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Acinetobacter baumanniiAcinetobacter InfectionsMicrobial Sensitivity TestsAnti-Bacterial AgentsDrug Resistance, BacterialDrug Resistance, Multiple, BacterialDrug Resistance, MicrobialAcinetobacterCarbapenemsAcinetobacter calcoaceticusColistinDrug Resistance, Multiplebeta-LactamasesCross InfectionImipenembeta-Lactam ResistanceDNA, BacterialElectrophoresis, Gel, Pulsed-FieldBacterial ProteinsMinocyclineP-GlycoproteinThienamycinsBacterial Typing TechniquesSequence Analysis, DNAMolecular Sequence DataDNA FingerprintingMultidrug Resistance-Associated ProteinsMolecular EpidemiologyMultilocus Sequence TypingIntegronsPolymerase Chain ReactionSulbactamMolecular TypingGram-Negative BacteriaGenes, BacterialGram-Negative Bacterial InfectionsPseudomonas aeruginosaHospitalsTuberculosis, Multidrug-ResistantGenotypeIntensive Care UnitsDrug Resistancebeta-LactamsRifampinDisease OutbreaksCluster AnalysisBacteremiaKlebsiella pneumoniaeAnti-Infective AgentsGenes, MDRPhylogenyPlasmidsAmikacinDisk Diffusion Antimicrobial TestsBase SequenceAntitubercular AgentsGenome, BacterialAminoglycosidesBiofilmsEscherichia coliFluoroquinolonesPseudomonas InfectionsDNA Transposable ElementsPneumonia, BacterialPolymyxin BMicrobial ViabilityDrug Resistance, NeoplasmBacterial Outer Membrane ProteinsMonobactamsEnterobacteriaceaeMutationPolymyxinsRandom Amplified Polymorphic DNA TechniqueMycobacterium tuberculosisBacteriaPhenotypeVerapamilGram-Positive BacteriaStaphylococcus aureusDrug SynergismKlebsiella InfectionsHospitals, UniversityAmino Acid SequencePneumonia, Ventilator-AssociatedCulture MediaEquipment and Supplies, HospitalDoxorubicinCiprofloxacinEnvironmental MicrobiologyGene Expression Regulation, BacterialMembrane Transport ProteinsVirulenceSiderophoresEnterobacteriaceae InfectionsGenomic IslandsMultiplex Polymerase Chain ReactionCephalosporinsColony Count, MicrobialRNA, Ribosomal, 16SHousekeeping, Hospital
PseudomonasInfectionsKlebsiellaEscherichiaPathogensEnterobacteriaceaeCarbapenem-resistant Acinetobacter baumannii isolatesBacteriaStaphylococcusCarbapenemsOrganismsDrug-resistantGenesPathogen2017AntibioticsBacterial isolatesAureusPneumoniaeClonalSusceptibility of multidrug-resistantTherapeuticSpeciesCharacterization of multidrug resistantSpecimensHospitalsEnterococcusEnterobacteralesInfectionGenomicAntimicrobial Agents and CBlood culture isolatesRelatednessMicrobiologyAbstractAntibiotic resistanceBiofilmVentilator-associateOutbreaks causedTigecyclineCarbapenemases2018Pulsed Field Gel ElectEfflux pump activityExtended-spectrumMultilocusKing Hussein Medical CentreOrganismMolecular characterizationAntibacterialAminoglycosidesSusceptibleCalcoaceticus
Pseudomonas14
Infections31
  • Multi-drug resistant (MDR) Acinetobacter baumannii is one of the most important causes of nosocomial infections. (biomedcentral.com)
  • The ability of A. baumannii to form biofilms on living and non-living surfaces is an important factor in the persistence of bacteria because it protects them against environmental stress conditions, such as desiccation and exposure to antibiotics and disinfectants, which makes biofilm infections persistent and challenging to treat [ 9 ]. (biomedcentral.com)
  • Over the last decade, nosocomial infections due to Acinetobacter baumannii have been described with an increasing trend towards multidrug resistance, mostly in intensive care units. (biomedcentral.com)
  • We examined the clinical data from patients with CPE infections and their outcomes, concentrating on Klebsiella pneumoniae isolates. (biomedcentral.com)
  • The clinical characteristics of 33 hospitalised patients with confirmed CPE, including patient-related factors associated with the development of CPE infections, were examined. (biomedcentral.com)
  • Infections caused by carbapenemase-producing Enterobacteriaceae (CPE), which have increased worldwide in number to become a significant clinical problem over the last decade, are associated with high morbidity and mortality [ 1 ]. (biomedcentral.com)
  • The management of infections due to A. baumannii is difficult because of rapidly developing resistance, however, tigecycline, a glycylcyline antimicrobial, is in use for several years. (ibu.edu.tr)
  • Infections caused by multidrug-resistant Acinetobacter baumannii have become a therapeutic challenge for clinicians worldwide. (tmu.edu.tw)
  • Therefore, since it is a global public health problem involving several sectors, it also requires a global solution in the context of the One Health approach to achieve adequate control through the prevention, reduction, and mitigation of drug-resistant infections. (who.int)
