AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bone Marrow TransplantationMultiple MyelomaBone MarrowTransplantation, HomologousBone Marrow CellsTransplantation, AutologousGraft vs Host DiseaseWhole-Body IrradiationBone and BonesHematopoietic Stem Cell TransplantationTransplantation ConditioningLeukemiaAnemia, AplasticLiver TransplantationTransplantation ChimeraGraft SurvivalBusulfanTissue DonorsBone Marrow PurgingCyclophosphamideHistocompatibility TestingHematopoietic Stem CellsHistocompatibilityHematologic NeoplasmsMelphalanTransplantation, IsogeneicBone Marrow DiseasesRecurrenceCombined Modality TherapyTreatment OutcomeKidney TransplantationBoronic AcidsBone Marrow ExaminationRemission InductionHematopoiesisPyrazinesMyeloma ProteinsMice, Inbred C57BLLeukemia, Myeloid, AcuteTime FactorsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveRadiation ChimeraStem Cell TransplantationImmunosuppressive AgentsPlasma CellsThalidomideBone Marrow NeoplasmsLymphoma, Non-HodgkinPrecursor Cell Lymphoblastic Leukemia-LymphomaBone RemodelingAntineoplastic Combined Chemotherapy ProtocolsGraft RejectionSurvival AnalysisHepatic Veno-Occlusive DiseaseLeukemia, MyeloidRetrospective StudiesTransplantation ImmunologyGraft vs Host ReactionLymphocyte DepletionLeukocyte TransfusionImmunosuppressionAcute DiseaseT-LymphocytesHeart TransplantationMyelodysplastic SyndromesSurvival RateColony-Forming Units AssayHematologic DiseasesHLA AntigensParaproteinemiasSevere Combined ImmunodeficiencyChimeraLymphomaActuarial AnalysisCarmustineFollow-Up StudiesPrognosisLymphocyte TransfusionDisease-Free SurvivalFlow CytometryLung TransplantationCyclosporineGraft vs Tumor EffectBone DensityCell DifferentiationPancytopeniaBone ResorptionGranulocyte Colony-Stimulating FactorNuclear FamilyFatal OutcomeBone DiseasesAntineoplastic AgentsLeukocyte CountOrgan TransplantationCytarabineMice, Inbred BALB CGraft vs Leukemia EffectDexamethasoneEtoposideAntibodies, Monoclonal
LymphomaTransplantChemotherapyLeukemiaAllogeneic hematopoietic cell transplantationCancersHematopoietic stemHematological MalignancyHigh-risk smoldering multiCertain types of multiple myeloma2000TransplantsCases of multiple myelomaDonor hematopoietic cell transplantationLeukemiasNewly diagnosed myelomaAcuteHaematological malignancy2016SurvivalStem cellRelapsePlasma cells in the bone maTherapiesTreatmentLenalidomideMYELOID MALIGNANCIESDisordersPlatelets2022TherapyDiagnosisImmunoglobulinOutcomesIndication for transplantationInfection
Lymphoma19
Transplant32
  • Dr Roger Owen (Leeds General Infirmary) gives his opinion on the place of allogeneic transplant in myeloma following the debate. (medicalupdateonline.com)
  • 2 The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0102 study showed that patients receiving an autologous SCT (ASCT) followed by an allo-SCT had significantly higher CR rates that patients receiving double ASCTs. (medicalupdateonline.com)
  • Fludarabine and melphalan-based conditioning for patients with advanced hematological malignancies relapsing after a previous hematopoietic stem cell transplant. (uchicago.edu)
  • Performance status and comorbidity predict transplant-related mortality after allogeneic hematopoietic cell transplantation. (uchicago.edu)
  • The Greater Accra Regional Hospital - Ridge's BMT Ghana Transplant Unit has previously handled several bone marrow transplants. (bonemarrowtransplantations.com)
  • Dr. Zonder is referring to the bone marrow transplant that Raithel had just 15 months before he completed the climb across treacherous paths and jagged rocks to reach the Mount Everest base camp at 17,500 feet. (karmanos.org)
  • After further discussing his treatment options, Raithel opted for a bone marrow transplant (BMT) in January 2016, performed by Lois Ayash, M.D. , hematologist and medical oncologist, and member of the Bone Marrow and Stem Cell Transplant Multidisciplinary Team . (karmanos.org)
  • Risks of infection also vary with the type of transplant, the indication for transplantation, and other host factors. (medscape.com)
  • We are talking to Dr. Parameswaran Hari on his recent research on post-transplant outcomes in high risk myeloma patients. (curetalks.com)
  • On CureTalks today, we are talking post transplant outcomes in high-risk multiple myeloma with Dr. Parameswaran Hari. (curetalks.com)
  • Dr. Hari serves as the Director of the Adult Bone and Marrow Transplant Programs for Froedtert Hospital and Section Head for Hematologic Malignancies and Transplantation in the Division of Hematology and Oncology in the Department of Medicine. (curetalks.com)
  • So, to get to your question, Gary, the CIBMTR stands for Center for International Blood and Marrow Transplant Research. (curetalks.com)
  • Viral infection can lead to fatal complications in patients with weakened immune systems resulting from chemotherapy, bone marrow or cord blood transplant, and other forms of inherited or acquired disorders. (ca.gov)
