Multiple conjugated. Medical search. Frequent questions

Pneumococcal conjugate vaccines (PCVs) have been used in the United States since 2000. (cdc.gov)
Until the United States began a universal 7-valent pneumococcal conjugate vaccine (PCV7) immunization program for children in 2000, Streptococcus pneumoniae was the leading cause of bacterial meningitis ( 1 ). (cdc.gov)
KENILWORTH, N.J.--(BUSINESS WIRE)-- Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of VAXNEUVANCE™ (Pneumococcal 15-valent Conjugate Vaccine) for active immunization for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae in individuals 18 years of age and older. (merck.com)
KENILWORTH, N.J.--(BUSINESS WIRE)-- Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced the company has submitted applications to the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) for licensure of V114, Merck's investigational 15-valent pneumococcal conjugate vaccine, for use in adults 18 years of age and older. (merck.com)
V114 is Merck's investigational 15-valent pneumococcal conjugate vaccine candidate for the prevention of pneumococcal disease in adults and children. (merck.com)
V114 consists of pneumococcal polysaccharides from 15 serotypes conjugated to a CRM197 carrier protein and includes serotypes 22F and 33F, which are commonly associated with invasive pneumococcal disease in older adults worldwide and are not contained in the pneumococcal conjugate vaccine currently licensed for use in adults. (merck.com)
Title : Background and follow-up on the 2010-11 febrile seizure signal for trivalent inactivated influenza and pneumococcal 13-valent conjugate vaccines Personal Author(s) : Shimabukuro, Tom T. Corporate Authors(s) : National Center for Emerging and Zoonotic Infectious Diseases (U.S.). Immunization Safety Office. (cdc.gov)
Pneumococcal conjugate vaccines (PCV) have been introduced by 351 AFRO countries and rotavirus vaccines by 272 AFRO countries. (who.int)

Mouse splenocytes either (A) stimulated to induce Th1 cells or (B) unstimulated were stained with Rat Anti-Mouse IFN-gamma Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # IC485N) and Rat Anti-Mouse CD4 PE-conjugated Monoclonal Antibody (Catalog # FAB554P ). (rndsystems.com)
Mouse splenocytes either (A) stimulated for 4 hours with Cell Activation Cocktail 500x ( 5476 ) or (B) unstimulated were stained with Rat Anti-Mouse IFN-gamma Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # IC485N) and Rat Anti-Mouse CD4 PE-conjugated Monoclonal Antibody ( FAB554P ). (rndsystems.com)
Alexa Fluor® 680 and Alexa Fluor® 790 conjugates are used for very sensitive Western blots, ELISAs, and multiplexing arrays. (jacksonimmuno.com)
Alexa Fluor® 680 conjugates are excited with a peak around 684 nm and fluoresce with a peak around 702 nm. (jacksonimmuno.com)
Alexa Fluor® 790 conjugates are excited with a peak around 792 nm and fluoresce at a peak around 803 nm. (jacksonimmuno.com)

We developed a dynamic, age-structured transmission and cost-effectiveness model that simulated multiple vaccination strategies with a typhoid Vi conjugate vaccine from a societal perspective. (unboundmedicine.com)
In the United States, the Advisory Committee on Immunization Practices (ACIP) recommends that children aged 11-12 years receive tetanus, diphtheria, and acellular pertussis vaccine (Tdap), meningococcal conjugate vaccine (MenACWY), and human papillomavirus (HPV) vaccine (HPV vaccine can be started at age 9 years). (medscape.com)
Meningococcal conjugate vaccination coverage represents coverage with the quadrivalent meningococcal conjugate vaccine or meningococcal-unknown type vaccine. (medscape.com)

In addition to a combined portfolio of vaccines and antibacterial, antiviral and antifungal medicines, Merck has multiple programs that span discovery through late-stage development. (merck.com)
While new Vi conjugate vaccines hold promise for averting disease, the optimal programmatic delivery remains unclear. (unboundmedicine.com)
We aimed to identify the strategies and associated epidemiologic conditions under which Vi conjugate vaccines would be cost-effective. (unboundmedicine.com)
Typhoid Vi conjugate vaccines would be highly cost-effective in low-income countries in settings of moderate typhoid incidence (50 cases/100000 annually). (unboundmedicine.com)

