Multiple genetic vectors. Medical search. Frequent questions

It takes advantage of using a single expression plasmid that contains multiple functionally independent protein expressing cassettes to achieve protein co-expression. (jove.com)
Here, we present a suite of tools for genetic manipulation in the tomato pathogen C. michiganensis including a markerless deletion system, an integrative plasmid, and an R package for identification of permissive sites for plasmid integration. (biorxiv.org)
dbDNA has shown superior yield and genetic stability compared to conventional plasmid methods in mRNA production as well as faster GMP manufacturing. (swissbiotech.org)
Our advanced vector technology and enzymatic process will support the tremendous growth of mRNA technology as well as enabling other plasmid DNA reliant technologies to deliver beyond what is possible with current methods. (swissbiotech.org)
Vectors can be DNA molecules, bacteria or viruses and are engineered to integrate into chromosomes (i.e. retroviruses) or cell nuclei (i.e. plasmid DNA). (ondrugdelivery.com)
The combination of a DNA fragment with a plasmid or vector DNA backbone generates a recombinant DNA molecule, which can be used to study DNA fragments of interest, such as genes. (addgene.org)

Malaria control in Somaliland depends on the effective identification of potential malaria vectors, particularly those that may be invasive. (biomedcentral.com)
not determine which sibling species of the complex are present in those provinces, Mosquitoes of the Anopheles maculipennis and since then no further studies have been complex have been incriminated as some of carried out to determine current distribu- the main malaria vectors in Europe and the tion. (who.int)

BMSCs can also be engineered to secrete a variety of different proteins in vitro and in vivo that could potentially treat a variety of serum protein deficiencies and other genetic or acquired diseases [ 13 ]. (hindawi.com)
Even bipartite networks, with only two types of nodes, have furthered our understanding on disease-gene relationships, and provided insight into the pathophysiological relationship across multiple diseases 6 . (nature.com)
Now at UT Southwestern, Dr. Bailey continues her pioneering work in gene therapies for neurological disorders, including pediatric conditions and complex diseases like Alzheimer's disease, employing advanced AAV vector engineering and translational research. (wtnh.com)
Oxitec hopes to release millions of autocidal Aedes aegypti mosquitoes in the Keys because that species is a vector for deadly diseases, and Oxitec is hoping that reducing mosquito populations will protect residents. (discovermagazine.com)
For the first time, researchers can identify diseases based on a specific gene's presence or absence within a patient's genetic make-up. (ondrugdelivery.com)
As such knowledge grew, so too did researchers' understanding of the mechanisms of genetic diseases and the technology needed to combat conditions once thought to be untreatable. (ondrugdelivery.com)
Two ocular characteristics make gene therapy advantageous and, in some cases, the only option for some genetic diseases, cancers and viral infections. (ondrugdelivery.com)
Plans are being implemented to use dried blood spots on filter paper, as is commonly performed for many other genetic diseases. (medscape.com)

Our system provides an efficient targeting strategy for multiplex genome/epigenome editing, simultaneous activation/repression of multiple genes and beyond. (nature.com)
Present study was designed to explore the genetic diversity of plasmodium vivax genotypes based on Pvmsp-3α and Pvmsp - 3β genes using allelic specific nested PCR and RFLP assays markers from field isolates in district Mardan, Pakistan. (scielo.br)
For analysis the genetic diversity of the sub allelic variants of Pvmsp3α and Pvmsp3β genes, Chi-Square test was performed by utilizing Minitab programming software 18. (scielo.br)
After cloning the antibody genes into an expression vector, this is then transfected into an appropriate host cell line for antibody expression. (cellsignal.com)
It can accommodate genes of interest of more than 20kb and is linearly scalable, making it highly adaptable to support a range of genetic medicines. (swissbiotech.org)
The concept of genes as carriers of phenotypic information was introduced in the early 19th century by Gregor Mendel, who later demonstrated the properties of genetic inheritance in peas. (addgene.org)
These domestication traits likely consisted of a few major genes controlling dramatic changes in crop physiology, as is suggested by genetic studies comparing maize to its ancestor teosinte (Doebley et al. (springer.com)
The virulence of this bacterium results from the 32 Y pestis chromosomal genes and two Y pestis -specific plasmids, constituting the only new genetic material acquired since its evolution from its predecessor. (medscape.com)
With roughly 30,000 genes in mammalian genomes, fection with a vector encoding MyoD (Tapscott et al. (lu.se)
The lab was working on viral vectors for delivering genes to treat cancer. (medscape.com)