  • Acinetobacter baumannii is the most common species to cause infections, followed by Acinetobacter nosocomialis and Acinetobacter pittii [ 4 , 5 ]. (pfmjournal.org)
  • including A. baumannii , have long been known as colonizers in humans, but they do not cause severe infections [ 10 ]. (pfmjournal.org)
  • In the United States, A. baumannii has been estimated to cause more than 2% of the healthcare-associated infections [ 14 ]. (pfmjournal.org)
  • Although β-lactam antibiotics are the preferred choice for susceptible A. baumannii infections, carbapenems have become the main therapeutic option because of an increase in resistance [ 2 , 6 ]. (pfmjournal.org)
  • In conclusion, cytotoxicity against tumor cells, cytokine-mediated immunomodulatory properties, and broad-spectrum antimicrobial activity suggest that the Ps-1Pb and Ps-2Pa represent templates for design of non-hemolytic analogs for tumor therapy and for treatment of infections in cancer patients produced by multidrug-resistant pathogens. (ulster.ac.uk)
  • Used for pseudomonal infections and infections due to multidrug-resistant gram-negative organisms. (medscape.com)
  • The work herein provides evidence that carvacrol may have therapeutic potential as a treatment for MDR A. baumannii infections. (edu.mx)
  • The results of this study strongly suggest that phage Βϕ-R2096, a novel A. baumannii lytic phage, could be an alternative antibacterial agent to control CRAB infections. (biomedcentral.com)
  • Acinetobacter baumannii , a Gram-negative coccobacillus, is an important global nosocomial pathogen species that causes infections such as bacteremia, pneumonia, urinary tract infections, wound infections, and meningitis in critically immunocompromised patients in intensive care units (ICUs) [ 5 ]. (biomedcentral.com)
  • Carbapenems have been the most effective antibiotics against the serious infections caused by Acinetobacter spp. (biomedcentral.com)
  • A prospective multicenter study on the evaluation of antimicrobial resistance and molecular epidemiology of multidrug-resistant Acinetobacter baumannii infections in intensive care units with clinical and environmental features. (jsurgmed.com)
  • Development of non-antibiotic alternatives to treat infections caused by multidrug-resistant (MDR) microbes represents one of the top priorities in healthcare and community settings, especially in the care of combat trauma-associated wound infections. (theholisticgoat.com)
  • Acinetobacter species cause infections that are difficult to control due to multi-drug resistance and are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance for the production of beta-lactamases and Aminoglycoside-modifying enzymes. (microbiologyjournal.org)
  • These include the antibiotics of the carbapenem family, which are a mainstay for the treatment of antibiotic-resistant bacterial infections. (wikipedia.org)
  • The aminoglycoside apramycin has demonstrated preclinical efficacy against aminoglycoside- and multidrug-resistant (MDR) Gram-negative bacilli (GNB) and is currently in clinical development for the treatment of critical systemic infections. (ox.ac.uk)
  • We collected 126 consecutive methicillin-resistant Staphylococcus aureus (MRSA) causing blood stream infections (BSIs) at 10 tertiary hospitals from 2007 to 2009. (ophrp.org)
  • CDC researchers analyzed data from eight US metropolitan areas between 2012 and 2015 as part of CDC's Emerging Infections Program (EIP) healthcare-associated infections - community interface activity, which conducts surveillance for CRE and other drug-resistant gram-negative bacteria. (medscape.com)
  • More than 70% of these infections are caused by multi-drug resistant (MDR) pathogens, which contribute to increased morbidity and mortality (Black and Hawks, 2009). (seceij.net)
  • Enterobacter infections do not have a clinical presentation that is specific enough to differentiate them from other acute bacterial infections. (medscape.com)
  • Teicoplanin, a glycopeptide antibiotic, is widely used in clinical practice for the treatment of infections caused by mult. (cn1699.cn)
  • Clinical and pathophysiological overview of Acinetobacter infections: A century of challenges. (msdmanuals.com)
  • Also, the number of multidrug-resistant AB infections has increased in service members who were injured and treated in Iraq, Kuwait, and Afghanistan. (msdmanuals.com)
Klebsiella11
Escherichia2
Pathogens5
  • The Infectious Diseases Society of America (IDSA) identified A. baumannii among the top seven pathogens threatening our healthcare-delivery system and as a crucial example of unmet medical need [ 18 ]. (biomedcentral.com)
