• In wild-type mice, AS160 expression is relatively high in adipose tissue and soleus muscle, low in EDL (extensor digitorum longus) muscle and detectable in liver only after enrichment. (dundee.ac.uk)
  • Adipose tissue inflammation appears to be a risk factor for the progression of chronic kidney disease (CKD), but the effect of CKD on adipose tissue inflammation is poorly understood. (mdpi.com)
  • The purpose of this study was to clarify the involvement of uremic toxins (indoxyl sulfate (IS), 3-indoleacetic acid, p-cresyl sulfate and kynurenic acid) on CKD-induced adipose tissue inflammation. (mdpi.com)
  • Besides, a role could be ascribed to molecules secreted by the visceral adipose tissue that can impact on barrier functions. (hindawi.com)
  • White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in regulating energy homeostasis and insulin sensitivity. (springer.com)
  • Conversely, brown adipose tissue (BAT) and browning of WAT represent potential therapeutic approaches, since dysfunctional white adipocyte-induced lipid overspill can be halted by BAT/browning-mediated oxidative anti-lipotoxic effects. (springer.com)
  • Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities. (springer.com)
  • White adipose tissue (WAT) plays a key homeostatic role, not only by ensuring efficient energy storage but also by its quick mobilisation (lipids) to ensure peripheral demands. (springer.com)
  • The 'adipose tissue expandability model' identifies the limited capacity and dysfunctionality of WAT, preventing its expansion and accommodation of surplus of energy, as key determinants for the onset and progression of obesity-associated metabolopathologies as a result of ectopic deposition of toxic lipid species in metabolic organs (i.e. muscle or liver [also known as lipotoxic insult]) [ 7 ]. (springer.com)
  • There is also evidence that the deleterious effects mediated by dysfunctional white adipocyte-induced lipid overspill can be halted by the pro-oxidative anti-lipotoxic effects mediated by brown adipose tissue (BAT) activation. (springer.com)
  • Tissues mounted on positively charged glass slides are organized either by organs (major organ multiple tissue panels), or by integrated major systems (organ systems multiple tissue panels). (biochain.com)
  • This may ultimately influence the function of tissues and organs in health and disease. (springer.com)
  • Cells Tissues Organs (2001) 169 (4): 347-354. (karger.com)
  • generalized hemorrhages in all tissues and organs (2). (cdc.gov)
  • Sepsis arises when the body's response to infection injures its own tissues and organs. (who.int)
  • Since organs are in such short supply compared with the thousands of people on the transplant waiting list, screening for infectious diseases in organ donors is not as restrictive as for blood and tissue donors. (cdc.gov)
  • Better screening of donors has reduced the risk of transmitting HIV, hepatitis B, and hepatitis C. However, there will always be a risk of infectious diseases being transmitted from donated blood, organs, and tissues - no matter what screening or testing is done - because pathogens can evade testing, and sometimes testing can't be done because laboratory methods have not been developed yet for the pathogen. (cdc.gov)
  • For blood, these questions can be asked directly of the donor, while for organs and tissues, the donor is most commonly deceased, so the history is obtained from next of kin or a very close friend. (cdc.gov)
  • We examined the virulence, transmission dynamics and response to antibiotic treatment of coral species exhibiting different types of tissue loss lesions from two regions in Florida. (frontiersin.org)
  • Montastraea cavernosa with subacute tissue loss lesions in the southeast Florida region near Fort Lauderdale was compared to corals (multiple species) with acute tissue loss lesions in the Middle Keys. (frontiersin.org)
  • Fibroblastic connective tissue nevus (FCTN) represents a rare and distinct benign cutaneous mesenchymal lesion of fibroblastic/myofibroblastic lineage, which broadens the spectrum of lesions presently recognized as connective tissue nevus. (lww.com)
  • Oral tissue biopsy may be necessary for lesions that cannot be diagnosed on the basis of the history and clinical findings alone. (medscape.com)
  • Malignancy is suspected when persistent oral mucosal lesions are red or red and white or when they are ulcerated, indurated, or fixed to deeper tissues. (medscape.com)
  • Bowel lesions that are exudative or cause significant tissue edema, leading to obstruction. (cdc.gov)
  • METHODS: We have analysed short- and long-read RNA sequencing data from breast tumours, breast cancer cell lines, and normal tissues to create a. (lu.se)
