Multivariate cd4 cd8 ratio. Medical search. Frequent questions

Data were analyzed using univariate and multivariate statistical methods. (biomedcentral.com)
Prognostic related IRGs in RTK patients were analyzed using univariate and multivariate analysis, based on which a prognostic model with IRGs was constructed. (aging-us.com)
A suggestive association of a heterozygous CCR5 delta 32 mutation status with prolonged disease duration was implied by univariate analyses but could not be confirmed by hierarchical multivariate testing. (biomedcentral.com)

Nomogram and multivariate Cox Regression analysis indicated increased Tc cells was related to reduced risk death(p = 0.001,HR = 0.217 95%CI = 0.085-0.551). (researchsquare.com)

In multivariate analyses, a high density of FoxP3 − CD4 + helper T cells in the tumor margin was independently associated with favorable PFS and OS. (e-crt.org)
Furthermore, GSEA and immune infiltrating analyses showed that the signature had close interactions with immune-related pathways and was closely related to CD8 T cells and monocytes in the tumor environment. (scielo.br)

Median survival was 45.81 months and patients of increased Tc cells, activated T helper cells(CD4 + CD25 + T cells or activated Th cells), activated Tc cells and normal CD4 + /CD8 + ratio presented encouraging outcomes (p = 0.007;0.016;0.028;0.016 respectively). (researchsquare.com)

Controlling for age, the proportions of memory CD4+ T cells, memory CD8+ T cells, CD28null T cells, and CD57+CD8+ T cells correlated negatively with the humoral response, whereas the proportions of memory CD4+ T cells and CD28null T cells correlated negatively and the CD4/CD8 ratio positively with the cellular response. (bvsalud.org)
We demonstrated that circIGF2BP3 (hsa_circ_0079587) expression was increased in NSCLC and negatively correlated with CD8 + T cell infiltration. (biomedcentral.com)

Multivariate Cox analysis exhibited that risk score were independent prognostic factors. (biomedcentral.com)
Sex, TNM stage, B7-H1, B7-H3, and T-cell intracellular antigen-1 expression remained significant prognostic factors after adjusting for other prognostic factors in a multivariate Cox proportional hazards regression model. (oncotarget.com)

In a multivariate model, only the proportions of memory CD4+ T cells and CD28null T cells independently predicted the cellular response. (bvsalud.org)
In the high CDK5 subgroup, CD8 + T cells revealed a dysfunction phenotype with decreased granzyme B, and more regulatory T cells were identified. (e-crt.org)
The density of CD8 + T cells, FoxP3 − CD4 + helper T cells, and FoxP3 + CD4 + regulatory T cells was significantly higher in the tumor margin than in the stroma and tumor core. (e-crt.org)
A high density of FoxP3 − CD4 + helper T cells in the tumor margin showed a trend toward better progression-free survival (PFS) (p=0.092) and significantly better overall survival (OS) (p=0.012). (e-crt.org)
The density of tumor margin-infiltrating FoxP3 − CD4 + helper T cells may be associated with clinical outcomes in BTC patients treated with gemcitabine plus cisplatin. (e-crt.org)
Among the different immune subsets, T cell subsets such as cytotoxic CD8 + T cells, helper CD4 + T cells, and regulatory T cells are recognized as key components in anti-tumor immune responses [ 9 - 11 ]. (e-crt.org)
Functionally, elevated circIGF2BP3 inactivated cocultured T cells in vitro and compromised antitumor immunity in an immunocompetent mouse model, and this effect was dependent on CD8 + T cells. (biomedcentral.com)
Proinflammatory islet antigen reactive CD4 T cells are linked with response to alefacept in type 1 diabetes. (immunetolerance.org)
CCR5 is known to play a decisive role as a chemotactic receptor abundantly expressed on monocytes, macrophages and T-cells and its heterozygous mutation-related deficiency implies impaired memory CD4 + T-cell response [ 5 ]. (biomedcentral.com)
The objective of this study was to investigate the expression of FOXP3+ Treg cells in leprosy skin lesions and to correlate their clinical forms, laboratory characteristics (CD4, CD8, and CV), and the immune reconstitution syndrome in HIV-leprosy co-infection. (bvsalud.org)

0.009 at month-1) and IL-10 ( P = 0.005 at month-1 and P = 0.006 at month-2) transcripts, whereas CD8 was elevated ( P = 0.016 at month-2). (biomedcentral.com)

A pre-SABR CD8+CD28+ T-cell count could predict early tumor response to SABR in patients with lung metastases from NSCLC. (biomedcentral.com)
The density of LAG3 - or TIM3-expressing CD8 + T cell and FoxP3 − CD4 + helper T cell infiltrates was also higher in the tumor margin. (e-crt.org)
Tumor PD-L1 deletion completely blocked the impact of the circIGF2BP3/PKP3 axis on the CD8 + T cell response. (biomedcentral.com)

