Multiple therapies combination. Medical search. Frequent questions

In a phase III trial published in the journal Lancet Oncology on September 18, 2014, researchers San-Miguel et al investigated the potential of combination therapy with panobinostat, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma. (pharmacytimes.com)
In a press release, lead author of the 215-site clinical trial Jesus San-Miguel, MD, stated, "The PANORAMA-1 study is the first Phase III trial to show the superiority of LBH589 plus bortezomib and dexamethasone over one of the standard two-drug regimens for patients with relapsing and/or refractory multiple myeloma. (pharmacytimes.com)
Further research will determine whether panobinostat affects overall survival and whether the tradeoff of clinical benefits and adverse events justify approval of the treatment for patients with relapsed multiple myeloma. (pharmacytimes.com)
Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial. (pharmacytimes.com)
CHICAGO and RARITAN, NJ, June 4, 2017 - Janssen Research & Development, LLC today announced new data from updated analyses of the pivotal Phase 3 CASTOR and POLLUX clinical studies, demonstrating that DARZALEX ® (daratumumab) in combination with bortezomib and dexamethasone, or lenalidomide and dexamethasone, improved progression-free survival (PFS) and the overall response rate (ORR) for previously-treated patients with multiple myeloma, regardless of cytogenetic risk. (jnj.com)
Additionally, data from the Phase 1b MMY1001 study will show the potential of daratumumab in combination with carfilzomib, lenalidomide and dexamethasone (KRd) for newly diagnosed patients with multiple myeloma. (jnj.com)
These data represent the first assessment of daratumumab in combination with a next generation proteasome inhibitor (PI) and an immunomodulatory agent earlier in the treatment paradigm for multiple myeloma. (jnj.com)
Combination of bortezomib, thalidomide, and dexamethasone (VTD) as a consolidation therapy after autologous stem cell transplantation for symptomatic multiple myeloma in Japanese patients. (stembook.org)
Maintenance therapy for multiple myeloma (MM) occurs after successful treatment. (medicalnewstoday.com)
HealthDay News) - For patients with relapsed or refractory multiple myeloma, combination treatment with elotuzumab, lenalidomide, and low-dose dexamethasone is generally well tolerated, with encouraging response rates, according to a study published online April 30 in the Journal of Clinical Oncology . (cancertherapyadvisor.com)
Sagar Lonial, MD, of the Winship Cancer Institute at Emory University in Atlanta, GA, and colleagues conducted a Phase 1 study to evaluate the dose-limiting toxicities and response rates associated with elotuzumab, lenalidomide, and low-dose dexamethasone treatment in 28 patients with relapsed or refractory multiple myeloma (median, 3 prior multiple myeloma therapies). (cancertherapyadvisor.com)
Multiple myeloma (MM) is treated with several categories of medications. (medscape.com)
It is indicated for the palliative treatment of multiple myeloma. (medscape.com)
Bortezomib is indicated for patients with multiple myeloma. (medscape.com)
It is indicated as monotherapy, in combination with dexamethasone, or in combination with lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma in patients who have received at least 1 prior line of therapy. (medscape.com)
Our goal is to improve the outcomes for patients with multiple myeloma and we believe that developing a robust clinical data set across BCMA modalities and treatment lines can help us demonstrate where within the multiple myeloma treatment landscape nirogacestat has the greatest opportunity to maximize clinical benefit. (advfn.com)
Approvals issued in July, August, and September 2023 included a new treatment for prostate cancer harboring BRCA mutations, two new bispecific T-cell engagers for multiple myeloma, a special kit to treat liver metastases from uveal melanoma, and more. (aacr.org)
The FDA has approved another T-cell engager therapy for patients with heavily pretreated multiple myeloma The U.S. Food and Drug Administration (FDA) has granted accelerated approval to elranatamab-bcmm (Elrexfio) for the treatment of adult. (aacr.org)
Certain patients with advanced multiple myeloma may be eligible for treatment with a new immunotherapy drug. (aacr.org)
Multiple myeloma is a cancer that affects plasma cells in the bone marrow. (healthline.com)
In multiple myeloma , these cells grow and divide out of control, leading to tumors in the bones . (healthline.com)
These tumors can crowd out healthy blood cells, leading to the symptoms associated with multiple myeloma like bone pain and bruising easily. (healthline.com)
The National Cancer Institute estimates that multiple myeloma makes up about 1.8 percent of all new cancer diagnoses each year. (healthline.com)
There are several risk factors for multiple myeloma, including age, genetics, and environmental exposures. (healthline.com)
Below, we'll take a closer look at the different risk factors for multiple myeloma as well as how the condition is diagnosed and treated. (healthline.com)
Before we jump in, it's important to know that having risk factors for multiple myeloma doesn't mean that you'll develop it in the future. (healthline.com)
It's possible to have one or more risk factors and never get multiple myeloma. (healthline.com)
By the same token, an individual can have no risk factors and still develop multiple myeloma. (healthline.com)
The risk of multiple myeloma increases with age. (healthline.com)
At the time of diagnosis most people with multiple myeloma are aged 65 or older. (healthline.com)
It's possible for multiple myeloma to occur in young individuals, but this is rare. (healthline.com)
According to the American Cancer Society (ACS), less than 1 percent of multiple myeloma diagnoses are in people under age 35. (healthline.com)
Multiple myeloma happens at a slightly higher rate in males than in females. (healthline.com)
Research from 2011 found differences in specific genetic events between males and females with multiple myeloma. (healthline.com)
The researchers theorized that these differences could influence further genetic changes that contribute to multiple myeloma. (healthline.com)
Having other plasma cell conditions can raise a person's risk of getting multiple myeloma. (healthline.com)
However, in some people with MGUS, the condition can progress into multiple myeloma. (healthline.com)
It's believed that almost all instances of multiple myeloma are due to MGUS progression. (healthline.com)
However, solitary plasmacytoma can often develop into multiple myeloma. (healthline.com)
About 65 to 84 percent of solitary plasmacytomas progress to multiple myeloma in 10 years. (healthline.com)
Family history has been found to be associated with increased multiple myeloma risk. (healthline.com)
A large cohort study in Sweden found that, compared to a control group, close relatives of people with multiple myeloma had about twice the risk of developing the condition themselves. (healthline.com)
So, if a close family member, such as a parent or sibling, has been diagnosed with multiple myeloma, you may be more likely to develop it as well. (healthline.com)
A total of 23 genetic regions , which are also associated with MGUS, have been identified as related to multiple myeloma risk. (healthline.com)
However, it's important to note that you can have no family history of multiple myeloma and still develop it. (healthline.com)
According to the ACS, multiple myeloma is over twice as common in African Americans compared to white Americans. (healthline.com)
One reason for this disparity may have to do with MGUS, which is a precursor condition to multiple myeloma. (healthline.com)
Treatment protocols for multiple myeloma are provided below. (medscape.com)
In general, the first decision made in the management of patients with myeloma who require systemic therapy is whether stem cell transplantation is part of the strategy. (medscape.com)
Patients who present with active (symptomatic) multiple myeloma are treated with induction therapy. (medscape.com)