  • The aim was to evaluate the antimicrobial activity of essential oils-derived volatile compounds against nosocomial pathogens, including representative multidrug-resistant (MDR) Acinetobacter baumannii clinical isolates. (edu.mx)
  • From all tested compounds, carvacrol had markedly lower MIDs (3.89-48.8 mg/L) against A. baumannii than against the other nosocomial MDR pathogens. (edu.mx)
  • Background/Aim: In recent years, the consumption of broad-spectrum antibiotics used in hospitals and the number of multidrug-resistant pathogens are increasing. (jsurgmed.com)
  • Acinetobacter species are increasingly important nosocomial pathogens and are capable of rapid adaptation to the hospital environment. (microbiologyjournal.org)
Enterobacteriaceae3
  • As of June 2010[update], there were three reported cases of Enterobacteriaceae isolates bearing this newly described resistance mechanism in the US, the Centers for Disease Control and Prevention (CDC) stated that "All three U.S. isolates were from patients having received recent medical care in India. (wikipedia.org)
  • These isolates were obtained as part of a hospital surveillance programme for carbapenem non-susceptible Enterobacteriaceae. (who.int)
  • The Centers for Disease Control and Prevention (CDC) has expanded its guidelines for preventing the spread of carbapenem-resistant Enterobacteriaceae (CRE). (medscape.com)
Carbapenem-resistant Acinetobacter baumannii isolates1
  • M. Kresken, P. G Higgins, D. Stefanik , J. Wille, B. Körber-Irrgang, H. Seifert The evolution of carbapenem resistance determinants and major epidemiological lineages among carbapenem-resistant Acinetobacter baumannii isolates in Germany, 2010 -2016. (antiinfectives-intelligence.de)
Bacteria23
  • The impervious outer membrane and environmental exposure to a large pool of resistance genes are considered as selective pressures that cause XDR isolates in these bacteria [ 7 ]. (biomedcentral.com)
  • Molecular approaches such as PFGE that compare the DNA differences of bacteria have been accepted because of establishing the clonal association in many bacteria including A. baumannii isolates [ 10 ]. (biomedcentral.com)
  • A. baumannii is developing into multidrug resistant (MDR), extensively drug resistant (XDR), and pandrug resistant (PDR) bacteria, and its adaptation to the environment with drug resistance has previously been reported ( Durante-Mangoni and Zarrilli, 2011 ). (frontiersin.org)
  • Colistin is an old drug, and its use has recently resurged because of increasing antibiotic resistance in gram-negative bacteria such as Acinetobacter baumannii . (pfmjournal.org)
  • Although the colistin resistance rates in gram-negative bacteria are currently not high, many colistin-resistant isolates are being identified and the possibility of horizontal transmission of colistin resistance has increased because of the plasmid-borne colistin resistance gene mcr-1 (mobilized colistin resistance). (pfmjournal.org)
  • In 1954, Brisou and Prévot proposed the genus Acinetobacter to indicate that the bacteria were non-motile because they lacked flagella: the Greek "akineto" means "immobile" [ 1 ]. (pfmjournal.org)
  • are the seventh most-isolated bacteria in Korean hospitals [ 15 ], and they are the most frequent isolates from adults with hospital-acquired pneumonia or ventilator-associated pneumonia in Asian countries, including South Korea [ 16 ]. (pfmjournal.org)
  • Ps-1Pb potently (MIC≤10μM) inhibits growth of multidrug-resistant clinical isolates of the Gram-positive bacteria methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis, and the Gram-negative bacteria Acinetobacter baumannii and Stenotrophomonas maltophilia. (ulster.ac.uk)
  • Ps-2Pa shows the same high potency (MIC ≤ 10 μM) against the Gram-positive bacteria but is 2-4 fold less potent against the Gram-negative isolates. (ulster.ac.uk)
  • Currently, multidrug resistant bacteria, residing in ecological niches in hospitals, present therapeutic challenges when they manifest as bacteremias [ 7 ]. (hindawi.com)
  • The emergence and rise of antibiotic-resistant bacteria related to the use of broad-spectrum antibiotics has been reported [ 1 , 2 , 3 ]. (biomedcentral.com)
  • Here, we investigate efficacy of oregano oil against pathogenic bacteria including MDR isolates from the combat casualties in vitro and in a mouse burn model. (theholisticgoat.com)
  • Gram-negative bacteria were the most represented microorganisms (60.8%) with MDROs accounting for 31.8% of the total isolates. (uniroma1.it)