Among people who have already sustained substantial immune deficiency at the time they start ART, CD4 cell counts usually rise, but may never reach normal levels. (hivandhepatitis.com)
Immune cell analysis revealed that the genes in the signature were correlated with B cell, CD4 T cell, CD8 T cell, dendritic cell, macrophage, and neutrophil. (hindawi.com)
Multivariate analysis grouped genes expressed in meningeal and white matter immune infiltrates into artificial factors that were characterized primarily by genes involved in type 1 immunity effector mechanisms and type I interferon pathway activation. (biomedcentral.com)
Our results reveal the function of circIGF2BP3 in causing immune escape from CD8 + T cell-mediated killing through a decrease in PD-L1 ubiquitination and subsequent proteasomal degradation by stabilizing OTUB1 mRNA in a PKP3-dependent manner. (biomedcentral.com)

Considering other associations of response with different parameters, multivariate analysis showed a modest association of LDH, with a P of roughly .04. (medscape.com)
When these were analyzed by multivariate analysis, the significant factor when antibody titers were set to 0.8 U/ml was CD19 ≥100/µl. (spandidos-publications.com)
In a multivariate analysis of the prospective MACS data, thrush and persistent fever (temperature of greater than 100 degrees F) were additional independent predictors of the development of PCP among patients with CD4+ counts of less than 200/mm3at their most recent evaluation (Panel of experts,* Phair and Munoz). (cdc.gov)
Adjusted on the other haematological toxicities as a multivariate analysis, neutropenia was significantly associated to non-adherence to chemotherapy (OR: 0.43). (bvsalud.org)

Baseline CD4 count and CD4:CD8 ratio, however, were not significant predictors of 10-year immunological outcomes. (hivandhepatitis.com)

Significant factors of antibody acquisition were identified when i) antibody titers were 0.8 U/ml or higher (CD4 ≥400/µl), ii) no anti‑CD20 antibody maintenance therapy was undertaken (CD19 ≥100/µl), iii) patients were not on treatment (CD4 ≥400/µl), or 4) at least six months had passed since treatment ended (CD19 ≥100/µl). (spandidos-publications.com)

Differences in T-cell immunophenotyping were seen between VACC-IS and VACC-IC, with lower CD8 + activation and T-effector memory phenotype observed in VACC-IS. (medrxiv.org)

One-third of people who started combination antiretroviral therapy (ART) many years ago using first-generation protease inhibitors did not achieve complete immunological recovery with normal CD4 T-cell counts despite good viral suppression, according to a French study presented at the recent 8th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention in Vancouver. (hivandhepatitis.com)

132 of the 399 patients (33%) did not experience CD4 response. (hivandhepatitis.com)
Collectively, the PKP3/PD-L1 signature and the infiltrating CD8 + T cell status stratified NSCLC patients into different risk groups. (biomedcentral.com)
In the sample studied, there was a positive correlation between FOXP3+ cell density and viral load, negative correlation with blood CD4+ (not statistically significant), significant positive correlation in CD8 count in patients with leprosy reaction, and positive relationship in patients with IRIS. (bvsalud.org)

In a case-to-case comparison among MSD cases, tEPEC was independently associated with presentation at enrolment with a loss of skin turgor (adjusted odds ratio (aOR) 2.08, 95% confidence interval (CI) 1.37-3.17), and convulsions (aOR 2.83, 95% CI 1.12-7.14). (cdc.gov)

Pre-SABR peripheral CD8+ T cell count, CD8+CD28+ T-cell count, CD8+CD28− T-cell count, CD4+ T-cell count, and Treg-cell count were measured using flow cytometry. (biomedcentral.com)

In contrast, when setting them to 264 U/ml or higher, CD4 ≥400/µl was not significant, but there was a tendency for it to be related. (spandidos-publications.com)

Black race, greater BMI and physical inactivity remained associated with physical function impairment in the multivariate model. (natap.org)

and there was no relationship of CD-4:CD-8 ratios to how a patient was going to respond. (medscape.com)
Aerosolized droplets are produced en masse in dental practices;these aerosols disperse in the surrounding space, posing a health threat if the patient is infected with a transmittable disease, particularly COVID-19. (bvsalud.org)

Multivariate Cox regression was used to identify independent risk factors associated with CD4/CD8 ratio normalization. (bvsalud.org)
HR: Cox regression shilly-shallyingty ratios with 95% confidence interval. (upb.ro)
We sequentially used the univariate, least absolute shrinkage and selector operation (LASSO), and multivariate Cox regression analyses to build a gene signature. (frontiersin.org)
Multivariate regression analysis confirmed that GM-CSF, CXCL10 and IL-10 levels were independently associated with the duration of mechanical ventilation. (biomedcentral.com)

