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  • therapies
  • CSN does not claim that any applications, or potential applications, using these autologous stem cell therapies are approved by the FDA, or are even effective. (gulfcoaststemcell.com)
  • Totipotent stem cells, however, out of all the other types, presents an ideal approach to deal with the therapies related to the diseases . (medcraveonline.com)
  • An understanding of this blueprint has implications for our understanding of development and stem cell therapies. (yu.edu)
  • Previous studies have produced conflicting results, and some researchers have questioned whether stem cell therapies for failing. (bionews.org.uk)
  • Adult stem cells are frequently used in various medical therapies (e.g., bone marrow transplantation). (wikipedia.org)
  • MSCs
  • PLA cells expressed multiple CD marker antigens similar to those observed on MSCs. (gulfcoaststemcell.com)
  • Finally, PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression. (gulfcoaststemcell.com)
  • autologous
  • Cell Surgical Network is offering patient funded research to treat individual patients with their own autologous stem cells and CSN is not involved in the use or manufacture of any investigational drugs. (gulfcoaststemcell.com)
  • ATTENTION: If you have ANY concern with our autologous stem cell therapy product, methods, website, or technique and think we may be violating any U.S. law, please contact us so that we can investigate the matter or concern immediately. (gulfcoaststemcell.com)
  • Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial," The Lancet , vol. 364, no. 9429, pp. 141-148, 2004. (hindawi.com)
  • Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial," The Lancet , vol. 367, no. 9505, pp. 113-121, 2006. (hindawi.com)
  • Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial," Journal of the American Medical Association , vol. 308, no. 22, pp. 2369-2379, 2012. (hindawi.com)
  • There are three known accessible sources of autologous adult stem cells in humans: Bone marrow, which requires extraction by harvesting, that is, drilling into bone (typically the femur or iliac crest). (wikipedia.org)
  • Of all stem cell types, autologous harvesting involves the least risk. (wikipedia.org)
  • By definition, autologous cells are obtained from one's own body, just as one may bank his or her own blood for elective surgical procedures. (wikipedia.org)
  • novel
  • Catherine Verfaillie and colleagues at the University of Minnesota first described these novel stem cells in 2002, but other teams have had difficulty in replicating the work. (bionews.org.uk)
  • distinct
  • In the forebrain, three regionally distinct sources have been shown to generate polydendrocytes sequentially: an early ventral source from the medial ganglionic eminence marked by Nkx2.1, followed by progenitor cells in the lateral ganglionic eminence marked by Gsh2, and finally the dorsal neocortical germinal zone marked by Emx1. (wikipedia.org)
  • 2002
  • In 1981, he became an Assistant Professor, was promoted to Associate Professor in 1986, and has served as Professor in the Department of Anatomy and Cell Biology at the University of Toronto from 1991 until 2002, when he became a Professor in the Department of Medical Genetics and Microbiology. (wikipedia.org)
  • progeny
  • The two fundamental characteristics of stem cells are the ability of unlimited self-regeneration and the production of at least one type of differentiated progeny cells . (medcraveonline.com)
  • Those stem cells and their differentiated progeny are organized into columns named epidermal proliferation units. (wikipedia.org)
  • demonstrate
  • B ) Morphologically, most hBMSCs demonstrate round morphology with a cell size of less than 15 μm in diameter. (jci.org)
  • clonal
  • The SP cells exhibited clonal growth and continued to express ABCG2 and also PAX6, product of a homeobox gene not expressed in adult keratocytes. (mendeley.com)
  • Most T cells are, in time, eliminated in the thymus by a process of clonal deletion. (wikipedia.org)
  • human
  • This study sought to identify progenitor cells for human keratocytes. (mendeley.com)
  • These appear to be the first human cells identified with keratocyte progenitor potential. (mendeley.com)
  • To our knowledge, this is the first demonstration that a specific population of multipotent human BM-derived stem cells can induce both therapeutic neovascularization and endogenous and exogenous cardiomyogenesis. (jci.org)
  • Human umbilical vein ECs (lane 4) and immortalized cell lines with high telomere length, provided by the Roche Diagnostics Corp. (lane 5), were used as controls. (jci.org)
  • The new cells also expressed biomarkers typical of pigment cells and when placed in an artificial human skin construct, produced melanin and responded to chemical cues from normal epidermis skin cells. (webwire.com)
  • In some cases, the nucleus may contain up to 64N DNA, or 32 copies of the normal complement of DNA in a human cell. (wikipedia.org)
  • One of these responses, the induction of intestinal cell surface fucose residues, is elicited by a prominent human intestinal symbiont, Bacteroides thetaiotaomicron, which can harvest and use the host fucose as a carbon and energy source. (wikipedia.org)
