Needed to treat multidrug-resistantCaused by multidrug-resistant bacteriaIsolatesBacteriaReduced susceptibilityExtensively drug-resistaAcinetobacterTuberculosis PatientsUrinary tract infePathogensPrevalenceMycobacteriumBacterial infectionsPlasmodiumEmergenceMalariaSPREADPulmonaryTreatmentIsoniazid2018DOTS-PlusRecurrentEpidemiology2021Methicillin-resistantInfectionPatients with Multi-Drug ResiMechanismsClinicalIncidenceTumor cellsCasesCancerSusceptibleAntibioticsProteinHighly resistantTrialsEffectivenessHealth
Needed to treat multidrug-resistant1
- While tenofovir is the one of recommended first-line nucleotide reverse transcriptase inhibitors (NRTIs), there is a risk of nephrotoxicity when using tenofovir together with the aminoglycosides needed to treat multidrug-resistant (MDR) TB. (scielo.org.za)
Caused by multidrug-resistant bacteria3
- ST. LOUIS , July 26, 2017 /PRNewswire/ -- Sequoia Sciences announced it has received Fast Track Designation from the U.S. Food and Drug Administration (FDA) for its novel, investigational vaccine designed to treat recurrent urinary tract infections (UTI) caused by multidrug-resistant bacteria. (prnewswire.com)
- In granting Fast Track status, the FDA acknowledges that recurrent UTI caused by multidrug-resistant bacteria is a serious condition for which there is an unmet medical need. (prnewswire.com)
- PARIS - Infections caused by multidrug-resistant bacteria, which are common in patients with cirrhosis , are associated with a significant elevation in risk for in-hospital mortality, results from a global study show. (medscape.com)
Isolates10
- Tuberculosis (TB) is one of the major causes of death related to antimicrobial resistance worldwide because of the spread of Mycobacterium tuberculosis multi- and extensively drug resistant (multi-drug resistant (MDR) and extensively drug-resistant (XDR), respectively) clinical isolates. (frontiersin.org)
- To this aim, in this work an in vitro generation of M. tuberculosis mutants resistant to BDQ was performed starting from two MDR clinical isolates as parental cultures. (frontiersin.org)
- Isolates were found less resistant to gentamycin, chloramphenicol, and ciprofloxacin. (scielo.br)
- All CPE isolates carrying either bla OXA-232 or bla NDM-1 were resistant to meropenem, but only 40 from 45 were susceptible to colistin. (biomedcentral.com)
- We studied susceptibility of several Japanese isolates of multi-drug-resistant M. tuberculosis against disinfectants, which are commonly used in clinical and research laboratories. (biomedcentral.com)
- We selected a laboratory reference strain (H37Rv) and eight Japanese isolates, containing five drug-susceptible strains and three multi-drug-resistant strains, and determined profiles of susceptibility against eight disinfectants. (biomedcentral.com)
- Its in vitro activity was assessed against 472 gram-positive cocci, largely selected as epidemiologically unrelated isolates with multidrug resistance. (uea.ac.uk)
- The MIC at which 50% of isolates are inhibited (MIC(50)) and MIC(90) of RWJ-54428 for methicillin-resistant Staphylococcus aureus (MRSA) were 1 and 2 microg/ml, respectively, whereas they were 0.5 and 0.5 microg/ml, respectively, for methicillin-susceptible S. aureus. (uea.ac.uk)
- The MIC(50) and MIC(90) were 1 and 4 microg/ml, respectively, for methicillin-resistant coagulase-negative staphylococci (MRCoNS), whereas they were 0.25 and 1 microg/ml, respectively, for methicillin-susceptible isolates. (uea.ac.uk)
- Extended-spectrum beta-lactamase produc- ing Enterobacteriaceae was found in 37.5% (54) isolates and carbapenem resistant bacteria were identified in 27.8% of patients. (who.int)
Bacteria15
- Multidrug-resistant tuberculosis (MDR-TB) is a form of tuberculosis (TB) infection caused by bacteria that are resistant to treatment with at least two of the most powerful first-line anti-TB medications (drugs): isoniazid and rifampin. (wikipedia.org)
- Currently the majority of multidrug-resistant cases of TB are due to one strain of TB bacteria called the Beijing lineage. (wikipedia.org)
- Acquired MDR-TB develops when a person with a non-resistant strain of TB is treated inadequately, resulting in the development of antibiotic resistance in the TB bacteria infecting them. (wikipedia.org)
- Mutations: Spontaneous mutations in the TB genome can alter proteins which are the target of drugs, making the bacteria drug-resistant. (wikipedia.org)
- 2 It is estimated that about half of these patients have UTI caused by antibiotic-resistant bacteria. (prnewswire.com)
- The North American Emerging Infections Network reported that about 80 percent of responding infectious disease physicians had treated a UTI caused by the most resistant bacteria, carbapenem-resistant Enterobacteriaceae (CRE). (prnewswire.com)