  • METHODS: We have analysed short- and long-read RNA sequencing data from breast tumours, breast cancer cell lines, and normal tissues to create a comprehensive annotation of ER transcripts and combined it with experimental studies of full-length protein and six alternative isoforms. (lu.se)
  • Here, we used oligonucleotide and tissue microarrays to survey HE4 gene and protein expression in a large group of malignant and normal tissues from adults. (nature.com)
  • BioChain's human adult normal multiple tissue panels are designed for studying tissue specific cellular localization of genes or proteins of interest in different human normal tissues. (biochain.com)
  • The repository covers a wide variety of species and diseases, including human adult normal tissues, human diseased and tumor tissues, as well as mouse, rat, and monkey tissues. (biochain.com)
  • Fibroblastic Connective Tissue Nevus: A Rare Cutaneous Lesio. (lww.com)
  • Arrector pilli are small muscles located in the connective tissue. (pearson.com)
  • Arrector pilli are small muscles located in the connective tissue beneath the skin and are connected to the base of each hair. (pearson.com)
  • Drugs used to manage connective tissue disease (CTD) associated with interstitial lung disease (ILD) (CTD-ILD) include nintedanib, corticosteroids, and antineoplastic agents. (medscape.com)
  • BACKGROUND: Multiple sclerosis (MS) is a progressively debilitating neurological condition in which the immune system abnormally erodes the myelin sheath insulating the nerves. (cellmedicine.com)
  • Pain affecting multiple joints in the absence of inflammation may be due to increased joint laxity with excessive trauma, as in benign hypermobility syndrome. (msdmanuals.com)
  • This study in Iraq used in situ hybridization to detect the frequency and genotyping of HPV in tissue specimens from 129 patients diagnosed with malignant breast cancer, 24 with benign breast tumours and 20 healthy controls. (who.int)
  • Only 3 benign breast tumour tissues (12.5%) and none of the healthy breast tissue specimens were HPV-DNA-positive. (who.int)
  • Featuring fast 1 , efficient resection, advanced fluid management and pathology optimized tissue removal devices, the TruClearâ„¢ system offers a complete technology platform for the removal of a range of intrauterine abnormalities. (medtronic.com)
  • Ability to visualize multiple targets simultaneously is important in cancer immunology research, where it is necessary to catalog subsets of immune and cancer cells within the tumor microenvironment. (cellsignal.com)
  • In vitro spermatogenesis could indeed be proposed to patients with testicular localization of residual tumor cells, for whom testicular tissue autografting is not indicated (about 30% of patients with acute leukemia). (elifesciences.org)
  • Matrix metalloproteinases ( MMPs ) and tissue inhibitor of metalloproteinases (TIMPs) play a vital role in the pathogenesis of multiple myeloma (MM), especially for tumor invasion and osteolytic osteopathy. (bvsalud.org)
  • Identical format total RNA Northern Blots are available, and cDNA from those tissues may also be available for PCR detection. (biochain.com)
  • We demonstrate the general use of our approach by 4D imaging of organelles and fine structures in epithelial human cells, colonies of mouse embryonic stem cells, brain cells, and organotypic tissues. (nature.com)
  • This study reports useful information on the limits of the organotypic culture of neonatal mouse testes, which has been regarded as an experimental strategy that can be extended to humans in the clinical setting for the conservation and subsequent re-use of testicular tissue. (elifesciences.org)
  • The organotypic culture procedure, which preserves testicular tissue architecture, microenvironment and cell interactions, has been used successfully to obtain spermatozoa from fresh or frozen/thawed mouse prepubertal testicular tissues ( 3 - 6 ). (elifesciences.org)
  • It has been previously shown that supplementing organotypic culture media with retinol improves the in vitro production of spermatids and spermatozoa in prepubertal mouse testicular tissues cultured at a gas-liquid interphase ( 5 , 7 ). (elifesciences.org)
  • Of the 77 cases evaluated, 56 (72%) had at least some clinical information available, and 35 (45%) had preliminary autopsy reports submitted with the tissue specimens. (cdc.gov)
  • Documentation of tissues' clinical histories is available upon request. (biochain.com)