gambiae and the arbovirus vector Aedes aegypti both require another IR, IR93a, to maintain host attraction and feed efficiently on warmed blood. (washington.edu)
Initially identified in a rhesus monkey from Uganda's Zika forest in 1947 and subsequently isolated from humans in 1968 in Nigeria, 1 Zika virus (ZIKV) is a flavivirus transmitted by Aedes mosquitoes, the same vector transmitting other arboviruses of public health impact such as yellow fever virus, dengue virus (DENV) and chikungunya virus (CHIKV). (who.int)

Next, linearize the final protein expression backbone vector POC 18, and vector CAMBIA 1300, by adding four units of small one into a final 10 microliter reaction volume. (jove.com)
These vectors are designed for protein transient expression and genetic transformation. (jove.com)
Here, we report an easy and efficient construction system for all-in-one CRISPR/Cas9 vectors expressing Cas9 protein and up to seven gRNAs. (nature.com)
Gene therapy strategy refers to the process of placing a healthy gene into a viral vector (a tool that delivers genetic material into the cells of a mouse model) to express the protein missing from the mutated gene. (jax.org)
Proceeds from the financing will be used to further advance the company's technology platforms - Life Edit gene editing, induced pluripotent stem cells (iPSCs), and RNA, cell, protein, vector engineering - and BaseCamp ® , its end-to-end genetic medicine current Good Manufacturing Practice (cGMP) manufacturing and process development business, to accelerate the design, manufacturing, and development of cell and gene therapies. (biospace.com)
When a cell needs to make a protein, it copies the appropriate instructions onto a messenger RNA molecule - a single strand of genetic material. (livescience.com)
The order of these 4 nucleotides makes up the genetic code and provides the instructions to make every protein within an organism. (addgene.org)

In [ 19 ], best individuals are selected as donor vectors for the DE, and the parameter of every mutation vary within the range of the statistical data of each generation. (hindawi.com)
A genetic mutation that confers a fitness advantage, namely increased transmissibility, can rapidly replace previously circulating variants. (msdmanuals.com)

Lyme disease, the most common vector-borne disease in North America and Europe, is caused by the bacteria Borrelia burgdorferi sensu lato, which can be transmitted by tick bite from animals (vertebrate reservoir) to humans, where it may spread to multiple organs manifesting as arthritis, carditis and neuropathy. (wadsworth.org)

This means that sexual recombination is likely to be common if strains from different genetic heritages infect the same animal or person. (biomedcentral.com)
The vector pSelAct-KO is a recombination based, markerless knockout system that uses dual selection to engineer seamless deletions of a region of interest, providing opportunities for repeated higher-order genetic knockouts. (biorxiv.org)
Traditional polyclonal and monoclonal antibodies are the product of normal B cell development and genetic recombination. (cellsignal.com)

Recombinant antibodies are monoclonal, but their production involves in vitro genetic manipulation. (cellsignal.com)
This platform is used to produce viral vectors for gene transfer, both in vivo and in vitro. (lu.se)

The production of life-altering gene editing vectors, cancer killing viruses, and life- saving vaccines currently depends on traditional cell culture techniques. (sbir.gov)
Thus, increasing the efficiency and speed of culture of production cell lines are common goals for manufacturing of gene editing vectors, oncolytic viruses, and vaccines. (sbir.gov)
Our hypothesis is that elimination of shear stress and the low flow media delivery through the HDCR, enabled by the decoupling of gas exchange via membrane oxygenation of cells, will allow for improved yield, decreased cost, and increased speed of production of therapeutic viral vectors and viruses. (sbir.gov)
Our research team at XDemics Corporation, the California Institute of Technology, and the City of Hope National Medical Center has created a new technology for growing cells and producing genetic medicines, named high density cell respirator (HDCR), which delivers oxygen and nutrients separately, that should make it at least 10 times more efficient and two to ten times faster at producing viruses and gene medicines, compared to current technologies. (sbir.gov)