- The antibiogram study revealed that Gram-negative bacteria were highly resistant to penicillin while Staphylococcus was resistant to streptomycin, amoxicillin, and lincomycin. (scielo.br)
- Given the rising occurrence of antibiotic resistance due to the existence and ongoing development of resistant bacteria and phenotypes, the identification of new treatments and sources of antimicrobial agents is of utmost urgency. (biomedcentral.com)
- Extracts and phases obtained from the medicinal plant M. albicans demonstrated synergistic effects when combined with the commercial antibiotics ampicillin and ciprofloxacin, against multi-drug resistant bacteria S. aureus and A. baumannii , restoring their antibacterial efficacy. (biomedcentral.com)
- Our findings reveal that M. albicans exhibits remarkable adjuvant potential for enhancing the effectiveness of antimicrobial drugs against resistant bacteria. (biomedcentral.com)
- Therefore, new treatments are urgently needed to deal with multi-drug resistant bacteria (MDR), and, in this scenario, plants can provide a valuable source of bioactive molecules. (biomedcentral.com)
- Herein we report the identification and characterisation of two linear antimicrobial peptides (AMPs), HG2 and HG4, with activity against a wide range of multi-drug resistant (MDR) bacteria, especially methicillin resistant Staphylococcus aureus (MRSA) strains, a highly problematic group of Gram-positive bacteria in the hospital and community environment. (microbiologyresearch.org)
- Age 65 years, presence of septic shock, and presence of carbapenem-resistant bacteria were independently associated with in- creased in-hospital mortality. (who.int)
- Conclusion High number of resistant microorganisms was isolated, and increased mortality was documented from infections caused by carbapenem-resistant bacteria. (who.int)
- All were treated at one of 46 centers in North and South America, Europe, Africa, and Asia, and bacteria were considered multidrug-resistant if they were impervious to at least one agent in three or more antibiotic classes. (medscape.com)
Reduced susceptibility1
- Multidrug-resistant (MDR) HIV refers to strains of HIV with reduced susceptibility to drugs within all three classes of antiretroviral therapies (ARTs). (managedhealthcareexecutive.com)
Extensively drug-resista4
- Is the Subject Area "Extensively drug-resistant tuberculosis" applicable to this article? (plos.org)
- Extensively drug-resistant tuberculosis (XDR-TB) represents an emerging public health problem worldwide. (who.int)
- In May 2009, recognizing the emergence and spread of multidrug-resistant and extensively drug-resistant tuberculosis, the Health Assembly in resolution WHA62.15 urged all Member States to achieve universal access to diagnosis and treatment of multidrug-resistant and extensively drug-resistant tuberculosis as part of the transition to universal health coverage. (who.int)
- By 2009, 57 countries, had reported at least one case of extensively drug-resistant tuberculosis. (who.int)
Acinetobacter1
- Multidrug-resistant Acinetobacter spp. (who.int)
Tuberculosis Patients1
- The Phase 3 clinical trial is called PHOENIx MDR-TB, short for Protecting Households on Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients. (mlo-online.com)
Urinary tract infe1
- Many of my patients with multidrug-resistant recurrent urinary tract infections have tried multiple antibiotics for years without success," said Liz D'Antonio, CRNP, director of clinical research Anne Arundel Urology. (prnewswire.com)
Pathogens4
- The present study aimed to determine the effectiveness of five essential oils (EOs) against multidrug-resistant foodborne pathogens. (scielo.br)
- The emergence of multidrug-resistant (MDR) Gram-negative pathogens is an urgent global medical challenge. (monash.edu)
- Multidrug-resistant pathogens represent a considerable health burden worldwide, leading to thousands of deaths each year. (contagionlive.com)
- The objective of the current ering new classes of antimicrobials and the increasing study was, therefore, to assess the bacteriologic pro- emergence and reemergence of resistant pathogens, file, resistance pattern, and patient's outcome in Lan- mortality from infectious disease is increasing [1]. (who.int)
Prevalence2
- Results from studies on Multidrug Resistant Tuberculosis prevalence carried out in 2008 in two pilot regions of Tajikistan revealed that multidrug resistance concerned 16% of new infections and 60% of prior infections. (fondation-merieux.org)
- In addition, the prevalence of drug-resistant TB is increasing worldwide. (medscape.com)