  • NDM-1 is an enzyme that makes bacteria resistant to a broad range of beta-lactam antibiotics. (wikipedia.org)
  • In March 2010, a study in a hospital in Mumbai found that most carbapenem-resistant bacteria isolated from patients carried the blaNDM-1 gene. (wikipedia.org)
  • However, US experts stated that it is unclear as to whether this strain is any more dangerous than existing antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus, which are already common in the USA. (wikipedia.org)
  • As previously, the bacteria were fully resistant to all the aminoglycoside, β-lactam, and quinolone antibiotics, but were susceptible to tigecycline and colistin. (wikipedia.org)
  • CREs are a group of multidrug-resistant bacteria considered an urgent health threat by the CDC because they can rapidly spread between patients, especially those who are most seriously ill and vulnerable, and because they are so difficult to treat. (medscape.com)
  • Given the rising occurrence of antibiotic resistance due to the existence and ongoing development of resistant bacteria and phenotypes, the identification of new treatments and sources of antimicrobial agents is of utmost urgency. (biomedcentral.com)
  • Extracts and phases obtained from the medicinal plant M. albicans demonstrated synergistic effects when combined with the commercial antibiotics ampicillin and ciprofloxacin, against multi-drug resistant bacteria S. aureus and A. baumannii , restoring their antibacterial efficacy. (biomedcentral.com)
  • Our findings reveal that M. albicans exhibits remarkable adjuvant potential for enhancing the effectiveness of antimicrobial drugs against resistant bacteria. (biomedcentral.com)
  • Therefore, new treatments are urgently needed to deal with multi-drug resistant bacteria (MDR), and, in this scenario, plants can provide a valuable source of bioactive molecules. (biomedcentral.com)
  • and multidrug-resistant bacteria causing pyogenic liver abscesses. (uni-frankfurt.de)
Staphylococcus1
  • Her first author manuscript titled: "Evaluation of Apramycin Activity Against Methicillin-Resistant, Methicillin-Sensitive, and Vancomycin-Intermediate Staphylococcus aureus Clinical Isolates" was just accepted into Diagnostic Microbiology and Infectious Diseases, more commonly referred to as DMID. (kirbylab.org)
Carbapenems8
Organisms5
  • It was developed with input from state and local health departments and serves as general guidance for the initial response following the identification of novel or targeted multidrug-resistant organisms (MDROs) or resistance mechanisms. (cdc.gov)
  • Please refer to the complementary document, Public Health Strategies to Prevent the Spread of Novel and Targeted Multidrug-resistant Organisms (MDROs) , for information about the development, implementation, and coordination of activities designed to prevent transmission of targeted MDROs at all epidemiologic stages (from pre-introduction through endemicity) across healthcare facilities within a jurisdiction. (cdc.gov)
  • Healthcare facilities and laboratories should contact state or local public health authorities promptly when targeted resistant organisms (e.g., pan-not susceptible organism) or mechanisms are identified (e.g. (cdc.gov)
  • Bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (MDROs). (uniroma1.it)
  • Their effects are primarily against Gram-positive organisms, including community-acquired and resistant strains of S. aureus , multidrug-resistant S. pneumoniae , and vancomycin-resistant Enterococcus faecium . (acepnow.com)
Drug-resistant4
  • His research considered the epidemiology of multi-drug resistant Salmonella. (wikipedia.org)
  • Molecular epidemiology of multi-drug resistant Salmonella in swine production systems (PDF). (wikipedia.org)
  • Thus, CC92 A. baumannii carrying OXA-23 is a major drug-resistant strain spreading in China. (frontiersin.org)
  • 2014). If a bacterial cell carries several resistance genes, relating to more than just one antibiotic, it is termed MDR, for multiple drug-resistant. (seceij.net)
Genes9
  • Whole genome sequences of these isolates were determined and analysed to compute bacterial multilocus sequence types and plasmid replicon types, infer phylogenetic relationships, and identify antimicrobial resistance and virulence genes. (biomedcentral.com)
  • Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
  • A total of 110 clinical isolates of A. baumannii , collected in a recent 2-year period, were tested for carbapenem antibiotic susceptibility, followed by a molecular analysis of carbapenemase genes. (frontiersin.org)
