Murine antigens cd4. Medical search. Frequent questions

Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
Innate lymphoid cells (ILCs) lack antigen receptors but are equipped with receptors for cytokines, hormones, and paracrine signals enabling them to sense their environment and respond quickly by producing factors that influence parenchymal cells and other resident immune cells. (elifesciences.org)
Class II major histocompatibility complex mutant mice to study the germline bias of T cell antigen receptors. (nationaljewish.org)
Current vaccine strategies against influenza focus on Antigen-specific ligation of T-cell receptors induces generating robust antibody responses. (cdc.gov)
HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. (novoprolabs.com)

DC vaccines treated with IL-15 and p38 MAPK inhibitor are more effective than standard DC vaccines at generating antigen-specific Th17 T cells in vivo. (bmj.com)

CD4 + CD25 + FoxP3 + regulatory T cells (Tregs) are also involved in the mechanism of immune regulation against Plasmodium infection. (omicsonline.org)
Transplantation of human neural stem cells (hNSCs) is a promising regenerative therapy to promote remyelination in patients with multiple sclerosis (MS). Transplantation of hNSCs has been shown to increase the number of CD4 + CD25 + Foxp3 + T regulatory cells (Tregs) in the spinal cords of murine models of MS, which is correlated with a strong localized remyelination response. (aai.org)
Both invariant natural killer T (NK T) cells and CD4(+)CD25(+) T regulatory cells (T(regs)) regulate the immune system to maintain homeostasis. (ox.ac.uk)
Tregs are divided into two categories: "naturally occurring" CD4+CD25+ T regulatory cells (NTregs), that constitutively express Foxp3 and CD25, and "inducible" CD4+CD25- T regulatory cells (iTregs), which up-regulate CD25 and Foxp3 after exposure to inhaled antigen in the lung. (creighton.edu)
Flt3-L significantly decreased levels of BALF IL-5, IFN-γ, eosinophilia and substantially increased IL-10 and the number of CD4+CD25+Foxp3+IL-10+ T-cells in the lung. (creighton.edu)
Finally, the functional effect and migration of Tregs was examined by adoptively transferring naturally occurring CD4+CD25+ T- regulatory cells (NTregs) and CD4+CD25- inducible T-regulatory cells (iTregs) from lung and spleens of GFP-transgenic BALB/c mice into cockroach-sensitized and challenged mice. (creighton.edu)
We report that both the expression of PrP message and cell surface PrP(C) levels are increased in murine CD4(+) CD25(+) regulatory T cells compared with CD4(+) CD25(-) cells. (ox.ac.uk)

Monoclonal antibody 2F10 is an "internal-image" anti-idiotype (anti-id) antibody capable of mimicking the group-specific "a" determinant of human hepatitis B surface antigen (HBsAg). (uthscsa.edu)
Postexposure prophylaxis (PEP) with hepatitis B immune globulin (HBIG) and/or hepatitis B vaccine series should be considered for occupational exposures after evaluation of the hepatitis B surface antigen status of the source and the vaccination and vaccine-response status of the exposed person. (cdc.gov)

Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of antigenic epitopes capable of evoking the most potent CAR activation is an important objective in optimizing immune therapy. (nature.com)

We propose a model of antigen-induced tolerance that involves cell-cell contact with regulatory CD4(+) T cells that coexpress membrane-bound TGF-beta and FOXP3. (nih.gov)
Flt3-L significantly decreased the expression of cell surface receptor CD62L, increased expression of cell surface receptor ICOS and Foxp3 transcripts in CD4+CD25+ T-cells isolated from lungs of CRA-sensitized and challenged mice. (creighton.edu)
Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3 + CD4 + T-regulatory cell and CD4 + T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. (frontiersin.org)