BRAF and BRAF/MEK inhibitor combinations are useful in some patients to slow the progression of disease. (medscape.com)
In patients with no BRAF mutation (ie, wild-type BRAF ), current guidelines from the National Comprehensive Cancer Network (NCCN) recommend single-agent immunotherapy with the programmed cell death-1 (PD-1) inhibitor pembrolizumab or nivolumab or combination therapy with nivolumab plus ipilimumab. (medscape.com)
[ 1 ] This is not currently offered to patients unless there are contraindications to giving PD-1 inhibitors or BRAF/MEK inhibitor combinations. (medscape.com)
The FDA approved a combination of the PARP inhibitor niraparib with a hormone therapy agent for certain patients with metastatic prostate cancer The U.S. Food and Drug Administration (FDA) has approved the combination of. (aacr.org)
The FDA has approved an immune checkpoint inhibitor in combination with chemotherapy to treat certain adult patients with endometrial cancer The U.S. Food and Drug Administration (FDA) has approved dostarlimab-gxly (Jemperli) in combination with. (aacr.org)
The FDA has approved an inhibitor of FLT3 for use across multiple phases of acute myeloid leukemia treatment. (aacr.org)
Like the developers of LSD1 combination therapies, 4SC AG researchers are pairing an epigenetic drug, in this case an HDAC inhibitor, with immunotherapies. (genengnews.com)
Clinical trials are also ongoing with the unarmed enadenotucirev virus in different tumor types and in combination trials with a checkpoint inhibitor and with a chemotherapeutic. (biospace.com)
Methods This non-randomized, multicohort, phase II study evaluated the efficacy and safety of the anti-PD-1 antibody nivolumab 240 mg administered every 2 weeks in combination with the CDK4/6 inhibitor abemaciclib 150 mg twice daily and either fulvestrant (FUL) or letrozole (LET) as a first-line or second-line treatment for HR-positive HER2-negative metastatic breast cancer. (bmj.com)
Because alternatives to the use of rifampin for antituberculosis treatment are now available, the previously recommended practice of stopping protease inhibitor therapy to allow the use of rifampin for TB treatment is no longer recommended for patients with HIV-related TB. (cdc.gov)
Immune-Checkpoint-Inhibitor Therapy-Principles and Relevance of Biomarkers for Pathologists and Oncologists. (bvsalud.org)
Immune-checkpoint-inhibitor (ICI) therapy has been one of the major advances in the treatment of a variety of advanced or metastatic tumors in recent years. (bvsalud.org)