argued that the populations of C. parvum in the UK were panmictic, based on genetic diversity whereas those of C. hominis are more clonal [ 9 ]. (biomedcentral.com)
To better understand the basis for this increase, more data on the geographic distribution of the vector populations are needed. (biomedcentral.com)
The multiple island study showed that a population of Kauai Amakihi is phylogenetically distinct from those on Maui and Hawaii and that the Maui and Hawaii populations share mitochondrial haplotypes. (hawaii.edu)
Additionally, genetic relatedness was observed between the northeastern and east central Ethiopian A. stephensi populations and the Somaliland A. stephensi populations. (bvsalud.org)
These results reveal population differentiation and genetic connectivity within HoA A. stephensi populations. (bvsalud.org)
stephensi populations in Ethiopia to inform vector control strategies. (bvsalud.org)
Ixodes ricinus ticks ( 11 ) and is carried by a large variety of ize genetic variations of natural populations of a bacterial hosts, including birds and small- to medium-sized mam- pathogen ( 1 , 2 ). (cdc.gov)
Plague is most often vector borne, transmitted by fleas, to a variety of rodent populations. (medscape.com)

Furthermore, based on genetic network analysis, we uncovered that Dire Dawa, the site of a spring 2022 malaria outbreak, was one of the major hubs from which sequential founder events occurred in the rest of the eastern Ethiopian region. (bvsalud.org)
As of first of January 2022, StemTherapy and MultiPark have decided to merge the former iPSC, CRISPR and vector platforms into the new Cell and Gene Therapy Core . (lu.se)

We utilize multiple genetic, biochemical, microbiological, and vector biological approaches to define the transmission of Lyme disease bacteria, and other pathogens transmitted by ticks, in the infection cycle. (wadsworth.org)
Based on their properties, researchers have also been exploring CNTs potential for biological and biomedical applications as drug delivery systems, substrate for cells growth in tissue regeneration, therapeutic agents, or as vectors for gene transfection. (cdc.gov)

The vectors produced here are onco-retroviral and lentiviral vectors. (lu.se)

Multiple vaccines are available. (radiopaedia.org)
Current technologies to produce viral based medicines and vaccines are too expensive and too inefficient to meet the demands of the growing field of genetic medicine, and will be unable to supply the global need for vaccines if a pandemic occurs. (sbir.gov)

We recently demonstrated that heat-seeking in the malaria vector Anopheles gambiae is driven by cooling-activated neurons requiring the Ionotropic Receptor (IR) subunit IR21a. (washington.edu)

The genetic homogeneity of ospC -A isolates was confi rmed agent, Borrelia burgdorferi , a spirochete that parasitizes by sequences at 6 additional chromosomal housekeeping vertebrates, is transmitted by hard-bodied ticks through- loci ( gap, alr, glpA, xylB, ackA, and tgt ). (cdc.gov)
aegypti ), implicating these species as likely lin (Ig) M-capture ELISA with DENV antigen confi rmed epidemic or enzootic vectors ( 3 - 5 ). (folkhalsomyndigheten.se)

In this lab bacteria are grown to produce DNA, which we use in further experiments such as viral vector production. (lu.se)

The hypothesis that genetic diversity at GP60 locus mirrors notification rates of human cryptosporidiosis was not rejected based on the data presented. (biomedcentral.com)
Genetic diversity of C. hominis and C. parvum may therefore be an independent and complementary measure for quantifying disease incidence, for which only a moderate number of stool samples from each nation are sufficient data input. (biomedcentral.com)
Here, we test the hypothesis that the genetic diversity of Cryptosporidium at the GP60 locus from human isolates positively correlates with the population risk. (biomedcentral.com)
The malaria vector Anopheles stephensi has been detected in multiple countries in the Horn of Africa (HOA), but data on its geographic distribution and population genetic diversity are incomplete. (biomedcentral.com)
genetic diversity revealed three cytochrome oxidase I ( COI ) haplotypes, all of which have been observed in other countries in East Africa and one also observed in South Asia. (biomedcentral.com)
Genetic diversity in nested PCR products was determined by Restriction Fragment Length Polymorphism (RFLP) utilizing Alu1 and PstI restriction enzymes for alpha and beta gene products digestion, respectively. (scielo.br)
In the multiple location study, diversity was found for the Common Amakihi (Hemignathus virens). (hawaii.edu)