CD4 + T cells stimulate B cells to induce significant level of antimalarial antibody response and also help in the induction of CD8 + T-cell responses which help in arresting the growth of liver-stage parasites in the host. (omicsonline.org)
Non-depleting anti-CD4 monoclonal antibody induces immune tolerance to ERT in a murine model of Pompe disease. (ox.ac.uk)
Here we show that a short-course treatment with non-depleting anti-CD4 monoclonal antibody successfully induced long-term ERT-specific immune tolerance in Pompe disease mice. (ox.ac.uk)
Antibody M-T441 recognizes an extracellular epitope within the domain 2 region of the CD4 molecule and reacts with human CD4 cell transfectants (1). (ancell.com)
We conclude that a 15-mer peptide derived from the anti-id sequence can duplicate the B- and T-cell stimulatory activity of the intact anti-id antibody and the antigen that is mimicked, HBsAg. (uthscsa.edu)
CD154) is a transmembrane protein expressed on the surface of activated T cells, particularly on CD4 T cells, which stimulates CD40-dependent activation of antigen-presenting cells (APCs), resulting in enhancement of T cell and antibody responses. (biospace.com)

Homocitrullinated peptides were identified and assessed in vitro for HLA-A2 binding and in vivo in human leukocyte antigen (HLA) transgenic mouse models for immunogenicity. (scancell.co.uk)
Importantly, in vivo the homocitrullinated aldolase specific response was associated with efficient CD8 dependent antitumor therapy of the aggressive murine B16 tumor model indicating that this epitope is naturally presented in the tumor. (scancell.co.uk)
Clemmensen HS, Dube J-Y, McIntosh F, Rosenkrands I, Jungersen G, Aagaard C, Andersen P, Behr MA, Mortensen R . In vivo antigen expression regulates CD4 T cell differentiation and vaccine efficacy against Mycobacterium tuberculosis infection. (ssi.dk)
This study used a transgenic murine model expressing human major histocompatibility complex (MHC) class II and human CD4 in which, without additional toxic sensitization, human-like responses to the bacterial superantigen (SAg) streptococcal pyrogenic exotoxin A (SpeA) could be simulated, as determined by studying multiple biologic effects of the SAgs in vivo. (elsevierpure.com)
To activate antigen-specific CD4 T cells in vivo, the investigators utilized the nucleic acid vaccine platform, UNITE (UNiversal Intracellular Targeted Expression), which fuses a tumor-associated antigen with lysosomal-associated membrane protein 1 (LAMP1). (biospace.com)

The amino terminal region of CD4 is a receptor for the HIV-1 viral protein gp120. (ancell.com)
CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen presenting cell. (novoprolabs.com)
CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. (novoprolabs.com)
Viral protein U (VpU) of HIV-1 plays an important role in downregulation of the main HIV-1 receptor CD4 from the surface of infected cells. (novoprolabs.com)
Paramagnetic spin labels were attached at three sequence positions of a CD4 peptide comprising the transmembrane and cytosolic domains of the receptor. (novoprolabs.com)

Antiviral CD8 + T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion. (nationaljewish.org)
We review the literature express CD8 and induce apoptosis of cells on which they on the role of CD4+ and CD8+ T cell-mediated immunity in recognize foreign antigens presented by MHC class I mol- influenza infection and the available data on the role of ecules, providing a defense against intracellular pathogens these responses in protection from highly pathogenic such as viruses. (cdc.gov)
The CD4 molecule is currently the object of intense interest and investigation both because of its role in normal T-cell function, and because of its role in HIV infection. (novoprolabs.com)
Clemmensen HS, Knudsen NPH, Billeskov R, Rosenkrands I, Jungersen G, Aagaard C, Andersen P, Mortensen R . Rescuing ESAT-6 specific CD4 T cells from terminal differentiation is critical for long-term control of murine Mtb infection. (ssi.dk)
This presentation reports results of pre-clinical mouse studies of a cancer vaccine that promotes potent, antigen-specific CD4 T cell responses to MCPγV-LT. The majority of Merkel cell carcinomas (MCC), a rare and highly aggressive type of neuroendocrine skin cancer, are associated with Merkel cell polyomavirus (MCPyV) infection. (biospace.com)
this was found to be the direct result of higher viral loads, and thus higher antigen burden in the chronic infection model. (acir.org)

Some tumour cells, including those associated with viral infections, have clear, tumour-specific antigens that can be targeted by T cells. (scancell.co.uk)
Influenza-specific CD8+ T cells recognize multiple of reagents and genetically modified mouse models has viral epitopes on target cells and antigen-presenting cells. (cdc.gov)
MCPyV integrates into the host genome, resulting in expression of a truncated form of the viral large T antigen (LT) in infected cells, and makes LT an attractive target for therapeutic cancer vaccines. (biospace.com)

