• Despite great advances in understanding the mechanisms underlying blood production, lineage specification at the level of multipotent progenitors (MPPs) remains poorly understood. (nih.gov)
  • How cell-extrinsic niche-related and cell-intrinsic cues drive lineage specification of hematopoietic multipotent progenitors (MPPs) in the bone marrow (BM) is partly understood. (sciety.org)
  • The ability to expand multipotent Sox9 + lung progenitors should avail multiple future applications including the generation of lung organoids and gene editing, with ramifications for disease modeling, drug screening and regenerative medicine. (researchsquare.com)
  • While only airway-restricted and alveolar-restricted stem cells subsist in the adult lung, multipotent Id2 + and Sox9 + distal tip lung progenitors that have the ability to generate both airway and alveolar lineages transiently exist during mouse embryonic development (~E11.5-E15.5) 11-13 . (researchsquare.com)
  • Here we describe in detail the steps necessary to isolate and expand multipotent Sox9 + lung progenitors from lung tissue at day 12.5 (E12.5) of mouse embryonic development. (researchsquare.com)
  • Despite their transient nature in vivo , we show here that these multipotent lung progenitors can be captured and stably expanded in vitro , while maintaining their undifferentiated, proliferative state and their competence to differentiate into both airway and alveolar cell-types. (researchsquare.com)
  • Procedures for passaging (==~2 hours) and the cryopreservation of Sox9 + lung multipotent progenitors are also provided. (researchsquare.com)
  • Polyclonal T-cell reconstitution of X-SCID recipients after in utero transplantation of lymphoid-primed multipotent progenitors. (ox.ac.uk)
  • Herein, we demonstrate in a congenic setting that recently identified lymphoid-primed multipotent progenitors are superior to hematopoietic stem cells in providing rapid lymphoid reconstitution after IUHCT of X-SCID recipients, and sustain in the long-term B cells, polyclonal T cells, as well as short-lived B-cell progenitors and thymic T-cell precursors. (ox.ac.uk)
  • Feline adult adipose tissue-derived multipotent stromal cell isolation" by C. Fargason, N. Zhang et al. (lsu.edu)
  • MSC = multipotent mesenchymal stromal cell. (hindawi.com)
  • Figure 1 Illustration demonstrating a hypothetical summary of the potential effect of aryl-hydrocarbon receptor activation on multipotent mesenchymal stromal cell function. (wjgnet.com)
  • Inference, validation, and dynamic modeling of transcription networks in multipotent hematopoietic cells. (ox.ac.uk)
  • OBJECTIVE: This study was undertaken to isolate and characterize multipotent mesenchymal stem cells from term human placenta (placenta-derived mesenchymal stem cells, PD-MSCs). (uzh.ch)
  • Through fluorescence-activated cell sorting, microarray analysis, in vitro differentiation assays, mixed lymphocyte reaction, and a model of ischemic kidney injury, this study sought to identify and characterize multipotent organ stem/progenitor cells in the adult kidney. (tau.ac.il)
  • The development of practical T lymphocytes happens in the thymus and is maintained from the periodic immigration of multipotent progenitor cells (MPPs) from either the embryonic liver or the adult bone marrow (1). (bio-biz-navi.com)
  • In a study of one affected family, phacomatosis pigmentokeratotica was found to be caused by a postzygotic HRAS mutation in a multipotent progenitor cell. (medscape.com)
  • and [3] therapeutic innovation - FMOD reprogrammed (FReP) multipotent cells can be easily differentiated into skeletal myocytes and osteoblasts in vitro and in vivo, respectively, and will have significant clinical value in regenerative medicine to establish skeletal muscle and bone by autologous cells. (ca.gov)
  • Background: There have been conflicting observations regarding the receptors utilized by human multipotent mesenchymal bone marrow stromal cells (hMSC) to adhere to endothelial cells (EC). (mst.edu)
  • By culturing these multipotent cells with proteins and minerals, Dr. Xu has already gotten the hair follicle stem cells to differentiate into skin, nerve, muscle, bone, cartilage, and fat tissue. (loe.org)
  • Primary myelofibrosis results from neoplastic transformation of a multipotent bone marrow stem cell. (msdmanuals.com)
  • Reprogramming of human fibroblasts into multipotent cells with a single ECM proteoglycan, fibromodulin. (ca.gov)
  • Since FMOD reprogramming clearly involves neither oncogenes nor genome integrative approaches and FReP cells do not generate teratoma in vivo, FMOD reprogramming fulfills the requirements of the FDA to produce safe multipotent cells without known undesirable side effects. (ca.gov)