Heart function in mice with heart failure improved by 58 percent when they were given sTGFβR2 alone or in combination with either of the other two genes, showing that a combined therapeutic treatment of FGF21 and sTGFβR2 could successfully treat all four age-related conditions, therefore improving health and survival. (technologynetworks.com)
Combination therapy has gained momentum in oncology in recent years, with various studies demonstrating higher response rates with combinations of drugs compared to monotherapies, and the FDA recently approving therapeutic combination regimens that demonstrated superior safety and efficacy to monotherapies. (wikipedia.org)
Monotherapy, or the use of a single therapy, can be applied to any therapeutic approach, but it is most commonly used to describe the use of a single medication. (wikipedia.org)
A single-pill combination promotes less therapeutic inertia, more patient adherence and monetary savings. (escardio.org)
We are here for our patients - from the most advanced and complex genetic testing in our Center for Cancer Genetics and Prevention, to the lightest touch of therapeutic massage in our Zakim Center for Integrative Therapies. (dana-farber.org)
The platform uses the enadenotucirev oncolytic virus as a vector to deliver combinations of therapeutic transgenes to carcinomas to fight cancer. (biospace.com)
A research team led by a scholar from City University of Hong Kong (CityU) has recently developed a novel artificial intelligence (AI) framework that can make synergistic anti-cancer drug combination predictions on both the therapeutic and toxic effects. (eurekalert.org)
To achieve the best therapeutic effect, multiple types of drugs are commonly prescribed by doctors to treat complex diseases like cancers and HIV/AIDS. (eurekalert.org)
According to the public dataset that the team obtained, the therapeutic effect of one of the drug combinations is considered not so significant. (eurekalert.org)
Stoyanova lab utilizes multiple approaches to develop new therapeutic strategies for late-stage cancers including discovery and testing new therapeutic targets and new small molecule inhibitors. (stanford.edu)
We are testing multiple experimental agents in combination with FDA-approved cancer therapies to enhance therapeutic responses. (stanford.edu)
Nonetheless, some phytochemicals in combination with IR may play a significant role in enhancing the therapeutic index of cancer treatment. (nih.gov)

Artemisinin-based Combination Therapy ACTs and only 10% of them on average slept under ITN. (who.int)
interventions, such as antiretroviral therapy, long-lasting insecticide-treated bednets, artemisinin-based combination therapy, vaccines against pneumonia and diarrhoeal disease, and new and better diagnostic tests for multiple diseases. (who.int)

Recent precision medicine approaches have focused on targeting multiple biomarkers found in individual tumors by using combinations of drugs. (wikipedia.org)
I think the future of oncology, in terms of treating solid tumors , will be these combination therapies," Dr. Hermann says. (genengnews.com)
OXFORD, England and SAN FRANCISCO , Nov. 15, 2018 /PRNewswire/ -- PsiOxus Therapeutics Limited (PsiOxus) and the Parker Institute for Cancer Immunotherapy (Parker Institute) today announced a research project to investigate the use of PsiOxus' virus-based gene therapy for treating solid tumors that have been historically resistant to immunotherapy. (biospace.com)
Our work is product and platform based with a focus on discovering and developing gene-based immuno-oncology therapies for the treatment of solid tumors. (biospace.com)
Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. (lu.se)
Therefore, ICI- therapy is already approved in first-line therapy for multiple tumors , either as monotherapy or as combination therapy . (bvsalud.org)

As stand-alone maintenance therapies, there is limited evidence to confirm that proteasome inhibitors work. (medicalnewstoday.com)
In particular, tests have looked at whether lenalidomide may work better in combination with various other medications including proteasome inhibitors. (medicalnewstoday.com)
Monotherapy remains an option for PAH treatment 14 , 15 , 16 recommended in guidelines 17 as first-line therapy for World Health Organization functional class (FC) II-III patients, with the same grade of evidence and recommendation (IA-IB) for endothelin receptor antagonists (ERA) and phosphodiesterase-5 (PDE5) inhibitors. (jrheum.org)
Our study was designed to evaluate the longterm efficacy and safety of combination therapy with PDE5 inhibitors and ERA versus monotherapy in a large Spanish nationwide SSc-related PAH cohort. (jrheum.org)
What could be truly exciting, Dr. Lee notes, is the combination of LSD1 inhibitors with antibodies that block programmed cell death-1 (PD-1), a cell surface receptor that keeps the immune system in check. (genengnews.com)
Background Hormone receptor (HR)-positive breast cancer is a disease for which no immune checkpoint inhibitors have shown promise as effective therapies. (bmj.com)
Our results suggest that Ras pathway inhibitors in combination with KSP inhibition represent a promising treatment strategy against neuroblastoma. (lu.se)

