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  • secretion
  • We report here that protein kinase C (PKC) activity is required for synapse formation by sensory neurons with L7 and for the target-dependent increases in sensorin synthesis and secretion. (jneurosci.org)
  • Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. (wikipedia.org)
  • receptors
  • Neurotrophin interaction with receptors leads to activation of multiple signaling pathways including mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K), and phospholipase C (PLC) [for review, see Huang and Reichardt (2001) and Segal (2003) ]. (jneurosci.org)
  • In response, these receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism. (wikipedia.org)
  • molecule
  • Kinetic studies of the controlled proteolysis of the molecule by elastase showed that the protein was not attacked at random by the protease but rather was successively cleaved into at least six well-defined proteolytic fragments. (mysciencework.com)
  • The initial cleavage converted the intact molecule into a 190,000-dalton species which appeared to retain all of the catalytic and regulatory functions of the native protein. (mysciencework.com)
  • Sequence identity between the a2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. (springer.com)
  • Similarity in the size of exons and their distribution in the domains of the protein molecule indicates that the evolutionary development of lactoferrin gene occurred by duplication. (wikipedia.org)
  • molecules
  • This review also highlights the different oxidized, apoprotein and metalated forms of MTs, the diversity of interactions they can establish with different molecules and their central and multifunctional cellular role. (rsc.org)
  • Pyrx with Autodock vina was used to screen the compounds from Drug bank and Protein Data Bank to find the molecules that can bind to the active site between 1 to 142 amino acids. (ibbj.org)
  • amino
  • In this report, employing a large number of methods and deletion and amino acid substitution mutants, we provide evidence for the cooperation between the extreme C terminus and a putative amphipathic α-helix located between aa 73 and 85 (AAH 73-85 ) at the N terminus of ΔN72, a mutant that lacked the N-terminal 72 aa of nonstructural protein 4 (NSP4) from Hg18 and SA11. (asm.org)
  • Furthermore, a peptide spanning amino acids (aa) 114 to 135 was reported to induce diarrhea at an approximately 100-fold molar excess compared to the full-length protein ( 6 ). (asm.org)
  • RtxA in L. pneumophila is a large protein (around 7.000 amino acids) with several repeated structures belonging to, at least, three protein family domains. (biomedcentral.com)
  • However, when looking at the proteins encoded by LVX and other potexviruses, there were significant similarities between the amino acid sequences. (wikipedia.org)
  • In addition, there are infant formulas using soybean as a protein source in place of cow's milk (mostly in the United States and Great Britain) and formulas using protein hydrolysed into its component amino acids for infants who are allergic to other proteins. (wikipedia.org)
  • These proteins had a high degree of amino acid identity but were determined to be distinct mitogens. (wikipedia.org)
  • HADHA is a 82.9 kDa protein composed of 763 amino acids. (wikipedia.org)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • Examination of the 24 kDa protein of LVX reveals that it contains a nucleoside triphosphate binding motif (GXXGXGKS/T). This motif also found in the lily symptomless virus 25 kDa protein, as well as the 25-26 kDa proteins of other potexviruses, such as potato virus X and potato virus S. LVX also contains a supposed potexvirus subgenomic promoter sequence (GGTTAAGTT---GAA) upstream (5') of the 24 kDa protein. (wikipedia.org)
  • This sequence is also found upstream of initiation codons of coat proteins in similar viruses, most notably lily symptomless virus. (wikipedia.org)
  • In the LVX sequence, there is a region between the 12 kDa ORF and the 22 kDa (coat protein) ORF that is not translated. (wikipedia.org)
  • genomes
  • Among compared genomes, the N-terminal region of the protein presents highly dissimilar repeats with functionally similar domains. (biomedcentral.com)
  • role
  • Role of NuMA in vertebrate cells: review of an intriguing multifunctional protein. (nih.gov)
  • Previous studies showed a peptide spanning aa 114 to 135 to induce diarrhea in newborn mouse pups with the 50% diarrheal dose approximately 100-fold higher than that for the full-length protein, suggesting a role for other regions in the protein in potentiating its diarrhea-inducing ability. (asm.org)
  • Surface location and high affinity for calcium of a 500 kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. (springer.com)
  • biological
  • The multifunctional protein particles prepared with the PASS method have the advantages of high loading of analytical biomolecules, integrated biological functions, porous structure, and more importantly, they are optically transparent and fluorescence inactive. (diva-portal.org)
  • The C-terminal tail (CT) appears to exhibit all the known biological properties of the protein ( 18 ). (asm.org)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • enzymes
  • The discovery of restriction enzymes allows DNA to be manipulated, leading to the development of recombinant DNA technology that has many applications, for example, allowing the large scale production of proteins such as human insulin used by diabetics. (wikipedia.org)
  • bind
  • CTCF protein is known to favourably bind to unmethylated sites, so it follows that methylation of CpG islands is a point of epigenetic regulation. (wikipedia.org)