Mycobacterium3
- Here we report that members of the family, ivermectin, selamectin, and moxidectin, are bactericidal against mycobacterial species, including multidrug-resistant and extensively drug-resistant clinical strains of Mycobacterium tuberculosis. (nih.gov)
- This report offers suggestions for evaluating and managing persons (i.e., contacts) who have been exposed to patients with infectious MDR-TB (TB due to strains of Mycobacterium tuberculosis resistant to both isoniazid {INH} and rifampin {RIF}), provides background information on alternative preventive therapy regimens with drugs other than INH or RIF, and presents considerations relevant to making a decision to offer one of these alternative regimens. (cdc.gov)
- Multi-drug-resistant Mycobacterium tuberculosis has been an important problem in public health around the world. (biomedcentral.com)
Bacterial infections2
- A 1st Invitation for Expression of Interest (EOI) for treatment of multi-drug resistant bacterial infections has been published by the WHO Prequalification Unit - Medicines Assessment Team (PQT/MED). (who.int)
- MONTRÉAL, Gladius Pharmaceuticals Inc., a Montréal-based biotechnology firm developing novel drugs to treat life-threatening, multi-drug-resistant bacterial infections, announced today the closing of a $4.1 million Series A financing. (lumiraventures.com)
Plasmodium1
- The continuing spread of multidrug resistance in Plasmodium falciparum malaria makes the search for alternative treatments ever more urgent. (nih.gov)
Emergence1
- The emergence of multidrug-resistant TB (MDR-TB) poses a major health security threat and could risk gains made in the fight against TB. (who.int)
Malaria1
- However, evidence of possible cardiotoxicity will need to be investigated fully before a role can be established for halofantrine in the treatment of multidrug-resistant malaria. (nih.gov)
SPREAD1
- This process accelerates if incorrect or inadequate treatments are used, leading to the development and spread of multidrug-resistant TB (MDR-TB). (wikipedia.org)
Pulmonary2
- The European Commission has granted marketing authorisation for Deltyba (delamanid) for use as part of an appropriate combination regimen for pulmonary multidrug-resistant tuberculosis (MDR-TB) in adults when other therapies are resisted or cannot be tolerated. (pharmatimes.com)
- RARITAN, N.J., September 5, 2012 - Janssen Research & Development, LLC (Janssen) announced today that the U.S. Food and Drug Administration (FDA) has granted Priority Review to the New Drug Application (NDA) for bedaquiline (TMC207) to treat pulmonary, multi-drug resistant tuberculosis (MDR-TB) in adults as part of combination therapy. (jnj.com)
Treatment13
- Multidrug-resistant tuberculosis has a variety of causes, but resistance usually due to treatment failure, drug combinations, coinfections, prior use of anti-TB medications, inadequate absorption of medication, underlying disease, and noncompliance with anti-TB drugs. (wikipedia.org)
- Patients infected with multidrug-resistant (MDR)-TB (defined as resistance to at least rifampicin and isoniazid, the two most powerful anti-TB drugs) require longer, more expensive treatment regimens than drug-susceptible TB, with poorer treatment success [ 2 ], [ 3 ]. (ersjournals.com)
- Multi-drug-resistant cancer strains are those that fail to respond to more than one standard drug treatment. (naturalnews.com)
- There is a growing public health need for new treatment options for multi-drug resistant tuberculosis. (jnj.com)
- Cancer multidrug resistance (MDR) is one of the main challenges for cancer treatment efficacy. (up.pt)
- This study aims to explore the effect of multi-disciplinary cooperative complete management mode in the treatment of multi-drug resistant tuberculosis (MDR-TB). (researchsquare.com)
- MDR-TB (multi-drug resistant tuberculosis) in China is still stuck in a tough situation due to the lack of unified and standardized management for MDR-TB patients in clinical practice, poor treatment compliance, irregular use of medicine, loss to follow-up, treatment refusal and so on1-4. (researchsquare.com)
- This week, Partners In Health announced a new partnership with UNITAID , Doctors Without Borders/ Médecins Sans Frontières (MSF), and IRD to revolutionize access to new multidrug-resistant tuberculosis (MDR-TB) treatment in 17 countries, especially among the poor. (bwhglobalhealthhub.org)
- We're grateful for this support from UNITAID, and particularly for their partnership, with which we're hoping to make diagnosis and treatment of drug-resistant tuberculosis more effective and more tolerable for patients, as well as more readily accessible and lower-cost," says Paul Farmer, MD, PhD, co-founder of Partners In Health and chief of BWH's Division of Global Health Equity. (bwhglobalhealthhub.org)
