Randomized ContrProspectiveStudyTrial to evaluateEvaluate the safetyClinical TrialPhaseReceptor antagonistDouble-blind randomizedDesigned to evaluateCrossover2016DosePracticeSuperiority trialEvidenceRandomizationTreatmentDesignAntibodiesNeurophysiologicalAssessPatients agedProtocolSensitivityStudiesIntravenousReviewMoxidectinRESULTSParticipantsPrimaryDataDiagnosticTherapyGroupYears
Randomized Contr6
- In this multicenter, three-arm parallel, single-blind randomized controlled trial, 301 patients with KOA were randomly assigned. (medscape.com)
- Methods: This is a multi-center, single-blind, two-arm parallel-group randomized controlled trial across 22 cardiac care hospitals in India. (ucl.ac.uk)
- A single-blind, randomized controlled trial. (nih.gov)
- The effect of a preoperative inspiratory muscle training program on the incidence of postoperative pneumonia in patients undergoing esophageal resection will be studied in a single blind multicenter randomized controlled trial (the PREPARE study). (biomedcentral.com)
- The PREPARE study is the first multicenter randomized controlled trial to evaluate the hypothesis that preoperative inspiratory muscle training leads to decreased pulmonary complications in patients undergoing esophageal resection. (biomedcentral.com)
- Clinical and functional connectivity outcomes of 5-hz repeated transcranial magnetic stimulation as an add-on treatment in cocaine use disorder: a double-blind randomized controlled trial. (crossref.org)
Prospective3
- A total of 1791 patients participated in this prospective, randomized, multicenter, multinational, single-blind, controlled study in patients undergoing abdominopelvic surgery, the majority of whom had inflammatory bowel disease. (nih.gov)
- We designed this multicenter prospective study to confirm the prognostic role of high MICs for vancomycin and to explore if increased MICs for other antistaphylococcal agents could also influence the risk for developing complicated MSSA CRBSI. (cdc.gov)
- Methods: A prospective longitudinal study of 200 patients who had had a myocardial infarction was performed in Augsburg, Germany. (nih.gov)
Study21
- This study aimed to compare the effects of single versus double transplantation of Wharton's jelly MSCs (WJ-MSCs) on LVEF post-AMI. (bvsalud.org)
- APPLICATIONS: Prestudy chemical validation of menus and continuous sampling and assay of diets throughout the study are essential to standardize experimental diets and to ensure that nutrient target goals are met and maintained throughout a controlled multicenter feeding study. (nih.gov)
- Neurophysiological biomarkers of spinal and brainstem activity (the RIII flexion reflex, the N13 component of somatosensory evoked potentials (SEP) and the R2 component of the blink reflex) will be recorded before and at three distinct time points after administration of three medications known to act on the nociceptive system (lacosamide, pregabalin, tapentadol), and placebo, given as a single oral dose in separate study periods. (ox.ac.uk)
- METHODS: Studies were double-blind, randomized, active-controlled, multicenter studies except the Mexico study (open-label, single-arm). (ox.ac.uk)
- Biomarkers derived from scalp EEG measurements (laser-evoked brain potentials [LEPs], pinprick-evoked brain potentials [PEPs], resting EEG) will be obtained before and three times after administration of three medications known to act on the nociceptive system (lacosamide, pregabalin, tapentadol) and placebo, given as a single oral dose in separate study periods. (ox.ac.uk)
- To determine whether the triple combination of PGDM1400, PGT121 and VRC07-523LS is safe and active against HIV in humans, we initiated a two-step phase 1 study: Part 1 was a single-center, randomized, double-blind, dose-escalation, placebo-controlled trial to evaluate three intravenous doses of PGDM1400 alone or in combination with PGT121 (3, 10, and 30 mg/kg per antibody, respectively) in adults without HIV. (natap.org)
- The patients observed in this multicenter study had not been randomized, nor was the treatment compared with an accepted reference standard since ethical constraints precluded a randomized blind study design ( 23 ). (ajnr.org)
- This first-in-human study aimed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of MHV370 in healthy adults, as well as the effects of food consumption on a single dose of MHV370. (charite-research.org)
- Patients and methods: In this multicenter, randomized, double-blind, stratified, phase III study, 570 adult cancer patients were randomized to receive a single i.v. dose of palonosetron 0.25 mg, palonosetron 0.75 mg or ondansetron 32 mg, each administered 30 min before initiation of moderately emetogenic chemotherapy. (elsevierpure.com)
