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  • biochemical
  • Development of single-molecule tools has begun to enable the visualization of complex biochemical reactions with great resolution in the dynamic and crowded environment of the cell. (rupress.org)
  • Biochemical purification and functional genetic studies have assigned the various PcG genes into two distinct subsets, namely Polycomb Repressive Complex 1 (PRC1) and Polycomb Repressive Complex 2 (PRC2). (wikipedia.org)
  • genes
  • PRC2 The PRC2 core complex initiates repression by tagging genes with methyl groups (a process known as histone methylation). (wikipedia.org)
  • homolog
  • The other core PRC2 components, which comprise a homolog of Su(z), SUZ12, and a homolog of Esc, Eed, are necessary for complex assembly and for proper enzymatic activity. (wikipedia.org)
  • subunits
  • The Drosophila PRC1 core complex is formed by the Polycomb (Pc), Polyhomeotic (Ph), Posterior sex combs (Psc), and Sex combs extra (Sce, also known as Ring) subunits. (wikipedia.org)
  • It includes organisations from simple dimers to large homooligomers and complexes with defined or variable numbers of subunits. (wikipedia.org)
  • Formal and Greco-Latinate names are generally used for the first ten types and can be used for up to twenty subunits, whereas higher order complexes are usually described by the number of subunits, followed by -meric. (wikipedia.org)
  • functional
  • I will argue that the unexpectedly dynamic design of this repair pathway is adapted to functional constraints and discuss implications for other chromatin-associated multiprotein complexes. (uni-freiburg.de)
  • In this network we find that all multi-protein complexes that belong to the same functional class are regulated in the same direction as a group (either induced or repressed). (biomedcentral.com)
  • methods
  • These methods have shown that the behavior of multicomponent protein complexes is highly stochastic and less linear and deterministic than previously thought. (rupress.org)
  • cells
  • In contrast to this view, we have observed in living cells that the core components of a DNA repair pathway, nucleotide excision repair, exchange rapidly between the bound state in repair complexes and the freely diffusible state in the nucleoplasm. (uni-freiburg.de)
  • HSP90
  • Analysis of the effects of Geldanamycin on steroid receptor activation indicates that the antibiotic blocks the chaperone cycle at the intermediate complex, preventing the release of the receptor from Hsp90 and, eventually, resulting in its degradation. (wikipedia.org)
  • immune
  • Editing and loading complexes associated with the MHC-I play a key role in controlling the immune response. (cef-mc.de)
  • In this period, we have also discovered that neutrophil synthesis of LTB4 and BLT1-induced neutrophil responses to LTB4 are absolutely required for the development of immune complex-induced inflammatory arthritis. (grantome.com)
  • structure
  • The molecular structure of this complex is in the form of a hexamer. (wikipedia.org)
  • The physical role of the centromere is to act as the site of assembly of the kinetochores - a highly complex multiprotein structure that is responsible for the actual events of chromosome segregation - i.e. binding microtubules and signalling to the cell cycle machinery when all chromosomes have adopted correct attachments to the spindle, so that it is safe for cell division to proceed to completion and for cells to enter anaphase. (wikipedia.org)
  • chromosome
  • DSN1 along with MIS12, DC8, PMF1, CBX5, ZWINT is a component of the kinetochore-associated multiprotein complex which is required for correct chromosome alignment during the metaphase of cell mitosis. (wikipedia.org)
  • It is now believed that this complex is mostly released from chromosome arms during prophase, so that by the time the chromosomes line up at the mid-plane of the mitotic spindle (also known as the metaphase plate), the last place where they are linked with one another is in the chromatin in and around the centromere. (wikipedia.org)
  • nuclear
  • Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). (wikipedia.org)
  • form
  • Nucleic acids may be labeled by complexing the alkylating moiety of a labeling reagent into a single-stranded nucleic acid to form a complex and activating the complex to cause covalent bonding between the reagent and the nucleic acid. (google.com)
  • When cells enter mitosis, the sister chromatids (the two copies of each chromosomal DNA molecule resulting from DNA replication in chromatin form) are linked along their length by the action of the cohesin complex. (wikipedia.org)
  • formation
  • Consistent with this, Smads2/3/4 attenuated complex formation between MPK38 and its negative regulator thioredoxin (Trx), whereas Smad7 increased this complex formation. (deepdyve.com)
  • However, an opposite effect was observed on complex formation between MPK38 and its positive regulator zinc-finger-like protein 9 (ZPR9). (deepdyve.com)
  • WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. (wikipedia.org)
  • thus
  • Viruses have developed sophisticated strategies to interfere with the antigen-loading of the MHC-I complexes and thus escape the notice of T-cells. (cef-mc.de)
  • site
  • The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. (wikipedia.org)