Daratumumab appeared to improve poor outcomes associated with high risk cytogenetics, and these data support its consistent clinical benefit in combination with two of the most widely used treatment classes. (jnj.com)
The evidence to date suggests that adherence to therapy and clinical outcomes in developing world programmes are at least the equal of those observed in developed countries. (lww.com)
Therefore, the funding bodies responsible for the roll-out of antiretroviral access across the globe must mandate, incorporate and fund clinical research as an intrinsic aspect of combination ART roll-out programmes. (lww.com)
In a recent study about solid cancers, Martin Nowak, Bert Vogelstein, and colleagues showed that in most clinical cases, combination therapies are needed to avoid the evolution of resistance to targeted drugs. (wikipedia.org)
This included a face-to face meeting where the available evidence was discussed as well as individual clinical experience with this therapy was shared. (researchgate.net)
While the net clinical benefit favours an initial two-drug therapy, physicians should be vigilant in relation to vulnerable patients and individualise therapy accordingly. (escardio.org)
Neoadjuvant therapy for high-risk resectable melanoma has demonstrated significant efficacy in early clinical trials. (medscape.com)
Updated clinical data from the Phase 1/2 study sponsored by GSK plc (LSE/NYSE: GSK) evaluating nirogacestat in combination with low-dose belamaf (belantamab mafodotin-blmf), GSK's antibody-drug conjugate targeting BCMA, in patients with RRMM will be presented in a poster presentation. (advfn.com)
In addition, new data from the Phase 1b clinical trial sponsored by Janssen Research & Development, LLC (Janssen) evaluating nirogacestat in combination with teclistamab, Janssen's bispecific antibody targeting BCMA and CD3, will be presented in an oral presentation. (advfn.com)
A recent clinical study involving 144 youth (ages 8 to 17) with clinical depression compared the effectiveness of antidepressant therapy combined with behavior-based counseling to antidepressant medication alone. (rightstep.com)
PsiOxus' first gene therapy program is partnered with Bristol-Myers Squibb and is in clinical development. (biospace.com)
However, the knowledge of the best combinations of drugs is usually based on clinical experience and judgements. (eurekalert.org)
A longer study that tracked SAD patients undergoing BLT for short-term (2-8 weeks) and long-term (fall and winter months for 3-6 years) treatment found that "light therapy yields about 75% clinical remissions" and was as effective as an antidepressant. (amenclinics.com)
RAPD) and antifungal drug susceptibility testing were per- concern, as the organisms exhibit low susceptibility to formed on clinical and environmental isolates recovered multiple antifungal drugs, and outcomes have been uni- from our hospital from 1999 to 2003. (cdc.gov)
However, in reviewed for clinical data (demographics, underlying dis- recent years, IA has been increasingly caused by non- fumi- ease, transplantation characteristics, antifungal therapies, gatus Aspergillus species. (cdc.gov)
Following the positive results of the IMbrave150 study ( 1 ), atezolizumab plus bevacizumab (Atz/Bev) combination therapy is widely used as 1st-line treatment in clinical practice for patients with advanced hepatocellular carcinoma (HCC) ( 2 ). (iiarjournals.org)
According to the Clinical Practice Guidelines for the Treatment of Hepatocellular Carcinoma ( 4 ), all these five agents are equally recommended as 2nd-line therapy for patients with advanced HCC after disease progression (PD) with Atz/Bev. (iiarjournals.org)
The model uses a combination of Machine Learning (ML) and a GlobalData proprietary algorithm to process data points from the Drugs, Clinical Trials, Regulatory Milestones, Company, and Financial databases. (globaldata.com)
The most notable changes in these guidelines reflect both the findings of clinical trials that evaluated new drug regimens for treating and preventing TB among HIV-infected persons and recent advances in the use of antiretroviral therapy. (cdc.gov)
The patient had some improvement in his clinical condition after anti-tuberculosis treatment, but once the diagnosis of Brucella meningitis was made, antibiotic therapy was changed to doxycycline (200 mg/day), trimethoprim/sulfmethoxazole (TMX/SMP) (2 double-strength tablets every 12 hours) and rifampicin (900 mg/day). (who.int)

Although FDC formulations simplify TB therapy, the current evidence does not indicate that these formulations improve treatment outcomes among patients with active TB. (ersjournals.com)
Combination therapies involving multiple antimicrobial agents or combining antimicrobials with non-antibiotic agents offer opportunities for improved treatment outcomes. (medgadget.com)
Combination therapy aims to optimize treatment outcomes by addressing multiple factors contributing to sleep apnea. (e-architect.com)
It is also important to note that the combination group took lower doses of antidepressant medication and nonetheless showed better outcomes compared to the youth who received stronger doses in the medication-only treatment group. (rightstep.com)

Given the potential of PsiOxus' IV-delivered cancer gene therapy platform, establishing strategic relationships with world leaders in immuno-oncology will accelerate our ability to bring gene therapy treatment to cancer patients," said Brian Champion , Ph.D., Chief Scientific Officer of PsiOxus. (biospace.com)
We are thrilled to collaborate with the Parker Institute to jointly accelerate research on innovative cancer immuno-oncology therapy. (biospace.com)

The team created separate gene therapy constructs for each gene using the AAV8 serotype as a delivery vehicle, and injected them into mouse models of obesity, Type 2 diabetes, heart failure, and renal failure both individually and in combination with the other genes to see whether there was a positive synergistic effect. (technologynetworks.com)
Synergistic combinations can enhance efficacy, broaden the spectrum of activity, and reduce the development of resistance. (medgadget.com)
It is a novel AI framework that can make synergistic chemotherapy drug combination predictions. (eurekalert.org)
By analysing the relations between the protein modules targeted by drugs and the protein modules associated with cancer cell lines in the human protein-protein-interaction network (PPI), and the interrelations among the protein modules, this deep-learning-based algorithm can identify synergistic drug combinations that yield effective therapy with less toxicity. (eurekalert.org)
So, we used AI to analyse the proteins that are targeted by drugs and the cancer cells, as well as the interrelations among the proteins, to help predict synergistic cancer drug combinations accurately,' said Dr Zhang. (eurekalert.org)
He emphasised that the predictions are made by examining not only the directly targeted proteins by drugs and the cancer cells, but also the relations between the proteins, thus yielding a superior performance in identifying the best synergistic anti-cancer drug combination of low toxicity. (eurekalert.org)
They found that GraphSynergy's prediction performance is better in identifying synergistic drug combinations of low toxicity. (eurekalert.org)
To verify the predictions made by GraphSynergy, the team selected clinically verified synergistic drug combinations to run the algorithm. (eurekalert.org)
And GraphSynergy predicted such combination is synergistic too. (eurekalert.org)
Overall, this review highlights the possibilities of synergistic therapy by building on existing research. (nature.com)

