ChemotherapyMalignant pleural mesotheliomaTherapyPancreatic cancersUnresectableHistologically provenRectal cancerNeoadjuvantResectionPatientsCancersPrognosticModalityTumorsLung cancerSurgeryTreatmentSurvivalConsidered for a multimodality approachBorderline resectable pancreatic cancerMetastasesOperable and resectableTherapyRadiotherapyChemoradiationLung CancerResectabilityLocally advancedRegimenDiseaseManagementApproach
Chemotherapy5
- However, surgery is increasingly incorporated in a multimodality approach that includes neoadjuvant and adjuvant chemotherapy and/or radiation therapy. (medscape.com)
- However, we now know that improved outcomes can be achieved by combining surgery with chemotherapy under the broad umbrella of multimodality therapy [5, 6]. (edu.au)
- Although surgical advances including total mesorectal excision continue to decrease rates of local recurrence, the management of locally advanced disease (T3-T4 or N+) benefits from a multimodality approach including neoadjuvant concomitant chemotherapy and radiation. (biomedcentral.com)
- Delivering oncologically specific treatment that involves multimodality management (surgery, chemotherapy, radiotherapy), particularly in a resource-constrained community, is a significant challenge. (binayfoundation.org)
- This study assessed activity and safety of an innovative integration of multimodality treatment-induction chemotherapy (ICT), surgery and radiotherapy (RT)-modulated by histology and response to ICT. (uninsubria.it)
Malignant pleural mesothelioma4
- Neragi-Miandoab S. Multimodality approach in management of malignant pleural mesothelioma. (smw.ch)
- Multimodal treatment for resectable epithelial type malignant pleural mesothelioma. (smw.ch)
- However, investigators evaluating the feasibility of the Surgery for Mesothelioma After Radiation Therapy (SMART) approach for resectable malignant pleural mesothelioma reported that preoperative radiation therapy may improve survival. (medscape.com)
- [ 21 , 22 ] In a study of 25 patients with resectable malignant pleural mesothelioma, a 1-week course of high-dose hemithoracic intensity-modulated radiation therapy (IMRT) before extrapleural pneumonectomy proved feasible and prolonged survival. (medscape.com)
Therapy8
- A systematic review was conducted to address 3 clinical questions: whether patients with resectable esophageal cancer should receive preoperative versus postoperative therapy, how to choose between these options, and whether surgery be avoided in patients who are candidates for both definitive chemoradiotherapy and definitive combined modality therapy. (nccn.org)
- MPM has a median overall survival of 7-13 months from the time of diagnosis with 5-year survival of less than 10%, although patients who are treated with multimodality therapy have shown median survival of 13-23.9 months (Beebe-Dimmer et al. (atlasgeneticsoncology.org)
- Clinical trials have investigated the use of multimodality therapy to decrease the incidence of both local and distant recurrence. (biomedcentral.com)
- This document summarizes the major clinical trials and the role for multimodality therapy. (biomedcentral.com)
- Integration of surgery in multimodality therapy for esophageal cancer. (rush.edu)
- Cost-effectiveness of Total Neoadjuvant Therapy With Short-Course Radiotherapy for Resectable Locally Advanced Rectal Cancer. (wustl.edu)
- Despite these improvements in the staging and use of multimodality therapy, only modest improvements in patient survival have been observed. (jnccn.org)
- His research interests include targeted therapies for lung cancer, multimodality therapy, the development of new anticancer drugs, and symptom management with a focus on preventing emesis. (medscape.com)
Pancreatic cancers1
- High-quality multidetector computed tomography imaging is the gold-standard diagnostic and staging modality, because it can classify pancreatic cancers as resectable, borderline resectable, locally advanced, or metastatic. (mhmedical.com)
Unresectable2
- Multimodality conversion of initially unresectable patients to resectable is possible in some patients. (nih.gov)
- There is no consensus on the distinction between resectable and unresectable N2 disease. (cancer.org.au)
Histologically proven1
- Previously untreated, histologically proven, surgically resectable primary squamous cell carinoma of the head and neck, stage III or IV (HPV positive or negative non-metastatic disease). (urotoday.com)
Rectal cancer1
- The management of resectable rectal cancer continues to be guided by clinical trials and advances in technique. (biomedcentral.com)
Neoadjuvant3
- Primary resection versus neoadjuvant chemoradiation followed by resection for locally resectable or potentially resectable pancreatic carcinoma without distant metastasis. (biomedcentral.com)