  • In addition, a discussion of the clinical implications, as a result of the latest developments in research in tissue and organ mechanosensitivity will provide valuable insights for clinicians, whilst pharmacological and pharmacokinetics focused reviews, will be of particular interest to researchers, searching for targets for new drugs and therapies. (springer.com)
  • Simulex soft tissue replacement insert for single leg model. (anatomywarehouse.com)
  • Soft Tissue Biopsy Ultrasound Training Block Model CAE Healthcare designed all their CAE Blue Phantom signature Blue Blocks entirely of their patented Simulex tissue. (anatomywarehouse.com)
  • William D. Tap, MD , of Memorial Sloan Kettering Cancer Center, discusses negative study findings on doxorubicin plus olaratumab vs doxorubicin plus placebo, which showed no difference in overall survival between the two treatments in patients with advanced soft-tissue sarcomas. (ascopost.com)
  • All bacteria were evaluated by a broad-range PCR assay that targets a segment of the 16S ribosomal DNA gene in DNA extracted from formalin-fixed, paraffin-embedded tissue ( 2 ). (cdc.gov)
  • The other study looks at immune cells in multiple tissues from adult individuals, providing a framework for prediction of cell type identity and insights into immunological memory. (sanger.ac.uk)
  • In the second study **, scientists from the Wellcome Sanger Institute, the University of Cambridge, and their collaborators simultaneously analysed immune cells across 16 tissues from 12 individual adult organ donors. (sanger.ac.uk)
  • We have created a catalogue of immune cells within the adult human body, allowing us to automatically identify cell types across multiple tissues. (sanger.ac.uk)
  • however, the expression in normal and malignant adult tissues has not been examined in detail. (nature.com)
  • Here, we examined the expression of the HE4 gene and protein in a large series of normal and malignant adult tissues by oligonucleotide microarray and tissue microarray, respectively. (nature.com)
  • In conclusion, this study reports the failure of adult Leydig cell development and altered steroid production and signaling in tissue cultures. (elifesciences.org)
  • Tissue typing is a procedure in which the tissues of a prospective donor and recipient are tested for compatibility prior to transplantation. (wikipedia.org)
  • Mismatched donor and recipient tissues can lead to rejection of the tissues. (wikipedia.org)
  • If HLA from the donor is recognized by the recipient's immune system as different from the recipient's own HLA, an immune response against the donor tissues can be triggered. (wikipedia.org)
  • DSAs are strongly associated with the rejection of donor tissues in the recipient, and their presence is considered an indicator of antibody-mediated rejection. (wikipedia.org)
  • When donor and recipient HLA are matched, donor tissues are significantly more likely to be accepted by the recipient's immune system. (wikipedia.org)
  • It's very important for everyone to consider giving consent to be an organ and tissue donor, and to share that decision with their family. (cdc.gov)
  • The proteasome, a key component of the ubiquitin-proteasome pathway (UPP), has emerged as a validated target of multiple myeloma (MM) therapeutics. (scienceopen.com)
  • Multiple myeloma. (scienceopen.com)
  • Sagar Lonial, MD , of Winship Cancer Institute of Emory University, discusses the potentially practice-changing phase III findings showing that lenalidomide substantially delayed progression of smoldering multiple myeloma to aggressive disease when compared with observation alone (Abstract 8001). (ascopost.com)
  • Matrix metalloproteinases and tissue inhibitors in multiple myeloma: promote or inhibit? (bvsalud.org)
  • A comparison of hysteroscopic mechanical tissue removal with bipolar electrical resection for the management of endometrial polyps in an ambulatory care setting: preliminary results. (medtronic.com)
  • The research team developed new technologies to submit these tissues to mechanical deformations. (medicalnewstoday.com)
  • This book series, Mechanosensitivity in Cells and Tissues, is devoted to the specific response of cells and tissues to mechanical stimulation and has been intensively studied during recent years. (springer.com)
  • Looking for multiple donors or additional samples? (biochain.com)
  • CDC receives tissue specimens routinely from patients with confirmed or suspected infectious diseases and provides histopathologic, immunohistochemical, and molecular evaluations. (cdc.gov)
  • Early in the 2009 influenza A (H1N1) virus pandemic, CDC provided guidelines for submission of tissue specimens for evaluation of influenza virus infections. (cdc.gov)