  • A double Tar Heel alumnus, Shea dedicated 27 years of service to the University of North Carolina School of Medicine and UNC Lineberger Comprehensive Cancer Center as a hematologist-oncologist, researcher, teacher and as founder and director of the bone marrow transplant program. (unclineberger.org)
  • Because bone marrow transplant requires long-term hospitalization and often longer post-discharge stays in town, Tom was a leader in helping families and patients," Earp said. (unclineberger.org)
  • Bone marrow transplant and now cell therapies can significantly increase the chance of recovery," says Abraham Schwarzberg. (floridatrend.com)
  • Tampa General's new bone marrow transplant unit targets aggressive blood cancers. (floridatrend.com)
  • Located in downtown Tampa's burgeoning medical district - which TGH and the University of South Florida have been developing over the last four years - the unit is less than a dozen miles from Moffitt Cancer Center's Blood and Marrow Transplant and Cellular Immunotherapy Program center, which was established in 1989 and is one of the largest programs of its kind in the Southeast. (floridatrend.com)
  • As a matter of fact, our first bone marrow transplant patient came from Palm Beach County. (floridatrend.com)
  • By adding a bone marrow transplant and cellular therapy program, we're giving the residents of the Tampa Bay region and Florida more options. (floridatrend.com)
  • Couris says the unit's opening followed two years of planning, including consulting with Massachusetts General Hospital in Boston, which has had a bone marrow transplant program since 1992 and does about 150 transplants annually. (floridatrend.com)
  • A bone marrow transplant is referred to as a procedure, replaces one's faulty bone marrow stem cells. (blogstoread.com)
  • To know more about best bone marrow transplant hospitals in india, you can consult a doctor. (blogstoread.com)
  • Bone marrow transplant or BMT is a special type of therapy for patients involved with certain cancers or some diseases. (blogstoread.com)
  • A bone marrow transplant is associated with taking cells, normally discovered in the bone marrow, filtering such cells, and providing them back to the donor or to another individual. (blogstoread.com)
  • Nevertheless, patients experience diseases in a different way and bone marrow transplant might not be suitable for everybody, who is suffering from such diseases. (blogstoread.com)
  • To know more about bone marrow transplant hospitals india, you can take help from the reliable internet sources. (blogstoread.com)
  • All transplant-eligible multiple myeloma patients should receive a triplet induction therapy (immunomodulatory agents, proteasome inhibitor and dexamethasone). (medscape.com)
  • Frailty score predicts outcome in transplant-ineligible patients with newly diagnosed myeloma and is incorporated into the staging criteria. (medscape.com)
  • 1. Bone marrow transplant has improved and evolved dramatically since its inception decades ago. (managedhealthcareexecutive.com)
  • Outcomes among patients with blood and marrow transplants have improved, thanks to better donor-recipient matching (such as through human leukocyte antigen typing), improved patient support systems, and less toxic treatment regimens, says Devine, who is also senior vice president and senior medical director of research operation at the Center for International Blood and Marrow Transplant Research. (managedhealthcareexecutive.com)
  • The treatment is also referred to as a bone marrow transplant. (santaclara.com)
Chemotherapy13
  • He has carried out studies of stem cell transplantation following high-dose chemotherapy and radiation for acute myelogenous leukemia, one of the most common types of leukemia in adults. (uclahealth.org)
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
  • The patient went on to have chemotherapy and autologous stem cell transplantation with a good outcome. (2011globalhealth.org)
  • It is also interested in Mozobil as a potential treatment for leukaemia, on the premise that the drug can mobilise leukaemic cells out of the bone marrow and into the blood, where they become more susceptible to chemotherapy. (pharmatimes.com)
  • Angiocrine is developing a cell therapy aimed to improve the availability and engraftment of blood stem cell transplants for cancer patients who have had their cancerous bone marrow removed by chemotherapy. (ca.gov)
  • Replace the bone marrow as well as restore its usual function following the radiation and/or high doses of chemotherapy that are provided for the treatment of a malignancy. (blogstoread.com)
  • High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
  • Sargramostim is a colony stimulating factor that is FDA approved for the treatment of granulocytopenia following induction chemotherapy in acute myelogenous leukemia , mobilization and following transplantation of autologous peripheral blood progentior cells, myeloid reconstitution after autologous bone marrow transplantation, myeloid reconstitution after allogeneic bone marrow transplantation and bone marrow transplantation failure or engraftment delay. (wikidoc.org)