Second-line combination antiretroviral therapy in resource-l. (lww.com)
Combination antiretroviral therapy (ART) has dramatically altered the prognosis of individuals infected with HIV. (lww.com)
The year 2006 marked 25 years since the first description of AIDS and 10 years since the advent of the potent, combination antiretroviral therapy (ART) that has had such a dramatic success in reducing AIDS and prolonging the duration and quality of life of those living with HIV infection [1-4] . (lww.com)
In September 1997, when CDC convened a meeting of expert consultants to discuss current information about HIV-related TB, special emphasis was given to issues related to coadministration of TB therapy and antiretroviral therapy and how to translate this information into management guidelines. (cdc.gov)
All HIV-infected patients undergoing treatment for TB should be evaluated for antiretroviral therapy, because most patients with HIV-related TB are candidates for concurrent administration of antituberculosis and antiretroviral drug therapies. (cdc.gov)
Physicians and patients also should be aware that paradoxical reactions might occur during the course of TB treatment when antiretroviral therapy restores immune function. (cdc.gov)
more detailed information about antiretroviral therapy is published elsewhere (4). (cdc.gov)

In effect, the T-SIGn viruses work by turning tumor cells into "drug factories" to express gene therapy products, such as cytokines or antibodies, designed to engage the immune system to attack cancer cells. (biospace.com)
T-SIGn gene therapy products are "armed" through the addition of genes that cause the tumor to express combinations of biologics including antibodies, cytokines, immunomodulatory proteins, or nucleotides (RNA). (biospace.com)

PsiOxus has multiple additional preclinical gene therapy programs in development. (biospace.com)

The tumor cells then express the encoded genes, producing biologic therapies to alter the tumor microenvironment. (biospace.com)
Sustained and inadequately controlled hypertension can promote the development of age-related macular degeneration (AMD) through multiple biologic pathways. (cdc.gov)

The choice of chemotherapy depends on several factors, including the patient's performance status, age, renal function, desire for inpatient or outpatient therapy, and likelihood of receiving future autologous stem cell transplantation. (medscape.com)
This is a very different approach from that taken by pioneer chemotherapists in Africa, where it was felt that the host response provided an important part of therapy, and too much chemotherapy could, by abrogating immunological defences against the tumor, lead to a negative result. (hindawi.com)
Nonetheless, today, most patients with BL can be cured with intensive conventional chemotherapy by accepting the fact that some will be over-treated, but directing research towards trying to identify such patients and minimizing therapy to the extent possible. (hindawi.com)

Various systems biology methods must be used to discover combination therapies to overcome drug resistance in select cancer types. (wikipedia.org)
However, with 300 FDA-approved cancer drugs on the market, there almost 45,000 possible two-drug combinations and almost 4.5 million three-drug combinations for to choose from. (wikipedia.org)
We want you to take advantage of everything Cancer Therapy Advisor has to offer. (cancertherapyadvisor.com)
Want to view more content from Cancer Therapy Advisor ? (cancertherapyadvisor.com)
The Leonard P. Zakim Center for Integrative Therapies and Healthy Living is dedicated to enhancing the quality of life for cancer patients and their families by incorporating complementary therapies into traditional cancer care. (dana-farber.org)
The FDA approved a combination of trifluridine, tipiracil, and bevacizumab for the treatment of heavily pretreated metastatic colorectal cancer. (aacr.org)
AACR Fellow Lewis C. Cantley, PhD, leads a national effort targeting triple-negative breast cancer and ovarian cancer with a novel drug combination. (aacr.org)
The talks highlighted a promising trend-epigenetic modification could be the next wave in cancer therapy, especially when exploited in tandem with the administration of other medications, 4SC AG's Chief Development Officer Frank Hermann, M.D., told GEN . (genengnews.com)
PsiOxus aims to be the world's leading cancer gene therapy company, delivering medicines of value to patients with cancer. (biospace.com)
The study revealed the potential of applying AI and machine learning to discover effective combinations in therapies for cancer and other complex diseases. (eurekalert.org)
Cancer cells are usually associated with multiple proteins, which have direct and indirect interrelations among each other and with other proteins in the PPI network. (eurekalert.org)
How to mix and match multiple drugs to treat cancer is therefore very challenging. (eurekalert.org)
Over half of cancer patients undergo radiation therapy (RT). (nature.com)
3) Targeted cancer therapies. (stanford.edu)
Ionizing radiation (IR)-induced cellular damage is implicated in carcinogenesis as well as therapy of cancer. (nih.gov)
Because radioresistance involves multiple mechanisms, more studies are needed to discover novel phytochemicals having multiple mechanisms of radiosensitization and to overcome radioresistance of cancer cells. (nih.gov)
Approximately 80% of all patients with lung cancer are considered for systemic therapy at some point during the course of their illness. (medscape.com)
In addition to PD-L1 testing of tumor tissue , liquid biopsy provides a noninvasive way to monitor disease in cancer patients and identify those who would benefit most from ICI- therapy . (bvsalud.org)