Sanofi and Seagen Inc. (Nasdaq:SGEN) today announced an exclusive collaboration agreement to design, develop, and commercialize antibody-drug conjugates (ADCs) for up to three cancer targets. (sanofi.com)
Antibody-drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. (wikipedia.org)
Antibody drug conjugates (ADCs) constitute a family of cancer therapeutics designed to preferentially direct a cytotoxic drug to cells expressing a cell-surface antigen recognized by an antibody. (aspetjournals.org)
Antibody-drug conjugates (ADCs) are one such class of drugs. (umass.edu)
In this dissertation, we utilize antibody-nanoparticle conjugates (ANCs) to address the limitations of ADCs as well as to develop a platform technology toward achieving targeted delivery of chemotherapeutics to cancer cells. (umass.edu)

Extending the applicability of antibody-conjugated polymeric nanoparticle, anionic polymer-antibody conjugates were formulated for developing a technique to achieve targeted electroporation of biologics into cancer cells. (umass.edu)
After phycobiliproteins are conjugated to secondary antibodies, there is little fluorescence quenching, which results in conjugates of high specific fluorescence compared with conventional fluorophore-antibody conjugates. (jacksonimmuno.com)
Choose from an extensive portfolio of trusted dyes across multiple laser lines with a variety of antibody conjugates and get the flexibility you need to take your research to the next level. (bdbiosciences.com)
Defence's Accum TM platform has been primarily developed and tested in vitro and in vivo to enhance the intranuclear drug delivery on multiple FDA approved antibody-conjugates or new conjugates under development. (pharmiweb.com)

Antibody-drug conjugates are an example of bioconjugates and immunoconjugates. (wikipedia.org)
Belantamab mafodotin-blmf is in a class of medications called antibody-drug conjugates. (medlineplus.gov)

For example, viral-like nanoparticles that comprise (e.g., are conjugated to) photosensitive molecules may be selectively delivered to tumor cells and photoactivated by exposure to light. (justia.com)
Viral-like nanoparticles (also referred to as virus-like particles (VLPs)) of the present disclosure, generally, are assembled from L1 capsid proteins, or a combination of L1 and L2 capsid proteins, and the photosensitive molecules, in some embodiments, are conjugated to a capsid protein that forms the viral-like nanoparticle. (justia.com)
Thus, various aspects of the disclosure provide tumor-targeting viral-like nanoparticles that comprise photosensitive molecules conjugated to capsid proteins. (justia.com)

This is not a complete list of Meningococcal (Groups A, C, Y and W-135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccinedrug interactions. (rxwiki.com)

A "photosensitive viral-like nanoparticle," (also referred to herein as a "photosensitive virus-like particle") refers to a viral-like nanoparticle conjugated to a photosensitive molecule. (justia.com)

A conjugated polyelectrolyte, or CPE-K, consists of a central conjugated backbone, with alternating single and double bonds, and multiple charged side chains with ions attached. (sciencedaily.com)
One of the advantages of those materials is a possibility to fine-tune useful properties by simply varying of the π-conjugated backbone and side-chain substituents [1-5] . (beilstein-journals.org)
Herein, 1,4,5,8-naphthalene tetracarboxylic acid dianhydride - 2,3-diamino phenothiazine (NTDP) featuring multiple active sites (6 with CN and 2 with CO) and large π-conjugated backbone, was designed and synthesized utilizing solid-phase method . (bvsalud.org)

Conjugated linoleic acids (CLA) are essential fatty acids that have been reported in animal studies to decrease catabolism, promote fat loss, increase bone density, enhance immunity, and serve as an antiatherogenic and anticarcinogenic agent. (lww.com)

CCK2R Ligand-Linker Conjugates 1 is a ligand-linker conjugate, which conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) via a hydrophilic peptide linker. (adooq.com)

The rationale of this study was to determine the myelotoxicity in nude mice of the α-emitter 211 At conjugated to monoclonal antibodies (mAbs) and to compare the effect with an electron emitter, 99m Tc, and external irradiation from a 60 Co source, for estimation of the relative biological effectiveness (RBE). (snmjournals.org)
MMACA quantifies antibodies to multiple antigens in a single reaction, using extremely low amount of capture antigen and sample volume (Rajam, et. (cdc.gov)
Green Fluorescent Protein, GFP) and staining with fluorescently conjugated antibodies or fluorescent dyes. (sigmaaldrich.com)
Conjugated haptenicpeptides synthesized from benzene or naphthalene (adduction to form S-phenylcysteine) substituted cysteines complexed to keyhole limpet hemocyanin (KLH) were synthesized and the antibodies produced using New Zealand white rabbits. (cdc.gov)

An antibody-drug conjugate consists of 3 components: Antibody - targets the cancer cell surface and may also elicit a therapeutic response. (wikipedia.org)