  • Therefore, FMOD reprogramming provides an alternative strategy for engineering patient-specific multipotent cells for basic research and therapeutic application. (ca.gov)
  • We report here a technique using a single molecule, recombinant human fibromodulin protein (FMOD), to reprogram human fibroblasts into multipotent cells. (ca.gov)
  • Overall, single protein, FMOD-based, cell reprograming bypasses the risks of mutation, gene instability, and malignancy associated with genetically-modified iPS cells, and provides an alternative strategy for engineering patient-specific multipotent cells for basic research and therapeutic application. (ca.gov)
  • We used the paradigmatic GATA-PU.1 axis to explore, at the systems level, dynamic relationships between transcription factor (TF) binding and global gene expression programs as multipotent cells differentiate. (lu.se)
  • Multipotent progenitor cells can be isolated from postnatal. (pubpeer.com)
  • Metformin Increases Proliferative Activity and Viability of Multipotent Stromal Stem Cells Isolated from Adipose Tissue Derived from Horses with Equine Metabolic Syndrome. (labgenexp.eu)
  • Access to systems in which multipotent lung stem or progenitor cells with the ability to generate both airway and alveolar cell-types, can be cultured and expanded in vitro would be an advantageous starting point to study lung developmental biology, organ function and lung diseases. (researchsquare.com)
  • Purdon, S & Glassberg, MK 2019, ' Multipotent mesenchymal stromal cells and lung disease: Not ready for prime time ', Annals of the American Thoracic Society , vol. 16, no. 6, pp. 669-671. (arizona.edu)
  • Objective Human multipotent mesenchymal stromal cells (MSC) have the potential to differentiate into multiple cell types, although little is known about factors that control their fate. (buyresearchchemicalss.net)
  • Tissue engineering and cell therapy approaches aim to take advantage of the repopulating ability and plasticity of multipotent stem cells to regenerate lost or diseased tissue. (tau.ac.il)
  • Rapidly Self-Renewing Human Multipotent Marrow Stromal Cells (HMSC) Ex" by Harris E. McFerrin, Scott D. Olson et al. (mst.edu)
  • Rapidly Self-Renewing Human Multipotent Marrow Stromal Cells (HMSC) Express Sialyl Lewis X and Actively Adhere to Arterial Endothelium in a Chick Embryo Model System," PLoS ONE , vol. 9, no. 8, PLOS, Aug 2014. (mst.edu)
  • Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra-Synovial Tendinopathy. (ox.ac.uk)
  • These data indicate that the disorders in these three patients are clonal and involve multipotent stem cells. (ashpublications.org)
  • The chemokine receptor CCR9 controls the immigration of multipotent hematopoietic progenitor cells into the thymus to sustain T cell development. (bio-biz-navi.com)
  • Identification of multipotent luminal progenitor cells in human prostate organoid cultures. (bvsalud.org)
  • Multipotent mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have the capacity to differentiate into a variety of cell types (Figure 1 ), including adipocytes, chondrocytes, and osteocytes [ 9 , 10 ]. (hindawi.com)
  • Osteoblasts arise from multipotent mesenchymal stem cells. (medscape.com)
  • In this study, we present integrated quantitative proteome, transcriptome, and methylome analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) populations. (lu.se)
  • Normal multipotent tissue stem cells (SCs) are the driving force behind tissue turnover and repair. (medscape.com)
  • Normal proliferative tissues contain multipotent stem cells (SCs) that drive tissue turnover. (medscape.com)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • Pluripotent and/or multipotent stem cell-based therapeutics are a vital component of tissue engineering and regenerative medicine. (ca.gov)
  • The disorder has some clinical and laboratory features that resemble those seen in the clonal multipotent stem cell disorders chronic myelogenous leukemia, polycythemia vera, and agnogenic myeloid metaplasia. (ashpublications.org)
  • He calls it "multipotent," because it can transform into many kinds of tissue. (loe.org)
  • methods applied to synthetic compounds led to the identification of new AChE inhibitors, NMDA antagonists, multipotent hybrids targeting different AD processes and metal-organic compounds acting as A inhibitors. (bioerc-iend.org)
  • The remit of this protocol is to enable the derivation of a highly-pure multipotent Sox9 + lung progenitor population. (researchsquare.com)
  • Although previous studies have shown that yolk-sac-derived erythromyeloid progenitors and HSCs emerge from distinct populations of HE, it remains unknown whether the earliest lymphoid-competent progenitors, multipotent progenitors, and HSCs originate from common HE. (github.io)
