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  • axolotl
  • To investigate the role of macrophages during scar-free tissue repair in an efficiently regenerating model, we dissected the inflammatory response to injury in regenerating limbs of the axolotl aquatic salamander ( Ambystoma mexicanum ) at the cellular and molecular level. (pnas.org)
  • We screened the blastema of resected axolotl limbs with a cross-reactive mouse cytokine protein detection array, revealing a rapid induction of cytokines, chemokines, and inflammatory markers within 1 d of limb resection. (pnas.org)
  • We have found that pseudotyped Maloney Murine Leukemia Virus (MMLV) retroviruses can very efficiently infect axolotl cells in vitro and in vivo , and can be used for both lineage and functional analyses in regenerating limbs. (biologists.org)
  • induced plur
  • We therefore propose a link between partially reprogrammed induced pluripotent stem cells and the half way state of blastema cells and suggest that a common mechanism might be regulating these two processes. (biomedcentral.com)
  • formation
  • Each model offers different opportunities and techniques that add to the general picture of blastema cell formation. (biomedcentral.com)
  • Although other cell types contribute to blastema formation, fibroblasts appear to play a central role [ 5 , 6 ]. (jcancer.org)
  • Our findings also identify satellite cells as potential targets in promoting mammalian blastema formation. (rupress.org)
  • adult
  • Earlier studies identified a cell population that is closely apposed to the myofiber in the adult newt limb as well. (rupress.org)
  • lack
  • Drosophila mutants lacking Dll function die as embryos because they lack the rudimentary larval limbs ( Cohen and Jurgens, 1989 ). (biologists.org)