These lentivirus-based shRNA libraries deliver unparalleled coverage and are available in multiple formats that include whole-genome, individual RNAi clones/vectors, and gene family sets. (sigmaaldrich.com)
While polyclonal antibodies are secreted by many different B cell clones and recognize multiple antigenic epitopes, monoclonals originate from a single B cell clone and are specific for just one epitope. (cellsignal.com)

This study determined the genetic relatedness of USA, 2009-2010 the DENV-1 isolates from dengue patients in Key West and 4 other Florida counties during 2009-2010, including the blood donor and mosquito isolates. (cdc.gov)
Although heat is a powerful short-range mosquito attractant, genetic disruption of heat seeking alone only modestly impacts overall host detection, suggesting other cues act in parallel with heat near hosts. (washington.edu)
These data show that two major vectors of human disease use similar mechanisms to locate hosts and oviposition sites and demonstrate the overall importance of short-range cue detection for complex mosquito behaviors. (washington.edu)
The PCR test was used to estimate prevalence of avian malaria in Hawaiian birds living at high elevations above the normal range of mosquito vectors. (hawaii.edu)

We have developed a novel method for co-expressing multiple chimeric fluorescent fusion proteins in plants to overcome the difficulties of conventional methods. (jove.com)
The main advantage of this technique is the high efficiency of co-expressing cellular fusion proteins in one expression vector. (jove.com)
Versameb's proprietary VERSagileplatform can both enhance the effectiveness of RNA and target multiple proteins simultaneously within a single molecule. (swissbiotech.org)
The payload is a circular piece of DNA, a vector, that encodes the healthy gene and other regulatory components-the latter are essentially translators that communicate with the host cell to turn the genetic code into proteins. (singularityhub.com)
Its first version, pre-RNA, faithfully translates DNA-including genetic code that makes proteins, but also junk letters without any meaning. (singularityhub.com)
During these nip-tucks, depending on what parts gets snipped out, one RNA strand can produce multiple variations of proteins, or sometimes none at all. (singularityhub.com)

Based on 296 C. hominis and 195 C. parvum GP60 sequences from human origin, the genetic diversities of Cryptosporidium was estimated for several nations. (biomedcentral.com)
In other words, the exposure to infectious oocysts in a human population could be indirectly measured by quantifying the genetic diversities of C. hominis and C. parvum DNA sequences, as found in human fecal samples. (biomedcentral.com)
During transposition, the PiggyBac™ transposase recognises transposon-specific inverted terminal repeat sequences (ITRs) located on both ends of the transposon vector and efficiently moves the contents from the original sites and efficiently integrates them into TTAA chromosomal sites. (bioscience.co.uk)
Because these approaches will rely on novel data types such as DNA sequences and high-throughput phenotyping images, Breeding 4 will call for analyses that are complementary to traditional quantitative genetic studies, being based on machine learning techniques which make efficient use of sequence and image data. (springer.com)

We implemented a vector surveillance program and performed molecular analysis of Anopheles in three urban areas in Somaliland. (biomedcentral.com)
and the long-established HOA malaria vector Anopheles arabiensis . (biomedcentral.com)
While significant progress has been made to reduce malaria cases and mortality over the last decade, the recent detection of a new vector, Anopheles stephensi, in the Horn of Africa (HOA) threatens to reverse this progress. (biomedcentral.com)
Anopheles stephensi , a vector found in South Asia and the Middle East, including large parts of the Arabian Peninsula, was first detected in Djibouti in 2012 [ 2 ]. (biomedcentral.com)
stephensi and the long-established HOA malaria vector Anopheles arabiensis. (bvsalud.org)
Anopheles stephensi is a malaria vector that has been recently introduced into East Africa, where it threatens to increase malaria disease burden. (bvsalud.org)

however, Oropsylla montana has been incriminated as the primary vector for this disease in North America. (medscape.com)