- Sensitivity and specificity of reflectance-mode confocal microscopy for in vivo diagnosis of basal cell carcinoma: a multicenter study. (cdc.gov)
- METHODS: This was a retrospective study of RCM images from 4 institutions of 152 skin lesions representing a variety of benign and malignant diagnoses. (cdc.gov)
- Methods MOSAIC ( NCT03783026 ) was a phase 4, multicenter, single-arm, open-label study in patients (pts) with active PsA (≥3 months but ≤5 years since diagnosis, meeting CASPAR criteria for PsA) evaluating APR as monotherapy or in combination with stable methotrexate. (bmj.com)
- This multi-center, open-label, single-arm Phase 2b study, enrolled and treated 44 patients with rGBM following surgery or radiotherapy ± adjuvant therapy or other experimental therapies. (drug-dev.com)
- Must agree to practice a highly effective method of contraception throughout the study until completion. (who.int)
- The purpose of this study is to determine the ability of the non-invasive Cardiac Profiles (CP) algorithms (based on ECG and pulse oximetry sensors) to measure cardiac blood flow during exercise by assessing how well the CP method works during exercise (movement artifact and noise), how well the CP method tracks our established method, and its sensitivity to small changes in work intensity. (mayo.edu)
- A total of 25,620 patients were randomized in this international multicenter study: 8,576 to ramipril, 8,542 to telmisartan, and 8,502 to the combination of the two. (acc.org)
- The results of this large, multicenter study show that telmisartan is noninferior to ramipril in reducing the incidence of major adverse cardiovascular events in high-risk patients with cardiovascular disease or diabetes, but combination therapy with both agents is not superior to either agent alone. (acc.org)
- 2. Bendamustine-120 plus rituximab therapy for relapsed or refractory follicular lymphoma: a multicenter phase II study. (nih.gov)
- 3. Multicenter, Open-Label, Phase II Study of Bendamustine and Rituximab Followed by 90-Yttrium (Y) Ibritumomab Tiuxetan for Untreated Follicular Lymphoma (Fol-BRITe). (nih.gov)
- 4. Bendamustine plus Rituximab Versus R-CHOP as First-Line Treatment for Patients with Follicular Lymphoma Grade 3A: Evidence from a Multicenter, Retrospective Study. (nih.gov)
- More precise and comparable data about the risk of poliomyelitis could be obtained in future surveys by incorporating a standard case definition, by using house- to- house case- finding methods in representative community- based samples, by analyzing and presenting rates in more clearly defined ways, and by selecting stable populations for study. (who.int)
Trial to evaluate1
- A Phase I/II Randomized, Double Blinded, Placebo Trial to Evaluate the Safety and Potential Efficacy of Intravenous Infusion (IV) of Zofin™ for the Treatment of Chronic Obstructive Pulmonary Disease (COPD) Scottsdale/Phoenix, Ariz. (mayo.edu)
Evaluate the safety1
- This article reports safety results, including the postoperative incidence of abdominal and pelvic abscess and pulmonary embolism, from a large, multicenter trial designed to evaluate the safety and effectiveness of Seprafilm for reduction of adhesion-related postoperative bowel obstruction after abdominopelvic surgery. (nih.gov)
Clinical Trial1
- In this randomized, single-blind clinical trial, we randomly assigned children with sickle cell anemia to receive regular blood transfusions (transfusion group) or standard care (observation group). (blogspot.com)
Phase5
- The blinded survival data from the matched ECA (established by matching with the bizaxofusp-treated population based on 11 different prognostic factors using propensity scoring methods) were then used as a control arm versus survival data from the Phase 2b bizaxofusp trial. (drug-dev.com)
- This is a proposed design and protocol for a multicenter, randomized, active-controlled, double-blind, parallel group, phase III superiority trial, including a total of 452 patients with cirrhosis and esophageal varices that are at high risk of bleeding. (ppcr.org)
- Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of the Congo: a randomised, controlled, double-blind phase 3 trial. (qxmd.com)
- After a single-blind run-in phase to assess for compliance and tolerability, patients were randomized in a 1:1:1 pattern to receive either 80 mg of telmisartan daily, 5 mg of ramipril daily, or combination therapy at the same doses. (acc.org)
- In a multicenter phase one dose-escalation cohort expansion trial [ 18 ], 129 patients with advanced NSCLC were evaluated and Nivolumab was divided into three dose groups: 1 mg/kg, 3 mg/kg, and 10 mg/kg. (springer.com)
