Although a single point mutation is sufficient for developing rifampin resistance, a number of articles ( 2 , 3 ) describe multiple rpoB mutants for M. tuberculosis , i.e., rifampin-resistant strains harboring mutations in different codons of rpoB . (cdc.gov)
Therefore, hypermutability in some strains of this species resulting in multiple rpoB mutants might develop under certain special (in vivo) circumstances through inactivation or down-regulation of some mutT genes. (cdc.gov)
In contrast, the DNA damage accumulation and sensitivity of smc-5 mutant strains to replication impediments are suppressed by mutations in the C. elegans BRCA1/BARD1 homologs, brc-1 and brd-1. (uni-koeln.de)
Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020. (cdc.gov)
Mutations1
This assumption seems likely because both of the aforementioned particular mutations were described in in vitro-obtained spontaneous mutants of H37Rv and had a Darwinian fitness slightly less than and equal to that of the rpoB wild-type-susceptible parental strain ( 9 ). (cdc.gov)
Substitutions2
The other mutant (U7) has two substitutions (I3V and I13V). (rcsb.org)
Finally, although multiple amino acid substitutions of T4 abolished glycosylation at N2 but were not toxic, similar substitutions of T17 were not tolerated, suggesting that the carbohydrate moiety at N15 is critical for cell viability. (jneurosci.org)
Separate1
Separate multiple emails with a comma. (neatorama.com)
Gene1
Additionally, it can knock out genes, facilitating efforts to elucidate gene functions through the analysis of mutant phenotypes. (mdpi.com)
Identify3
The overall goals of this program were to produce and distribute mutant models for infertility and to investigate underlying causes in order to identify new genes and pathways contributing to reproductive function. (jax.org)
ENU-mutagenesis of male mice was followed by a standard three-generation breeding scheme, with fertility testing of all G3 offspring in order to identify putative reproductive mutants. (jax.org)
These data support the development of mutation-specific correctors for optimal treatment of different CFTR trafficking mutants, and identify C5 and bithiazoles as the most promising compounds for correction of CFTR-p.Ala455Glu. (ersjournals.com)
Source1
The primary change from the source material is that these mutants aren't gathered by Professor Charles Xavier at his school in Westchester, but instead are in a hospital in a remote location and kept imprisoned until they prove not to be a danger to themselves. (tor.com)
Models1
Transgenic animal models expressing rhodopsin glycosylation mutants also exhibit light exacerbated retinal degeneration (RD). In this study, we used transgenic Xenopus laevis to investigate the pathogenic mechanism connecting light exposure and RD in photoreceptors expressing T4K or T17M rhodopsin. (jneurosci.org)
Friend1
Inspired by the Claremont/Sienkiewicz run in particular, Josh Boone-fresh off the success of The Fault in Our Stars -created a pitch for a trilogy of New Mutants movies with his best friend Knate Lee and sent it to Simon Kinberg. (tor.com)
Issue3
Key Issue & First Appearance Lot of Random Comics - Buy Multiples for More! (picclick.com)
Following the lead of the revived X-Men team, the New Mutants came from all around the world: the Vietnamese Karma (first introduced in an issue of Marvel Team-Up by Claremont and Frank Miller), the Brasilian Sunspot, the Scots Wolfsbane, the Cheyenne Mirage, and Cannonball, from the heartland of America. (tor.com)
Some of Claremont's best work was done in The New Mutants , including the Special Edition that had the mutants travel to Asgard, and issue #45 of the monthly series, "We Was Only Foolin'," one of the best issues of a superhero comic in the ninety-year history of the medium. (tor.com)
Time1
Last week, we looked at The Old Guard , and this time 'round it's The New Mutants . (tor.com)
Mouse Mutants2
By illustration, a large number of zebrafish and mouse mutants with vestibular system involvement have been developed. (nih.gov)
Notable exceptions are the tilted and tilted head mouse mutants, having only one identified phenotypic defect, the absence of otoconia, and 100% penetrance. (nih.gov)
Zebrafish1
The generation of mutant and transgenic animal models, involving such species as the mouse, Drosophila, zebrafish and Caenorhabditis elegans (C. elegans), provides powerful tools for elucidation of these functions. (nih.gov)
Proteins5
The present invention further provides nucleic acids comprising nucleotide sequences that encode mutant capsid proteins, and host cells comprising the nucleic acids. (justia.com)
In the study, the research team, led by Tricia Serio, associate professor of medical science, explains how two different beneficial mutant prions managed to foil the amplification of harmful clumps of misfolded proteins in yeast. (scienceblog.com)
One mutant prion, Q24R, hinders the ability of misfolded proteins to aggregate into harmful clumps. (scienceblog.com)
Another helpful mutant prion known as G58D, assists the cell by speeding up its ability to unfold and refold misfolded proteins. (scienceblog.com)
Instead of simply inhibiting mutant proteins as other drugs do, PROTAC drugs help to destroy and remove them. (cancer.org)
Mutation3
BTW: Mutant is a mutation testing tool, which is a form of code coverage. (github.com)
Conversely, with mutants displaying accelerated Na + i -dependent inactivation, block of NCX1.1 by SEA was either enhanced or unchanged, depending upon the phenotype of the particular mutation. (aspetjournals.org)
Nevertheless, recognition of mutants RBD K417N and RBD N501Y was 2.5-3-fold reduced while RBD E484K and the triple mutant were 10-fold less well recognized, demonstrating that the mutation at position 484 was key for the observed loss in cross-reactivity. (biorxiv.org)
Recognize2
Results These binding assays showed that vaccination induced antibodies recognize both wildtype and mutant RBDs with higher avidities than those raised by infection. (biorxiv.org)