- Treatment success rates of multidrug-resistant tuberculosis (MDR-TB) is a key issue that cannot be ignored. (biomedcentral.com)
- The Gladius technology is demonstrating strong promise to restore treatment options for resistant Gram-negative infections which have become a global challenge. (lumiraventures.com)
- Improvements in identifying Shigella species, expanding treatment options for multidrug resistant infections , and developing public health partnerships are needed. (bvsalud.org)
- Multi-center studies should be done to determine the extent of resistant organisms in health facilities throughout the country.epidemiology, and the findings should be factored into clinical decision making and program design for disease prevention, screening, and treatment. (who.int)
Isoniazid4
- Of particular concern is the occurrence of multidrug-resistant (MDR)-TB defined by bacillary resistance to at least isoniazid and rifampicin, and extensively drug-resistant (XDR)-TB, which is MDR-TB with additional resistance to any fluoroquinolone, and at least one of the three second-line injectable drugs (kanamycin, amikacin and capreomycin). (ersjournals.com)
- MDR-TB is a form of TB that is resistant to at least the medicines rifampicin (R) and isoniazid (H). This makes it more difficult and expensive to treat. (citizen-news.org)
- BACKGROUND: The increasing problem of multi-drug-resistant (MDR) tuberculosis (TB) [ie resistant to at least isoniazid (INH) and rifampicin (RIF)] is becoming a global problem. (up.ac.za)
- Globally, 5% of TB cases were estimated to have developed multidrug-resistant TB (MDR-TB) (defined as resistance to at least isoniazid and rifampin) in 2013 (3.5% new and 20.5% previously treated TB cases). (biomedcentral.com)
20181
- Globally, in 2018 about half a million TB infections were rifampicin-resistant, of which 78% were multi-drug resistant (MDR)-TB ( World Health Organization [WHO], 2019a ). (frontiersin.org)
DOTS-Plus1
- Guidelines for establishing DOTS-Plus pilot projects for the management of multidrug-resistant tuberculosis (MDR-TB) / writing committee: Scientific Panel of the WHO Working Group on DOTS-Plus for MDR-TB. (who.int)
Recurrent2
- In a 2010 survey, 83 percent of urologists reported having administered intravenous antibiotics to recurrent UTI patients who were resistant to all available oral antibiotics. (prnewswire.com)
- One of the causes is the recurrent infection that leads to development of multidrug resistance (MDR). (biomedcentral.com)
Epidemiology2
- To describe the epidemiology and possible risk factors for the development of multidrug-resistant tuberculosis (MDR-TB) in Namibia. (biomedcentral.com)
- Two refugees and a foreign student on a visa brought multi-drug resistant (MDR) tuberculosis (TB) to Milwaukee, Wisconsin in 2009 and 2011, according to a 2014 article in an epidemiology publication written with the cooperation of the doctors who treated them. (drrichswier.com)
20211
- Increased invasive bloodstream infections caused by multidrug resistant Shigella sonnei were noted in Vancouver, British Columbia , Canada , during 2021-2023. (bvsalud.org)
Methicillin-resistant1
- RWJ-54428 (MC-02479) is a novel cephalosporin that binds to penicillin-binding protein (PBP) PBP 2' (PBP 2a) of methicillin-resistant staphylococci. (uea.ac.uk)
Infection2
- AbstractIdentification of risk factors influencing the duration of carriage of multidrug-resistant Gram-negative bacilli (MDR-GNB) may be useful for infection control. (medworm.com)
- The scope of this work is to build a Machine Learning model able to predict patients risk to contract a multidrug resistant urinary tract infection (MDR UTI) after hospitalization. (biomedcentral.com)
Patients with Multi-Drug Resi1
- The study authors tested the drug in 40 patients with multi-drug-resistant HIV in this phase 3 study. (medicalbag.com)
Mechanisms1
- One of the things that makes drug-resistant cancers so difficult to deal with is that cancers can evolve drug resistance through several separate mechanisms. (naturalnews.com)
Clinical2
- These BDQ resistant mutants were further characterized by studying their growth rate that could be related to their spreading in clinical settings. (frontiersin.org)
- A large clinical trial to assess treatments for preventing people at high risk from developing multidrug-resistant tuberculosis (MDR-TB) has begun. (mlo-online.com)
Incidence2
- South Africa (SA) has the fourth-highest incidence of multidrug-resistant (MDR) TB worldwide! (scielo.org.za)