Receptor antagonist2
- Montelukast, a once-daily leukotriene receptor antagonist, in the treatment of chronic asthma: a multicenter, randomized, double-blind trial. (nih.gov)
- METHODS: Pigs underwent left anterior descending artery occlusion through an angioplasty balloon for 90â min and were then randomized into two groups: standard therapy [ACE inhibitor, beta blocker, mineralocorticoid receptor antagonist (MRA), aspirin] plus colchicine (nâ =â 14) or standard therapy alone (nâ =â 13). (bvsalud.org)
Double-blind randomized1
- Two replicate, double-blind, randomized, 12-week studies (ANHELTO 1 [NCT01694771] and ANHELTO 2 [NCT01696058]) evaluated the efficacy and safety of olodaterol 5 µg once daily (via Respimat ® ) combined with tiotropium 18 µg once daily (via HandiHaler ® ) versus tiotropium 18 µg once daily (via HandiHaler ® ) combined with placebo (via Respimat ® ) in patients with moderate to severe COPD. (dovepress.com)
Designed to evaluate1
- OBJECTIVE: To describe the process and results of diet standardization, diet validation, and monitoring of diet composition, which were key components of protocol 1 of Dietary Effects on Lipoproteins and Thrombogenic Activity (DELTA-1), the initial protocol in a program of multicenter human feeding studies designed to evaluate the effects of amount and type of fat on lipoproteins and hemostasis parameters in various demographic groups. (nih.gov)
Crossover3
- DESIGN: DELTA-1 was based on a randomized, blinded, crossover experimental design. (nih.gov)
- IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity. (ox.ac.uk)
- IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG). (ox.ac.uk)
20161
- Fifty-two post-menopausal women with distal radius fractures were enrolled in a randomized single-blinded multicenter trial from January 2015 to January 2016 (IRCT registration number: IRCT20160830029603N7). (traumamon.com)
Dose8
- In part C, participants received an open-label single dose of 200 mg MHV370 under fasted or fed conditions. (charite-research.org)
- Conclusions: A single i.v. dose of palonosetron 0.25 mg was significantly superior to i.v. ondansetron 32 mg in the prevention of acute and delayed CINV. (elsevierpure.com)
- Prelicensure studies demonstrated safety and efficacy, inferred through immunogenicity, against tetanus, diphtheria, and pertussis when Tdap was administered as a single booster dose to adults. (cdc.gov)
- 65 years, child-care providers, and health-care personnel) should receive a single dose of Tdap to reduce the risk for transmitting pertussis. (cdc.gov)
- 4) health-care personnel who work in hospitals or ambulatory care settings and have direct patient contact should receive a single dose of Tdap as soon as feasible if they have not previously received Tdap. (cdc.gov)
- Combining bronchodilators with different mechanisms of action may improve efficacy and reduce risk of side effects compared to increasing the dose of a single agent in chronic obstructive pulmonary disease (COPD). (dovepress.com)
- Participants were randomly allocated, stratified by sex and level of infection, to receive a single oral dose of 8 mg moxidectin or 150 μg/kg ivermectin as overencapsulated oral tablets. (qxmd.com)
- For injection: 0.9 mg of thyrotropin alfa as a lyophilized powder in a single-dose vial. (nih.gov)
Practice1
- To evaluate the current evidence on acoustic CR neuromodulation as a method for the treatment of tinnitus and to assess whether the method can be implemented in daily clinical practice. (frontiersin.org)
Superiority trial1
- This double-blind, parallel group, superiority trial was done in four sites in Ghana, Liberia, and the Democratic Republic of the Congo. (qxmd.com)
Evidence1
- Most HTA programs rely on integrative methods (especially systematic reviews), particularly to formulate findings based on available evidence from primary data studies that are identified through systematic literature searches. (nih.gov)
Randomization1
- A controlled trial in which participants are assigned to treatment and control groups using a method other than randomization, yet intended to form similar groups. (nih.gov)
Treatment6
- A 2-week, single-blind, placebo run-in period was followed by a 12-week, double-blind treatment period (montelukast sodium, 10 mg, or matching placebo, once daily at bedtime) and a 3-week, double-blind, washout period. (nih.gov)
- Therapeutic outcome was assessed 6 months after treatment by using a modified MacNab method. (ajnr.org)
- There are growing technological advances in the development of sound-based methods for the treatment of tinnitus. (frontiersin.org)