New Mutants fanatics absolutely recognize him, as his groundbreaking art helped to elevate the mutant team's comic books in the 1980s, during their early run. (cinemablend.com)
Libraries2
Scholars@Duke publication: Generation of random mutant libraries with multiple primers in a single reaction. (duke.edu)
The present invention further provides methods of generating the mutant AAV and mutant AAV libraries, and compositions comprising the mutant AAV. (justia.com)
Mice2
This FOA issued by the Office of Strategic Coordination, Office of the Director, National Institutes of Health, solicits grant applications from institutions/ organizations that propose to perform broad phenotyping of the International Knockout Mouse Consortium's (IKMC) mutant mice. (nih.gov)
Applicants for this RFA must have a proven track record of producing or developing existing ES lines, preferably from C57BL/6 mice, and have themselves or their collaborators used such lines to create mutant germline competent ES cells by targeted, gene trap or transposon mutagenesis. (nih.gov)
Species1
Therefore, hypermutability in some strains of this species resulting in multiple rpoB mutants might develop under certain special (in vivo) circumstances through inactivation or down-regulation of some mutT genes. (cdc.gov)
Infection4
Using standard and avidity ELISAs, we determined the binding capacities to mutant RBDs of antibodies induced by infection versus vaccination. (biorxiv.org)
Conclusion Our binding data demonstrate improved recognition of mutant viruses by BNT162b2-induced antibodies compared to those induced by natural infection. (biorxiv.org)
Adding the mutant G58D, for example, could cure a cell of infection by the Sup35 prion, but if she perturbed the cell's quality assurance system then G58D would not work. (scienceblog.com)
Serio noted that while beneficial mutant prions confer resistance to prion infection in nature, they haven't been successful in reversing an established infection because sustained delivery into the body is too challenging. (scienceblog.com)
Unusual2
Deoxynybomycin (DNM) is a natural-product antibiotic with an unusual mechanism of action, inhibiting the mutant DNA gyrase that confers FQR. (nature.com)
His roughed-up and unusual style made The New Mutants comic book covers stand out on the spinner rack. (cinemablend.com)
Phenotypes2
This novel method can serve as a powerful tool to study the biological phenotypes of genes whose functions are determined by multiple sites. (duke.edu)
Most have phenotypes with multiple defects and variable penetrance and expression. (nih.gov)
Properties4
To test this hypothesis, we examined the effects of SEA on mutant exchangers with altered ionic regulatory properties. (aspetjournals.org)
We combine an in silico screen with these assays to identify and characterize known and novel UPF1 mutants with altered helicase, ATPase, and RNA binding properties. (nih.gov)
The present invention provides mutant adeno-associated virus (AAV) that exhibit altered capsid properties, e.g., reduced binding to neutralizing antibodies in serum and/or altered heparin binding and/or altered infectivity of particular cell types. (justia.com)
16. Predicting transcriptional activity of multiple site p53 mutants based on hybrid properties. (nih.gov)
Mechanisms1
Serio says the molecular mechanisms appear to explain how similar mutants solve protein misfolding in mammals, including people. (scienceblog.com)
Combinations1
Seven hyper-stable multiple mutants have been constructed in staphylococcal nuclease by various combinations of eight different stabilizing single mutants. (rcsb.org)
Single1
The crystal structures of four single and five multiple stabilizing mutants of staphylococcal nuclease were solved to high resolution. (rcsb.org)
Molecular3
There are multiple steps that you could target," said Susanne DiSalvo, a Brown biology graduate student and lead author of a paper published online March 20, 2011, in Nature Structural and Molecular Biology . (scienceblog.com)
By showing how two beneficial mutants cure the cell of prions, this study has revealed that small changes applied to distinct components of a molecular network can dramatically alter the outcome for the cell. (scienceblog.com)
The expanded use of mutant and transgenic animals offers many promising tools for investigating molecular bases of balance function and sensorimotor performance. (nih.gov)
Gain-of-funct2
Functional analyses of the corresponding mutant homomeric channels in vitro suggested gain-of-function effects. (frontiersin.org)
18. Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers. (nih.gov)
Comic1
This might come as a shock, but a comic with the title Teenage Mutant Ninja Turtles was not intended to be very serious. (listverse.com)
Cells3
DiSalvo was the first to observe that the mutants act at distinct stages to tip the balance back in favor of the cells, allowing them to overcome the problem. (scienceblog.com)
DiSalvo's experiments showed how the mutants and cells work together. (scienceblog.com)
Cells would only be cured when she both added a mutant and allowed the cells' own quality assurance system to work. (scienceblog.com)
Volume1
It is surprising that detailed structural analysis showed that packing had improved, with the volume of the mutant protein's hydrophobic cores decreasing as protein stability increased. (rcsb.org)
Lines1
Enter multiple addresses on separate lines or separate them with commas. (aspetjournals.org)
System1
The application of the Cre-loxP system for generating multiple knock-out and knock-in targeted loci. (nih.gov)
Effects1
With mutants where Na + i -dependent inactivation is absent, the effects of SEA were greatly reduced. (aspetjournals.org)
Target1
If multiple enemies are equally distant, determine the target randomly. (mrlizard.com)
Application1
More than one PD/PI (i.e., multiple PDs/PIs), may be designated on the application. (nih.gov)