80 expression by cells in C57BL/6 mouse spleen. (bdbiosciences.com)
- Myeloid suppressor cells with high arginase activity are found in tumors and spleen of mice with colon and lung cancer. (aacrjournals.org)
- Germinal centers where B cells proliferate and differentiate are poorly developed in all lymphoid tissue, including the spleen. (medscape.com)
- Murine monoclonal antibodies are produced by injecting a mouse with an antigen, harvesting its spleen to obtain B cells that are producing antibody specific to that antigen, fusing those cells with immortal mouse myeloma cells, growing these hybridoma cells (eg, in cell culture), and harvesting the antibody. (msdmanuals.com)
Cytotoxic T-cel1
- Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
Lymphocytes5
- In addition, diabetic mice presented a reduced influx of TCD4+ cells, TCD8+ cells, B lymphocytes, NK cells, and dendritic cells compared to control infected groups. (hindawi.com)
- Insulin treatment restored the leukocyte number in PeLF and restored the presence of B lymphocytes, dendritic cells, and NK cells in lungs of diabetic animals. (hindawi.com)
- IL-27 binds to IL-27ra and gp-130 complex, which is expressed on multiple cell types, including T lymphocytes [ 2 ]. (hindawi.com)
- Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (nwbio.com)
- Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
Mice9
- For prophylactic vaccination, mice were vaccinated three times in weekly intervals prior to tumor challenge with Panc02 cells. (uni-muenchen.de)
- Murine models of PCM have been used to study the several aspects of Pb infection, the outcomes varying from cure to a progressive granulomatous disease, according to the susceptibility of the strain of mice [ 15 ]. (hindawi.com)
- Injection of a lentiviral vector encoding an MHC class I-restricted T cell epitope of lymphocytic choriomeningitis virus (LCMV) and CD40 ligand induced an antigen-specific cytolytic CD8 + T lymphocyte response that protected the mice from infection. (jci.org)
- The injection of chronically infected mice with a lentiviral vector encoding LCMV MHC class I and II T cell epitopes and a soluble programmed cell death 1 microbody rapidly cleared the virus. (jci.org)
- Vaccination by direct injection of lentiviral vector was more effective in sterile alpha motif and HD-domain containing protein 1-knockout (SAMHD1-knockout) mice, suggesting that lentiviral vectors containing Vpx, a lentiviral protein that increases the efficiency of dendritic cell transduction by inducing the degradation of SAMHD1, would be an effective strategy for the treatment of chronic disease in humans. (jci.org)
- The results of this study demonstrate that the stratum corneum, hair follicles, and associated sebaceous glands in mice are dendritic cell accessible reservoirs for TDI-hp and thus identify a mechanism for immune recognition following epicutaneous exposure to TDI. (cdc.gov)
- A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 enhances cell-mediated immune response and longevity of the total IgG to influenza A virus M2e protein in mice. (southernbiotech.com)
- Murine gene mutations in human counterparts may be associated with a clinical illness different from the illness seen in mice. (medscape.com)
- Fully human monoclonal antibodies are produced using transgenic mice that contain human immunoglobulin genes or using phage display (ie, a bacteriophage-based cloning method) of immunoglobulin genes isolated from human B cells. (msdmanuals.com)
Soluble4
- This inhibition was cell contact-dependent and soluble factor-independent, as indicated by trans-well experiments. (nih.gov)
- Several studies shown that Axl could mediate cell adhesion and aggregation through homotypic ectodomain associations (9 23 Both CUDC-305 (DEBIO-0932 ) murine and human being Axl proteins undergo proteolytic processing to yield a soluble form of this molecule. (exposed-skin-care.net)
- Murine Axl is definitely cleaved extracellularly to generate a soluble ectodomain of approximately 65 kDa (23) whereas cleavage of human being Axl is definitely mapped to the 14-amino-acid (aa) stretch in the extracellular region and corresponds to the soluble CUDC-305 (DEBIO-0932 ) form with a higher molecular mass of 80 kDa (50). (exposed-skin-care.net)
- En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
Uptake1
- We examined dNCOs sensitization by using a dermal murine model of toluene diisocyanate (TDI) exposure to characterize the disposition of TDI in the skin, identify the predominant haptenated proteins, and discern the associated antigen uptake by dendritic cells. (cdc.gov)