Multiple approaches to conjugation have been developed for attachment to the antibody and reviewed. (wikipedia.org)
The oligomers synthesized in this way are cross-conjugated systems, in which two conjugation pathways are possible: π-conjugation of 1,8-bis(dimethylamino)naphthalene (DMAN) fragments through a butadiyne linker and a donor-acceptor aryl-C≡C-DMAN conjugation path. (beilstein-journals.org)

π-Conjugated oligomers consisting of alternating C≡C bonds and aromatic nuclei, commonly, have a rigid, rod-like structure and exhibit high charge carriers' mobility [6] . (beilstein-journals.org)
Design and synthesis of Ð¿-conjugated aromatic heterocyclic materials with dual active sites and ultra-high rate performance for aqueous zinc-organic batteries. (bvsalud.org)

Diluted serum specimens are incubated with antigen-conjugated fluorescent beads. (cdc.gov)

Ligand binding induces receptor dimerization and autophosphorylation on multiple tyrosine residues. (rndsystems.com)

This is a phase 1b, open-label, multicenter, dose-escalation study of STI-6129 administered intravenously once in a 4-week cycle in subjects with relapsed or refractory multiple myeloma. (sorrentotherapeutics.com)
Belantamab mafodotin-blmf injection is used to treat multiple myeloma (a type of cancer of the bone marrow) that has returned or has not improved in adults who have received at least 4 other medications. (medlineplus.gov)

The targeting effects of IONPs conjugated to the EGFR inhibitor, cetuximab (cetuximab-IONPs), were determined with EGFR- and EGFRvIII-expressing human GBM neurospheres and GSCs. (oncotarget.com)

Retinal is a polyene organic compound, meaning that this molecule contains multiple alkene functional groups. (dummies.com)

L'incidence des méningites à H. influenzae type b a diminué de près de 100 % après la mise en œuvre du programme national de vaccination en 2001, alors que celle des cas dus à S. pneumoniae et N. meningitidis est restée stable. (who.int)

The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules. (justia.com)

For formula-fed infants who are jaundiced after age 2 weeks or otherwise-well, breast-fed infants who are icteric at age 3 weeks, obtain serum total and conjugated bilirubin levels. (medscape.com)

The world-renowned Curie Institute, one of Defence's collaborator, is currently performing therapeutic efficacy study of Accum TM -T-DM1 Antibody Drug Conjugate ("ADC") in patient-derived xenograft ("PDX") model of breast cancer, including in 3 HER2+ and in 1 triple-negative PDX. (pharmiweb.com)

CAMBRIDGE, England & BOSTON--( BUSINESS WIRE )-- Bicycle Therapeutics Limited (NASDAQ: BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide ( Bicycle ® ) technology, today announced that it has entered into a strategic collaboration agreement with Novartis to develop, manufacture and commercialize Bicycle ® radio-conjugates (BRCs) for multiple agreed upon oncology targets. (biospace.com)
This collaboration builds on the groundbreaking clinical work we have been doing in the toxin conjugate field and provides new and additional validation for this unique technology," said Kevin Lee, Ph.D., Chief Executive Officer of Bicycle Therapeutics. (biospace.com)

Nguyen KL, Lamerand SR, Deshpande RP, Taylor BK (2021) Featured Article: Selective ablation of IB4+ primary afferent neurons reduces mechanical and cold hyperalgesia in an EAE mouse model of multiple sclerosis. (atsbio.com)
Sanna F, Bratzu J, Angioni L, Pina Sorighe M, Cocco C, Argiolas A, Melis MR (2021) Oxytocin-conjugated saporin injected into the substantia nigra of male rats alters the activity of the nigrostriatal dopaminergic system: A behavioral and neurochemical study. (atsbio.com)

Having conjugated bonds throughout the polymer makes it conductive, because the delocalized electrons have high mobility across the length of the polymer," explains lead author Tung Nguyen-Dang, a postdoctoral researcher in Nguyen's lab who is co-advised by Visell. (sciencedaily.com)

In July 2018, Daiichi Sankyo Company, Limited and Glycotope GmbH have inked a pact regarding the combination of Glycotope's investigational tumor-associated TA-MUC1 antibody gatipotuzumab and Daiichi Sankyo's proprietary ADC technology for developing gatipotuzumab antibody drug conjugate. (wikipedia.org)

To minimize the adverse effects of chemotherapy, multiple ways of achieving targeted drug delivery have evolved. (umass.edu)

Example for: conjugate_gradients(), molecular_dynamics(), model.switch_trace() # This will optimize stereochemistry of a given model, including # non-bonded contacts. (salilab.org)