  • Dr. Gordon's laboratory has investigated epithelial cell interaction with human-associated pathogens, including uropathogenic Escherichia coli, Helicobacter pylori, and Listeria monocytogenes. (wikipedia.org)
  • All islet cells can be observed in the first trimester in human. (wikipedia.org)
  • molecular
  • Further analysis of these cells will aid elucidation of molecular mechanisms of corneal development, differentiation, and wound healing. (mendeley.com)
  • In contrast to research using biochemistry, genetics, or molecular biology, where mutagenesis can provide a new version of the organism, cell, or biomolecule of interest, chemical biology probes systems in vitro and in vivo with small molecules that have been designed for a specific purpose or identified on the basis of biochemical or cell-based screening (see chemical genetics). (wikipedia.org)
  • epithelial
  • Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA (2009) Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. (springer.com)
  • Syndecan-1 expression in prostate cancer and the role of p27 in primary prostate epithelial cell transformation. (wikipedia.org)
  • proliferation
  • The mechanisms of proliferation and differentiation of hematopoietic multipotent stem cells. (nii.ac.jp)
  • The physiological roles of these factors in the regulatory mechanisms of stem cell proliferation are still unknown. (nii.ac.jp)
  • Proliferation of these cell types were characterized in further experiments that were reported in articles in Development and the Journal of Neuroscience. (wikipedia.org)
  • Based on the observation that these cells require PDGF for their proliferation and expansion, the expression of the alpha receptor for platelet-derived growth factor (Pdgfra) was used to search for the in vivo correlates of the A2B5+ cells, which led to the discovery of a unique population of Pdgfra+ cells in the CNS whose appearance and distribution were consistent with those of developing oligodendrocytes. (wikipedia.org)
  • After the committed progenitor cells exit the germinal zones, they begin to express NG2 and Pdgfra and expand by local proliferation and migration and eventually occupy the entire CNS parenchyma. (wikipedia.org)
  • myocardial infarction
  • Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction," The New England Journal of Medicine , vol. 355, no. 12, pp. 1210-1221, 2006. (hindawi.com)
  • Transcoronary transplantation of progenitor cells after myocardial infarction," The New England Journal of Medicine , vol. 355, no. 12, pp. 1222-1232, 2006. (hindawi.com)
  • Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction," The New England Journal of Medicine , vol. 355, no. 12, pp. 1199-1209, 2006. (hindawi.com)
  • Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI): final 5-year results suggest long-term safety and efficacy," Clinical Research in Cardiology , vol. 100, no. 10, pp. 925-934, 2011. (hindawi.com)
  • Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety," Circulation , vol. 112, no. 9, pp. (hindawi.com)
  • biochemical
  • Toxicity of organotin compounds: shared and unshared biochemical targets and mechanisms in animal cells. (semanticscholar.org)
  • In contrast to biochemistry, which involves to study of the chemistry of biomolecules and regulation of biochemical pathways within and between cells, chemical biology deals with chemistry applied to biology. (wikipedia.org)
  • bone-marrow cell
  • A megakaryocyte (mega- + karyo- + -cyte, "large-nucleus cell") is a large bone marrow cell with a lobulated nucleus responsible for the production of blood thrombocytes (platelets), which are necessary for normal blood clotting. (wikipedia.org)
  • population
  • The ABCG2-expressing cell population was isolated as a side population (SP) by cell sorting after exposure to Hoechst 33342 dye. (mendeley.com)
  • Two mechanisms exist to ensure that a stem cell population is maintained: Obligatory asymmetric replication: a stem cell divides into one mother cell that is identical to the original stem cell, and another daughter cell that is differentiated. (wikipedia.org)
  • Using stain-retaining assay (with bromodeoxyuridine, or BrdU), a low-cycling cell population was found in the papillary region, which was able to divide rapidly to repair the damaged caused by transcient renal ischemia. (wikipedia.org)
  • These evidence suggests a stem cell population exists within the renal capsule. (wikipedia.org)
  • The notion that there exists a population of glial progenitor cells in the developing and mature CNS began to be entertained in the late 1980s by several independent groups. (wikipedia.org)
  • In one series of studies on the development and origin of oligodendrocytes in the rodent CNS, a population of immature cells that appeared to be precursors to oligodendrocytes was identified by the expression of the GD3 ganglioside. (wikipedia.org)
  • Comparison of NG2 and Pdgfra expression revealed that NG2 and Pdgfra are expressed on the same population of cells in the CNS. (wikipedia.org)
  • The high turnover rate of the intestinal lining is due to a dedicated population of stem cells found at the base of the intestinal crypt. (wikipedia.org)