Our strategy involves delivering different vectors at the same time to rapidly determine which one is the best therapeutic possible. (jax.org)

Currently, two or more kinds of plasmids or DNA fragments are generally used for multiple targeting in cultured cells 7 . (nature.com)
However, cotransfection of multiple plasmids can cause low targeting efficiency in cells that are inefficient in DNA transfection. (nature.com)
In addition, the plasmids for the second-step reaction retained the structure of a CRISPR/Cas9 expression vector harboring single gRNA and Cas9 expression cassettes and can therefore be used separately for single gene targeting. (nature.com)
In this study, we constructed plasmids to create all-in-one vectors expressing two to seven gRNAs with Cas9 nuclease or nickase ( Figure 1 ). (nature.com)

Lastly, the dramatic population increase will contribute to conditions of overcrowding and poor sanitation-conditions ripe for the flourishing of plague hosts and vectors. (medscape.com)

Four ospC clonal complexes dence of genetic endemism, recent migration events, and (A, B, I, and K groups) were found to be more likely than recombinant genomic types. (cdc.gov)

Genetic changes in microbes, animal vectors, and humans were included. (cdc.gov)

CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic modifications, not only for single gene targeting, but also for multiple targeted mutagenesis. (nature.com)
To make the most of the multiplexity of CRISPR/Cas9, we established a system for constructing all-in-one expression vectors containing multiple guide RNA expression cassettes and a Cas9 nuclease/nickase expression cassette. (nature.com)
We further demonstrated successful examples of multiple targeting including chromosomal deletions in human cells using the all-in-one CRISPR/Cas9 vectors constructed with our novel system. (nature.com)
The Cell and Gene Therapy core is an open-access infrastructure and our services include AAV and LV vector production, cloning services, iPS reprogramming, iPS-edits and CRISPR experimental designs. (lu.se)

Ocular disease patients can receive vectors through topical eye drops, oral medication or injections. (ondrugdelivery.com)
The vectors can be produced at very high titers and used directly for in vivo injections. (lu.se)

We found some articles related to environmental interactions with inherited genotype and others on environmental exposures that damage genetic material and initiate molecular pathways of pathogenesis. (cdc.gov)

Recently, we developed a vector that mediates suppression of gene expression through RNA interference. (uu.nl)

[ 9 ] These acquired genetic changes have allowed the pathogen to colonize fleas and to use them as vectors for transmission. (medscape.com)

This method has proven valuable for maize, rice, and sugar cane, species that are outside the host range for vector transfer by Agrobacterium . (jrank.org)
Of the 1500 flea species identified, only 30 of them have been shown to act as vectors of plague. (medscape.com)

The expression cassettes of the gRNAs are tandemly ligated into a single vector using the Golden Gate cloning method. (nature.com)
To establish an all-in-one vector system, we modified the pX330 vector, originally developed by the Feng Zhang laboratory 4 , 8 , containing a single gRNA expression cassette and a Cas9 nuclease expression cassette. (nature.com)
The constructed vectors harboring single gRNA expression cassettes are then assembled into an all-in-one vector harboring multiple gRNA cassettes using the Golden Gate assembly method (STEP 2). (nature.com)
Pioneering work in the late 1990s through early 2010s resulted in vectors for gene deletion and expression in Clavibacter , but there is still reliance on these tools despite known limitations. (biorxiv.org)
In contrast, hybridoma-based systems for producing monoclonal antibodies are subject to genetic drift and instability, increasing the potential for lot-to-lot variability or loss of antibody expression. (cellsignal.com)
of this vector to specifically and stably inhibit expression of only the oncogenic K-RASV12 allele in human tumor cells. (uu.nl)