Combination therapy may seem costlier than monotherapy in the short term, but when it is used appropriately, it causes significant savings: lower treatment failure rate, lower case-fatality ratios, fewer side-effects than monotherapy, slower development of resistance, and thus less money needed for the development of new drugs. (wikipedia.org)
This protection is not short-lived, as fewer cardiovascular events were observed after one year in hypertensive patients started with combination treatment compared to those with monotherapy [7]. (escardio.org)
We are pleased that updated data from the GSK-sponsored trial continue to support our thesis that the combination with nirogacestat may further optimize the benefit-risk profile of belamaf monotherapy. (advfn.com)
As of the December 9, 2022 data cut-off, patients received a median of 4 (range 1-20) cycles of the combination and a median of 3 (range 1-9) monotherapy cycles. (advfn.com)
Monotherapy is an option as first-line therapy for pulmonary arterial hypertension (PAH). (jrheum.org)
Our objective was to evaluate the efficacy of monotherapy versus combination therapy in patients with systemic sclerosis (SSc)-associated PAH. (jrheum.org)
Patients were split into 3 groups: monotherapy versus sequential combination versus upfront combination therapy. (jrheum.org)
Survival from PAH diagnosis among monotherapy, sequential, and upfront combination groups was 78% versus 95.8% versus 94.1% at 1 year, 40.7% versus 81.5% versus 51.8% at 3 years, and 31.6% versus 56.5% versus 34.5% at 5 years (p = 0.007), respectively. (jrheum.org)
Although in guidelines 17 the grade of evidence and recommendation for combination therapy is the same as for monotherapy, more recent reports, including the AMBITION trial 18 and its posthoc analysis 19 , which focused on CTD-PAH patients, suggest combination therapy as a better option to treat PAH, demonstrating its superiority regarding morbidity and mortality. (jrheum.org)

As long as maintenance therapy is effective, individuals with MM will not need these treatments again. (medicalnewstoday.com)
Strategic management of populations of interacting biological species routinely requires interventions combining multiple treatments or therapies. (alexbrowning.me)
This approach involves combining oral appliance therapy with other treatments, such as Continuous Positive Airway Pressure (CPAP) or surgery. (e-architect.com)
Another BLT study showed remission of SAD symptoms and an "antidepressant effect" over placebo after 3 weeks of regular light therapy treatments. (amenclinics.com)
Through a combination of revolutionary treatments and extraordinary patient experiences, our care does more than heal. (akronchildrens.org)

Because the definitive treatment of cutaneous melanoma is surgery, medical management is reserved for adjuvant therapy of patients with advanced melanoma. (medscape.com)
Multiple options for adjuvant treatment of node-positive melanoma have become available. (medscape.com)
In this case-control study of 228 participants, patients with melanoma had a different structure of microbiome, with lower abundance of multiple beneficial commensals, compared with control participants. (cdc.gov)

Pharmaceutical' combination therapy may be achieved by prescribing/administering separate drugs, or, where available, dosage forms that contain more than one active ingredient (such as fixed-dose combinations). (wikipedia.org)

The combination of elotuzumab, lenalidomide, and dexamethasone appears to be active, with results from this Phase 1 study suggesting enhanced efficacy over lenalidomide and low-dose dexamethasone alone," the authors write. (cancertherapyadvisor.com)

An example of this is the treatment of multiple sclerosis, where the pharmaceutical agents have to produce their effect above all in the central nervous system. (sciencedaily.com)
To review the published literature over the last 5 years on the use of electroconvulsive therapy (ECT) in multiple sclerosis (MS), focusing on efficacy, safety, and tolerability. (psychiatrist.com)

Experimental therapies include intralesional administration of interferons and retinoids. (lu.se)

Patients had a median of 5 (range 3-14) prior lines of therapy. (advfn.com)

WASHINGTON-(BUSINESS WIRE)-A breakthrough study presented today at the annual meeting of the Congress of Neurological Surgeons found that a combination of remote cognitive behavioral therapy with in-home virtual reality sessions, Vx® Therapy, is effective in reducing pain and behavioral health conditions in patients with chronic cervical and lumbar pain. (digitalproducer.com)
While cognitive behavioral therapy (CBT) has been proven effective for chronic pain and associated anxiety, depression, and physical disability, many patients cannot access this therapy because of a shortage of trained care providers, lack of adequate transportation for in-person encounters, and inconsistent engagement in the therapy. (digitalproducer.com)
In the study, 145 workers' compensation patients with chronic degenerative neck/back pain participated in a guided 14-week virtual reality and cognitive behavioral therapy program, Vx® Therapy. (digitalproducer.com)
Then, while still on the medication, they received six months (eight to 11 sessions) of cognitive behavioral therapy or CBT. (rightstep.com)
What Is Cognitive Behavioral Therapy? (rightstep.com)
The specific form of CBT used in this trial was Relapse Prevention Cognitive Behavioral Therapy. (rightstep.com)
While there's little research specifically on psychotherapy (talk therapy) and morning depression, cognitive behavioral therapy (CBT) is well-established to help symptoms of depression. (psychcentral.com)