Fatty acid-amino acid conjugates (FACs) are HAMPs present in oral secretions (OS) of lepidopteran larvae that induce defense responses in many plant species. (springer.com)
Detritylation frees the 3′-terminal amine with the conjugate acid of a non-nucleophilic heterocycle, typically 4-cyanopyridine in dichloromethane-trifluoroethanol (DCM/TFE) mixtures. (nature.com)

Opsoclonus refers to rapid, conjugate oscillations of the eyes in multiple directions, which may occur as a parainfectious or paraneoplastic condition (e.g. (bvsalud.org)

Here we have determined the 2.2 A crystal structure of an intermediate of UbcH5b~ubiquitin (Ub) conjugate, which is assembled into an infinite spiral through the backside interaction. (rcsb.org)

E2 ubiquitin-conjugating enzymes catalyze the attachment of ubiquitin to lysine residues of target proteins. (rcsb.org)

Our antibody specificities are confirmed for multiple applications, and all our flow cytometry reagents are titrated on the relevant positive and/or negative cells. (bdbiosciences.com)
Flow cytometry is a technology that uses single or multiple lasers to provide a multi-parametric analysis of single cells. (sigmaaldrich.com)
Numerous fields of study use flow cytometry and often analyze multiple parameters within diverse populations of cells. (sigmaaldrich.com)

Alternative splicing results in multiple transcript variants. (origene.com)
We extend recent results of Ono and Raji, relating the number of self-conjugate 7-core partitions to Hurwitz class numbers. (uni-koeln.de)

The first immunology antibody-drug conjugate (iADC), ABBV-3373, showed an improvement in disease activity in a Phase 2a study of patients with rheumatoid arthritis and a study with the second iADC, ABBV-154 to evaluate adverse events and change in disease activity in participants treated with subcutaneous injection of ABBV-154 is ongoing. (wikipedia.org)

African swine fever virus (ASFV) is an acute and persistent swine virus with a high economic burden that encodes multiple genes to evade host immune response. (mdpi.com)

Summary: Researchers investigated the effects of injecting oxytocin-conjugated Saporin into the substantia nigra of male rats. (atsbio.com)
Combining the Accum TM technology to the radio-immuno-conjugate is expected to amplify the therapeutic index of the drug while minimizing side effects observed in patients undergoing the therapy. (pharmiweb.com)

Two different methods to produce antisera failed, most likely, due to cross-linking of difunctional acrylate to multiple nonspecific sites. (cdc.gov)

π-Conjugated oligomers and polymers attracted considerable attention from the very start as a promising class of semiconductors, chemosensors, and various electronic devices [1,2] . (beilstein-journals.org)

The XMap technology platform is used to populate the antigen conjugated beads and simultaneously detect the PE reporter. (cdc.gov)

These forms reflect the concentration of conjugated and unconjugated levels respectively. (medscape.com)
[ 26 ] Note that although the directly reacting bilirubin concentration approximates the conjugated bilirubin concentration in most cases, the two terms do not mean the same thing. (medscape.com)
However, the van den Bergh method is dated and may not accurately show the concentration of conjugated and unconjugated bilirubin owing to other substances interfering with the diazo reaction. (medscape.com)
Devgun et al indicate a direct bilirubin concentration of 10 μmol/L or higher should be used to consider the presence of conjugated hyperbilirubinemia, provided that the total bilirubin concentration is also above the reference interval. (medscape.com)

I have found that multiple sets of singles are a great way to increase my Deadlift. (startingstrength.com)

This active complex may provide multiple E2 active sites, enabling efficient ubiquitination of substrates. (rcsb.org)

method with an atom selection then performs a number of optimizing iterations using a modified version of the Beale restart conjugate gradients method [ Shanno & Phua, 1980 , Shanno & Phua, 1982 ]. (salilab.org)

Pneumococcal8

Alexa Fluor5

Vaccine3

Vaccines4

ADCs5

Antibody conjugates4

Drug Conjugates2

Nanoparticles3

CRM1971

Nanoparticle1

Backbone3

Linoleic1

Cytotoxic1

Antibodies4

Consists1

Conjugation2

Aromatic2

Fluorescent1

Induces1

Myeloma2

Inhibitor1

Molecule1

Vaccination1

Molecules1

Serum1

Cancer1

Therapeutics2

20212

Bonds1

Tumor1

Adverse effects1

Molecular1

Acid2

Refers1

Intermediate1

Proteins1

Flow cytometry3

Results2

Injection1

High1

Effects2

Methods1

Class1

Technology1

Concentration4

Found1

Active sites1

Method1