During her postdoctoral fellowship at the University of North Carolina Chapel Hill, she contributed to developing AAV-based gene therapies for Giant Axonal Neuropathy, Charcot-Marie-Tooth disease type 4J, and Multiple Sulfatase Deficiency. (wtnh.com)
That said, drug developers and laboratory partners must understand the challenges that have already been encountered - and those that lay ahead - for novel genetic therapies. (ondrugdelivery.com)

Multiple Objective Vector-Based Genetic Programming Using Human-Derived Primitives, In Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation, Association of Computing Machinery, New York, pp. 1127-1134. (emergencyresponsetips.com)

This process can be used repeatedly to generate plants with multiple disease resistance, combined with other desirable characters. (jrank.org)
After six years, INADcure has multiple disease models and a gene therapy strategy and has manufactured vectors that are in various stages of testing. (jax.org)
What worries public health scientists, entomologists, etc. is that our environment and ecology, particularly in the tropical Keys, make us very vulnerable to the threat of disease,' explains vector ecologist Tanjim Hossain from the University of Miami. (discovermagazine.com)
This immunity occurs because those sites are insulated from direct contact with systemic circulation and thus are protected from strong immune reactions to foreign antigens like disease or viral vectors. (ondrugdelivery.com)
Depending on the genetic disease, we can then swap out those Legos for others-pretty much plug-and-play. (singularityhub.com)
More than half (23 of 39) of the articles represent epidemiologic studies including candidate gene and genome-wide association studies (GWAS) examining genetic effect modification on disease risk. (cdc.gov)
Occupational exposures involving crystalline silica and multiwalled carbon nanotubes were also studied in relation to genetic damage and initiation of disease processes. (cdc.gov)
Although plague has been considered a disease of the Middle Ages, multiple outbreaks in India and Africa during the last 20 years have stoked fears of another global pandemic. (medscape.com)
Ar- asthma, permanent allergic rhinitis and atopic dermatitis thropod vectors of infectious disease agents have special (eczema) among sensitive individuals ( 4,5 ). (who.int)

The agreement enables Versameb to use Touchlight's proprietary doggybone DNA (dbDN) vector technology to support the development of novel mRNA-based therapeutics addressing unmet needs in urology and oncology. (swissbiotech.org)

After describing its operation, we illustrate its use on problems in two domains, matrix/vector manipulation and list manipulation, which require its generality. (mit.edu)

Oligonucleotides corresponding to each target sequence are annealed and inserted into BpiI-digested pX330A or pX330S vectors (STEP 1). (nature.com)

In Cas9 nuclease-mediated genome editing, we constructed an all-in-one vector expressing Cas9 nuclease and seven gRNAs and targeted seven genomic loci. (nature.com)
To this end, we take a landscape genomic approach to assess A. stephensi origins and spread throughout the HoA, information essential for vector control. (bvsalud.org)

Whether a condition calls for gene replacement, editing, suppression or growth, researchers must engineer vectors to deliver the suitable genetic material to the right place in the ocular microenvironment. (ondrugdelivery.com)

The collaboration underscores ElevateBio's strategy to form new industry partnerships where the company's technology is at the foundation, while selectively advancing its own portfolio of genetic medicines. (biospace.com)

Viral tracers are useful tools for neuroanatomical mapping and genetic payload delivery. (2bscientific.com)

So, as new evolutionary optima have been set by environmental changes (e.g., domestication, management practices, biotic or abiotic pressures) or major shifts in genetic background, plant breeders have selected better-adapted genotypes while pursuing faster genetic gains through technological innovations and scientific breakthroughs. (springer.com)

Each cell division is a potential event for a novel genetic variant. (biomedcentral.com)

Since the early 1990's, different genetic transformation systems have been successfully developed in sugarcane, including electroporation, Agrobacterium tumefaciens and biobalistics. (frontiersin.org)

Multiple variants have emerged, and some variants are more transmissible (see "Variants" in Pathology below) 211, 212 . (radiopaedia.org)
Genetic variants of the SARS-CoV-2 virus emerge as it evolves. (msdmanuals.com)