Depletion of CD4+CD25+ regulatory T cells enhances natural killer T cell-mediated anti-tumour immunity in a murine mammary breast cancer model. (ox.ac.uk)
CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. (novoprolabs.com)
One mechanism by which the ratio of TH1 and TH2 cells is maintained is by the immune T cell subset T-regulatory cells (Tregs) (CD4+CD25+). (creighton.edu)

Post-translational modification of proteins has the potential to alter the ability of T cells to recognize major histocompatibility complex (MHC) class -I and class-II restricted antigens, thereby resulting in altered immune responses. (scancell.co.uk)
Homocitrullination occurs in the tumor microenvironment and CD4-mediated immune responses to Hcit epitopes can target stressed tumor cells and provide a potent antitumor response in mouse models. (scancell.co.uk)
The enhancing role of CD4 was further demonstrated by reduced levels of T cell adhesion and late responses of CD4- T cell hybridomas. (ox.ac.uk)
Our data suggest a link between antigen-induced T cell adhesion and late responses and also suggest that signals mediated by TCR and CD4 coengagement may induce a greater activation and/or recruitment of molecules involved in T cell adhesion. (ox.ac.uk)
By contrast, T(regs) intrinsically suppress antigen-specific immune responses and are often found to be elevated in tumour patients. (ox.ac.uk)
Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
The demonstration of antibodies, mixed T-helper (Th) type 1/2 responses diisocyanate occupational asthma in a murine model after sub- and the involvement of CD8 T lymphocytes in chronic inhalation exposure at relevant exposure levels should diisocyanate OA. (cdc.gov)
In silico, the authors demonstrated VENUS' ability to select 19 out of 20 neo-antigens inducing spontaneous CD8 or CD4 T cell mediated immune responses, from the top 60 ranked mutated peptides from 9 cancer patients. (nouscom.com)
Therefore, murine airway CD8 + T cell-responses to aspiration of Aspergillus conidia may be mediated in part by the ability of conidia to germinate in the host lung tissue. (cdc.gov)

Human CD4 is a cell surface glycoprotein of 55 kd expressed on most thymocytes, on about two thirds of peripheral T cells, and on some monocyte macrophage lineage cells. (ancell.com)
T-cell surface glycoprotein CD4, is a single-pass type I membrane protein. (novoprolabs.com)

The CD4(+) T cells expressed both cell surface and soluble TGF-beta and inhibited the development of an allergic phenotype when adoptively transferred to naive recipient mice. (nih.gov)
Here we demonstrate that Cd44v7 -deficient T cells - like Cd44 wild-type ( Cd44 WT ) T cells - provoked disease in two different colitis models: the model induced by CD4 + CD45RB high T-cell transfer into Rag2 -deficient mice and a new model based on ovalbumin (OVA)-specific T-cell transfer into Rag -sufficient, OVA-challenged mice. (nature.com)
Kumar V, Rakha A, Saroa R, Bagai U (2015) CD4+T Cells Expansion in P. berghei (NK-65) Infected and Immunized BALB/C Mice. (omicsonline.org)
Expression of human leukocyte antigen (HLA)-DQ8 rendered the mice susceptible to SpeA-induced lethal shock that was accompanied by massive cytokine production and marked elevation of serum alanine and aspartate aminotransferase levels. (elsevierpure.com)
Therefore, the effect of Flt3-L on CD4+CD25+ T cells in cockroach-sensitized and challenged mice was examined. (creighton.edu)
We reported previously that CD4 + T cells and B cells in mice with retrovirus-induced murine acquired immunodeficiency syndrome (MAIDS) caused by LP-BM5 murine leukemia virus (MuLV) mixtures increased the expression of Fas antigen (Fas) during progression of the disease. (elsevierpure.com)
We found that the Thy1.2 - CD4 T cells and Igκ dull B220 + cells, which are characteristic of MAIDS, increased after the inoculation of LP-BM5 MuLV in B6 lpr/lpr mice. (elsevierpure.com)
CD4 + B220 + TCR αβ T cells increased profoundly among the B220 + TCR αβ T cells from LP-BM5 MuLV-infected B6 lpr/lpr mice, while the B220 + TCR αβ T cells observed in non-infected B6 lpr/lpr mice were largely of the CD4 - CD8 - phenotype. (elsevierpure.com)
Taken together, these results suggest that MAIDS is inducible independently with functional Fas expression and the possibility of accelerated progression of murine AIDS and lpr-associated autoimmune disease in B6 lpr/lpr mice infected with LP-BM5 MuLV. (elsevierpure.com)
Vaccination with LTS220A-UNITE (ITI-3000) induced antigen-specific CD4 Th1 cells that was associated with delayed tumor growth and enhanced survival in treated mice in both the prophylactic and therapeutic settings. (biospace.com)