- The study investigates the effect of neoadjuvant chemoradiation in locally resectable or probably resectable cancer of the pancreatic head without distant metastasis on median overall survival time compared to primary surgery. (biomedcentral.com)
- Neoadjuvant oncological treatment for gastro-oesophageal junction cancer previously consisted of the intravenous administration of epirubicin, cisplatin and fluorouracil (ECF) or epirubicin, cisplatin and capecitabine (ECX) combination (Group I). In the course of the new protocol (FLOT-, F: 5-FU, L: leucovorin, O: oxaliplatin, T: docetaxel), patients were included with resectable gastro-oesophageal junction cancer who had a clinical-stage cT2 or higher nodal positive cN+ disease (Group II). (akjournals.com)
Resection3
- METHODS: Eighty-four patients with resectable esophageal adenocarcinoma, who completed the planned preoperative chemoradiation and underwent a potentially curative esophageal resection were retrospectively evaluated. (who.int)
- This multimodality approach is best suited to only 20% of patients with pancreatic cancer who present when the disease is still amenable to surgical resection. (edu.au)
- In carefully selected patients who present with a resectable primary tumour and a concurrent single metastasis (Stage 4), surgical resection of the metastasis, in conjunction with removal of the kidney may be done. (oncologybuddies.com)
Patients7
- Abdel-Latif and colleagues recently suggested that esophageal adenocarcinoma patients with GERD might be resistant to multimodality treatment. (who.int)
- Patients with confirmed N2 disease should not be treated by surgery as the sole modality, but resectable cases may be considered for a multimodality approach. (cancer.org.au)
- Patients often present with Stage 4 disease and many patients who initially are resectable eventually experience recurrence. (oncologybuddies.com)
- For patients with resectable locoregional cancer, the guidelines recommend gastrectomy with a D1+ or a modified D2 lymph node dissection (performed by experienced surgeons in high-volume centers). (jnccn.org)
- For patients with localized disease, we generally employ a stepwise multimodality approach. (mhmedical.com)
- Overall, these findings suggest a possible role of ICT as the primary approach in newly diagnosed, resectable sinonasal tumours-especially SNUC-to select patients with favourable prognosis. (uninsubria.it)
- AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: By the AFC-IHCC-2009 study group. (cancercentrum.se)
Cancers1
- Unambiguously squamous Epstein-Barr virus (EBV)-negative nasopharynx cancer will be excluded nor will unambiguously squamous cancers of the skull base that are clearly surgically resectable and clearly squamous. (urotoday.com)
Modality1
- Many different treatment approaches have been studied, with a multimodality approach associated with a 10% to 15% greater survival advantage compared with a single-modality approach. (nccn.org)
Tumors1
- Localized, resectable tumors can be cured by surgery alone. (mhmedical.com)
Lung cancer1
- Identify new treatments for resectable lung cancer. (broadcastmed.net)
Surgery1
- Surgery has traditionally been considered the cornerstone in the management of resectable pancreatic cancer [3, 4]. (edu.au)
Treatment2
- We also discuss the mechanism of development and multimodality treatment available for the management in such an uncommon situation. (jocr.co.in)
- This article highlights the feasibility of delivering multimodality, protocol-based treatment in a resource-constrained set-up. (binayfoundation.org)
Survival1
- For all stages, 5 year overall survival rate is 6% form en and 3% for women[ 1 ]. (biomedcentral.com)
Considered for a multimodality approach1
- Patients with confirmed N2 disease should not be treated by surgery as the sole modality, but resectable cases may be considered for a multimodality approach. (cancer.org.au)
Borderline resectable pancreatic cancer7
- 1. Borderline resectable pancreatic cancer: conceptual evolution and current approach to image-based classification. (nih.gov)
- 9. Surgery after FOLFIRINOX treatment for locally advanced and borderline resectable pancreatic cancer: increase in tumour attenuation on CT correlates with R0 resection. (nih.gov)
- 10. Radiological and surgical implications of neoadjuvant treatment with FOLFIRINOX for locally advanced and borderline resectable pancreatic cancer. (nih.gov)
- 12. Extended neoadjuvant chemotherapy for borderline resectable pancreatic cancer demonstrates promising postoperative outcomes and survival. (nih.gov)
- 15. Borderline resectable pancreatic cancer: the importance of this emerging stage of disease. (nih.gov)
- Management of Borderline Resectable Pancreatic Cancer beschrijft de ontwikkelingen van de laatste jaren hoe borderline alvleesklierkanker (wel of niet operabel) te behandelen. (kanker-actueel.nl)
