Multiple myeloma (also known as MM , myeloma , plasma cell myeloma , or as Kahler's disease after Otto Kahler) is a presently incurable hematological malignancy of plasma cells, the cells of the immune system that produce antibodies. (the-medical-dictionary.com)
Often, the diagnosis of multiple myeloma is made incidentally during routine blood tests for other conditions. (the-medical-dictionary.com)
Multiple myeloma, a rare malignancy of plasma cells, was first described in 1950 as an abnormal production of immunoglobulins. (the-medical-dictionary.com)
Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma . (ucbraid.org)
To evaluate the proportion of patients with objective response (OR) to targeted study agent(s) in patients with advanced refractory cancers/lymphomas/multiple myeloma. (ucbraid.org)
To evaluate the proportion of patients alive and progression free at 6 months of treatment with targeted study agent in patients with advanced refractory cancers/lymphomas/multiple myeloma. (ucbraid.org)
Celgene Inc. said on Sunday its cancer drug Thalomid improved survival by a significant amount in elderly patients with multiple myeloma, a form of blood cancer. (health.am)
The average age of multiple myeloma patients is about 63. (health.am)
blood transfusion), spinal cord, lung cancer (oncology), respiratory cancer, radiology Background Multiple myeloma is a malignant proliferation of plasma cells mostly affecting the bone marrow and commonly presents with anaemia, hypercalcaemia, renal dysfunction, bone and skeletal involvement. (2011globalhealth.org)
The most common sites of extramedullary solitary plasmacytoma include upper airway tract, digestive tract, lymphatic systems and head and neck regions.4 5 An extramedullary plasmacytoma can arise in a myeloma patient during the disease irrespective of duration of illness, and it typically represents advanced disease. (2011globalhealth.org)
Multiple Myeloma Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)
2019). Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma. (who.int)
Metastasis2
The prognosis of angiosarcoma in the head and neck region is poor, and the risk of local recurrence and metastasis is high. (kjhno.org)
Angiosarcoma of the head and neck is a rare type of vascular sarcoma associated with high rates of local recurrence and distant metastasis and a poor prognosis. (kjhno.org)
Pathology4
Pathology in the brain stem segment is most often due to demyelination by multiple sclerosis. (radiologyassistant.nl)
Other types of pathology in the brain stem segment are neoplasms (mostly glioma and metastases), vascular lesions (infarction, cavernoma) and infections (rhombencephalitis). (radiologyassistant.nl)
One challenging feature of head and neck pathology is that a dizzying array of spindle cell lesions occurs here which ranges all the way from reactive, very aggressive forms to malignant lesions. (oldcitypublishing.com)
Significant abnormality or disease of the salivary glands, such as that associated with Sjögren syndrome or neoplasm, necessitates additional evaluation by an otolaryngologist or an otolaryngologist/head and neck surgeon for comprehensive treatment of the gland pathology itself. (medscape.com)
Diagnosis6
Symptoms such as fever, night sweats, malaise, or unexplained weight loss should prompt the physician to consider an alternative diagnosis such as neoplasm or an autoimmune disease. (aafp.org)
On histopathological analysis, all the classic features were noted and diagnosis of a spindle cell neoplasm was made without any obscurity. (oldcitypublishing.com)
There are many lesions like rhabdomyosarcoma, fibrosarcoma, liposarcoma, multiple peripheral nerve sheath tumour, angiosarcomas, melanomas, kaposi sarcoma, solitary fibrous tumors, etc., which mimic leiomyosarcoma clinically and histopathologically and therefore immunohistochemical staining with specific markers plays a vital role in arriving at a conclusive diagnosis. (oldcitypublishing.com)
Overall, median time from diagnosis of first to second neoplasm was 4 years (2.9 -5.2), without significant differences if primary tumor was LC or another neoplasm (p = 0.39). (esmo.org)
Smoking was significantly associated with shorter time to diagnosis of a second neoplasm (3.4 years vs 4.7 years for non-smokers, p = 0.03). (esmo.org)
Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
Cancers3
Dr.Hyunseok "Hyu" Kang is a medical oncologist and a clinician scientist focusing on head and neck cancers including squamous cell carcinomas of head and neck (SCCHN), salivary gland cancers, thyroid cancers and other rare cancers of head and neck. (ucsf.edu)
