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  • vivo
  • These results represent the first demonstration of adult stem cells with the potential to be differentiated into different types of ECs in vitro and in vivo and provide a useful human model to study arteriovenous specification. (cun.es)
  • phenotype
  • In vitro, in the presence of VEGF(165), hAC133(+) cells only adopted a venous and microvascular EC phenotype, while hMAPCs differentiated into both arterial and venous ECs, possibly because hMAPCs expressed significantly more sonic hedgehog (Shh) and its receptors as well as Notch 1 and 3 receptors and some of their ligands. (cun.es)
  • flow cytometry
  • 12. The method according to claim 10, wherein the cell sorting is a fluorescence-activated cell sorting (FACS) flow cytometry. (patentsencyclopedia.com)
  • Recent studies have shown that several blood-vessel-derived precursor cell populations, purified by flow cytometry from multiple human organs, give rise to bona fide MSCs, suggesting that the vasculature serves as a systemic reservoir of MSC-like stem/progenitor cells. (hindawi.com)
  • Moreover
  • Moreover, the cells did not stimulate the growth of the abnormal MDS clone, as shown by fluorescent in situ hybridization analysis on BM cells from patients with a known genetic abnormality. (uhasselt.be)
  • tissue-specific
  • Increasing evidence further suggests that MSCs and some tissue-specific progenitor cells are anatomically and functionally associated with vascular/perivascular niches in various tissues [ 18 - 21 ]. (hindawi.com)
  • autologous
  • Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial," The Lancet , vol. 364, no. 9429, pp. 141-148, 2004. (hindawi.com)