Monocytes1
- Infiltrating monocytes take up the modified low-density lipoproteins and become foam cells, which make plaques unstable, resulting in acute myocardial infarction [ 5 ]. (hindawi.com)
Antibody5
- Each cell line was incubated with Anti-ACE2-PE antibody for 1 hour at 4°C. Cell surface staining was analyzed by flow cytometry. (invivogen.com)
- Lysates from A549-ASCoV2 (1) and A549-ASCoV2-NLRP1 (2) cells were analyzed by western blot using an anti‑human NLRP1 and an anti-human ASC antibody, followed by HRP conjugated secondary antibody. (invivogen.com)
- Continuous cultures of fused cells secreting antibody of predefined specificity. (scriptiebank.be)
- In both cases, the process usually begins as above with production of mouse hybridoma cells that make antibody to the desired antigen. (msdmanuals.com)
- The resultant DNA is placed in a mammalian cell culture, which then expresses the resultant gene, producing the desired antibody. (msdmanuals.com)
Interleukin1
- Cell culture supernatants were analyzed for presence of tumor necrosis factor (TNF)-α and interleukin (IL)-6 to determine the effects of LAB on DC activation. (uoguelph.ca)
Antibodies3
- FcRn expressed in endosomal compartment of intestinal epithelium, vascular endothelium and macrophages regulates the serum IgG levels by binding to the pinocytosed antibodies and recirculating them to cell surface without intracellular degradation. (academie-medecine.fr)
- Monoclonal antibodies specific for TDI-haptenated protein (TDI-hp) and antibodies to various cell markers were utilized with confocal microscopy to determine co-localization patterns. (cdc.gov)
- In the absence of mature B cells, patients lack lymphoid tissue and fail to develop plasma cells, the cells that manufacture antibodies. (medscape.com)
Epithelium3
- Langerhans cells (LCs) populate the mucosal epithelium, a major entry portal for pathogens, yet their ontogeny remains unclear. (nih.gov)
- Representative models of differentiated human intes- transmission are ingestion of contaminated food and water tinal epithelium can be established by growing cells in 3 and person-to-person contact ( 5 ). (cdc.gov)
- We present cultured in the RWV bioreactors, with the rotation speed the results of our first attempts to infect a physiologically adjusted to maintain the cell aggregates in suspension dur- relevant 3-D small intestinal epithelium model (INT-407) ing the entire culture duration (18-20 rotations/min ini- with genogroup I and II human noroviruses. (cdc.gov)
Infection5
- IL-23 induces the earliest recruitment of neutrophils to the site of infection and promotes the development and maintenance of Th17 cells. (rndsystems.com)
- Upon SARS-CoV-2 infection, viral RNA is released in target cells and immediately translated to produce viral polyprotein including the 3CL protease (NSP5). (invivogen.com)
- Autocrine IL-10 Signaling Promotes Dendritic Cell Type-2 Activation and Persistence of Murine Cryptococcal Lung Infection. (umassmed.edu)
- Unlike murine-based MMLV or MSCV retroviral systems, lentiviral-based particles permit efficient infection and integration of the specific shRNA construct into differentiated and non-dividing cells, such as neurons and dendritic cells, 1 overcoming low transfection and integration difficulties when using these cell lines. (sigmaaldrich.com)
- An inverted CD4/CD8 T-cell ratio occurs in some types of SCID and in human immunodeficiency virus (HIV) infection. (medscape.com)
Proteins3
- In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)
- His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
- In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)
Hematopoietic stem2
- Ligation of Flk-2 with Flt3 ligand regulates the growth of hematopoietic stem cells and promotes the survival of primitive hematopoietic progenitor cells with myeloid as well as B lymphoid potential. (biolegend.com)
- Regulate the growth of hematopoietic stem cells and promote the survival of primitive hematopoietic progenitor cells. (biolegend.com)
Human6
- We have previously shown that gemcitabine sensitizes human pancreatic carcinoma cells against CTL-mediated lysis. (uni-muenchen.de)
- Products listed include human and murine Dendritic Cell Cytokine Packages and Hematopoietic Stem Cell Expansion Cytokine Packages. (peprotech.com)
- Human noroviruses are the leading cause of nonbacter- attachment to, entry into, and replication within cells of the ial, self-limiting gastrointestinal illness worldwide human gastrointestinal tract, and the resulting symptoms. (cdc.gov)
- Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA. (nwbio.com)
- A549-ASCoV2-NLRP1 cells have been additionally engineered to stably express the human NLRP1 inflammasome sensor. (invivogen.com)
- Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells. (invivogen.com)
Blockade1
- Ossendorp, F. & Cruz, L.J. (2023), Effective combination of liposome-targeted chemotherapy and PD-L1 blockade of murine colon cancer, Journal of Controlled Release 353: 490-506. (universiteitleiden.nl)
Tumor cells1
Induction1
- Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
Inflammatory3
- Akilimali NA, Muema DM, Specht C, Chang CC, Moosa MS, Levitz SM, Lewin SR, French MA, Ndung'u T. Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome Is Associated With Dysregulation of IL-7/IL-7 Receptor Signaling Pathway in T Cells and Monocyte Activation. (umassmed.edu)
- He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
- CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)
Lung3
- The current standard of care for locally advanced non-small cell lung cancer (NSCLC) includes radiation, chemotherapy, and surgery in certain individualized cases. (frontiersin.org)
- Approximately 80-90% of newly diagnosed lung cancers are classified as NSCLC, primarily consisting of adenocarcinoma, squamous cell carcinoma, or large cell carcinoma histologies. (frontiersin.org)
- Indeed, the NLRP1 sensor is activated upon cleavage by the SARS-CoV-2 3CL protease NSP5 in lung epithelial cells [2]. (invivogen.com)
Tumors2
- Therapeutic vaccination has the major advantage that the induced immune response selectively attacks tumors while leaving the healthy cells untouched. (universiteitleiden.nl)
- Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
Protein3
- 13 Morphine has been shown to decrease IL-23 production in murine models, decreasing dendritic cell antimicrobial protein production. (uspharmacist.com)
- A common heterophilic ligand for these RTK family members is definitely Gas6 a vitamin K-dependent protein that is widely secreted by most cells including the lungs intestine Serping1 and vascular endothelium (43). (exposed-skin-care.net)
- Mapping cytoskeletal protein function in cells by means of nanobodies. (scriptiebank.be)
Cancer8
- Combination with other treatment modalities such as chemotherapy may overcome immunoresistance of cancer cells. (uni-muenchen.de)
- Even in patients with a healthy immune response, cancer cells can escape the immune system during tumorigenesis. (koreamed.org)
- Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses. (nwbio.com)
- He followed his postdoc research in the Netherlands Cancer Institute on the role of T cell functions in cancer. (universiteitleiden.nl)
- Cancer cells have proven efficient in educating fibroblasts, within their microenvironment, to secrete EVs as communicative vessels for mediating phenotypic changes in recipient cells. (springer.com)
- Using this vesicular delivery system, cancer cells can establish a new metastatic niche within distant sites, away from the primary tumor, thus favoring cancer progression. (springer.com)
- Cancer Cell 30(6):836-848. (springer.com)
- Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)
Cytokine2
- The DCs are then pulsed with synthetic peptide or cell lysate and matured with cytokine or TLR agonists. (jci.org)
- These patients had a markedly decreased cytokine production and expressed low levels of T cell receptor CD3ζ chain. (aacrjournals.org)
Antigen-prese1
- IL-27 is a member of the IL-12 family and is composed of Epstein-Barr virus-induced gene3 (EBI3) and p28 subunits, which are produced by active antigen-presenting cells [ 1 ]. (hindawi.com)
Activation4
- Its activation can be monitored in real-time by following the formation of fluorescent ASC specks and measuring pyroptotic cell death with the LDH assay. (invivogen.com)
- A549-ASCoV2 cells not only serve as a control cell line for A549-ASCoV2-NLRP1 cells but also offer the possibility to monitor ASC-dependent inflammasome activation of NLRP3 after its transgenic expression. (invivogen.com)
- Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. (southernbiotech.com)
- Activation of Btk results in a cascade of signaling events resulting in calcium mobilization and fluxes, cytoskeletal rearrangements, and transcriptional regulation involving nuclear factor-kappaB (NF-kappaB) and nuclear factor of activated T cells (NFAT). (medscape.com)