In this work we use optimal control theory to calculate optimal strategies for applying combination therapies to a model of acute myeloid leukaemia. (alexbrowning.me)

The use of rifabutin-containing antituberculosis regimens should always include an assessment of the patient's response to treatment to decide the appropriate duration of therapy (i.e., 6 months or 9 months). (cdc.gov)

CyBorD is the standard-of-care treatment for AL amyloidosis and is a combination of cyclophosphamide, bortezomib, and dexamethasone. (ajmc.com)
Subsequently, a combination of cyclophosphamide (CTX), vincristine (VCR), and methotrexate (MTX) was shown to be active, but a survival advantage compared to CTX alone could not be demonstrated because effective CNS prophylactic therapy, in the form of intrathecal therapy, was not given. (hindawi.com)

Adding panobinostat to a combination treatment of bortezomib and dexamethasone in heavily pretreated patients boosts progression-free survival, but overall survival data are not yet mature. (pharmacytimes.com)

In elderly patients or patients in whom autologous transplantation is not possible in the future, melphalan and prednisone (MP) therapy is preferred because of its ease of administration and low toxicity. (medscape.com)
This ongoing Phase 1/2 trial, which is sub-study 3 of GSK's DREAMM-5 platform trial (NCT04126200), aims to determine if low-dose belamaf in combination with nirogacestat results in similar efficacy with an improved ocular toxicity profile compared to belamaf alone at a higher dose. (advfn.com)
Some infectious diseases lack effective treatment options or face limitations in existing therapies, either due to resistance, toxicity, or other factors. (medgadget.com)

In the Wyss study, a single administration of an adeno-associated virus (AAV)-based gene therapy, which delivered combinations of three longevity-associated genes to mice, dramatically improved or completely reversed multiple age-related diseases, suggesting that a systems-level approach to treating such diseases could improve overall health and lifespan. (technologynetworks.com)

Drug combinations--administration and dosage. (who.int)

Most countries are implementing either single interventions or multiple interventions piecemeal but have yet to scale up their interventions. (who.int)

Blood, tissue, and fecal samples were collected at multiple points for correlative studies to evaluate immunity biomarkers. (bmj.com)
Researchers like Jose U. Scher, MD, director of the Psoriatic Arthritis Center at New York University and the NYU Colton Center for Autoimmunity, are in the thick of using multiple "-omics" tools and other sophisticated technologies to identify new targets and biomarkers. (medscape.com)
This overview focuses on the use of ICI- therapy and how it relates to common and potential future biomarkers for patient -directed treatment planning . (bvsalud.org)

Rituximab may improve the results in some patient groups and allow less intensive therapy without a reduction in survival in others. (hindawi.com)
Nonunion and segmental bone loss after fracture, reconstructive surgery, or lesion excision can present complex orthopedic problems, and the multiple surgical procedures often needed are associated with patient morbidity and reduced quality of life. (who.int)
When after 2 days the patient showed no response to therapy, isoniazid, rifampicin, streptomycin and pyrazinamide were added to the regimen to empirically treat tuberculous meningitis. (who.int)
Within a week of initiating anti-Brucella therapy, the patient became afebrile, had no further vomiting and his esotropia improved. (who.int)
Different response to ICI- therapy has been observed in the pivotal trials, so PD-L1 diagnostic testing is used for patient selection . (bvsalud.org)
Conclusion: The appropriate choice of techniques and patient compliance to the periodontal support therapy led to treatment success and periodontal health maintenance in the region during the whole follow-up period. (bvsalud.org)

New oral hormonal therapy offers alternative to injections for some women with metastatic disease. (aacr.org)
4) Antibody-based therapies for advanced prostate and other metastatic epithelial cancers. (stanford.edu)

As a result, there is no standardized treatment regimen for these drugs in the context of MM maintenance therapy. (medicalnewstoday.com)
However, scientists are unsure how effective combination therapy can be or how the side effects of combining the drugs will affect a person. (medicalnewstoday.com)
One major benefit of combination therapies is that they reduce development of drug resistance since a pathogen or tumor is less likely to have resistance to multiple drugs simultaneously. (wikipedia.org)
Furthermore, they find that the simultaneous administration of multiple targeted drugs minimizes the chance of relapse when no single mutation confers cross-resistance to both drugs. (wikipedia.org)
A recent re-evaluation of this regimen in Africa with multiple doses of intrathecal therapy compares favourably with recent studies of single agent CTX, and other drugs have been shown to be non-cross resistant. (hindawi.com)
Optimal results for patients with extensive disease probably require 5 or 6 effective drugs along with intrathecal therapy, using MTX and Ara-C. In Africa, doses must be lower, because of limitations in supportive care, but in technically advanced countries cure rates in excess of 90% can be obtained. (hindawi.com)
Ideally, the management of TB among HIV-infected patients taking antiretroviral drugs requires a) directly observed therapy, b) availability of experienced and coordinated TB/HIV care givers, and in most situations, c) use of a TB treatment regimen that includes rifabutin instead of rifampin. (cdc.gov)
However, few studies evaluated risks according to the use of different classes of antihypertensive drugs or took combinations of use into account. (cdc.gov)
In women treated with a combination of antihypertensive drugs, we observed no increased risk of AMD for any individual class of drugs. (cdc.gov)
In paper IV, we performed a high-throughput combination drug screen with the aim of finding drugs that work synergistically with KSP inhibition. (lu.se)