Dr.Kang's research focus is development of clinical trials with novel therapeutic agents for patients with head and neck cancers. (ucsf.edu)
Given that more than 90% of diagnosed head and neck cancers are positive for HPV-16, public health initiatives should focus on primary levels of prevention based on the unique behaviors of HPV-associated cancers such as demographic, behavioral, and clinical characteristics ( J Natl Compr Canc Netw . (oncologynurseadvisor.com)
Melanoma2
Malignant melanoma is a neoplasm of pigment-producing cells called melanocytes that occurs most often in the skin, but may also occur in the eyes, ears, gastrointestinal tract, leptomeninges, and oral and genital mucous membranes (summary by Habif, 2010). (nih.gov)
If a melanoma becomes thicker and involves multiple layers of skin, it can spread to other parts of the body (metastasize). (nih.gov)
Carcinoma8
7]LEWIS GH, WANG H, BELLIZZI AM, et al.Prognosis of minimally invasive carcinoma arising in mucinous cystic neoplasms of the pancreas[J].Am J Surg Pathol, 2013, 37 (4) :601-605. (lcgdbzz.org)
Clinical Trial Development in TP53-Mutated Locally Advanced and Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma. (ucsf.edu)
The incidence of head and neck squamous cell carcinoma (HNSCC) associated with human papillomavirus (HPV) has increased and is expected to continue to do so because of the prevalence of HPV infections and commonness of oral-genital sex in the overall population ( Clin J Oncol Nurs . (oncologynurseadvisor.com)
Currently, the safety and tolerability of SEA-CD40 have been evaluated in clinical phase I dose escalation studies in patients with multiple solid tumor such as non-small-cell lung carcinoma, pancreatic adenocarcinoma, and head and neck neoplasms. (creative-biolabs.com)
One was a chordoma, a rare type of bone cancer, and the other was a squamous cell carcinoma of the head and neck. (medscape.com)
Predictors of Survival After Head and Neck Squamous Cell Carcinoma in South America: The InterCHANGE Study. (who.int)
[ 3 , 4 ] These antibodies are approved for the treatment of advanced EGFR-expressing colorectal cancer, and cetuximab is also approved for treatment of squamous cell carcinoma of the head and neck. (medscape.com)
Second primary tumors (SPTs) have a significantly worse prognosis on patients with head and neck squamous cell carcinoma (HNSCC) (1). (bvsalud.org)
Tumor5
We report a case of malignant proliferating trichilemmal tumor showing multiple distant metastases. (nih.gov)
This case illustrates the metastatic potential for amyloid-producing odontogenic tumor in dogs and asynchronous occurrence of multiple APOTs in the oral cavity. (umn.edu)
Even though developed for AML patients, our pan-cancer analyses demonstrate a wider application of the IPRP signature for prognostic prediction and analysis of tumor-immune interplay also in multiple solid tumors. (nature.com)
The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the image below. (medscape.com)
The signs and symptoms of hormonally nonfunctional parathyroid cancer are related to the tumor obstructing nearby structures in the neck. (medlineplus.gov)
Tumors7
However elective treatment of the N0 neck region remains a controversial topic Radiotherapy If a salivary gland tumour is cancerous, Radiation Therapy may be necessary Fast neutron therapy has been used successfully to treat salivary gland tumors, and has shown to be significantly more effective than photons in studies treating unresectable salivary gland tumors. (wikipedia.org)
Benign salivary gland tumors represent a diverse group of neoplasms with varied clinical behaviors. (medscape.com)
[ 1 ] which included multiple newly described benign tumors. (medscape.com)
Tumors of the major and minor salivary glands account for only 2-4% of head and neck neoplasms. (medscape.com)
Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
Benign and malignant3
Objective To investigate the clinicopathological features of pancreatic mucinous cystic neoplasm ( MCN) and influencing factors for benign and malignant MCN. (lcgdbzz.org)
3]LI L, SUN B, ZHANG GQ, et al.Risk factors analysis of benign and malignant pancreatic cystic neoplasm and prognosis[J].Chin J Dig Surg, 2016, 15 (6) :562-566. (lcgdbzz.org)
Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. (medscape.com)
Recent evidence suggests that the bicellular stem cell theory is the more probable etiology of salivary gland neoplasms. (medscape.com)
Lung cancer1