  • Molecular detection of OXA carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolates from Iraq and Georgia. (microbiologyresearch.org)
  • Chlorine being the most commonly used disinfectant in water, the study investigated the effect of chlorine on the survival of A. baumannii in water and transcription of genes conferring antibiotic resistance. (uconn.edu)
  • In addition, real-time quantitative PCR (RT-qPCR) analysis of the antibiotic resistance genes (efflux pump genes and those encoding resistance to specific antibiotics) of three selected A. baumannii strains following exposure to chlorine was performed. (uconn.edu)
  • Additionally, there was an up-regulation of all or some of the antibiotic resistance genes in A. baumannii , indicating a chlorine-associated induction of antibiotic resistance in the pathogen. (uconn.edu)
  • The carbapenemase genes were detected using PCR technology, and the most prevalent genes were MBL genes, which were carried by 17/33 (51%) of the isolates. (edu.iq)
  • However, results revealed that bla IMP -type genes were the most common MBL gene combination among the isolates. (edu.iq)
Pathogen5
  • The natural habitats and potential reservoirs of the nosocomial pathogen Acinetobacter baumannii are poorly defined. (uni-koeln.de)
  • A. baumannii has become a representative pathogen that threatens human health. (pfmjournal.org)
  • Acinetobacter baumannii is an opportunistic pathogen that causes serious nosocomial infection in intensive care units. (biomedcentral.com)
  • Acinetobacter baumannii: evolution of a global pathogen. (jsurgmed.com)
  • Acinetobacter baumannii is a multidrug resistant pathogen capable of causing a wide spectrum of clinical conditions in humans. (uconn.edu)
20171
  • Higgins, P.G. , Prior, P., Harmsen, D., Seifert, H. (2017) Development and evaluation of a core genome multilocus typing scheme for whole-genome sequence-based typing of Acinetobacter baumannii . (uni-frankfurt.de)
Antibiotics13
  • Recently, due to the use of broad-spectrum antibiotics, antimicrobial resistance between A. baumannii isolates has increased significantly. (biomedcentral.com)
  • A. baumannii in our hospital were highly resistant to all antibiotics, including tigecycline, except for minocycline and colistin which are considered the last resort treatment for multidrug-resistant A. baumannii . (who.int)
  • Conclusions: Although bacterial agents isolated in PP were lower, antibiotics consumption was higher. (jsurgmed.com)
  • In initial assays the bacterium was fully resistant to all antibiotics tested, while later tests found that it was susceptible to tigecycline and colistin. (wikipedia.org)
  • Aminoglycoside antibiotics such as gentamicin or amikacin are essential medicines in the treatment of BSIs, but their clinical efficacy is increasingly compromised by antimicrobial resistance. (ox.ac.uk)
  • However, biofilm-forming strains were more likely to be multidrug resistant (three or more non-β-lactam antibiotics) than biofilm non-forming ones [79.2% vs. 59.2%, p = 0.015, odds ratio (OR) 2.629, 95% confidence interval (CI) 1.92-5.81]. (ophrp.org)
  • Overall, 30% of CREs carry a carbapenemase - an enzyme that can make them resistant to carbapenem antibiotics. (medscape.com)
  • They are going to start treating you immediately, and they might miss it because you've got this organism that's resistant to all the best antibiotics…The gateway to the blood is the UTI. (medscape.com)
  • Furthermore, their individual effects and synergistic potential in combination with antibiotics were examined against clinical strains of both S. aureus and Acinetobacter baumannii . (biomedcentral.com)
  • Three key compounds commonly found in the samples, namely gallic acid, quercitrin, and corosolic acid, did not exhibit significant antibacterial activity when assessed individually or in combination with antibiotics against clinical bacterial strains. (biomedcentral.com)
  • The strains were resistant to all antibiotics tested except colistin. (who.int)
  • Two Gram-positive isolates, E. faecalis and S. aureus , were resistant to 14 of the 18 antibiotics used. (ophrp.org)
  • Recently, multidrug-resistant (MDR) AB has emerged, particularly in intensive care units (ICUs) in immunosuppressed patients, patients with serious underlying disorders, and patients treated with broad-spectrum antibiotics after an invasive procedure. (msdmanuals.com)
Bacterial isolates2
  • Pulsed Field Gel Electrophoresis (PFGE) was used to assess the genomic features of the bacterial isolates. (biomedcentral.com)