  • Tissue specimens also were evaluated by various immunohistochemical assays using antibodies that are specifically reactive with S. pneumoniae , Streptococcus pyogenes , Staphylococcus aureus, or Haemophilus influenzae . (cdc.gov)
  • Previously underexplored immune cell populations have been mapped across multiple tissues in development and adulthood to provide new insights into how our immune system works. (sanger.ac.uk)
  • But in pathological conditions or ageing tissue, fracking may cause or aggravate inflammatory diseases characterized by the infiltration of fluid in tissues. (medicalnewstoday.com)
  • Hand arm vibration syndrome (HAVS) involves pathological changes in multiple tissues. (cdc.gov)
  • One study focuses on the early development of the immune system and the localisation of immune cells across several tissues. (sanger.ac.uk)
  • Published today (12 May 2022) in Science , both studies explore the similarities and differences of immune cells across different tissues, which are understudied, compared to those circulating in the blood. (sanger.ac.uk)
  • They used spatial transcriptomics and single-cell RNA sequencing to map the exact location of specific cells within developing tissues. (sanger.ac.uk)
  • This comprehensive atlas of human immune development reveals tissues involved in the formation of blood and immune cells, enhancing our understanding of immune and blood disorders. (sanger.ac.uk)
  • Using CellTypist and further in-depth analysis, the researchers created a cross-tissue immune cell atlas that revealed the relationship between immune cells in one tissue and their counterparts in others. (sanger.ac.uk)
  • For example, some memory T cells show unique features depending on which tissue they are in. (sanger.ac.uk)
  • The Multiple Species Tissue Array (MSTA) slides were designed to study protein expression patterns in different cells and tissues from multiple species. (prosci-inc.com)
  • To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. (routledge.com)
  • Observing the interplay of organelles and macromolecular complexes inside living cells and tissues calls for the continuous development of minimally invasive optical systems performing at high spatio-temporal resolution. (nature.com)
  • A nanoscope able to record robust raw data rapidly and with sub-100 nm spatial resolution across the entire 3D space of cells and tissues is still missing. (nature.com)
  • All types of cells attempted grew extremely well in the gelatin balls: skin cells, connecting tissue cells, cartilage cells, early stages of fat cells, and mammary gland cells. (expertsvar.se)
  • Injection under the skin of spheres containing connecting tissue cells and fat cells led to good regeneration of tissue. (expertsvar.se)
  • Mast cells are numerous and widely distributed throughout the skin and the connective tissues that support arteries, veins, nerves, skeletal muscles and tendons in the tail. (cdc.gov)
  • of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)
  • A complete in vitro spermatogenesis has been obtained from mouse prepubertal testicular tissue, although with low efficiency. (elifesciences.org)
  • Histological, RT-qPCR, western blot analyses and steroid hormone measurements were performed on in vitro cultured mouse prepubertal testicular tissues and age-matched in vivo controls. (elifesciences.org)
  • Several fertility restoration approaches, whose aim is to mature cryopreserved tissues in vivo or in vitro in order to produce spermatozoa, are being developed. (elifesciences.org)
  • Derangement of blood clotting mechanism, plus degenerative changes in walls of blood vessels, resulting in multiple microscopic to massive hemorrhages (12). (cdc.gov)
  • Biopsy is often the definitive procedure that provides tissue for microscopic analysis when additional information is required to guide any indicated therapy. (medscape.com)
  • For decades, scientists have been looking for the molecules that are directly responsible for tissue damage during the course of fungal diseases. (abdn.ac.uk)
  • Using tissue microarrays and full tissue sections of normal and 448 neoplastic tissues, HE4 immunoreactivity was found in normal glandular epithelium of the female genital tract and breast, the epididymis and vas deferens, respiratory epithelium, distal renal tubules, colonic mucosa, and salivary glands, consistent with HE4 gene expression. (nature.com)
  • However, the involution can lead to tissue destruction and scarring that permanently impairs function. (medscape.com)
  • Outbreaks of coral disease, especially tissue loss diseases (white syndromes), have damaged coral reefs worldwide, with the first outbreaks reported from the Caribbean in the 1970s ( Dustan, 1977 ). (frontiersin.org)