  • Taken together, these findings suggest a revised model of developmental hematopoiesis in which the initial populations of multipotent progenitors and HSCs arise independently from HE with distinct phenotypic and transcriptional properties. (github.io)
  • Bankable human iPSC-derived retinal progenitors represent a valuable source of multipotent cells. (bvsalud.org)
  • Clonogenic progenitor cell assays of cells from the bone marrow and spleens of these infected mice suggest that EPO-R(R129C) can stimulate proliferation of committed megakaryocytic and erythroid progenitors as well as nonerythroid multipotent progenitors. (wustl.edu)
  • It is possible that progenitors of olfactory sensory neurons in the olfactory epithelium are multipotent. (nih.gov)
  • In the November 6 Nature Methods , the team led by Bing Lim and Massimo Nichane of the Genome Institute of Singapore and Kyle M. Loh of Stanford University School of Medicine, and including Siva V, Ph.D., of The Jackson Laboratory's Single Cell Biology Lab, showed that mouse Sox9+ multipotent embryonic lung progenitors can be isolated and expanded long-term in 3D culture. (jax.org)
  • Isolation and 3D expansion of multipotent Sox9 + mouse lung progenitors. (jax.org)
  • Differentiation of multipotent vascular stem cells contributes to vascular diseases. (ca.gov)
  • Lineage tracing demonstrates that neither multipotent vascular stem cells nor proliferative or synthetic smooth muscle cells arise from the de-differentiation of mature smooth muscle cells. (ca.gov)
  • These findings support a new hypothesis that the differentiation of multipotent vascular stem cells, rather than the de-differentiation of smooth muscle cells, contributes to vascular remodelling and diseases. (ca.gov)
  • On the other hand, we perform lineage tracing with smooth muscle myosin heavy chain as a marker and find that multipotent vascular stem cells and proliferative or synthetic smooth muscle cells do not arise from the de-differentiation of mature smooth muscle cells. (ca.gov)
  • The phenotypes and multipotent differentiation potential of these cells were also evaluated. (molvis.org)
  • Multipotent adult progenitor cells (MAPC) are a unique population of adult stem cells that can be isolated from the marrow of multiple mammalian species, including human, rat, and mouse. (medscape.com)
  • Multipotent vascular stem cells can differentiate into neural cells and mesenchymal stem cell-like cells that subsequently differentiate into smooth muscle cells. (ca.gov)
  • In response to vascular injuries, multipotent vascular stem cells, instead of smooth muscle cells, become proliferative, and differentiate into smooth muscle cells and chondrogenic cells, thus contributing to vascular remodelling and neointimal hyperplasia. (ca.gov)
  • Multipotent vascular stem cells express markers, including Sox17, Sox10 and S100beta, are cloneable, have telomerase activity, and can differentiate into neural cells and mesenchymal stem cell-like cells that subsequently differentiate into smooth muscle cells. (ca.gov)
  • The stem cells are multipotent and are not only able to differentiate into smooth muscle cells, but also into fat, cartilage and bone cells. (quantumday.com)
  • Synovial sarcoma is derived from multipotent stem cells, which can differentiate into mesenchyma and epithelial structures. (thieme-connect.com)
  • Multipotent cells are found in cord blood , adipose tissues, bone marrow and cardiac cells. (kenkyugroup.org)
  • Multipotent mesenchymal stromal cells (MSC) are potential candidates for cell-based therapy [2 4 These cells are most commonly derived or Nepicastat (free base) (SYN-117) isolated from bone tissue marrow (BM) adipose tissues (AT) or umbilical cable blood (CB). (techblessing.com)
  • Feline adult adipose tissue-derived multipotent stromal cell isolation" by C. Fargason, N. Zhang et al. (lsu.edu)
  • We identify a new type of stem cell in the blood vessel wall, named multipotent vascular stem cells. (ca.gov)
  • Early chromatin shaping predetermines multipotent vagal neural crest into neural, neuronal and mesenchymal lineages. (ox.ac.uk)
  • In addition, recent studies of neural development suggest that many neuronal precursors are multipotent and ultimately adopt a neuronal fate on the basis of local environmental factors. (nih.gov)
  • We focussen ons vooral op het begrijpen van de oorsprong van HSCs tijdens de embryonale ontwikkeling, de mechanismen die betrokken zijn bij het genereren en expanderen van HSCs, de samenstelling en functie van de verschillende HSC niches tijdens maturatie, en de cellulaire en moleculaire kenmerken van HSCs en hun voorlopers. (hubrecht.eu)