  • Surface swabs were tested for lytic phages and bacterial isolates for mitomycin C-inducible prophages. (mdpi.com)
Aureus4
  • Comparative in vitro studies of furazidin and nitrofurantoin activities against common uropathogens including multidrug-resistant strains of E. coli and S. aureus . (krakow.pl)
  • These NPs also showed antimicrobial and antibiofilm activity against E. coli , A. baumannii , S. aureus , and a mixed culture of A. baumannii and S. aureus . (dovepress.com)
  • 2 Supplemental treatment with linezolid in the moxifloxacin arm was authorized if methicillin-resistant S. aureus was suspected or confirmed by culture, while the lefamulin arm received matching placebo. (acepnow.com)
  • No lytic bacteriophages were detected, but S. aureus was isolated from the surroundings of all patients. (mdpi.com)
Pneumoniae4
  • Altogether, 88.9% (40/45) of the CPE isolates were K. pneumoniae . (biomedcentral.com)
  • The most abundant carbapenemase gene family in the K. pneumoniae isolates (33/39) was bla OXA-232 , with bla NDM-1 additionally identified in 19 of them. (biomedcentral.com)
  • However, we report here an ESBL-producing K. pneumoniae (ST394) isolate responsible for a nosocomial outbreak in an ICU dedicated to COVID-19 patients. (bvsalud.org)
  • NDM-1 β-lactamase was also found in an K. pneumoniae isolate from Croatia, and the patient arrived from Bosnia and Herzegovina. (wikipedia.org)
Clonal5
  • The purpose of this study was to identify antibiotic resistance patterns, biofilm formation and the clonal relationship of clinical and environmental isolates of A. baumannii by Pulsed Field Gel Electrophoresis method. (biomedcentral.com)
  • Therefore, in order to reduce the clonal contamination of MDR A. baumannii environmental and clinical isolates, it is necessary to use strict infection control strategies. (biomedcentral.com)
  • The aim of the present study was to determine the clonal relatedness of clinical isolates and to elucidate the genetic basis of imipenem resistance. (biomedcentral.com)
  • Whole genome sequencing revealed the close relationship of an antibiotic-susceptible chicken isolate from Germany with a multidrug-resistant human clinical isolate from China and additional linkages between livestock isolates and human clinical isolates related to international clonal lineages. (uni-koeln.de)
  • Clonal spread of carbapenem-resistant OXA-72-positive Acinetobacter baumannii in a Croatian university hospital. (microbiologyresearch.org)
Susceptibility of multidrug-resistant1
  • Apramycin susceptibility of multidrug-resistant Gram-negative blood culture isolates in five countries in South-East Asia. (ox.ac.uk)
Therapeutic3
  • Thus, a carbapenem-sulbactam combination may be a therapeutic alternative for multidrug-resistant Acinetobacter baumannii bacteremia in countries where colistin and tigecycline are not available for clinical use. (tmu.edu.tw)
  • Carbapenem-resistant Acinetobacter baumannii (CRAB) presents a serious therapeutic and infection control challenge. (frontiersin.org)
  • In the evaluation of its therapeutic potential against CRAB clinical isolates using two in vivo models, phage Βϕ-R2096 increased the survival rates of both G. mellonella larvae (from 0 to 50% at 24 h) and mice (from 30% with MOI = 0.1 to 100% with MOI = 10 for 12 days) in post-infection of CRAB. (biomedcentral.com)
Species3
Characterization of multidrug resistant1
  • Molecular characterization of multidrug-resistant Salmonella enterica subsp. (wikipedia.org)
Specimens1
  • The significance of Acinetobacter isolates from clinical specimens, such as respiratory secretions from intubated patients or specimens from open wounds, is difficult to determine because they often represent colonization. (msdmanuals.com)
Hospitals5
  • This study investigated the fluoroquinolone-resistant mechanism of 56 clinical cases of A baumannii infection from 23 non-tertiary hospitals, collected between 2004 and 2006. (ophrp.org)
  • Dijkshoorn L, Nemec A, Seifert H. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. (jsurgmed.com)
  • These isolates were obtained from four local general hospitals in Singapore. (who.int)
  • During the period of August 2010-August 2011, 52 non-duplicate carbapenem non-susceptible clinical isolates from local hospitals were analysed. (who.int)
  • The isolates were submitted from four hospitals that represented 40% of the general hospitals in Singapore. (who.int)
Enterococcus2
  • In this issue, a tertiary care center in Brazil reports a retrospective cohort study of the prevalence of vancomycin resistant Enterococcus faecium from BSI, and K. Gohel et al. (hindawi.com)