They hypothesized that providing extra copies of those genes to nonengineered mice via gene therapy would similarly combat age-related diseases and bring health benefits. (technologynetworks.com)
Polypharmacy is a related term, referring to the use of multiple medications (without regard to whether they are for the same or separate conditions/diseases). (wikipedia.org)
In September 1997, CDC convened a meeting of expert consultants who reviewed and considered background information about HIV-related TB in the United States and the scientific principles of therapy for both diseases (Part I of this report). (cdc.gov)

Treatment for systemic amyloid light-chain (AL) amyloidosis consisting of daratumumab (DARA) in combination with the standard treatment method, CyBorD, is more effective than CyBorD alone, according to findings presented by Mayo Clinic researchers at EHA25 Virtual, the annual meeting for the European Hematology Association (EHA). (ajmc.com)
However, leading researchers in rheumatology and dermatology believe that they're turning the corner toward a day when therapies are phenotype-targeted and diagnosis can be made early and treatment begun well before inflammation worsens and pain and joint damage ensue. (medscape.com)

In advanced HPV-related carcinomas, an experimental therapy involves treatment with a combination of 13-cis retinoic acid and interferon alpha or cholecalciferol analogues. (lu.se)

[ 21 ] Targeted therapy is preferred if clinically needed for early response. (medscape.com)

Analysis of KSP expression across multiple tumor types demonstrated that neuroblastoma is highly dependent on this protein. (lu.se)

Combination therapy or polytherapy is therapy that uses more than one medication or modality. (wikipedia.org)

The T-SIGn gene therapy platform is based on the company's oncolytic virus, enadenotucirev, which has properties that allow systemic IV delivery and payload capacity to deliver genes as a viral vector. (biospace.com)
Surgery, systemic therapy, and radiation are the main treatment options for NSCLC. (medscape.com)

However, the latest trend shifts the focus to precision medicine, with a single-pill combination (SPC) being at the forefront of the treatment algorithm. (escardio.org)

Adding to CDC's current recommendations for administering isoniazid preventive therapy to HIV-infected persons with positive tuberculin skin tests and to HIV-infected persons who were exposed to patients with infectious TB, this report also describes in detail the use of new short-course (i.e., 2 months) multidrug regimens (e.g., a rifamycin, such as rifampin or rifabutin, combined with pyrazinamide) to prevent TB in persons with HIV infection. (cdc.gov)
[ 3 ] Any one of the combination regimens below, most of them based on bortezomib, may be used for induction therapy. (medscape.com)

Achieving these results in nontransgenic mice is a major step toward being able to develop this treatment into a therapy, and co-administering multiple disease-addressing genes could help alleviate the immune issues that could arise from the alternative of delivering multiple, separate gene therapies for each disease," said Church, who is also a professor of genetics at HMS and professor of health sciences and technology at Harvard and MIT. (technologynetworks.com)
Current targeted therapies can slow tumor growth (eg, BRAF inhibition) or release the brakes on the immune response, resulting in tumor lysis (eg, PD-1 inhibition). (medscape.com)

Combination sequential therapy improved survival in our cohort. (jrheum.org)

Maintenance therapy aims to make this period last as long as possible, and it may improve survival rates for people with MM. (medicalnewstoday.com)
SSc-related PAH survival has improved since the 1980s owing to better disease knowledge, screening programs, and emerging therapies 9 , 10 , 11 , 12 , 13 . (jrheum.org)
In vivo, combination treatment resulted in slower tumor growth and increased survival of neuroblastoma PDX models. (lu.se)
KSP inhibition caused tumor regression in vivo and resulted in increased survival of multiple PDX models. (lu.se)

Myeloma50

Inhibitor12

Therapeutic12

Artemisinin-based2

Tumors6

Inhibitors7

Clinical20

Outcomes4

Immuno-Oncology2

Synergistic10

Antiretroviral therapy7

Antibodies2

Preclinical1

Biologic2

Chemotherapy3

Cancer18

Monotherapy9

Treatments5

Melanoma3

Fixed-dose combinations1

Lenalidomide and dexamethasone1

Sclerosis2

Intralesional1

Median1

Cognitive behavio7

Acute1

Antituberculosis1

Cyclophosphamide2

Bortezomib and dexamethasone1

Toxicity3

Adeno-assoc1

Drug combinations1

Interventions1

Biomarkers3

Patient6

Metastatic2

Drugs10

Diseases3

Researchers2

Carcinomas1

Clinically1

Tumor types1

Medication1

Systemic2

Algorithm1

Regimens2

Immune2

Cohort1

Survival4