CD4 + T cells play an important role in conferring protective immunity towards the liver stages of the malaria parasite [ 3 ]. (omicsonline.org)

To determine if Th17-inducing vaccines are therapeutically effective in OC, we created a murine model of Th17-inducing dendritic cell (DC) (Th17-DC) vaccination generated by stimulating IL-15 while blocking p38 MAPK in bone marrow-derived DCs, followed by antigen pulsing. (bmj.com)

This immunopeptidomics-based pipeline was carefully validated in a murine colon tumor model CT26. (elifesciences.org)

In addition, ITI-3000 induced changes in the tumor microenvironment, including increased numbers of CD4 and CD8 T cells, reduced frequency of myeloid cells, and enhanced pro-inflammatory cytokine production. (biospace.com)
However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)

Antibodies QS4120 (cat #147-020) and M-T441 each bind to a distinct epitope of CD4 and are suitable as a matched pair for EIA using QS4120 as capture and Biotinylated M-T441(cat# 148-030) as detector. (ancell.com)
Our results highlight the importance of the specific target antigen epitope in governing optimal CAR-T activity and provide a nanobody-based B7-H3 CAR-T product for use in solid tumor therapy. (nature.com)

Significantly, this peptide could also stimulate CD4 + T cells of human hepatitis B virus carriers. (uthscsa.edu)

T cell adhesion induced after physiological stimulation by antigen was investigated using murine T cell hybridomas specific for a tetanus toxin peptide. (ox.ac.uk)
Tlymphocyte recognition of MHC-peptide complexes on target cells is essential for mounting an antigen-specific immune attack ( 1 ), which may in turn select pathogens able to evade immune recognition by suppressing MHC expression on the infected cells ( 2 ). (silverchair.com)

The human CD4 molecule is readily detectable on monocytes, T lymphocytes, and brain tissues. (novoprolabs.com)

These posters to be presented at the AACR Meeting focus on the investigational nucleic acid platform, UNITE™ (UNiversal Intracellular Targeted Expression) for two vaccines, ITI-3000 for Merkel cell carcinoma (targeting the large T antigen of the Merkel cell polyomavirus) and Her2/Neu-LAMP DNA vaccine, both of which fuse a tumor associated antigen with lysosomal associated membrane protein 1 (LAMP-1). (biospace.com)
"VENUS, a Novel Selection Approach to Improve the Accuracy of Neoantigens' Prediction" (G. Leoni, A.M. D'Alise et al , reference below) has been published in the special issue of the peer-reviewed journal Vaccines focused on cancer neo-antigen vaccines. (nouscom.com)

CD4 interacts with MHC Class II molecules in an accessory role during foreign antigen recognition by T cells. (ancell.com)
CD4 interacts directly with MHC class II molecules on the surface of the antigen presenting cell via its extracellular domain. (novoprolabs.com)

The extracellular portion of CD4 is an array of four Ig-like domains. (ancell.com)

This review summarizes and integrates research on vitamin D and CD4 + T-lymphocyte biology to develop new mechanistic insights into the molecular etiology of autoimmune disease. (frontiersin.org)
Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
Finally, unanswered questions relating to vitamin D mechanisms in CD4 + T cells are highlighted to promote further research that may lead to a deeper understanding of autoimmune disease molecular etiology. (frontiersin.org)

In addition, an adenoviral vector vaccine encoding the top 60 ranked mutations, demonstrated efficacy and a potent T cell response, when used in combination with an anti-PD1 checkpoint inhibitor, in a murine cancer model. (nouscom.com)

The CD4 surface determinant, previously associated as a phenotypic marker for helper/inducer subsets of T lymphocytes, has now been critically identified as the binding/entry protein for human immunodeficiency viruses (HIV). (novoprolabs.com)