  • Antimicrobial resistance of Enterococcus isolates in Turkey: A meta-analysis of current studies. (jsurgmed.com)
Enterobacterales2
  • Occurrence of carbapenemase-producing strains among Enterobacterales urine isolates in three geographic areas in Germany. (antiinfectives-intelligence.de)
  • A new study from the Centers for Disease Control and Prevention (CDC) found that a surprising proportion of cases of carbapenem-resistant Enterobacterales (CRE) are found in isolates from patients in the community (CA-CRE). (medscape.com)
Infection5
  • Virulence of selected avian A. baumannii isolates was comparable to that of clinical isolates in the Galleria mellonella infection model. (uni-koeln.de)
  • Clinical Microbiology and Infection. (edu.iq)
  • in December 2009 in a Swedish national who fell ill with an antibiotic-resistant bacterial infection that he acquired in India. (wikipedia.org)
  • But in this study, published in the American Journal of Infection Control , of the 12 isolates that underwent whole-genome sequencing, 42% of the CA-CRE isolates carried the carbapenemase gene. (medscape.com)
  • The duration of therapy should be guided by the severity and site of the infection and the patients clinical and bacteriological progress. (drugcentral.org)
Genomic2
  • We analysed the clinical information, performed antimicrobial susceptibility testing, and conducted molecular epidemiological and genomic analyses on the isolates to identify patterns in the data. (biomedcentral.com)
  • This study has revealed the genomic features of colonising CPE isolates, focusing on antimicrobial resistance and virulence determinants. (biomedcentral.com)
Antimicrobial Agents and C1
  • Un 40% de esos trabajos han sido publicados en revistas del primer cuartil entre las que destacan New England Journal of Medicine, Lancet, Lancet Infectious Diseases, Clinical Infectious Diseases, Clinical Microbiology Reviews, Antimicrobial Agents and Chemotherapy, Journal Clinical Microbiology, Journal Antimicrobial Chemotherapy, Mayo Clinic Proceedings y Malaria Journal. (unav.edu)
Blood culture isolates1
Relatedness2
Microbiology1
Abstract1
  • abstract = "Pseudhymenochirin-1Pb (Ps-1Pb) and pseudhymenochirin-2Pa (Ps-2Pa) are host-defense peptides, first isolated from skin secretions of the frog Pseudhymenochirus merlini (Pipidae). (ulster.ac.uk)
Antibiotic resistance2
  • Antibiotic resistance of the isolates was assessed by the disk diffusion method, and the biofilm formation test was done by the microtiter plate method. (biomedcentral.com)
  • To analyze the antibiotic resistance patterns among Acinetobacter isolates and to detect Carbapenemase and MBL among MDR Acinetobacter isolates. (microbiologyjournal.org)
Biofilm6
  • Biofilm production capabilities revealed that 31 (44.9%), and 30 (43.5%) isolates had strong and moderate biofilm producer activity, respectively. (biomedcentral.com)
  • AgNPs also showed good biofilm disruption, with the highest of 88% in A. baumannii . (dovepress.com)
  • Microbial identification, antibiotic susceptibility and biofilm production were assessed in 135 clinical isolates from 87 patients. (uniroma1.it)
  • To investigate the biofilm-forming related factors against MRSA bloodstream isolates and evaluates their clinical features and treatment outcomes by biofilm production. (ophrp.org)
  • We compared the clinical characteristics and outcomes of patients infected with biofilm-forming and non-biofilm-forming MRSA isolates. (ophrp.org)
  • Clinical features of patients with BSIs caused by biofilm-forming MRSA strains were more likely to be hospital onset [77.9% vs. 60.0%, p = 0.024, OR 2.434, 95% CI 1.11-5.33) and more frequently occurred in patients with use of invasive devices [85.7% vs. 61.2%, p = 0.002, OR 3.879, 95% CI 1.61-8.97]. (ophrp.org)
Ventilator-associate1
  • Acinetobacter baumannii, a major causative agent of ventilator-associated pneumonia and catheter-related bloodstream infec. (cn1699.cn)
Outbreaks caused2
  • For epidemiological studies, several typing methods have been used to investigate outbreaks caused by A. baumannii . (biomedcentral.com)
  • Two sequential outbreaks caused by multidrug-resistant Acinetobacter baumannii isolates producing OXA-58 or OXA-72 oxacillinase in an intensive care unit in France. (microbiologyresearch.org)
Tigecycline1
  • Susceptibility profiling of the isolates indicated that 100% retained susceptibility to tigecycline while 11/12 (91.7%) were susceptible to colistin. (who.int)
Carbapenemases4
  • The carbapenemases in A. baumannii have belonged to the bla OXA-23- , bla OXA-24- , and bla OXA-58- type class D family of serine β-lactamases and IMP/VIM class B metallo-β-lactamases [ 3 , 4 ]. (biomedcentral.com)