Immunological indicators (cluster of differentiation 4 [CD4] counts and CD8 counts), viral load (VL), and metabolic indicators were collected at follow-up. (bvsalud.org)

Among T cell subsets, the total lymphocyte count (CD3 +) and specific subtypes (CD4 + , CD8 +) have strong associations with the survival outcomes of CRC patients. (biomedcentral.com)

Intratumoral CD4, CD8, and FOXP3 lymphocytes were examined by immunohistochemistry using a computer-assisted quantitative analysis in 136 PDAC patients who received neoadjuvant therapy and pancreaticoduodenectomy. (nih.gov)
High level of CD4 lymphocytes is associated with tumor differentiation and lower recurrence and is an independent prognostic factor for survival in PDAC patients treated with neoadjuvant therapy. (nih.gov)
This meta-analysis clarified that high level of CD8 + and CD3 + T cells infiltration in TS or TN, and high CD4 + T lymphocytes infiltration in TS showed better OS in lung cancer patients, whereas high density of FOXP3 + T cells infiltration in TS could be recognized as a negative prognostic factor. (karger.com)
The regulatory subtype of CD8 + T cells has been regarded as an immunosuppressive subtype of T lymphocytes, which play a vital role in self-tolerance [ 17 ]. (biomedcentral.com)
CD8 + T lymphocytes, in particular, are essential anti-tumor immune cells that directly eliminate tumor cells by releasing cytotoxic molecules. (biomedcentral.com)

3. Neoadjuvant immunotherapy of oral squamous cell carcinoma modulates intratumoral CD4/CD8 ratio and tumor microenvironment: a multicenter phase II clinical trial. (nih.gov)
Moreover, by analyzing resected specimens, we first proved that the existence of CD8 + CD122 + T cells in a tumor microenvironment (TME) depends on their proportion in peripheral blood. (biomedcentral.com)

Moreover, CD47 blockade not only increased the number of intratumoral CD8 + T cells, but also remodeled the T cell cluster toward a more activated one. (biomedcentral.com)

Similar to classical CD4 + Tregs, CD8 + T cells include both regulatory and effector subtypes. (biomedcentral.com)
Multiplex immunohistochemistry detected significantly lower fractions of CD8 + cells (p=0.036) and CD56 dim+ cells (p=0.016) in LM compared with PL. Single-cell RNA sequencing also characterized lower effector CD8 + T cells activation and NK cells cytotoxicity in LM. (bmj.com)
CS1-BATs and unarmed turned on T cells (ATC) had been incubated with MM cell goals at several effector to focus on ratios (E:T) within a quantitative stream cytometry-based assay to look for the amount of cell reduction relative to focus on cells incubated without ATC. (tech-strategy.org)

Median follow-up stood at 8 years and median CD4/CD8 ratio was 0.49 (interquartile range 0.27 to 0.79). (natap.org)

The immune markers Tim‑3, Gal‑9, CD3, CD8 and FOXp3 were immunostained in the TMA, and correlations with clinicopathological findings and prognosis were analyzed. (spandidos-publications.com)

Incidence rate and probability of CD4/CD8 ratio normalization were estimated through per 100 person-years follow-up (PYFU) and Kaplan-Meier curve, respectively. (bvsalud.org)

Univariate and multivariate Cox proportional hazard models were performed to identify the association between patient-, lymphoma-, and HIV-specific variables with progression-free survival (PFS) and overall survival (OS). (nih.gov)

We aimed to assess the association between the CD4:CD8 ratio and markers of age-associated disease in treated HIV-infected patients with good immunovirological response. (medscape.com)
Conclusions The CD4:CD8 ratio in treated HIV-infected subjects with good immunovirological response is independently associated with markers of age-associated disease. (medscape.com)

However, an appreciable number of individuals on long-term treatment still show a low ratio despite CD4 count normalization. (medscape.com)
CD4/CD8 ratio normalization was considered as the primary outcome and defined as a value ≥1. (bvsalud.org)
The overall incidence rate of CD4/CD8 ratio normalization was 8.9 (95% confidence interval [CI], 7.4-10.6) per 100 PYFU, and probabilities of CD4/CD8 normalization after initiating ART at 1 year, 2 years, 5 years, and 10 years follow-up were 11.7%, 23.2%, 44.0%, and 59.0%, respectively. (bvsalud.org)

Tim-3 was first identified as a molecule expressed in interferon (IFN)-γ-producing cluster of differentiation (CD)4 + T helper 1 (Th1) and CD8 + T cytotoxic 1 (Tc1) cells ( 4 ). (spandidos-publications.com)

The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to investigate the association between TIL subsets and lung cancer patients' outcome. (karger.com)