- 11 In an observational study from 2000 to 2006, 8% of patients with HIV who received prior ART therapy displayed triple-class resistance, with an overall incidence rate of 13 triple-class resistant cases per 1,000 person-years of ART exposure. (managedhealthcareexecutive.com)
Tumor cells2
- The active substances present in African medicinal plants may be capable of killing off tumor cells that are resistant to more than one drug," Efferth said. (naturalnews.com)
- MDR is a phenomenon by which tumor cells become resistant to several unrelated drugs. (up.pt)
Cases4
- During 1990 and 1991, four outbreaks of multidrug-resistant tuber- culosis (MDR-TB), involving nearly 200 cases, were investigated by CDC and local health departments in Florida and New York City (1,2). (cdc.gov)
- While new cases of TB are on the decline across Europe, the number of multidrug-resistant cases has more than doubled from 2008-2012, which has had the effect of nearly tripling the cost per case due to medical care and loss of productivity. (pharmatimes.com)
- Among these cases, 6.2% were estimated to have extensively drug-resistant (XDR)-TB ( World Health Organization [WHO], 2019a ). (frontiersin.org)
- Of those, 15 cases (17.9%) had ofloxacin resistance and 6.0% were resistant to kanamycin and capreomycin. (who.int)
Cancer5
- Promisingly, they have already uncovered at least four naturally occurring chemicals in the family known as the benzophenones that are effective at preventing the proliferation of cancer cells, including multi-drug resistant varieties. (naturalnews.com)
- The second, tumor-suppressor-gene-mediated resistance, results from a mutation to protein p53 that makes cancer cells enormously aggressive and resistant. (naturalnews.com)
- The benzophenones investigated are potentially cytotoxic substances that need to be more extensively investigated with the aim of developing new cancer drugs that are effective against susceptible and resistant cancers," they wrote recently in the journal Phytomedicine . (naturalnews.com)
- Multidrug resistance was an obstacle in cancer chemotherapy because the cells decreased their intracellular drug accumulation by energy-dependent compounds efflux pumps such as P-glycoprotein (P-gp). (thescipub.com)
- The drug accumulation of a human multidrug resistance 1 (mdr1) gene-transfected mouse lymphoma cell line and a multidrug resistance protein (MRP)-expressing human breast cancer cell line MDA-MB-231 was compared in the presence of sixteen flavonoids and five isoflavonoids. (iiarjournals.org)
Susceptible3
- these new agents should be evaluated in parallel for drug-resistant and drug-susceptible TB. (msfaccess.org)
- For penicillin-susceptible, -intermediate, and -resistant pneumococci, the MIC(90)s of RWJ-54428 were 0.03, 0.25, and 0.5 microg/ml, respectively, with the highest MIC for a pneumococcus being 1 microg/ml, recorded for a strain for which penicillin and cefotaxime MICs were 8 and 4 microg/ml. (uea.ac.uk)
- symptoms and radiographic findings do not differentiate multidrug-resistant TB (MDR-TB) from fully susceptible TB. (medscape.com)
Antibiotics2
- Some types of multidrug-resistant (MDR) P. aeruginosa are resistant to nearly all antibiotics, including carbapenems. (cdc.gov)
- Overall, this work shows that in an animal model, these 3 previously FDA-approved drugs can be repurposed to treat multidrug-resistant infections, either alone or in combination with available antibiotics. (contagionlive.com)
Protein1
- The expression of the 170-kDa P-glycoprotein (P-gp) (MDR1) and 190-kDa multidrug resistance protein (MRP) in both cell lines was confirmed by immunocytochemistry. (iiarjournals.org)
Highly resistant1
- We are delighted by the strong syndicate we have attracted to strengthen drug discovery and development against highly resistant infections, which respond to fewer and fewer drugs today" commented Michael Atkin CEO of Gladius. (lumiraventures.com)
Trials1
- We have investigated the relative efficacy of halofantrine and mefloquine in two paired randomised trials on the Thai-Burmese border, a multidrug-resistant area. (nih.gov)
Effectiveness2
- A phase III trial of the first-ever biologic medication directed against the human immunodeficiency virus (HIV) has demonstrated the safety and effectiveness of the ibalizumab monoclonal antibody in treating previously treated patients who are infected with multidrug resistant HIV-1. (contagionlive.com)
- However, poor information about disinfectant effectiveness against multi-drug-resistant (MDR) strain of M. tuberculosis is available. (biomedcentral.com)
Health1
- The growing number of multidrug resistant strains in Tunisia has become a serious health concern contributing to high rate of mortality and morbidity. (hal.science)