  • The recommended dose is 250 mcg/m2/day administered IV over a 2-hour period beginning two to four hours after bone marrow infusion, and not less than 24 hours after the last dose of chemotherapy or radiotherapy. (wikidoc.org)
  • A qualifying patient will still need to undergo high doses of chemotherapy or radiation as a conditioning treatment, so the infused stem cells can make their way to the bone marrow to begin the production of healthy blood cells. (santaclara.com)
  • Criteria relevant to hematology patient populations specifically include immunosuppressive disease or immunosuppressive treatment (thus post-allogeneic transplantation, active or recent chemotherapy or immunotherapy, active malignancy) or sickle cell anemia, in patients unlikely to respond optimally to vaccination, or in those not fully vaccinated. (hematology.org)
Leukemia8
Allogeneic hematopoietic cell transplantation4
Cancers5
  • His approach is to put into clinical trials new treatments developed in the laboratory for patients with blood stem cell diseases or cancers of the bone marrow and blood. (uclahealth.org)
  • After the second vaccine dose, breakthrough risk was reduced for all cancers (OR, 0.04), and risk was reduced for the Moderna mRNA-1273 versus Pfizer BNT162b2 vaccine (OR, 0.66), particularly in patients with multiple myeloma (OR, 0.35). (healthday.com)
  • Of all the other cancers, multiple myeloma causes this complication the most. (webmd.com)
  • 10 Data from the European Society for Blood and Marrow Transplantation (EBMT) megafile database indicates that the graft-versus-tumour effect achieved with allo-SCT is weaker and PFS rates lower in MM than in other types of haematological cancers. (medicalupdateonline.com)
  • Karmanos' BMT program is one of the largest in the country with numerous options for treating multiple myeloma and other cancers of blood-forming organs. (karmanos.org)
Hematopoietic stem2
Hematological Malignancy2
  • Retrospective 340 patients with hematological malignancy in Turkey, showing higher mortality with HCQ treatment. (c19hcq.org)
  • Treatments with hydroxychloroquine alone or in combination with azitromycin were associated with a higher rate of mortality in comparison with favipiravir use.In conclusion, patients with hematological malignancy infected with SARS-CoV-2 have an increased risk of severe disease and mortality. (c19hcq.org)
High-risk smoldering multi1
Certain types of multiple myeloma1
  • Idecabtagene vicleucel injection is used to treat certain types of multiple myeloma (a type of cancer of the bone marrow) in adults whose cancer has returned or is unresponsive to at least four other treatments. (medlineplus.gov)
20002
Transplants8
Cases of multiple myeloma1
Donor hematopoietic cell transplantation1
  • Identification by random forest method of HLA class I amino acid substitutions associated with lower survival at day 100 in unrelated donor hematopoietic cell transplantation. (uchicago.edu)
Leukemias1
Newly diagnosed myeloma1
  • Extramedullary plasmacytoma is an unusual mode of presentation for newly diagnosed myeloma patients, but in these unlucky cases the disease is often extensive, and the prognosis is poor.6 The causes of incidental pulmonary nodules can be categorised as benign or malignant. (2011globalhealth.org)
Acute1
  • MM is matological malignancies, which can be up characterized by monoclonal paraprotein to 75% in acute leukaemia. (who.int)
Haematological malignancy2
  • Multiple myeloma is a haematological malignancy affecting about 750,000 people worldwide. (szpiczak.org)
  • It is the second most common haematological malignancy with median age of presentation of approximately 70 years.1 There is a male predominance, and it is rare under 40 years of age. (2011globalhealth.org)
20162
Survival11
Stem cell29
Relapse1
Plasma cells in the bone ma2
  • The prevalence production, lytic lesions and increased of leptomeningeal infiltration in breast can- plasma cells in the bone marrow [ 1 ]. (who.int)
  • Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (msdmanuals.com)
Therapies2
  • Even in the era of novel therapies for newly-diagnosed and relapsed/refractory MM, there is a group of patients for whom the myeloma biology significantly shortens life expectancy. (medicalupdateonline.com)
  • Other promising developments to improve outcomes in allo-SCT include conditioning with radiolabelled anti-CD66, as well as salvage therapy with daratumumab 8 or newer imids which suggest that allo-SCT has the potential to enhance the efficacy of other therapies that may have been less effective pre-transplantation. (medicalupdateonline.com)
Treatment16
  • These mental health issues may be due to living with the illness or health problems that you may get because of myeloma medicines or treatment. (webmd.com)
  • Myeloma and treatment for myeloma can weaken your immunity , making the body prone to many infections. (webmd.com)
  • Physicians must understand both the natural history of multiple myeloma (MM) and the limitations of current therapy in the treatment of the disease. (medscape.com)