There are also combination therapies that affect multiple receptors such as lapatinib (approved for human epidermal growth factor receptor 2-positive [HER2+] breast cancer) and afatinib (approved for non-small cell lung cancer), which inhibit both the EGFR and HER2 receptors, and vandetanib (approved for advanced medullary thyroid cancer), which inhibits EGFR, vascular endothelial growth factor (VEGFR), and rearranged during transfection (RET) activities. (medscape.com)
Cystic5
1] Editorial Board of Chinese Journal of Pancreatology.Consensus on pancreatic cystic neoplasm in China (draft in 2013, Shanghai) [J].Chin J Pancreatol, 2013, 13 (2) :79-90. (lcgdbzz.org)
4]JANG KT, PARK SM, BASTURK O, et al.Clinicopathologic characteristics of 29 invasive carcinomas arising in 178 pancreatic mucinous cystic neoplasms with ovarian-type stroma:implications for management and prognosis[J].Am J Surg Pathol, 2015, 39 (2) :179-187. (lcgdbzz.org)
5]CRIPPA S, SALVIA R, WARSHAW AL, et al.Mucinous cystic neoplasm of the pancreas is not an aggressive entity[J].Ann Surg, 2008, 247 (4) :571-579. (lcgdbzz.org)
9] SUN JS, ZHANG YZ, ZHOU YY, et al.Mucinous cystic neoplasm of the pancreas:clinical features of 125 patients[J].Chin J Pancreatol, 2014, 14 (5) :321-325. (lcgdbzz.org)
10]HAN KW, HA R, KIM KK, et al.Surgical management and results for cystic neoplasms of pancreas[J].Korean J Hepatobiliary Pancreat Surg, 2013, 17 (3) :118-125. (lcgdbzz.org)
Cancer6
A prospective evaluation of neck and shoulder function following treatments of early-stage human papillomavirus-associated oropharynx cancer. (ucsf.edu)
Biomarkers predictive of response to pembrolizumab in head and neck cancer. (ucsf.edu)
Based on the current literature associating human papillomavirus (HPV) with head and neck cancer, what public health initiatives need to be implemented? (oncologynurseadvisor.com)
I am the multiple PI and Cancer Care Delivery Research Lead of the Wake Forest NCI Community Oncology Research Program (NCORP) Research Base (UM1 CA189824). (wakehealth.edu)
In this capacity, I co-direct the coordinating center and serve as the PI/co-I for multiple cancer symptom science and care delivery studies operating within the NCORP network of over 900 community oncology practices. (wakehealth.edu)
Nowadays, the leading cause of death amongst head and neck cancer patients is the development of a SPT (3,4). (bvsalud.org)
20221
Moore, C., Barron, J ., Manuscript: JNC-2022-0022.R1 Title: Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination. (mun.ca)
Cutaneous2
It mainly occurs in the head and neck, and cutaneous angiosarcoma in this region seems to be a distinctive neoplasm with characteristic clinicopathologic features that differ from those of angiosarcoma in other anatomical locations. (kjhno.org)
Although these drugs have been proven to be very effective for normally untreatable advanced neoplasms, EGFRIs cause cutaneous side effects in 50% or more of patients undergoing treatment. (medscape.com)
Sclerosis1
Due to embelin's ability to cross the blood-brain barrier, its neuroprotective effects have been studied in the past using in vitro models of neuronal disorders such as convulsion and epilepsy, Alzheimer's disease, anxiety and depression, traumatic brain injury, cerebral ischemia, Huntington's disease, and multiple sclerosis. (bvsalud.org)
Lesion1
It recurred on the neck area 4 months after excision and the lesion was removed with surgical resection again. (nih.gov)
Minor salivary1
Among salivary gland neoplasms, 80% arise in the parotid glands, 10-15% arise in the submandibular glands, and the remainder arise in the sublingual and minor salivary glands. (medscape.com)
Adenomas1
Salivary gland tumours, also known as mucous gland adenomas or neoplasms, are tumours that form in the tissues of salivary glands. (wikipedia.org)
Malignancies1
1) It accounts for approximately 10 to 15% of all hematologic malignancies, 1% of all malignant neoplasms in whites and 2% in blacks, and 2% of deaths from all malignancies. (the-medical-dictionary.com)
Cysts1
Lymphangioma is an uncommon and benign neoplasm characterized by thin-walled cysts. (ctisus.com)
Malignancy1
Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands. (medscape.com)
Clinical1
Successful management of these neoplasms relies on accurate clinical and diagnostic assessment, as well as appropriate therapeutic intervention. (medscape.com)
20201
2020). A molecular map of lung neuroendocrine neoplasms. (who.int)
Metastases1
There was evidence of multiple metastases on CNS and mediastinal lymph nodes after 6 months. (nih.gov)