Epithelial1
- Studies of viral attachment to cells on porous collagen-I coated microcarrier beads under cultured gastrointestinal epithelial cells (Caco-2) using conditions of physiological fluid shear in rotating wall ves- recombinant virus-like particles or infectious noroviruses sel bioreactors. (cdc.gov)
Progenitors1
- It is expressed on early B lymphoid lineage cells in bone marrow, on primitive myeloid progenitors within the BM CD34+ cell population. (biolegend.com)
Precursors2
- We further demonstrated that similar to non-lymphoid dendritic cells (DCs), CD103(+) LCs originate from pre-DCs, whereas CD11b(+) LCs differentiate from both pre-DCs and monocytic precursors. (nih.gov)
- Collectively, in a tissue-dependent manner, murine LCs differentiate from at least three distinct precursors (embryonic, pre-DC, and monocytic) in steady state. (nih.gov)
20222
- 2022. Cell Rep. 41:111677. (biolegend.com)
- 2022. Cell Res. (biolegend.com)
Transduction1
- In addition, the lentiviral transduction particles are pseudotyped with an envelope G glycoprotein from vesicular stomatitis virus (VSV-G), allowing transduction of a wide variety of mammalian cells. (sigmaaldrich.com)
Gene2
- Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)
- Small interfering RNAs (siRNAs) expressed from short hairpin RNAs (shRNAs) are a powerful way to mediate gene specific RNA interference (RNAi) in mammalian cells. (sigmaaldrich.com)
Adaptive immune1
- Opioids have considerable effects on cellular function across many immune cell lineages, affecting both the innate and adaptive immune systems. (uspharmacist.com)
Myeloid2
- CD200 knock-out macrophages produced more IFNα than wild-type macrophages in response to polyI:C, a MyD88-independent stimulus, consistent with CD200's known inhibitory effect on myeloid cells. (reading.ac.uk)
- The goal of this study was to determine whether myeloid suppressor cells producing high arginase existed in renal cell carcinoma patients. (aacrjournals.org)
Immune cells3
- Micro-aspiration of gut bacteria or movement of sensitized immune cells through lymph or bloodstream can also influence immune response of other organs. (frontiersin.org)
- Toluene diisocyanate (TDI) disposition and co-localization of immune cells in hair follicles. (cdc.gov)
- There were also significant differences in microbial composition in dust samples and in innate immune cells between the two groups of children. (medscape.com)
Vaccines1
- These properties have made lentiviral vectors advantageous for use in dendritic cell (DC) vaccines. (jci.org)
Apoptotic1
- In the beginning, UPR has protective effect, but in prolonged ER stress UPR triggers apoptotic cell death. (helsinki.fi)
Migration1
- Upon immobilization sAxl advertised cell migration and induced the phosphorylation of Axl and phosphatidylinositol 3-kinase. (exposed-skin-care.net)
Therapeutic1
- Here, we used a murine pancreatic carcinoma model to investigate whether combination with gemcitabine increases therapeutic efficacy of DCbased vaccination. (uni-muenchen.de)
Integrin1
- TDI-hp were co-localized with CD11b+ (integrin alphaM/Mac-1), CD207+ (langerin), and CD103+ (integrin alphaE) cells in the hair follicles and in sebaceous glands. (cdc.gov)
Stem Cell2
- 2021. Stem Cell Reports. (biolegend.com)
- He is a member of the Stem Cell Network Centre of Excellence (past member of the Stem Cell Policy Committee and Research Management Committee and current Sub-chair of the Training and Education Committee), and a member of the AllerGen Network Centre of Excellence (Research Management Committee and Co-Chair of the Biomarkers Program). (ubc.ca)
ELISA1
- The Quantikine Mouse IL-23 immunoassay is a 4.5 hour solid-phase ELISA designed to measure IL-23 in cell culture supernates, mouse serum, and plasma. (rndsystems.com)
Receptor4
- For example, low-density lipoprotein (LDL) is taken into the cell by binding to the LDL receptor at the cell surface. (wikipedia.org)
- Upon reaching early endosomes, the LDL dissociates from the receptor, and the receptor can be recycled to the cell surface. (wikipedia.org)
- IL-23 signals through a receptor complex consisting of IL-12 R beta 1 and IL-23 R. This complex is expressed in mouse Th1 and Th2 cells, bone marrow dendritic cells, activated macrophages and CD4+ CD45Rb(low) memory T cells. (rndsystems.com)
- It was reported that the receptor tyrosine kinase Flt3 is required for dendritic cell development. (biolegend.com)
20182
- 2018. Molecular cell. (biolegend.com)
- 2018. Cell Rep. 25:2992. (biolegend.com)