  • The tissue loss diseases are the most virulent (highest host mortality), and Florida's reefs have had multiple outbreaks. (frontiersin.org)
  • Our conversation is based on his report on infections in organ and tissue transplants, which appears in CDC's journal, Emerging Infectious Diseases . (cdc.gov)
  • The topics are discussed in a form of review articles, written by leading researchers who study the mechanosensitivity process at the molecular, cellular, tissue and whole organ levels. (springer.com)
  • The result was excellent regeneration of tissue inside the spheres, which were then degraded and disappeared, and there were no signs of rejection. (expertsvar.se)
  • Overall, as well as its catalytic function, AS160 influences expression of other proteins, and its loss deregulates basal and insulin-regulated glucose homoeostasis, not only in tissues that normally express AS160, but also by influencing liver function. (dundee.ac.uk)
  • Multiplex IHC enables a deeper understanding of co-expression and spatial organization of multiple targets within preserved tissue architecture, especially important when tissue samples are limited. (cellsignal.com)
  • The discovery of fracking in living tissues open avenues to new biotechnological applications. (medicalnewstoday.com)
  • SCTLD is causing extensive mortality of multiple coral species and disease signs vary among affected coral species with differences in rates of tissue loss (acute and subacute), lesion morphology (adjacent bleached zone or not) and lesion occurrence (focal and multi-focal). (frontiersin.org)
  • For blood and tissues, the screening is more stringent, and any risk for infection found, either through behavior history or laboratory testing, results in the donation being declined. (cdc.gov)
  • AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. (dundee.ac.uk)
  • HBTB also has brain samples (mainly from the cerebral cortex) with zero-hour postmortem delay, i.e., tissue samples were taken during neurosurgery and frozen on dry ice right in the surgical room. (msdiscovery.org)
  • a , b Histology of the wedge resection specimen, displaying a pancreatic duct in ectopic pancreatic tissue. (springeropen.com)
  • Clarke, P.G.H. (1990) Developmental cell death: Morphological diversity and multiple mechanisms. (karger.com)
  • In this study, we show that contactin associates with Na v 1.3 in P0 brain tissue and interacts with both the N and C termini of Na v 1.3. (jneurosci.org)
  • Note: The Human Brain Tissue Bank is a member of BrainNet Europe. (msdiscovery.org)
  • A head MRI (magnetic resonance imaging) is an imaging test that uses powerful magnets and radio waves to create pictures of the brain and surrounding tissues. (medlineplus.gov)
  • An MRI provides detailed pictures of the brain and nerve tissues. (medlineplus.gov)
  • During tissue typing, an individual's human leukocyte antigens (HLA) are identified. (wikipedia.org)
  • The tissue samples are made available after signing a statement about scientific collaborations with the HBTB ( http://humanbraintissuebank-budapest.sote.hu/dokument/FormNo1.pdf ) and a declaration of the proper use of human samples strictly for research studies ( http://humanbraintissuebank-budapest.sote.hu/dokument/FormNo2.pdf ). (msdiscovery.org)
  • Tissue samples were taken from the cervicothoracic region of normal human conceptuses. (karger.com)
  • The UK Human Tissue Act and consent: surrendering a fundamental principle to transplantation needs? (bmj.com)
  • Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
  • WBM Care facial tissue is 2-ply, high absorbent, ultra-soft and strong. (fredmeyer.com)
  • Benny Iswandy, Chief Executive for Asia Pulp & Paper's Indonesian-based global tissue business unit, also foresees impressive growth ahead: "We are servicing the worldwide market and we are seeing a much greater awareness of the importance of personal hygiene, so we expect the increased demand for tissue products such as toilet paper, facial and hand towel, sanitising wet wipes, and PPE to continue. (tissueworldmagazine.com)
  • Is it a problem for blood transfusions and tissue transplants, too? (cdc.gov)
  • It's been estimated that about one in 200, or half of one percent of organ transplants, possibly transmit unexpected infections, and this rate is likely much lower in blood and tissue. (cdc.gov)
  • Optimal tissue embedding is essential for smooth sectioning and ribboning. (leicabiosystems.com)
  • In this study, we investigated the metabolic stability, metabolite production, metabolic pathways and plasma protein binding (PPB) of FHND6081 along with its absorption, tissue distribution, excretion (ADME) and pharmacokinetics (PK) in animals. (scienceopen.com)