Cox proportional hazards model was used for multivariate analysis. (biomedcentral.com)

Because research ties low CD4/CD8 ratios to NADCs and mortality, NA-ACCORD investigators asked whether a low CD4/CD8 ratio predicts cancer risk in people with HIV. (natap.org)
IBD patients had a similar adjusted incidence of COVID-19 (OR 0.94;95% CI 0.86-1.02;P=0.42), and a similar associated mortality ratio (OR 0.83;95% CI 0.6-1.06;P=0.48), compared to the general population. (bvsalud.org)

Compared with HIV-uninfected women, frequencies of CD4(+)CD38(+)HLA-DR(+), CD8(+)CD38(+)HLA-DR(+), and CD8(+)CD28(-)CD57(+) T cells were higher among HIV-infected women, including those who achieved viral suppression while receiving antiretroviral treatment. (escholarship.org)

They suggested that further research could assess CD4/CD8 ratio as a tool to inform cancer prevention and screening in people with HIV. (natap.org)

Results of studies which looked at predictors of discordant responses (with virologic suppression but incomplete CD4 recovery) have been varied. (biomedcentral.com)
Macaques were primed with a transmitted-founder clade-B env mRNA lacking the N276 glycan, followed by multiple booster immunizations with glycan-repaired autologous and subsequently bivalent heterologous envs (clades A and C). This regimen was highly immunogenic and elicited neutralizing antibodies against the most prevalent (tier-2) HIV-1 strains accompanied by robust anti-Env CD4 + T cell responses. (nature.com)

The researchers noted that low CD4/CD8 ratio predicted higher cancer risk for some virus-associated cancers (non-Hodgkin lymphoma, Kaposi sarcoma, anal cancer, colorectal cancer) but not for others (cervical cancer, Hodgkin lymphoma). (natap.org)

In a few reports, regulatory CD8 + T cells were found to mediate antitumor immunity in the presence of cancer. (biomedcentral.com)

There were significant inverse correlations between the ACE ratio and dietary zinc intake from rice and rice products and shellfish, and a significant positive correlation between ACE ratio and dietary zinc intake from other beans and bean processed foods. (tokushima-u.ac.jp)

In a case-to-case comparison among MSD cases, tEPEC was independently associated with presentation at enrolment with a loss of skin turgor (adjusted odds ratio (aOR) 2.08, 95% confidence interval (CI) 1.37-3.17), and convulsions (aOR 2.83, 95% CI 1.12-7.14). (cdc.gov)

Effects of dietary zinc deprivation on zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in serum of mice. (tokushima-u.ac.jp)
We then used the ratio of apo/holo-activities of angiotensin converting enzyme (ACE ratio) that is a more sensitive index of zinc nutrition than zinc concentration in the serum and examined the correlation between their zinc intake and ACE ratio. (tokushima-u.ac.jp)

High CD4 TILs in treated PDAC were associated with high CD8 TILs (P = 0.003), differentiation (P = 0.04), and a lower frequency of recurrence (P = 0.02). (nih.gov)

Increased cancer risk with lower CD4/CD8 ratio among adults with HIV in NA-ACCORD. (natap.org)
Interleukin-6 (IL-6), a cytokine secreted by CD4 + T cell,has been shown to be a reliable marker ofdisease severity and a useful parameter for monitoring COVID-19 progression [ 4 - 6 ], but its value for predicting risk of severe illness has not been examined. (researchsquare.com)

Forkhead box (FOX)p3, a member of the forkhead family, is specifically expressed in Treg cells, including CD4 + CD25 high Treg cells and CD8 + CD25 high Treg cells ( 9 ). (spandidos-publications.com)

At 96 weeks, only 6% of the SCR group had CD4 ≥ 350 cells/μL compared with 67% in the non SCR group. (biomedcentral.com)

Anatomy32

Organisms5

Diseases14

Chemicals and Drugs113

Analytical, Diagnostic and Therapeutic Techniques and Equipment56

Phenomena and Processes36

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science7

Named Groups1

Health Care34

Geographicals1

Univariate3

0.0011

Analyses2

Helper cells1

Negatively2

Prognostic2

Cells10

0.0161

Tumor3

Immune4

Analysis4

Outcomes1

CD191

Phenotype1

Counts1

Patients3

Odds ratio1

Cell1

Significant1

Model1

Patient2

Regression4

Viral load1

Lymphocyte count1

Lymphocytes5

Tumor microenvironment2

Intratumoral1

Effector3

Median1

FOXP31

Kaplan-Meier1

Univariate1

Markers2

Normalization3

Cytotoxic1

Hazard ratios1

Proportional1

Mortality2

Antiretroviral1

Assess1

Responses2

Cancers1

Regulatory1

Correlations1

Odds1

Serum2

Differentiation1

Risk2

High1

Group1