Evolutionary algorithms in theory and practice : evolution strategies, evolutionary programming, genetic algorithms. (wikipedia.org)
Practical genetic algorithms with CD-Rom (2nd ed. (wikipedia.org)
In: Proceedings of the Third International Conference on Genetic Algorithms. (wikipedia.org)

[ 2 ] Three biovars (with minor genetic variations) have been identified within the Y pestis clone: Antiqua, Medievalis, and Orientalis. (medscape.com)

The triggers differ from quitoes, storage pests, biting insects, canine and feline person to person, most likely due to a combination of fleas, butterfly larvae, bedbugs, horseflies, silverfish and environmental and genetic factors. (who.int)

The last one decomposes an MOP into a set of single subproblems, and evaluates solutions with regard to reference vector. (hindawi.com)
single locations, single islands, and multiple islands. (hawaii.edu)
A single gene can have multiple exons. (singularityhub.com)
Carbon nanotube s (CNTs) are rolled-up cylindrical structures of single (single-walled carbon nanotube - SWCNT) or multiple (multi-walled carbon nanotube - MWCNT) sheets of graphene that have high aspect ratio, high electrical and thermal conductivity, ultra-light weight, and high mechanical strength. (cdc.gov)

The vectors are also used for in vivo modifications of cells, e.g. for reprogramming. (lu.se)

Multiple replication-defective or competent strains are available at 2B Scientific for research purposes. (2bscientific.com)

Likely reasons for this change include the use of more stringent methods of otitis media surveillance, including pneumatic otoscopy and tympanometry, as well as expansion of CF genetic testing and diagnostic criteria, bringing a larger, less severely affected patient population into contemporary CF clinics. (medscape.com)

Genetic diversities of C. hominis were estimated in 10 nations in 5 continents, and that of C. parvum of human origin were estimated in 15 nations. (biomedcentral.com)
Most human tumors harbor multiple genetic alterations, including dominant mutant oncogenes. (uu.nl)
The Human Genome Project has essentially created a genetic blueprint for human beings. (ondrugdelivery.com)
Some studies suggest that the transplantation of human amniotic epithelial cells transduced with adenoviral vectors can be used for the treatment of congenital lysosomal storage disorders. (medscape.com)

Frequently, the genetic material becomes destabilized and reorganized, so that previously-concealed characters are expressed. (jrank.org)

This relatively new tech, which relies on a synthetic strand of genetic code called messenger RNA (mRNA) to prime the immune system, had not yet been approved for any previous vaccine in the world. (livescience.com)

The results of this study will contribute in future studies about the genetic structure of parasite and vaccine development against the malaria. (scielo.br)
Proposed Phase II studies will consist of research and development of production processes for multiple viral vectors, including AAV and immuno- oncolytic poxvirus/vaccine. (sbir.gov)

Genetic transformation has the potential to improve economically important properties in sugarcane as well as diversify sugarcane beyond traditional applications, such as sucrose production. (frontiersin.org)
However, genetic transformation of sugarcane is a very laborious process, which relies heavily on intensive and sophisticated tissue culture and plant generation procedures that must be optimized for each new genotype to be transformed. (frontiersin.org)
The objective of this review is to summarize current techniques and state of the art in sugarcane transformation and provide information on existing and future sugarcane improvement by genetic engineering. (frontiersin.org)

Systematic genetic access to GABAergic cell types will facilitate studying the function and development of inhibitory circuitry. (nih.gov)
Although intersectional approaches improve precision, it remains unclear whether they can capture cell types defined by multiple features. (nih.gov)
Here we demonstrate that combinatorial genetic and viral approaches target restricted GABAergic subpopulations and cell types characterized by distinct laminar location, morphology, axonal projection, and electrophysiological properties. (nih.gov)
Once inside the cell, the vector does its magic. (singularityhub.com)

cite book}}: CS1 maint: multiple names: authors list (link) Oldenhuis, Rody. (wikipedia.org)

Anatomy6

Organisms27

Diseases3

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes27

Information Science6

Health Care7

Plasmid6

Malaria vectors2

Diseases8

Genes10

Aedes2

Protein7

Mutation2

Common vector-borne disease1

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20222

Biological2

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Molecular1

Gene expression1

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