  • However, imipenem-resistant isolates were found in the early 1990s [ 17 ], and the rate of carbapenem resistance in A. baumannii , mainly due to OXA-type (oxacillin-hydrolysing) carbapenemases, has increased rapidly [ 7 , 11 ]. (pfmjournal.org)
  • Emergence and widespread dissemination of OXA-23, -24/40 and -58 carbapenemases among Acinetobacter spp. (microbiologyresearch.org)
  • The modified Hodge test was used to identify carbapenem-resistant isolates, which detects the probability of isolates being able to produce carbapenemases enzyme and out of the isolates, 11 (33.3%) were Hodge positive. (edu.iq)
20181
  • After the replacement of the incubators suspected to be the reservoir of some outbreak-related isolates on Feb 1, 2018, E cloacae complex strains were screened again for 10 months (503 rectal swab samples from 163 newborns). (bvsalud.org)
Pulsed Field Gel Elect1
  • A. baumannii representative clones were selected by pulsed-field gel electrophoresis. (edu.mx)
Efflux pump activity2
  • These results suggest that triple mutations in clinical isolates of A baumannii contribute to the development of high levels of resistance to fluoroquinolones and that mutations in parC S80L or E84K (groups II and VII) may contribute to alterations in efflux pump activity in A baumannii . (ophrp.org)
  • After determining the MDR isolates, for evaluation of efflux pump activity the MIC of ciprofloxacin, levofloxacin was determined before and after treatment by CCCP inhibitor. (aejournal.ir)
Extended-spectrum1
  • AL-Muhannak FH, Al-Mohana A. Spread of Some Extended-spectrum Beta-lactamases: In Clinical Isolates of Gram-negative Bacilli in Najaf. (edu.iq)
Multilocus1
  • Multilocus sequence typing disclosed further kinship between avian and human isolates. (uni-koeln.de)
King Hussein Medical Centre1
  • Acinetobacter baumannii isolates in Al-Hussein Hospital at King Hussein Medical Centre in Amman, Jordan. (who.int)
Organism1
  • Collectively, our study suggests A. baumannii could be a zoonotic organism that may disseminate into livestock. (uni-koeln.de)
Molecular characterization2
  • In this study, we provide the molecular characterization and epidemiology for 12 NDM-1 positive clinical isolates. (who.int)
  • 6. Molecular characterization of isolated CRE from repetitive colonisation surveys to inform IPC. (who.int)
Antibacterial4
  • Cytostatic, cytotoxic, and antibacterial activities of essential oil isolated from Citrus hystrix . (krakow.pl)
  • We also conducted an in vitro study using isolates from these patients that showed that this drug combination had a synergistic effect with enhanced antibacterial activity against the isolates. (tmu.edu.tw)
  • In addition, 10 isolated compounds were obtained from the leaves phases and used for confirmation of the chemical profiles and for antibacterial assays. (biomedcentral.com)
  • The antibacterial potentiality of leaf extracts was monitored by the agar-well diffusion method with multidrug-resistant (MDR) strains of nine uropathogens. (ophrp.org)
Aminoglycosides2
  • Molecular determinants enabling the imipenem resistant strains to exhibit co-resistance to aminoglycosides and fluoroquinolones from this geographical region were delineated. (biomedcentral.com)
  • Here, we collected a panel of 470 MDR GNB isolates from health care facilities in Cambodia, Laos, Singapore, Thailand, and Vietnam for a multi-centre assessment of their antimicrobial susceptibility to apramycin in comparison to other aminoglycosides and colistin by broth microdilution assays. (ox.ac.uk)
Susceptible5
  • Isolates that are not susceptible to any available antimicrobials, but whose transmission dynamics are well-known, are now classified as Tier 2. (cdc.gov)
  • Note that this classification change does not change overall recommended response activities when a pan-not susceptible isolate is identified. (cdc.gov)
  • All CPE isolates carrying either bla OXA-232 or bla NDM-1 were resistant to meropenem, but only 40 from 45 were susceptible to colistin. (biomedcentral.com)
  • Susceptibility to gentamicin and tobramycin (MIC ≤ 4 µg/mL) was significantly lower at 122 (26.0%) and 101 (21.5%) susceptible isolates, respectively. (ox.ac.uk)
  • Microbiological laboratories should be aware of the unusual carbapenem-resistant but third-generation cephalosporin-susceptible profiles of these IMI-producing isolates. (medscape.com)
Calcoaceticus1
  • they were grouped into the so-called " A. calcoaceticus - A. baumannii (Acb) complex" [ 7 ]. (pfmjournal.org)