- Het abstract plus referentielijst van Management of Borderline Resectable Pancreatic Cancer staat onderaan dit artikel. (kanker-actueel.nl)
Metastases1
- Of the 16 patients with multiple resectable metastases, 7 had pump only and 9 had resection plus pump. (nih.gov)
Operable and resectable2
- The group of people we're talking about includes those who are both operable and resectable. (medscape.com)
- For those who are both operable and resectable, which one do you choose? (medscape.com)
Therapy8
- 2. CT-determined resectability of borderline resectable and unresectable pancreatic adenocarcinoma following FOLFIRINOX therapy. (nih.gov)
- 11. Opinions and use of neoadjuvant therapy for resectable, borderline resectable, and locally advanced pancreatic cancer: international survey and case-vignette study. (nih.gov)
- Often, anaplastic thyroid tumors are not surgically resectable and treatment is palliative and based on multimodality therapy. (iiarjournals.org)
- For patients with resectable stage III disease, options are surgery with preoperative or postoperative radiation therapy (the NCCN guideline panel generally prefers preoperative radiation therapy, particularly for patients with large treatment volumes), with consideration of adjuvant chemotherapy. (medscape.com)
- 53 patients with stage IIIA non-small cell carcinoma of the lung (NSCCL) were treated with multimodality therapy consisting of induction radiotherapy (55.8 Gy) and two cycles of concurrent chemotherapy with cisplatin, 25 mg/m 2 for 4 days by continuous infusion and bolus etoposide, 100 mg/m 2 on days 2 and 4 of each cycle followed by surgery and adjuvant chemotherapy. (mssm.edu)
- 47 patients were resectable after induction therapy, but 8 patients refused surgery and 6 patients were not eligible for surgery based on poor pulmonary function (medical contraindications). (mssm.edu)
- His research interests include targeted therapies for lung cancer, multimodality therapy, the development of new anticancer drugs, and symptom management with a focus on preventing emesis. (medscape.com)
- Patients who are planned for a multimodality approach incorporating surgery as defined in Recommendation 2.1 should receive systemic neoadjuvant therapy. (guidelinecentral.com)
Radiotherapy1
- In resectable cases, surgery followed by postoperative radiotherapy a chemotherapy can have better outcomes than non-surgical treatment. (standardofcare.com)
Chemoradiation5
- In the presence of a partial or incomplete response in the neck to chemoradiation, a completion neck dissection is mandatory (assuming the primary site is controlled or is resectable). (medscape.com)
- Multimodality Treatment of Locally Advanced Oral Cancer: Can the Optimal Dose of Chemoradiation be Lowered? (ijhns.com)
- Few centers have employed preoperative 50 Gy chemoradiation followed by surgery for resectable oral cancers. (ijhns.com)
- Since a significant percentage of patients after Def CRT require salvage surgery, the option of multimodality treatment with 50 Gy preoperative chemoradiation may be worth considering. (ijhns.com)
- For patients with resectable superior sulcus disease, neoadjuvant concurrent chemoradiation should be administered. (guidelinecentral.com)
Lung Cancer2
- Neoadjuvant chemotherapy or chemoradiotherapy is a therapeutic option that is used in patients with baseline resectable stage IIIA-N2 non-small cell lung cancer. (iaslc.org)
- How to Select Treatment for Resectable Stage III Lung Cancer Dr Mark Kris discusses treatment options for patients with stage III lung cancer. (medscape.com)
Resectability1
- This multimodality regimen is well-tolerated, induces a high response and resectability rate and prolongs survival in resected patients. (mssm.edu)
Locally advanced2
- Locally-advanced disease also merits aggressive multimodality management and these cases should ideally be discussed in a multidisciplinary tumor board setting to formulate an optimal plan of management. (itmig.org)
- We practice salvage surgery after Def CRT in our institution for some resectable locally advanced oral cancers due to patient, hospital, or logistical considerations. (ijhns.com)
Regimen1
- There is no track record for any kind of a regimen to take a patient who is not resectable and make them resectable. (medscape.com)
Disease1
- 6. White paper on pancreatic ductal adenocarcinoma from society of abdominal radiology's disease-focused panel for pancreatic ductal adenocarcinoma: Part I, AJCC staging system, NCCN guidelines, and borderline resectable disease. (nih.gov)
Management1
- 16. Multimodality management of borderline resectable pancreatic adenocarcinoma. (nih.gov)
Approach1
- 13. A patient-centered, multidisciplinary approach to treating borderline resectable pancreatic adenocarcinoma. (nih.gov)