A Rapid Method to Characterize Mouse IgG Antibodies and Isolate Native Antigen Binding IgG B Cell Hybridomas. (nationaljewish.org)
Various murine models have contributed to the understanding of the pathogenic role of antitype VII collagen antibodies and pathophysiology of epidermolysis bullosa acquisita. (medscape.com)

These peptides were then tested in our previously described oncolytic cancer vaccine platform PeptiCRAd, a vaccine platform that combines an immunogenic oncolytic adenovirus (OAd) coated with tumor antigen peptides. (elifesciences.org)

This presentation reports results of preclinical mouse studies on a HER2/Neu-LAMP DNA vaccine that included a bicistronic DNA construct in which both the tumor antigen (HER2) fused with LAMP-1 (lysosomal- associated membrane protein 1) and sCD40L were expressed separately. (biospace.com)

Induction of antigen-specific immune tolerance would greatly enhance ERT for these patients. (ox.ac.uk)
Induction of T cell adhesion by antigen stimulation and modulation by the coreceptor CD4. (ox.ac.uk)

This proprietary lysosomal targeting technology results in enhanced antigen presentation and a balanced T cell response. (biospace.com)

Using a murine model of tolerance induced by repeated exposure to a low dose of aerosolized antigen, we show an important contribution by CD4(+) T cells in the establishment and maintenance of tolerance. (nih.gov)
New target molecules and mediators as well animal model, diisocyanate, diphenyl-methane diisocyanate, as new therapeutic approaches for allergic asthma have hexamethylene diisocyanate, murine model, occupational been identified using animal models. (cdc.gov)

Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen-Mismatched Grafts. (nationaljewish.org)

The latter is a tool previously developed by Jacopo, 2020, able to identify tumor antigens similar to pathogen antigens in order to exploit molecular mimicry and tumor pathogen cross-reactive T cells in cancer vaccine development. (elifesciences.org)

These three cytokines are differentially expressed in activated CD4 + T cells. (hindawi.com)

Th17-DC vaccine efficacy, alone or with ICB, was mediated by CD4 T cells, but not CD8 T cells. (bmj.com)

To escape CD4 + T cell recognition, pathogens may need to inhibit the IFN-γ-inducible MHC class II expression. (silverchair.com)

Amino acids in both helices found in the cytoplasmic region of VpU in membrane-mimicking detergent micelles experience chemical shift perturbations upon binding to CD4, whereas amino acids between the two helices and at the C-terminus of VpU show no or only small changes, respectively. (novoprolabs.com)

The expression of these epithelial progenitor markers along with the pH91 antigen persists throughout thymic development in the murine thymus. (cuny.edu)
The time delay tial expression of CD4 and CD8 coreceptors. (cdc.gov)
Flt3-L significantly inhibited the effect of CRA sensitization to decrease GATA3 expression in lung CD4+CD25+ T-cells. (creighton.edu)

however, the challenge for T cells is to recognize tumour antigens whilst minimizing cross-reactivity with antigens associated with healthy tissue. (scancell.co.uk)

IL-17F is expressed in activated CD4 + T cells, basophils, and mast cells, three important cell types involved in allergic airway inflammation [ 3 ]. (hindawi.com)

The data suggest that MHC class II dextramers are useful tools for enumerating the frequencies of antigen-specific CD4 T cells in situ by direct staining without having to amplify the fluorescent signals, an approach commonly employed with conventional MHC tetramers. (unl.edu)

A well-balanced system of immune attack and immune tolerance mechanisms in response to these antigens is necessary for the maintenance of gut homeostasis. (nature.com)

Murine models have shown that the ability of A. fumigatus to germinate at physiological temperature may be an important factor that facilitates invasive disease. (cdc.gov)

We report here the utility of major histocompatibility complex (MHC) class II dextramers for in situ detection of self-reactive CD4 T cells in two target organs, the brain and heart. (unl.edu)

This effect was dependent on the CD4 T cells ability to produce IFNγ (interferon gamma), suggesting the potential mechanism of action of ITI-3000. (biospace.com)

Under normal circumstances, the respiratory tract maintains immune tolerance in the face of constant antigen provocation. (nih.gov)

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