  • For a summary of treatment approaches to MM, see Multiple Myeloma Treatment Protocols . (medscape.com)
  • Multiple myeloma is a chronic disease, and the management of patients requires an individualized approach, with extensive knowledge and expertise on the part of the multidisciplinary treatment team. (szpiczak.org)
  • In 2008 The Myeloma Treatment Foundation was established in Krakow, Poland. (szpiczak.org)
  • The most important goal of the Foundation is to establish a centre for diagnosis and treatment of multiple myeloma, The Multiple Myeloma Treatment Centre , and to support it with funding and equipment. (szpiczak.org)
  • The Multiple Myeloma Treatment Centre is to become a highly specialised medical facility offering comprehensive treatment to multiple myeloma patients. (szpiczak.org)
  • The treatment for Sickle Cell Disease and other blood problems is bone marrow transplantation, carried out at BMT cost in Greater Accra Regional Hospital. (bonemarrowtransplantations.com)
  • He sought treatment at the Karmanos Cancer Center, where he met with Dr. Zonder, leader of the Multiple Myeloma and Amyloidosis Multidisciplinary Team (MDT) and member of the Hematology Oncology MDT. (karmanos.org)
  • Treatment of patients with myeloma has changed dramatically in the past years due to development of new agents and myeloma specific targets. (curetalks.com)
  • Myeloma is classified as high-risk based on presence of cytogenetic abnormalities and poor treatment outcomes. (curetalks.com)
  • Research Objective We will use integrated gene editing techniques to develop a new CAR-T cell therapy for multiple myeloma treatment Impact Develop an improved CAR-T cell therapy for patients with refractory multiple myeloma and a new manufacturing strategy that circumvents the costs and inefficiencies of viral production. (ca.gov)
  • Treatment protocols for multiple myeloma are provided below. (medscape.com)
  • MM is considered relative paucity of CNS invasion by MM an incurable disease despite various meth- in comparison with other tumours, whether ods of treatment, including autologous bone solid or haematological, remain unknown, marrow transplantation [ 3 ]. (who.int)
  • Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
Lenalidomide2
  • 7 In the recently completed LenaRIC study patients undergoing allo-SCT with reduced-intensity conditioning received lenalidomide for 12 months from day 35 post-transplantation, with DLI for mixed chimerism or persistent disease. (medicalupdateonline.com)
  • 12 however, the finding in the Myeloma XI study that lenalidomide maintenance therapy was associated with a significant improvement in PFS but with little further improvement in depth of response 13 suggests that the graft is providing an adjunct to highly effective maintenance therapy rather than the other way around. (medicalupdateonline.com)
MYELOID MALIGNANCIES1
  • Characteristics and clinical outcomes of patients with myeloid malignancies and DDX41 variants. (cdc.gov)
Disorders1
  • Blood (hematologic) disorders can impact bone marrows, blood vessels, organs and the blood itself. (santaclara.com)
Platelets2
20221
Therapy6
Diagnosis3
Immunoglobulin2
  • Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)
  • For patients with immunoglobulin A (IgA) myeloma whose disease can only be reliably measured by quantitative immunoglobulin measurement, a serum IgA level =0.5g/dL. (who.int)
Outcomes1
  • Real-world evidence shows that patients with cancer, especially hematologic malignancies, are at higher risk for developing breakthrough infections and severe outcomes," the authors write. (healthday.com)
Indication for transplantation1
  • and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Infection7
  • Successful allogeneic transplantation of patients with suspected prior invasive mold infection. (uchicago.edu)
  • Patients with solid malignancies are more vulnerable to SARS-CoV-2 infection than healthy population. (c19hcq.org)
  • The outcome of SARS-CoV-2 infection in highly immunosupressed populations, such as in patients with hematological malignancies is a point of interest.We aimed to analyze the symptoms, complications, intensive care unit (ICU) admission and mortality rates of patients with hematological malignancies infected with SARS-CoV-2 in Turkey. (c19hcq.org)
  • Malignant cancer cells accumulate in the bone marrow, crowding out normal plasma cells that fight infection. (karmanos.org)
  • Adverse effects include infection, thrombosis, and second primary malignancy. (medscape.com)
  • Multiple myeloma originates from white blood cells called plasma cells, which are critical for the immune system as they create the antibodies the body needs to fight off infection. (santaclara.com)
  • HLH has been traditionally divided into a primary form, which typically manifests in children with documented genetic abnormalities of the cytotoxic function of NK cells and T cells, and a secondary form that tends to occur at older ages in the setting of an associated condition, such as infection and malignancy, without an identifiable genetic abnormality. (medscape.com)