- Studies regarding acoustic CR neuromodulation as a treatment method for tinnitus were included in the present review. (frontiersin.org)
- We are very encouraged by the 100% increase in survival benefit in unresectable rGBM achieved from a single treatment with bizaxofusp, even after 22 months of additional follow-up, which reinforces the robustness of the initial primary analysis," said Fahar Merchant, PhD, President and Chief Executive Officer of Medicenna. (drug-dev.com)
- The data demonstrated that a single treatment with bizaxofusp increased median overall survival (mOS) by 72% compared to the ECA (12.4 months vs. 7.2 months). (drug-dev.com)
Design1
- The research plan includes specific aims, background and significance, preliminary studies (where applicable), and research design and methods. (sccm.org)
Antibodies2
- HIV-1 therapy with single or dual broadly neutralizing antibodies (bNAbs) has shown viral escape, indicating that at least a triple bNAb therapy may be needed for robust suppression of viremia. (natap.org)
- A single infusion of 20 mg/kg of each of the three antibodies reduced plasma HIV RNA levels in viremic individuals by a mean of -2.04 Log10 HIV RNA drop by day 7 copies/ml, however, viral rebound occurred within a median of 20 days post nadir (range 13 and 70). (natap.org)
Neurophysiological1
- The neurophysiological basis of the method was claimed to be desynchronization, anti-kindling, and change of abnormal frequency couplings in a widespread tinnitus network comprising both auditory and non/auditory brain areas based on EEG analyses. (frontiersin.org)
Assess1
- The 'gold standard' method to assess humoral antibody responses fol owing vaccination is the neutralization assay. (who.int)
Patients aged1
- From January 1999 to March 2001, 600 patients aged 20-80 years were treated with a single session of oxygen-ozone therapy. (ajnr.org)
Protocol1
- Supplementary to the multicenter AIRGENE protocol, we assessed repeated plasma Lp-PLA2 concentrations. (nih.gov)
Sensitivity2
- The gold standard method in terms of sensitivity and specificity is the RT-PCR. (scienceopen.com)
- Blinded retrospective analysis of the images from the 152 lesions was carried out by a single novice reviewer to determine the sensitivity and specificity of these 5 RCM criteria for diagnosing BCC. (cdc.gov)
Studies1
- Developed, though no longer advocated by, the Cochrane Non-Randomised Studies Methods Group. (nih.gov)
Intravenous2
- Part 2 was a multi-center, open-label trial of a single intravenous (IV) administration of 20 mg/kg of PGDM1400, PGT121 and VRC07-523LS each or a single infusion of 30 mg/kg of PGDM1400+PGT121 each, in viremic adults with HIV not on ART. (natap.org)
- 1 Other methods include medical treatments (e.g., intravenous Lidocaine) and psychological approaches in combination with therapeutic sound, such as tinnitus retraining therapy. (frontiersin.org)
Review1
- A review of surveys conducted to date reveals considerable variation in both the choice and use of survey methods and in the assumptions made in the analysis and interpretation of findings. (who.int)
Moxidectin1
- A single application of fluralaner plus moxidectin spot-on was well tolerated by cats and highly effective for 12 weeks against ticks and fleas. (biomedcentral.com)
RESULTS1
- Results were evaluated by two observers blinded to patient distribution within the two groups. (ajnr.org)
Participants1
- METHODS: Twenty-eight participants (14 male, Mage = 44.10, SDage = 9.77) selected a favoured sexual fantasy and engaged in five repeated rounds of an EM task, either face-to-face or via telehealth. (sonomapti.com)
Primary2
- Primary assessment in daily life is made by experience sampling method (ESM) and daily monitoring with the PsyMate app. (iepaconference.org)
- Primary data methods involve collection of original data, ranging from more scientifically rigorous approaches for determining the causal effect of health technologies, such as randomized controlled trials (RCTs) , to less rigorous ones, such as case series . (nih.gov)
Data2
Diagnostic1
- Fiberoptic flexible colonoscopy is the initial diagnostic method of choice in most patients who are hemodynamically stable. (medscape.com)
Therapy1
- Six hundred patients were treated with a single session of oxygen-ozone therapy. (ajnr.org)
Group1
- The experimental group and control group were assigned into a 1∶1 ratio by random table method. (bvsalud.org)
Years1
- Although prematurity is the single largest cause of death in children under 5 years of age, the current definition of prematurity, based on gestational age, lacks the precision needed for guiding care decisions. (stanfordchildrens.org)